Digital Commons Network^™

Wine To Water, Jennifer Stangland

Social Sciences

Nearly one billion people in the world today do not have access to clean water (Siegfried, 2008). This is a crisis that society has faced for decades, and is not a problem that (to our knowledge) will be miraculously alleviated anytime in the near future. The implications of this resource deficit run deep for many people outside of America. But sadly, the affected places and people are not often visible to or noticed by the American society as a whole. The purpose of my research and analysis through this project is to change that. I desire to see a community …

Finger Lime Citrus Pearl Shelf Life Testing, Tim Romley, Heather Wilson

Industrial Technology and Packaging

Finger Limes are a micro citrus that is native to Australia. They are new to the United States and are now being grown in California. The pulp of the Finger Lime is mainly used as a luxury garnish. Shanley Farms is a small family run business that is located in Visalia and Morro Bay that is one of few growers of the fruit. The majority of their sales are to the food service industry. Much of their product is also sent over seas as an international commodity.

A large amount of fruit goes to waste every harvesting season. 15% of …

Melanopsin, Photosensitive Ganglion Cells, And Seasonal Affective Disorder., Kathryn A Roecklein, Patricia M Wong, Megan A Miller, Shannon D Donofry, Marissa L Kamarck, George C Brainard

Department of Neurology Faculty Papers

In two recent reports, melanopsin gene variations were associated with seasonal affective disorder (SAD), and in changes in the timing of sleep and activity in healthy individuals. New studies have deepened our understanding of the retinohypothalamic tract, which translates environmental light received by the retina into neural signals sent to a set of nonvisual nuclei in the brain that are responsible for functions other than sight including circadian, neuroendocrine and neurobehavioral regulation. Because this pathway mediates seasonal changes in physiology, behavior, and mood, individual variations in the pathway may explain why approximately 1-2% of the North American population develops mood …

Data Information Literacy: Multiple Paths To A Single Goal, Megan R. Sapp Nelson

Libraries Faculty and Staff Presentations

This lightning talk presentation briefly covers each DIL team's experience working with a specific discipline and their response to identified data management/curation needs.

Evaluation Of The Novel Folate Receptor Ligand [18f] Fluoro-Peg-Folate For Macrophage Targeting In A Rat Model Of Arthritis., Yooney Yj Gent, Karin Weijers, Carla Fm Molthoff, Albert D. Windhorst, Marc C. Huisman, Desirée Ec Smith, Sumith A. Kularatne, Gerritt Jansen, Philip S. Low, Adriaan A. Lammertsma, Conny J. Van Der Laken

Department of Chemistry Faculty Publications

Introduction

Detection of (subclinical) synovitis is relevant for both early diagnosis and monitoring of therapy of rheumatoid arthritis (RA). Previously, the potential of imaging (sub)clinical arthritis was demonstrated by targeting the translocator protein in activated macrophages using (R)-[¹¹C]PK11195 and positron emission tomography (PET). Images, however, also showed significant peri-articular background activity. The folate receptor (FR)-β is a potential alternative target for imaging activated macrophages. Therefore, the PET tracer [¹⁸F]fluoro-PEG-folate was synthesized and evaluated in both in vitro and ex vivo studies using a methylated BSA induced arthritis model.

Methods

[¹⁸F]fluoro-PEG-folate was synthesized in …

Adenosine Triphosphate (Atp) Is A Candidate Signaling Molecule In The Mitochondria-To-Nucleus Retrograde Response Pathway, Feng Zhang, Tammy Pracheil, Janet Thornton, Zhengchang Liu

Biological Sciences Faculty Publications

Intracellular communication from the mitochondria to the nucleus is achieved via the retrograde response. In budding yeast, the retrograde response, also known as the RTG pathway, is regulated positively by Rtg1, Rtg2, Rtg3 and Grr1 and negatively by Mks1, Lst8 and two 14-3-3 proteins, Bmh1/2. Activation of retrograde signaling leads to activation of Rtg1/3, two basic helix-loop-helix leucine zipper transcription factors. Rtg1/3 activation requires Rtg2, a cytoplasmic protein with an N-terminal adenosine triphosphate (ATP) binding domain belonging to the actin/Hsp70/sugar kinase superfamily. The critical regulatory step of the retrograde response is the interaction between Rtg2 and Mks1. Rtg2 binds to …

