Digital Commons Network^™

A Scaffolded Instructional Model To Teach Doctor Of Pharmacy Students To Evaluate Randomized And Non-Randomized Medical Studies On A Similar Topic To Reach A Clinical Conclusion, Stefani Dawn

Language, Literacy, and Sociocultural Studies ETDs

The goal of this study was to test a scaffolded instructional model in a complex Evidence Based Medicine (EBM) lesson where students evaluated three different medical studies (RCT, case-control, and cohort) on the same topic and used those studies to reach an evidence-based conclusion. The hypothesis was that the students literature evaluation skills and subsequent application of the literature to address a clinical question would more closely approximate the experts following implementation of the model. The results do not fully support the hypothesis. The conclusions were: (1) third-year doctor of pharmacy students at the college have a limited ability to …

The Comment, January 31, 2013, Bridgewater State University

The Comment

No abstract provided.

The Pan American (2013-01-31), Karen Antonacci, Daniella Diaz

UTPA Archives - The Pan American Newspaper

Vol. 69, No. 16

Topological Dynamics Of Spike-Timing Dependent Plastic Neural Networks, David Stone

Psychology ETDs

The effects of continual spike-timing dependent plasticity (STDP) on the topology of evolving neural networks were assessed. After a period of stabilization, a number of topological features were monitored periodically throughout simulations of network activity to quantify changes in network structure. Under a range of different input regimes and initial network configurations, each network maintained a robust and highly stable global structure. At the same time, a substantial set of small three-neuron subgraphs (triads) continued to undergo an array of changes and revealed a dynamic local topology. These findings suggest that on-going STDP provides an efficient means of selecting and …

Exploring The Phenomenon Of Self-Mutilation Among Adult Males In A Correctional Setting: A Quantitative And Qualitative Inquiry, Yolanda Morales

Nursing ETDs

The overall aim of this mixed method inquiry was to increase understanding of self-mutilation by adult males in a correctional setting. This study explored the self-mutilating attributes such as type and motivational factors, to identify factors associated with self-mutilation among adult males in a correctional setting. Self-mutilation has classically been associated with adolescents and females; however, behind the walls of many correctional institutions, adult males are engaging in self-mutilating behavior. Self-mutilation by this population can have serious health consequences, impact the safety of the institution, and also have fiscal consequences. While this remains a serious forensic issue, there is a …

Diffuse Axonal Injury Effect On Myelinating Cells And Axons, Jennifer Alison Zalk

Theses

There is no supporting evidence whether myelin degeneration in diffuse axonal injury (DAI) of the white matter is due to death of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been shown to be myelinated by cortical oligodendrocytes in culture. An in vitro stretch injury model was used to analyze the DRG axon pathology during and after injury. DRG myelinating Schwann cells are analyzed to demonstrate what is expected from injury to oligodendrocytes. DRG axons demonstrated a high tolerance to stretch …

Multifunctional Oxidation Electrocatalysts For Direct Alkaline Fuel Cells, Ulises Martinez

Chemical and Biological Engineering ETDs

The need for the development of new technologies to reduce our dependence on fossil fuels requires the combination of different energy sources such as wind, solar, nuclear as well as new energy storage and powering devices. Amongst these new technologies fuel cells are a promising technology capable of transforming chemical energy stored in fuels into electric power at higher efficiencies than combustion processes. However, the commercialization of fuel cells has been limited due to the high costs associated with electrocatalysts needed for the corrosive environments in which proton-exchange membrane fuel cells operate. Electrocatalysts for such fuel cells are based on …

Impact Of Carbon Support Chemistry, Morphology, And Structure On Platinum Catalyst Durability For Pemfc Applications, Anant Patel

Chemical and Biological Engineering ETDs

Polymer electrolyte membrane fuel cells are a promising alternative energy source, capable of being deployed as successful replacements in many stationary and mobile applications. These devices, however, lack durability, and this has become one of the limiting factors for commercialization. Many projects have focused on finding ways to improve their lifetimes, but few have tried to examine the underlying causes behind their corrosion. The goal of this project was to identify which parameters have a significant impact, both positive and negative, on PEMFC durability. To do this, three series of samples were analyzed using microscopic, spectroscopic, and electrochemical methods. Electron …

Imatinib Reverses Doxorubicin Resistance By Affecting Activation Of Stat3-Dependent Nf-Κb And Hsp27/P38/Akt Pathways And By Inhibiting Abcb1, Jonathan T. Sims, Sourik S. Ganguly, Holly Bennett, J. Woodrow Friend, Jessica Tepe, Rina Plattner

Pharmacology and Nutritional Sciences Faculty Publications

Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either resistant to chemotherapy (conventional or targeted) or develop resistance during treatment, and residual chemoresistant cells are highly metastatic. Metastatic cancer cells resist the effects of chemotherapeutic agents by upregulating drug transporters, which efflux the drugs, and by activating proliferation and survival signaling pathways. Previously, we found that c-Abl and Arg non-receptor tyrosine kinases are activated in breast cancer, melanoma, and glioblastoma cells, and promote cancer progression. In this report, we demonstrate that the c-Abl/Arg inhibitor, …

