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Spectrum, Volume 30, Issue 15, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: New Pope ordained in Rome -- Straws for a cause -- President Petillo published in HuffingtonPost regarding gun control -- Volunteer Programs travels the world to give back -- Hawley Lounge: Sacred Heart hot spot -- Best of Bob Dylan -- Horizons Literary Journal prepares for publication

Expression Of Growth Arrest And Dna Damage Protein 45-Alpha (Gadd45-Alpha) And The Ccaat/Enhancer Binding Protein-Delta (C/Ebp-Delta) In Fishes Exposed To Heat And Hypoxia, Daniel Omar Hassumani

Dissertations and Theses

The cellular stress response (CSR) is one of the most highly conserved mechanisms among all organisms. Cellular stress can be defined as damage or the threat of damage to proteins, macromolecules and/or DNA. The response to damage can involve cell cycle regulation, protein chaperoning, DNA repair or, if macromolecular damage is too severe, apoptotic mechanisms can be initiated. This thesis details experiments that were designed to examine the cellular response to non-lethal environmental stressors at the protein level, using two fish species as study models. Two proteins that can cause cell cycle arrest and apoptosis mechanisms were examined. Expression of …

Heritage And Health: A Political-Economic Analysis Of The Foodways Of The Paiute Indian Tribe Of Utah And The Bishop Paiute Tribe, April Hurst Eagan

Dissertations and Theses

Funded by Nellis Air Force Base (NAFB), my thesis research and analysis examined Native American knowledge of heritage foods and how diminished access to food resources has affected Native American identity and health. NAFB manages the Nevada Test and Training Range (NTTR), land and air space in southern Nevada, which includes Native American ancestral lands. During a research period of 3 months in the spring/summer of 2012, I interviewed members of Native American nations culturally affiliated with ancestral lands on the NTTR, the Paiute Indian Tribe of Utah (PITU) and the Bishop Paiute Tribe. My research included participant observation and …

The Negative Regulation Of The Antiviral Signaling Pathway, Soratree Charoenthongtrakul

Open Access Dissertations

A key feature of the innate antiviral immune response is a rapid nonspecific response to virus infection largely mediated by the induction and extracellular secretion of type I interferons (IFNs) that restrict virus replication. Cytoplasmic sensors such as RIG-I recognize viral RNA and trigger antiviral signaling pathways that upregulate IFN transcription. However, it remains largely unknown how antiviral signaling is negatively regulated to maintain homeostasis after the elimination of virus. We have identified the RING domain-containing protein RING finger 11 (RNF11) as a novel negative regulator of innate antiviral signaling. Overexpression of RNF11 downregulated IFN-β expression and enhanced viral replication …

Ua12/2/1 College Heights Herald, Vol. 88, No. 40, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Harrison, Taylor. Students Present Their Research During Second Full REACH Week – Research Experiences & Creative Heights
• French, Jackson. School of Nursing Relocating to the Medical Center in the Fall
• WKU Schedules Events for Sexual Assault Awareness Month
• Stukenborg, Sarah. Student Government Association Passes Resolution to Oppose Study Abroad Fee
• Vogt, Darren. Editorial Cartoon Big Red Learning About Sexual Assault
• Students May Not Be As Educated on Sexual Assault As They Think
• People Poll: Do You Think Sexual Assault Is A Problem on This Campus?
• Bratcher, Nick. Study Abroad …

Underrepresented Students Perceptions Of Their Second Year In College, Dena R. Kniess, Pamela A. Havice

Faculty Research & Creative Activity

No abstract provided.

Stony Brook Press, V. 34, N. 10, Stony Brook University. Stony Brook Press.

Stony Brook Press

v. 34, n. 10, v.:ill. ; 38 cm (original analog pub.)

