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Reporter - February 15th 2013, Rit Reporter Staff

University Publications

No abstract provided.

The Tiger Vol. 107 Issue 5 2013-02-15, Clemson University

Tiger Newspapers

No abstract provided.

Biomarkers And Bacterial Pneumonia Risk In Patients With Treated Hiv Infection: A Case-Control Study, Sonja M. Bjerk, Jason V. Baker, Sean Emery, Jacqueline Neuhaus, Brian Angus, Fred M. Gordin, Sarah L. Pett, Christoph Stephan, Ken M. Kunisaki

Medicine Faculty Publications

Background

Despite advances in HIV treatment, bacterial pneumonia continues to cause considerable morbidity and mortality in patients with HIV infection. Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do not currently exist.

Methods

We performed a nested, matched, case-control study among participants randomized to continuous combination antiretroviral therapy (cART) in the Strategies for Management of Antiretroviral Therapy trial. Patients who developed bacterial pneumonia (cases) and patients without bacterial pneumonia (controls) were matched 1:1 on clinical center, smoking status, age, and baseline cART use. Baseline levels of Club Cell Secretory Protein 16 (CC16), Surfactant Protein D (SP-D), …

February 15, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Matrix Metalloproteinase-28 Deletion Exacerbates Cardiac Dysfunction And Rupture After Myocardial Infarction In Mice By Inhibiting M2 Macrophage Activation, Yonggang Ma, Ganesh V. Halade, Jianhua Zhang, Trevi A. Ramirez, Daniel Levin, Andrew Voorhees, Yu Fang Jin, Hai Chao Han, Anne M. Manicone, Merry L. Lindsey

Internal Medicine Faculty Publications

Rationale: Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular matrix responses in cardiac aging, but the roles of MMP-28 after myocardial infarction (MI) have not been explored. Objective: To determine the impact of MMP-28 deletion on post-MI remodeling of the left ventricle (LV). Methods and Results: Adult C57BL/6J wild-type (n=76) and MMP null (MMP-28, n=86) mice of both sexes were subjected to permanent coronary artery ligation to create MI. MMP-28 expression decreased post-MI, and its cell source shifted from myocytes to macrophages. MMP-28 deletion increased day 7 mortality because of increased cardiac rupture post-MI. MMP-28 mice exhibited larger LV volumes, …

Flyer News, Vol. 60, No. 27 (Feb. 15, 2013), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

Variation In Sodium Current Amplitude Between Vasopressin And Oxytocin Hypothalamic Supraoptic Neurons, Reese Scroggs, Lie Wang, Ryoichi Teruyama, William E. Armstrong

Faculty Publications

Biophysical characteristics of tetrodotoxin-sensitive sodium (Na+) currents were studied in vasopressin (VP) and oxytocin (OT) supraoptic neurons acutely isolated from rat hypothalamus. Na+ current density (pA/pF) was significantly greater in VP neurons than in OT neurons. No significant difference between VP and OT neurons was detected regarding the voltage dependence of activation and steady-state inactivation, or rate of recovery from inactivation of Na+ currents. In both VP and OT neurons, the macroscopic inactivation of the Na+ currents was best fitted with a double-exponential expression suggesting two rates of inactivation. Also in both types, the time course of recovery from inactivation …

Decadal Variation In Egg Abundance Of A Mesopelagic Fish, Maurolicus Japonicus, In The Japan Sea During 1981-2005, Tadanori Fujino, Tsuneo Goto, Tsuyoshi Shimura, Hiroki Yasuma, Yongjun Tian, Hideaki Kidokoro, Shinya Masuda, Kazushi Miyashita

Journal of Marine Science and Technology–Taiwan

Egg abundance of Maurolicus japonicus, a dominant mesopelagic fish in the Japan Sea, was analyzed during 1981-2005 as an index of the spawning-adult abundance. There was a major change in egg abundance around 1988/1989, with negative anomalies occurring during 1981-1988 and positive anomalies occurring from l989. At about the same time (1986/1987), the Tsushima Current shifted from cold to warm conditions. Environmental indices were found to be positively correlated with egg abundance two years later. Our results suggest that the abundance of M. japonicus is affected by climatic regime shifts, and that it could be used as an indicator species.