Career Decision Self-Efficacy Of Pre-Service Teachers, Lori Miller

Individual, Family, and Community Education ETDs

This study investigated the level of confidence that pre-service teachers have in regards to Career Decision Self-Efficacy. Career Decision Self-Efficacy is a persons belief and personal judgment of one's capability to perform career decision-making and career development tasks. The goal of this study was to discover the Career Decision Self-Efficacy needs of the pre-service teacher population in order to identify possible interventions. A demographic questionnaire and the Career Decision Self-Efficacy Scale (CDSE) consisting of Total Score, and five subscales: Self-Appraisal, Occupational Information, Goal Selection, Planning, and Problem Solving were used to assess 195 students in two junior level college classes …

The Daily Gamecock, Thursday, January 31, 2013, University Of South Carolina, Office Of Student Media

January

No abstract provided.

Quantification And Propagation Of Nuclear Data Uncertainties, Michael Rising

Nuclear Engineering ETDs

The use of several uncertainty quantification and propagation methodologies is investigated in the context of the prompt fission neutron spectrum (PFNS) uncertainties and its impact on critical reactor assemblies. First, the first-order, linear Kalman filter is used as a nuclear data evaluation and uncertainty quantification tool combining available PFNS experimental data and a modified version of the Los Alamos (LA) model. The experimental covariance matrices, not generally given in the EXFOR database, are computed using the GMA methodology used by the IAEA to establish more appropriate correlations within each experiment. Then, using systematics relating the LA model parameters across a …

Human Inspired Pattern Recognition Via Local Invariant Features, Dominic Ron Maestas

Mechanical Engineering ETDs

Vision is increasingly becoming a vital element in the manufacturing industry. As complex as it already is, vision is becoming even more difficult to implement in a pattern recognition environment as it converges toward the level of what humans visualize. Relevant brain work technologies are allowing vision systems to add capability and tasks that were long reserved for humans. The ability to recognize patterns like humans do is a good goal in terms of performance metrics for manufacturing activities. To achieve this goal, we created a neural network that achieves pattern recognition analogous to the human visual cortex using high …

The Effect Of Oral Glutamine Supplementation On Gut Permeability And Heat Shock Protein Regulation In Runners With A History Of Gastrointestinal Distress, Micah Zuhl

Health, Exercise, and Sports Sciences ETDs

Gastrointestinal (GI) permeability increases during high intensity exercise leading to endotoxin leakage, and a pro-inflammatory immune response. The purpose of this study are to assess whether oral glutamine supplementation (1) reduces exercise induced permeability through up-regulation of the heat shock response resulting in occludin stabilization, and (2) depresses the exercise induced inflammatory response. Methods. Eight human subjects (n=8) participated in baseline (PRE) testing, a glutamine (GLN), and placebo (PLA) supplementation trial in a double blind design. After PRE measurements, subjects ingested .9g/kg fat free mass of glutamine per day or a sugar free lemon placebo drink for seven days with …

The Speed They Need, Sonia Scherr

UNH Today Archive

No abstract provided.

The Research And Engagement Academy: Advancing Faculty Scholarship And Partnerships Through External Funding Opportunities, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Synthetic Lethality Of Chk1 Inhibition Combined With P53 And/Or P21 Loss During A Dna Damage Response In Normal And Tumor Cells, Sofia Origanti, Shi-Rong Cai, A. Z. Munir, Lynn S. White, Helen Piwnica-Worms

Biological Sciences Faculty Research and Publications

Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we demonstrated that p21 is a key determinant of how cells respond to the combination of DNA damage and Chk1 inhibition (combination therapy) in normal cells as well as in tumors. Loss of p21 sensitized normal cells to the combination therapy much more than did p53 loss and the enhanced lethality was partially blocked by CDK inhibition. In …

Biofilm Formation By Shewanella Oneidensis Mr-1 Towards Fundamental Understanding Of Anode Respiring Communities, Jared Roy

Nanoscience and Microsystems ETDs

Microbial fuel cells are bioelectrochemical devices where, on the anode, microorganisms oxidize complex carbon sources and reduce the electrode via complex mechanisms of extra-cellular electron transfer (EET). To date, Geobacter sulfurreducens has been identified as producing not only the largest current density but also large population density biofilms, of the known model organisms commonly used within the field. Another common model organism associated with microbial fuel cells is Shewanella oneidensis, containing multiple EET mechanisms and an apparent inability to form multi-layered biofilms in anaerobic culturing, i.e. microbial fuel cell operating conditions. In contrast to G. sulfurreducens, S. oneidensis biofilm formation …