Single-Cell Measurements Of Ige-Mediated Fcεri Signaling Using An Integrated Microfluidic Platform, Yanli Liu, Dipak Barua, Peng Liu, Bridget S. Wilson, Janet M. Oliver, William S. Hlavacek, Anup K. Singh

Chemical and Biochemical Engineering Faculty Research & Creative Works

Heterogeneity in responses of cells to a stimulus, such as a pathogen or allergen, can potentially play an important role in deciding the fate of the responding cell population and the overall systemic response. Measuring heterogeneous responses requires tools capable of interrogating individual cells. Cell signaling studies commonly do not have single-cell resolution because of the limitations of techniques used such as Westerns, ELISAs, mass spectrometry, and DNA microarrays. Microfluidics devices are increasingly being used to overcome these limitations. Here, we report on a microfluidic platform for cell signaling analysis that combines two orthogonal single-cell measurement technologies: on-chip flow cytometry …

Iapp Aggregation And Cellular Toxicity Are Inhibited By 1,2,3,4,6-Penta-O-Galloyl-Β-D-Glucose, Edward Bruno, Catalina Pereira, Karla P. Roman, Marisa Takiguchi, Pei-Yu Kao, Luiza A. Nogaj, David A. Moffet

Chemistry and Biochemistry Faculty Works

The polyphenol, 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) has been found to exhibit a host of positive pharmacologic activities, including anti-cancer and anti-diabetic. Little is known about the mode of action of PGG in yielding these positive activities. We show here that PGG is a potent inhibitor of IAPP (islet amyloid polypeptide, amylin) aggregation. Preventing the initial aggregation event of IAPP is one strategy for slowing, and possibly preventing, the toxic effects of IAPP oligomeric intermediates. Equal molar ratios of PGG to IAPP substantially reduced the ability of IAPP to bind thioflavin T. Atomic force microscopy revealed that PGG prevented amyloid-based fiber formation under …

Ccl3 And Cxcl12 Production In Vitro By Dental Pulp Fibroblasts From Permanent And Deciduous Teeth Stimulated By Porphyromonas Gingivalis Lps, Carla Renata Sipert, Ana Carolina Morandini, Karin Cristina Da Silva Modena, Thiago José Dionísio, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha Oliveira, Ana Paula Campanelli, Carlos Ferreira Santos

All Dugoni School of Dentistry Faculty Articles

OBJECTIVE: The aim of this study was to compare the production of the chemokines CCL3 and CXCL12 by cultured dental pulp fibroblasts from permanent (PDPF) and deciduous (DDPF) teeth under stimulation by Porphyromonas gingivalis LPS (PgLPS).

MATERIAL AND METHODS: Primary culture of fibroblasts from permanent (n=3) and deciduous (n=2) teeth were established using an explant technique. After the fourth passage, fibroblasts were stimulated by increasing concentrations of PgLPS (0-10 µg/mL) at 1, 6 and 24 h. The cells were tested for viability through MTT assay, and production of the chemokines CCL3 and CXCL12 was determined through ELISA. Comparisons among samples …

A Multi-Centric Double-Blind Randomized Homoeopathic Pathogenetic Trial Of Gymnema Sylvestre, Goutam Rakshit, J Singh, S Pathak, Ch Banoth, P Chandra, Rajpal Rajpal, Sujata Choudhury, Vinay Singh

Indian Journal of Research in Homoeopathy

Objective: To elicit the pathogenetic response of Gymnema sylvestre in homoeopathic potencies on apparently healthy human volunteers. Methodology: Gymnema sylvestre was proved by the Central Council for Research in Homoeopathy through double-blind placebo-controlled method. The study was carried out at four centers. The drug was proved in two potencies (6C and 30C) on 63 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next two phases 56 doses (04 doses …

Genomics Unbound: The Scientific And Legal Case Against Patents Based On Naturally Occurring Dna Sequences, Fazal Khan, Lindsay Kessler

Nevada Law Journal

No abstract provided.