The Utah Statesman, March 19, 2013, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Function Of Yeast Pas Kinase, Dr. Julianne Grose

Journal of Undergraduate Research

PAS kinase is a newly discovered member of the nutrient sensing kinases that regulates glucose homeostasis in mice and yeast. The aim of our 2009 MEG “The Function of Yeast PAS kinase” was to characterize the role of a known PAS kinase substrate, Ugp1, as well as to identify novel PAS kinase substrates. We have made significant progress on each of these aims, which has facilitated the preparation of publications, presentations and abstracts. In addition, the findings described below have opened up further research as evidenced by our 2010 and 2011 MEG proposals as well as a 2009 NIH grant …

High-Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis And Method Of Generating The Same, Chang-Guo Zhan, Hoon Cho, Hsin-Hsiung Tai

Pharmaceutical Sciences Faculty Patents

A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, …

The Role Of Nuclear Bmp2 (Nbmp2) In Skeletal Muscle, Dr. Laura Bridgewater

Journal of Undergraduate Research

The goal of this project was to characterize the molecular pathway by which nBmp2 disrupts Ca2+ handling in skeletal muscle of nBmp2 mutant mice. Previously, we had worked with Dr. Chad Hancock’s lab to measure muscle function in nBmp2 mutant mice, and those results showed a slowing in the rate at which Ca2+ is pumped from the cytoplasm back into the sarcoplamic reticulum at the conclusion of a skeletal muscle contraction. Our rationale for this MEG study was that characterizing the muscle dysfunction phenotype in the nBmp2 mutant mice would ultimately lead to a molecular level understanding of the functions …

March 19, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Quantum Tricks In The Shadows Of Relativity And The Coulomb Force: Teaching Devices And Students How To Think Ultra-Fast, Ilias Perakis

Physics Seminars

The technological demand to bump the Gigahertz switching speed limit of today's magnetic memory and logic devices into the Terahertz regime underlies the entire field of spin-electronics and integrated multi-functional nano-devices. In this talk, I use theory and experiment to show how all-optical switching based on the quantum-mechanical manipulation of spins with a train of laser pulses could meet this challenge. The creation of magnetic correlations within femtoseconds, i.e. faster than one period of lattice oscillations, reveals a new temporal regime of magnetism. This field opened new directions for manipulating materials out-of-equilibrium using Terahertz, Mid-infrared, and X-ray pulses.

Patriot Talon (March 19, 2013), Archives Account

The Patriot Talon/The Patriot

The official newspaper for the University of Texas at Tyler before it was changed back to the UT Tyler Patriot. Articles in this issue include: 3 Year Degree program to be New Option for Freshmen; ‘It’s’ Just not Fair’; Student Launches Petition to Save Brother’s Life; New Standards Could Phase out Low-producing Fields of Study; Toll 49 Could Commute Time; Route Might Help Students Who Live West of Tyler; Spend Time Wisely to Avoid Regret; Stressing About the Title Things are Recipe for Disaster; Don’t Take Yourself too Seriously; Humor can be the Best Medicine; Vocalist Fulfills Passion, Performs with …

Method Of Activating Nk Cells, Joseph Wahle, William Garrow Kerr

USF Patents

The present invention provides a method of mediating hypo-activation of NK cells. Methods of the present invention comprise administering to a subject an effective amount of broad acting phosphotase inhibitor, such as sodium orthovanadate, SHP specific inhibitor. In one embodiment, the SHP specific inhibitor is NSC119910.

Science, Technology, And Catholic Identity In The Education Of Professionals, Keith Douglass Warner, David S. Caudill

Journal of Catholic Education

The reception of Ex corde ecclesiae has been uneven across the disciplines, with scant interest in distinctly Catholic pedagogies outside of the humanities. This essay argues that Catholic universities can distinguish themselves by how they present science and technology in their curriculum by drawing from the interdisciplinary field of “science, technology & society,” or STS. We argue that discussions about Catholic identity, science, and human values can and should extend into the curriculum while simultaneously safeguarding academic freedom, and that this can readily be done in professional schools, such as law and engineering. We outline the contributions that STS as …

March Science Cafe Focuses On Environmental Toxicology, Edwin Smith

University of Mississippi News

Professor's research examines whether pharmaceuticals and chemicals are present in potentially hazardous concentrations

Impact And Signatures Of Deglaciation On The Cryosphere, Landscape, And Habitability Of Earth And Mars, Nathalie A. Cabrol, Andrew G. Fountain, J. S. Kargel

Geology Faculty Publications and Presentations

Science questions can help bridge Astrobiology and Earth Science disciples around the theme of planetary deglaciation.

