Digital Commons Network^™

Maintenance Of Mitochondrial Genomic Integrity In The Absence Of Manganese Superoxide Dismutase In Mouse Liver Hepatocytes., Anthony R. Cyr, Kyle E. Brown, Michael L. Mccormick, Mitchell C. Coleman, Adam J. Case, George S. Watts, Bernard W. Futscher, Douglas R. Spitz, Frederick E. Domann

Journal Articles: Cellular & Integrative Physiology

Manganese superoxide dismutase, encoded by the Sod2 gene, is a ubiquitously expressed mitochondrial antioxidant enzyme that is essential for mammalian life. Mice born with constitutive genetic knockout of Sod2 do not survive the neonatal stage, which renders the longitudinal study of the biochemical and metabolic effects of Sod2 loss difficult. However, multiple studies have demonstrated that tissue-specific knockout of Sod2 in murine liver yields no observable gross pathology or injury to the mouse. We hypothesized that Sod2 loss may have sub-pathologic effects on liver biology, including the acquisition of reactive oxygen species-mediated mitochondrial DNA mutations. To evaluate this, we established …

Engineering A Bcr-Abl–Activated Caspase For The Selective Elimination Of Leukemic Cells, Manabu Kurokawa, Takahiro Ito, Chih-Sheng Yang, Chen Zhao

Dartmouth Scholarship

Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. Tyrosine kinase oncoproteins promote the genesis of leukemias through both increased cell proliferation and inhibition of apoptotic cell death. Although tyrosine kinase inhibitors, such as the BCR-ABL inhibitor imatinib, have demonstrated remarkable efficacy in the clinic, drug-resistant leukemias emerge in some patients because of either the acquisition of point mutations or amplification of the tyrosine kinase, resulting in a poor long-term prognosis. Here, we exploit the molecular mechanisms of …

The George-Anne, Georgia Southern University

The George-Anne

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Environmental And Occupational Interventions For Primary Prevention Of Cancer: A Cross-Sectorial Policy Framework, Carolina Espina, Miquel Porta, Joachim Schüz, Ildefonso Hernández Aguado, Robert V. Percival, Carlos Dora, Terry Slevin, Julietta Rodriguez Guzman, Tim Meredith, Philip J. Landrigan, Maria Neira

Faculty Scholarship

Nearly 13 million new cancer cases and 7.6 million cancer deaths occur worldwide each year; 63% of cancer deaths occur in low and middle-income countries. A substantial portion of all cancers are attributable to carcinogenic exposures in the environment and the workplace.

The objective of this study was to develop an evidence-based global vision and strategy for the primary prevention of environmental and occupational cancer.

The study concluded that opportunities exist to revitalize comprehensive global cancer control policies by incorporating primary interventions against environmental and occupational carcinogens.

The Current Volume 23 : Issue 19, Nova Southeastern University

Student Newspapers

No abstract provided.

Artistic Representations Of The Sea And Coast: Implications For Sustainability, Laura Stocker, Deborah Kennedy

Landscapes: the Journal of the International Centre for Landscape and Language

This article explores artistic representations of Australian seas and coasts, and the power of art to sustain seas and coasts. Research into artworks at the National Gallery of Australia was supplemented with a study of other local public and private works. A number of substantive themes emerged in viewing the paintings; the sea and coast has been represented as: sea country, sovereign territory, sublime spaces, a Romantic space of yearning, a psychological journey, a literal journey, a site of social and political comment, social places, ecological places and a site for industry. We discuss these themes, reflecting on the various …

Everywhere And Nowhere, Liana Christensen

Landscapes: the Journal of the International Centre for Landscape and Language

In 1788 Europeans arrived here to stay. Since then, between eighteen and twenty mammal species have been lost, depending on who‘s counting. Gone, too, are the Paradise Parrot and the Dwarf Emu. Alarmingly high numbers of animal (and plant) species hover just this side of oblivion. Not infrequently in Australia‘s natural history the first sighting of an animal by a colonial collector is followed fairly swiftly by a long disappearance. Very few come back. For the most part, expanding populations of exotic predators and feral competitors, combined with shrinking islands of natural habitats mean that the average Australian has few …

Botanic Field Aesthetics: A Methodology Of Embodied Research Into Indigenous Southwest Flora, John Ryan

Landscapes: the Journal of the International Centre for Landscape and Language

This article describes two prongs of a larger research approach I have termed botanic field aesthetics‘, which begins with living plants in their biodiverse habitats to create embodied poetic representation. The methodology has been designed to materialise and poeticise research into indigenous flora. As components of a broader qualitative field approach, both poetic enquiry and gestural walking constitute specific engagements with plants. The use of poetry and walking aims to show the possibility of an embodied aesthetics of plants and a progression from a visual floral aesthetics to an corporeal floraesthesis, from ocular speculation to multi-sensory experience, and from a …

Interactions Of Water, Plants And Ground-Dwelling Fauna: Water Harvesting And Tapping By Trapdoor Spiders, Barbara York Main

Landscapes: the Journal of the International Centre for Landscape and Language

No abstract provided.

Conclusion To Symposium: Horizons For Interdiscplinary Eco-Research, Glen Phillips

Landscapes: the Journal of the International Centre for Landscape and Language

No abstract provided.