Ovaries, Testicles, And Uteruses, Oh My! Regulating Reproductive Tissue Transplants, Valarie K. Blake

William & Mary Journal of Race, Gender, and Social Justice

This article will explore key regulatory and ethical challenges presented by reproductive tissue transplants (RTTs) as they are currently developing, recognizing that additional issues may reveal themselves as the technologies progress. Part I of this article will begin with a discussion of the current status of the technology, including the results and status of animal and human experiments for all three types of transplants. Part II will explore the demand for RTTs—who might consider such a transplant and why RTTS might be considered by some patients as more favorable than other reproductive options. Part III will explore the different regulatory …

(No) State Interests In Regulating Gender: How Suppression Of Gender Nonconformity Violates Freedom Of Speech, Jeffrey Kosbie

William & Mary Journal of Race, Gender, and Social Justice

Despite limited growth in legal protections for transgender people, dress and appearance are largely treated as unprotected matters of personal preference. In response, lawyers and scholars argue that dress and appearance are intimately connected to the expression of identity. Nonetheless, courts have generally deferred to the government’s proffered justifications for these laws.

This article refocuses on the government’s alleged interests in regulating gender nonconformity. Using a First Amendment analysis, the article reveals how seemingly neutral government interests are used to single out conduct because it expresses messages of gender nonconformity. This approach avoids impossible questions about the subjective intent of …

Purification And Characterization Of Acidic Protease From Aspergillus Oryzae Bcrc 30118, Li-Jung Yin, Ya-Hui Chou, Shann-Tzong Jiang

Journal of Marine Science and Technology–Taiwan

The acidic protease was purified from 4-day cultivation of Aspergillus oryzae BCRC 30118 by DEAE Sephacel and Sephacryl S-200 HR chromatographs. The specific activity, yield and purification fold were 117.62 kU/mg, 15.1% and 6.6, respectively. The molecular weight (M) was 41.0 kDa, while the optimal pH and temperature were 3.0 and 60°C, respectively. It was stable at pH 3.0-6.0 and 4-35°C. However, it was inhibited by Fe2+, Hg2+, Fe3+ and pepstatin A, and slightly by leupeptin and TPCK. According to substrate specificity and inhibitor study, it was a cysteine protease with activation energy of 37.5 kcal/mol. Its Km, Vmax, Kcat …

The Ideal Free Strategy With Weak Allee Effect, Daniel Munther

Mathematics and Statistics Faculty Publications

This paper examines the interplay between optimal movement strategies and the weak Allee effect within the context of two competing species in a spatially heterogenous environment. When both species have the same populations dynamics, previous studies identified an ‘ideal free’ strategy which is able to exclude any other competitor playing a ‘non-ideal free’ strategy. We find that if the ideal free disperser is subject to a weak Allee effect, a competing species utilizing very weak or very strong advection will still be excluded despite having superior population dynamics. However, for intermediate advection rates, such a competitor can invade the ideal …

Data Mining The Functional Characterizations Of Proteins To Predict Their Cancer-Relatedness, Peter Revesz, Christopher Assi

School of Computing: Faculty Publications

This paper considers two types of protein data. First, data about protein function described in a number of ways, such as, GO terms and PFAM families. Second, data about whether individual proteins are experimentally associated with cancer by an anomalous elevation or lowering of their expressions within cancerous cells. We combine these two types of protein data and test whether the first type of data, that is, the functional descriptors, can predict the second type of data, that is, cancer-relatedness. By using data mining and machine learning, we derive a classifier algorithm that using only GO term and PFAM family …

Identification Of A Human Myofibril-Inducing Rna, Ashley Moses

Honors Theses

No abstract provided.

The Bg News February 15, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 15, 2013. Volume 92-Issue 68.

Contested Nation: Freedman And The Cherokee Nation, Dave Watt

Undergraduate Research - History

The Freedmen are, most simply, those individuals that have been freed from bondage. In the United States this term is often used in reference to legally emancipated slaves and consequently, their descendants. The term “Cherokee Freedmen” refers to those freed slaves who joined with the Cherokee Nation, or, men and women who were formerly held in servitude within the Cherokee Nation. This term has also been given to the descendants of marriages involving freed Africans and Cherokee spouses, thus making the network of people labeled Freedmen an expansive group of people. Totaling roughly 3000 people in the present day, Cherokee …

The Parthenon, February 15, 2013, Crystal Myers

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Meeting Minutes, Wku Graduate Council

Graduate School

Meeting minutes.