Nonlinear Microscopy For Material Characterization, Reed Weber

Optical Science and Engineering ETDs

Making use of femtosecond laser sources, nonlinear microscopy provides access to previously unstudied aspects of materials. By probing third order nonlinear optical signals determined by the nonlinear susceptibility chi(3), which is present in all materials, we gain insight not available by conventional linear or electron microscopy. Third-harmonic (TH) microscopy is applied to supplement laser-induced damage studies of dielectric oxide thin film optical coatings. We present high contrast (S/N> 100 : 1) TH imaging of ~17 nm nanoindentations, individual 10 nm gold nanoparticles, nascent scandia and hafnia films, and laser induced material modification both above and below damage threshold conditions in …

The Montclarion, January 31, 2013, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Tissue Metabolic Responses To Salt Stress In Wild And Cultivated Barley, Dezhi Wu, Shengguan Cai, Mingxian Chen, Lingzhen Ye, Zhonghua Chen, Haitao Zhang, Fei Dai, Feibo Wu, Guoping Zhang

Publications

A thorough understanding of the mechanisms underlying barley salt tolerance and exploitation of elite genetic resource are essential for utilizing wild barley germplasm in developing barley varieties with salt tolerance. In order to reveal the physiological and molecular difference in salt tolerance between Tibetan wild barley (Hordeum spontaneum) and cultivated barley (Hordeum vulgare), profiles of 82 key metabolites were studies in wild and cultivated barley in response to salinity. According to shoot dry biomass under salt stress, XZ16 is a fast growing and salt tolerant wild barley. The results of metabolite profiling analysis suggested osmotic adjustment was a basic mechanism, …

The Prospector, January 31, 2013, Utep Student Publications

The Prospector

Headline: Lead Like a Boss: UTEP Hosts Leadership Conference

Potret Intelektual Muslim: Sebuah Tinjauan Sosiologi Pengetahuan Terhadap Pemikiran Ahmad Syafii Maarif, Arie Putra

Masyarakat: Jurnal Sosiologi

There are numerous Islamic actors whom undertook significant role in establishing Indonesian society understanding toward Islam. One of them is Ahmad Syafii Maarif, one of the Islamic figures who evokes Indonesian muslim optimism toward democracy. Through sociology of knowledge framework, this research will take a look on the formation process of Ahmad Syafii Maarif’s Islamic thought. Sociology of knowledge is considered to be the appropriate framework due to the interconnectivity it provided between historical, philosophical, and sociological framework in investigating knowledge formation. However, though being utilized in this research for its extensiveness, the framework tends to stress the connection between …

Altruisme, Solidaritas Dan Kebijakan Sosial, Robertus Robet

Masyarakat: Jurnal Sosiologi

This essay tries to re-conceptualized altruism as sociological idea. It argues that altruism is possible. As a moral action altruism could also be operationalized to provide a ground of social policy and a tool to shape certain form of society

Serita Frey’S Research Probes Climate Change’S Impact On Soils, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Vibrio Cholerae Exploits Sub-Lethal Concentrations Of A Competitor-Produced Antibiotic To Avoid Toxic Interactions, Jason R. Graff, Stephanie Forschner-Dancause, Susanne Menden-Deuer, Richard A. Long, David C. Rowley

Graduate School of Oceanography Faculty Publications

Vibrio cholerae is a human pathogenic marine bacterium inhabiting coastal regions and is vectored into human food and water supplies via attachment to particles including detritus, phytoplankton, and zooplankton. Particle colonization by the pathogen is inhibited by an antagonistic interaction with the particle-associated Vibrionales bacterium SWAT3, a producer of the antibiotic andrimid. By analyzing the individual movement behaviors of V. cholerae exposed to a gradient of andrimid in a microfluidics device, we show that the pathogen has a concentration dependent avoidance response to sub-lethal concentrations of the pure antibiotic and to the metabolites produced by a growing colony of SWAT3-wild-type. …

Physical Activity And Modernization Among Bolivian Amerindians, Michael Gurven, Adrian V. Jaeggi, Hillard Kaplan, Daniel Cummings

ESI Publications

Background: Physical inactivity is a growing public health problem, and the fourth leading risk factor for global mortality. Conversely, indigenous populations living traditional lifestyles reportedly engage in vigorous daily activity that is protective against non-communicable diseases. Here we analyze physical activity patterns among the Tsimane, forager-horticulturalists of Amazonian Bolivia with minimal heart disease and diabetes. We assess age patterns of adult activity among men and women, test whether modernization affects activity levels, and examine whether nascent obesity is associated with reduced activity.

Methods and Findings: A factorial method based on a large sample of behavioral observations was employed …

Montana Kaimin, January 31, 2013, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The George-Anne, Georgia Southern University

The George-Anne

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Has The Compass, As An E-Journal, Been Successful?, Larry E. Davis

The Compass: Earth Science Journal of Sigma Gamma Epsilon

No abstract provided.