Global Legal Responses To Prenatal Gender Identification And Sex Selection, Seema Mohapatra

Nevada Law Journal

No abstract provided.

Bulk Partitioning The Growing Season Net Ecosystem Exchange Of Co2 In Siberian Tundra Reveals The Seasonality Of Its Carbon Sequestration Strength, Benjamin R. K. Runkle, T. Sachs, C. Wille, E.-M. Pfeiffer, L. Kutzbach

Biological and Agricultural Engineering Faculty Publications and Presentations

This paper evaluates the relative contribution of light and temperature on net ecosystem CO2 uptake during the 2006 growing season in a polygonal tundra ecosystem in the Lena River Delta in Northern Siberia (72°22´ N, 126°30´ E). The occurrence and frequency of warm periods may be an important determinant of the magnitude of the ecosystem's carbon sink function, as they drive temperature-induced changes in respiration. Hot spells during the early portion of the growing season, when the photosynthetic apparatus of vascular plants is not fully developed, are shown to be more influential in creating positive mid-day surface-to-atmosphere net ecosystem CO2 …

March 2013 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

2013 Dru Program And Agenda, Uno-Chart

DRU Workshop 2013 Presentations – Disaster Resistant University Workshop: Linking Mitigation and Resilience

No abstract provided.

Bacterial Growth On Metal And Non-Metal Surfaces In A Static Bioreactor, Rolan Yuk Loong Liong

Master's Theses

Research was conducted to observe bacterial growth on the surface of metals in a static bioreactor. Metal and non-metal samples were subjected to bacterial exposure (1 day and 9 days). The metal samples were surface treated prior to bacterial exposure. The microstructures of the surface treated samples were analyzed by optical microscopy. After exposure, the microstructures of the samples were analyzed by scanning electron microscopy (SEM). The analysis suggested that microbial attachment on the surface was related to the underlying microstructure of steel. The preferential attachment of microbes could potentially be influenced by cathodic and anodic regions created by the …

Effects Of Ovariectomy And Anatomical Location On Osteonal Encroachment In Adult Cortical Ovine Bone, Paige Brell Ryan

Master's Theses

The purpose of this study is to further quantify adult ovine ovariectomized bone for new remodeling characteristics to obtain a better understanding of how remodeling is occurring and the effectiveness of this animal model for the study of postmenopausal osteoporosis. Postmenopausal osteoporosis is a major health concern and animal models to test new treatment options are needed. The ovine model is a good option because the ewes undergo Haversian remodeling, are a large sized animal, and have a similar hormone profile to humans. Ewes, however, do not undergo a natural menopause, so an ovariectomy surgery was conducted in the sheep …

Hydrologic Modeling Of The San Joaquin Valley Watershed For Purposes Of Nitrate Analysis, Stephen Carl Clayton

Master's Theses

The San Joaquin Valley is regarded as one of the most productive agricultural regions in the world. This extensive agriculture has, however, caused extensive pollution of both ground water and surface water. This thesis develops a hydrologic model of the surface and ground waters of the San Joaquin Valley. Such modeling is useful in the development and implementation of water quality regulations such as Total Maximum Daily Loads (TMDLs). A properly validated watershed simulation model can supplement data collection and can account for watershed characteristics including topography, soils, climate, land cover, anthropogenic activities, as well as simulate watershed responses including …

Three-Dimensional Engineered Matrix To Study Cancer Stem Cells And Tumorsphere Formation: Effect Of Matrix Modulus, Xiaoming Yang, Samaneh Kamali Sarvestani, Seyedsina Moeinzadeh, Xuezhong He, Esmaiel Jabbari