Archaeological Evidence Of Historic Mining At Forestville Saltpeter Cave (15ht94), Hart County, Kentucky, Darlene Applegate, Emily L. Duke

Mammoth Cave Research Symposia

Forestville Saltpeter Cave is 1.5 km east of Mammoth Cave National Park on the WKU Green River Preserve. Historically, miners removed sediment from the cave to extract saltpeter for the production of gunpowder. Though dozens of peter-mining sites are known in western Kentucky, Forestville Saltpeter Cave is only the third site investigated by archaeologists. Intensive surface survey documented evidence of mining activity in the cave: working bays, rock piles, tally and other marks, tool marks, inscriptions, and lighting material. The mining likely occurred during the early nineteenth century. The operations were extensive throughout all passages and extracted 856 cu m …

The Cave Beetle Neaphaenops Tellkampfi Erichson: Relationships Within And Among Related Genera Using Molecular Data, T. Keith Philips, Elise Valkanas, Kurt Helf

Mammoth Cave Research Symposia

Studies of North American cave beetle systematics have been based primarily on morphology. This project analyzes the relationships and validity of the four subspecies of the monotypic Neaphaenops based on monophyly, as well as relationships with the remaining four eastern N.A. cave beetle genera (Pseudanophthalmus, Nelsonites, Darlingtonea, and Ameroduvalius) using molecular methods. This study utilized 39 beetle samples collected from 27 Kentucky caves and one outgroup accessed from GenBank. Evidence for phylogenetic hypotheses is based on sequences of one nuclear protein-coding gene (arginine kinase) and one mitochondrial gene (CO1). Analyses support Neaphaenops as sister to all other taxa. One subspecies …

Influences Of A Cladophora Bloom On The Diets Of Amblema Plicata And Elliptio Dilatata In The Upper Green River, Kentucky, Jennifer Yates, Scott Grubbs, Albert Meier, Michael Collyer

Mammoth Cave Research Symposia

Freshwater mussels are the most imperiled group of freshwater invertebrates globally. Recent research suggests a better understanding of mussel feeding ecology may facilitate and improve conservation efforts. The use of stable isotopes is becoming an increasingly common method to study aquatic food webs. Carbon (C) and nitrogen (N) are two of the most frequently employed elements in food web studies. Differences in natural abundance of 13C/12C can indicate which food sources are the basal sources of carbon incorporated into a consumer’s tissue, while the ratio of 15N /14N provides a method of assessing trophic position within a food web. Attached …

Using Lidar To Link Forest Canopy Structure With Bat Activity And Insect Occurrence: Preliminary Findings, Luke E. Dodd, Nicholas S. Skowronski, Matthew B. Dickinson, Michael J. Lacki, Lynne K. Rieske

Mammoth Cave Research Symposia

Bats are an imperiled, yet ecologically-important group of vertebrate predators. Our ongoing research focuses on testing hypotheses about the relationships between the effects of fire on canopy structure and insect prey availability, and how these factors relate to use of foraging space by bats during the pre- and post-hibernation periods at Mammoth Cave National Park (MCNP). LiDAR-derived data (October 2010) were intersected with spatially explicit sampling of bat and insect populations (2010-2011) in order to characterize relationships between canopy structure, insect abundance, and bat activity. A canonical correspondence analysis for bat data suggested that forest canopy structure has a strong …

Diamond V. Chakrabarty: Oil Eaters: Alive And Patentable, Dennis J. Walsh

Pepperdine Law Review

Congress is empowered, under article I, section 8 of the United States Constitution, to create patent laws that encourage the promotion of arts and sciences. In the congressional fulfillment of this task, the courts have been confused as to what products are worthy of patent protection under the patent statutes. One illustration of this confusion is the recent controversy of whether living organisms fit into the statutory patentable classification of section 101 of the 1952 Patent Act. The recent United States Supreme Court decision of Diamond v. Chakrabarty has ended this confusion by holding that living micro bacteria is patentable …

Molecular Simulations Of "Real World" Systems, Michael Greenfield

Amgen Seminar Series in Chemical Engineering

Many molecular characteristics would be interesting to know but are not easy to access through experiments. What molecule arrangements are most effective for transmitting or damping applied forces? What configurations of a binding site enable or block substrate adsorption? Such questions can be investigated computationally through molecular simulations: large scale calculations that apply statistical mechanics toward quantifying the properties and mechanisms that occur in atomic and molecular systems.