Clotted Life And Brittle Waters, Perdita Phillips

Landscapes: the Journal of the International Centre for Landscape and Language

This paper discusses the beginnings of a soundscape project, The Sixth Shore, at Lake Clifton in the Yalgorup National Park, south of Mandurah, Western Australia. The final endpoint of the project is a site-specific art installation at Lake Clifton where audiences will be able to hear on headphones a 3D sound environment composed of strata of sound recordings. The route that participants walk through the landscape will determine what they hear. The kinds of sounds involved will include in situ ambient sound recordings and birdcalls, sounds and voices from scientific knowledge about the environment, from human communities and from the …

Introduction To The Post-Pastoral In Australian Poetry, Tom Wilson

Landscapes: the Journal of the International Centre for Landscape and Language

No abstract provided.

Rocks In Their Heads: The Landscape And You Experience, George Karpathakis

Landscapes: the Journal of the International Centre for Landscape and Language

Humanity has had a long relationship with rocks including collecting them. This article argues that humans collect and use rocks for many for many purposes: utilitarian, economic, scientific, sacred, decorative and mnemonic. The collected rock acquires meaning different from the rock in situ. This meaning can be communal or personal, connected to events, real or mythic, or to place. The rock can act as a sign or tell a story. It can be seen as a metonym of the landscape. Or it can be viewed as a synecdoche, the part standing in for the whole, for a landscape or an …

Wetland Landscapes: Towards An Ecological Vision, Hugo Bekle

Landscapes: the Journal of the International Centre for Landscape and Language

The extraction and interpretation of ecological information from historical sources has been successfully applied overseas especially in England, Germany and parts of North America. For example, various studies have examined the ecological effects of changes in land-use of the English countryside.

Prologue, George Seddon

Landscapes: the Journal of the International Centre for Landscape and Language

The following Prologue, by George Seddon, is from The Australian Garden; Designing with Australian Plants by Diana Snape, published by Bloomings books, Hawthorn, Victoria Australia, 2002.

Grand Valley Forum, Volume 037, Number 21, February 4, 2013, Grand Valley State University

2012-2013, Volume 37

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

The Statesman, V. 56, I. 16, Stony Brook University

Stony Brook Statesman-Sucolian

v. 56, i. 16

Ada News - 02/04/2013, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Inward Fdi In The United States And Its Policy Context, Lucyna G. Kornecki Ph.D.

Accounting, Economics, Finance, and Information Sciences - Daytona Beach

Inward foreign direct investment (IFDI) represents an integral part of the United States (U.S.)economy, with its stock growing from US$ 83 billion in 1980 to US$ 3.5 trillion in 2011. The United States, which had earlier been primarily a home for multinational enterprises (MNEs) rather than a host for affiliates of foreign MNEs, has become a preferred host country for FDI since the 1980s. Foreign MNEs have contributed robust flows of FDI into diverse industries of the U.S. economy, and total FDI inflows reached US$ 227 billion in 2011, equivalent to 15% of global inflows, the single largest share of …

The Parthenon, February 4, 2013, John Gibb, Tyler Kes

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

A Qualitative Study Of Women’S Decisions Not To Have A Hysterectomy, Erin Fredericks

The Qualitative Report

In focusing on individual and physician demographics and system characteristics that lead to hysterectomy rate variations, researchers overlook the impact of culturally mediated meanings women assign to their bodies, hysterectomy, and other treatments. In this study I sought to provide a fuller description of this decision - making process by examining the role of meaning making in women’s decision not to have a hysterectomy. Using a descriptive qualitative approach, nine women diagnosed with menstrual disorders in Halifax, Nova Scotia, Canada each took part in a semi - structured interview. Factors deemed “irrational” in bio medical understandings of informed choice played …

The Daily Egyptian, February 04, 2013, Daily Egyptian Staff

February 2013

No abstract provided.

Striatal Glutamate Release In L-Dopa-Induced Dyskinetic Animals, Nina Nevalainen, Martin Lundblad, Greg A. Gerhardt, Ingrid Strömberg

Neuroscience Faculty Publications

L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-l-alanine (l-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact from unilateral 6-hydroxydopamine lesions and l-DOPA (4 mg/kg, including benserazide 15 mg/kg) -induced dyskinetic behavior on striatal basal extracellular glutamate concentration and potassium-evoked glutamate release in urethane-anesthetized rats. Recordings were performed before and after local L-DOPA application in the striatum. In addition, effects from the 5-HT_1A receptor agonist (2R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin …

The Collegian (2013-02-04), Joe Molina

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 65, No. 18

Emu Today, February 4, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Grand Valley Forum, Volume 037, Number 22, February 4, 2013, Grand Valley State University

2012-2013, Volume 37

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Crow's Nest, February 4, 2013, Crow's Nest Staff

Crow's Nest

The February 4, 2013, issue of the Crow's Nest.

February 4, 2013

The Gavel Gazette

No abstract provided.

February 4th 2013, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Design Of A 2.4 Ghz Horizontally Polarized Microstrip Patch Antenna Using Rectangular And Circular Directors And Reflectors, Yosef Yilak Woldeamanuel

Electrical Engineering Theses

In the urban or indoor wireless environment, after a complicated multiple reflection or scattering effect, the polarization of the propagating radio waves may change significantly. Although many current wireless systems are vertically polarized it has been predicted that using horizontally polarized antenna at both the transmitter and receiver has many advantages. In this thesis, new designs are proposed to develop a horizontally polarized microstrip patch antennas for 2.4 GHz applications using directors and reflectors to guide the radiated power. The radiation characteristics of these designs with respect to various geometrical parameters such as the dimensions of the reflector and directors, …