Faculty Publications

Maintenance of cancer stem cells (CSCs) is regulated by the tumor microenvironment. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment. The objective of this work was to investigate the effect of matrix modulus on tumorsphere formation by breast cancer cells and maintenance of CSCs in an inert microenvironment without the interference of other factors. In that regard, 4T1 mouse breast cancer cells were encapsulated in inert polyethylene glycol diacrylate hydrogels and the effect of matrix modulus on tumorsphere formation and expression of CSC markers was investigated. The gel …

Diversification And Ecosystem Services For Conservation Agriculture: Outcomes From Pastures And Integrated Crop–Livestock Systems, Matt A. Sanderson, David Archer, John Hendrickson, Scott Kronberg, Mark Liebig, Kris Nichols, Marty Schmer, Don Tanaka, Jonathan Aguilar

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Conservation agricultural systems rely on three principles to enhance ecosystem services: (1) minimizing soil disturbance, (2) maximizing soil surface cover and (3) stimulating biological activity. In this paper, we explore the concept of diversity and its role in maximizing ecosystem services from managed grasslands and integrated agricultural systems (i.e., integrated crop–livestock–forage systems) at the field and farm level.We also examine trade-offs that may be involved in realizing greater ecosystem services. Previous research on livestock production systems, particularly in pastureland, has shown improvements in herbage productivity and reduced weed invasion with increased forage diversity but little response in terms of animal …

Warning: Shifting Liability To Manufacturers Of Brand-Name Medicines When The Harm Was Allegedly Caused By Generic Drugs Has Severe Side Effects, Victor E. Schwartz, Phil Goldberg, Cary Silverman

Fordham Law Review

   Can a product manufacturer be subject to liability for a competitor’s product? American tort law has always said, “No.” It does not matter if the products are identical. Companies are not to be their competitors’ keepers.

   Nevertheless, over the past few years, three courts have overturned this fundamental of tort law, holding that a manufacturer of a brand-name prescription drug can be subject to liability even when a plaintiff alleges that he or she was harmed by a generic drug made by the brand-name manufacturer’s competitor. Most courts, including four federal courts of appeal and dozens of federal district and …

Development Of Novel Fiber Optic Humidity Sensors And Their Derived Applications, Jinesh Mathew

Doctoral

The main focus of this thesis is on the design and development of novel fiber optic devices for relative humidity (RH) sensing with emphasis on high sensitivity, a wide humidity range, low temperature dependence, fast response time and good stability.
Novel RH sensors based on fiber bends are fabricated by coating the surface of the buffer stripped bent fiber with selected hygroscopic materials such as Polyethylene oxide or Agarose. It is shown that the Polyethylene oxide coated device has a high sensitivity in a narrow RH range while the Agarose coated fiber bend shows a linear RH sensitivity in a …

A Transdisciplinary Analysis Of Sweetened Carbonated Soft-Drink Consumption And Related Policy Options, Charles R. Rhodes Ph.D.

Doctoral Dissertations

In Essay One, I estimate how demographic characteristics associate with habitual purchase of sweetened carbonated soft drinks (sCSDs), as different demographic groups respond to marketing variables controlled by the sCSD industry. My method and assumptions cleave neither to conventional economic analysis nor to medical and nutrition literature interested in sugar and soft-drink consumption. No assumption in my estimation process violates arguments in later essays. Results identify household purchase behaviors for relatively fine demographic groupings, are not linear in income or education level, and further vary by gender of the head of household and by type of sCSD industry …

Matrix Adhesion Polarizes Heart Progenitor Induction In The Invertebrate Chordate Ciona Intestinalis, J. Norton, J. Cooley, A. Islam, C. D. Cota, Bradley Justin Davidson , '91