Molecular dynamics and Monte Carlo methods provide large numbers of representative molecule configurations (an "ensemble"), and statistical weighting over an ensemble provides the desired results as a numerical average. Improvements in force …

A Functional Visual System In The Cave Beetle Ptomaphagus Hirtus, Markus Friedrich, Rui Chen, Elke K. Buschbeck, Stewart Peck

Mammoth Cave Research Symposia

Cave species exhibit a suite of dramatic differences in comparison to their surface living relatives, commonly referred to as troglomorphy (Christiansen 2005). One hallmark feature of troglomorphy is the severe reduction or complete loss of eyes and functional vision. The two most abundant cave beetle species in Mammoth cave, the 2-3 mm small carrion beetle Ptomaphagus hirtus (Packard 1888; Peck 1973; Peck 1975; Tellkampf 1844) and the 6-8 mm long predatory ground beetle Neaphaenops tellkampfii are good examples of this (Barr 1979). P. hirtus tends to hide in crevices and usually goes unnoted to the regular visitor of Mammoth cave. …

Disjunct Eastern Hemlock Populations Of The Central Hardwood Forests: Ancient Relicts Or Recent Long Distance Dispersal Events?, F. Collin Hobbs, Keith Clay

Mammoth Cave Research Symposia

Eastern hemlock (Tsuga canadensis) is an evergreen conifer with a contiguous distribution extending from the southern Appalachian Mountains north to Nova Scotia and west across the Great Lakes region. Eastern hemlock is threatened with extirpation from much of this range by an introduced pest, the hemlock woolly adelgid (Orwig et al. 2002). In addition to the contiguous distribution, many small, isolated populations are located within the central hardwood forest region of Kentucky, Indiana, and Ohio (Braun 1928, Potzger and Friesner 1937, Van Stockum 1979). These disjunct populations form clearly delineated, often monospecific stands associated with unique natural features such as …

Corporate Homicide: The Stark Realities Of Artificial Beings And Legal Fictions , Douglas S. Anderson

Pepperdine Law Review

In the aftermath of one of the most highly publicized trials in product liability annals-the celebrated Pinto case-the legal question raised by that litigation remains unresolved. Controversy continues as to whether a corporation should be convicted of homicide when it knowingly markets an unsafe product that results in death. Today the answer is a resounding "no", in light of state statutes defining homicide as the killing of one human being by another, difficulties in finding the requisite criminal intent; and the practical problems of placing a legal fiction behind bars. However, there are recent indications that these present obstacles to …

Landscape Genetics Of The Marbled Salamander, Ambystoma Opacum, In A Nationally Protected Park, Kevin Tewell, Jarrett Johnson

Mammoth Cave Research Symposia

Landscape features may influence the patterns of migration and dispersal of amphibian species and create genetic structure. A primary goal of landscape genetics is to analyze these influences in order to make more informed management decisions. We sampled larvae from 50 breeding ponds within the boundaries of Mammoth Cave National Park and genotyped 12 individuals per pond at 10 microsatellite loci to estimate gene fl ow between ponds. We used GIS layers of habitat types to conduct a least-cost path analysis and determine the relative cost of movement through each habitat type. We were interested in answering two questions: does …

Punitive Damages And The Drunken Driver, William C. Cooper

Pepperdine Law Review

A discussion of the history and theory of punitive damages which results in advocating their application in a drunk driving context after giving due consideration to the pros and cons of such a sanction. An analysis of case law will reveal the underlying rationale that has motivated certain jurisdictions in applying this severe penal approach in an attempt to deter and curtail the senseless destruction on our nation's highways as well as exploring the impetus behind those other jurisdictions that do not utilize the remedy of punitive damages. The culminating focus is on California's position in this regard. Finally, there …

Mammoth Cave National Park's 10th Research Symposium: Celebrating Diversity Of Research In The Mammoth Cave Region, Shannon Trimboli ,Editor

Mammoth Cave Research Symposia

No abstract provided.