Biology Faculty Works

Cell-matrix adhesion strongly influences developmental signaling. Resulting impacts on cell migration and tissue morphogenesis are well characterized. However, the in vivo impact of adhesion on fate induction remains ambiguous. Here, we employ the invertebrate chordate Ciona intestinalis to delineate an essential in vivo role for matrix adhesion in heart progenitor induction. In Ciona pre-cardiac founder cells, invasion of the underlying epidermis promotes localized induction of the heart progenitor lineage. We found that these epidermal invasions are associated with matrix adhesion along the pre-cardiac cell/epidermal boundary. Through targeted manipulations of RAP GTPase activity, we were able to manipulate pre-cardiac cell-matrix adhesion. …

Nonmarket Values In Family Businesses, Benjamin Means

William & Mary Law Review

Despite the economic importance of family businesses, legal scholarship has often overlooked their distinctive character. Instead, scholars focus on the chosen form of business organization— partnership, corporation, LLC—and assume that the participants are economically rational actors who seek to maximize their individual preferences. This Article contends that family businesses are extensions of family relationships and that nonmarket values affect their goals and governance choices.

Just as family law scholars have shown that contract principles can be applied to regulate intimate relationships, corporate law scholars should recognize that the intimacy of family life often substitutes for arm’s length bargaining in family …

Social Relations, Health Behaviors, And Health Outcomes: A Survey And Synthesis, Louis Tay, Kenneth Tan, Ed Diener, Elizabeth Gonzalez

Research Collection School of Social Sciences

The primary goal of this paper is to summarise current evidence on social relations and health, specifically how social integration and social support are related to health behaviors and health outcomes, using results from published reviews. Our analysis revealed that social relations are beneficial for health behaviors such as chronic illness self-management and decreased suicidal tendency. The salutary effects of general measures of social relations (e.g. being validated, being cared for, etc.) on health behaviors (e.g. healthy diet, physical activity, smoking, alcohol abuse) are weaker, but specific measures of social relations targeting corresponding health behaviors are more predictive. There is …

Rapid Change In Shallow Water Fish Species Composition In An Historically Stable Antarctic Environment, Bradley A. Buckley

Biology Faculty Publications and Presentations

McMurdo Sound, Antarctica, is home to a unique marine biota with an ecology that has evolved in this frigid environment over millions of years. The region is one of the least disturbed, and possibly the last pristine, marine ecosystem on Earth. Here, the results of three seasons of fishing in the shallow nearshore waters of McMurdo Sound are reported. A shift in the composition of small fish species at one site, Inaccessible Island, has been observed in just five years. The shift in shallow water species composition occurred during a period that followed the maturation of a commercial fishery for …

Exercises In Style: 21st Century Remix, Bethany M. Brownholtz

College of Liberal Arts & Social Sciences Theses and Dissertations

Exercises in Style: 21st Century Remix is an extension of Raymond Queneau’s Exercises in Style, first published in French in 1947. In Queneau’s book, the same two-paragraph passage (Notation) is written in 99 different ways. In this project, THE GIST serves as “Notation,” and 40 variations ensue. The author focuses on styles that have emerged over the last 60 years and styles reflecting course work in DePaul University’s Master’s in Writing and Publishing (MAWP) program. The collection concludes with an essay on the process of writing the exercises and an appendix containing stylistic analyses for each exercise.

The Family And The Market At Wal-Mart, Naomi Schoenbaum

DePaul Law Review

No abstract provided.

The Status Of A Pa Endangered Bird- The Upland Sandpiper, Paul A. Di Salvo, Kalley S. Hansel, Jessica L. Zupancic, Andrew M. Wilson

Student Publications

The upland sandpiper (Bartramia Longuardia) has experienced a steep population decline in the northeastern U.S. since the mid-20^th Century. In Pennsylvania it was found in less than 0.5% of atlas blocks during the Second Atlas of Breeding Birds in Pennsylvania project (2^nd PBBA; 2004-09) and breeding was confirmed at only two locations. Due to continued declines and a small population size, the upland sandpiper was listed as PA endangered in 2012. During May 2012 the areas around 15 2^nd PBBA upland sandpiper sightings were resurveyed by Gettysburg College students and volunteer birdwatchers. The aim was …