Mitochondrial Genetics Of Alzheimer's Disease And Aging, Perry Gene Ridge

Theses and Dissertations

Mitochondria are essential cellular organelles and the location of the electron transport chain, the site of the majority of energy production in the cell. Mitochondria contain their own circular genome approximately 16,000 base pairs in length. The mitochondrial genome (mtDNA) encodes 11 protein-coding genes essential for the electron transport chain, 22 tRNA genes, and two rRNA genes. Mitochondrial malfunction occurs in many diseases, and changes in the mitochondrial genome lead to numerous disorders. Multiple mitochondrial haplotypes and sequence features are associated with Alzheimer's disease. In this dissertation we utilized TreeScanning, an evolutionary-based haplotype approach to identify haplotypes and sequence variation …

Marked Improvement Of Cytotoxic Effects Induced By Docetaxel On Highly Metastatic And Androgen-Independent Prostate Cancer Cells By Downregulating Macrophage Inhibitory Cytokine-1., M Mimeault, Sonny L. Johansson, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Overexpression of macrophage inhibitory cytokine-1 (MIC-1) frequently occurs during the progression of prostate cancer (PC) to androgen-independent (AI) and metastatic disease states and is associated with a poor outcome of patients.

METHODS: The gain- and loss-of-function analyses of MIC-1 were performed to establish its implications for aggressive and chemoresistant phenotypes of metastatic and AI PC cells and the benefit of its downregulation for reversing docetaxel resistance.

RESULTS: The results have indicated that an enhanced level of secreted MIC-1 protein in PC3 cells is associated with their acquisition of epithelial-mesenchymal transition features and higher invasive capacity and docetaxel resistance. Importantly, …

The Current Volume 23 : Issue 24, Nova Southeastern University

Student Newspapers

No abstract provided.

The First Mission Of The Twelve Apostles: 1835, Maclane Elon Heward

Theses and Dissertations

The Quorum of the Twelve Apostles for the Church of Jesus Christ of Latter-day Saints is an administrative and ecclesiastical quorum. The Church, first organized in 1830, did not organize the Quorum of Twelve Apostles until 1835. When it was organized, Joseph Smith outlined the quorum's responsibilities through revelation. The Twelve were assigned two unique and specific responsibilities: to take the gospel to the nations of the earth and to form a traveling high council for the regulating of the Church outside of its stakes. The first opportunity for the Twelve to fulfill their responsibilities was in May 1835 when …

Protein-Surface Interactions With Coarse-Grain Simulation Methods, Shuai Wei

Theses and Dissertations

The interaction of proteins with surfaces is a major process involved in protein microarrays. Understanding protein-surface interactions is key to improving the performance of protein microarrays, but current understanding of the behavior of proteins on surfaces is lacking. Prevailing theories on the subject, which suggest that proteins should be stabilized when tethered to surfaces, do not explain the experimentally observed fact that proteins are often denatured on surfaces. This document outlines several studies done to develop a model which is capable of predicting the stabilization and destabilization of proteins tethered to surfaces. As the start point of the research, part …

Montana Kaimin, March 19, 2013, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The New Kentucky Nitrogen and Phosphorus Risk Assessment Tool to Protect Water Quality, Tibor Horvath and others, USDA-NRCS, Lexington, KY
• Groundwater Phosphorus in Kentucky Relative to Karst, Groundwater Sensitivity, and Groundwater Physiographic Region, Caroline Chan, Kentucky Division of Water, Frankfort, KY
• Comparison of Irrigation Scheduling Based on Daily Water Use or Plant Water Demand of Container Grown Nursery Plants, Susmitha Nambuthiri and others, Dept of Horticulture, UK
• Arsenic Species in Broiler (Gallus gallus domesticus) Litter, Soils, Maize (Zea mays L.), and Groundwater from Litter-Amended Fields, Georgia Zeigler and others, Dept Plant and Soil Science, UK
• Cyberinfrastructure …

Aquifer Guardians In Urban Areas V. Federal Highway Administration, Bradley R. Jones

Public Land & Resources Law Review

No abstract provided.

Session 2d, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• A Stability Index for Northern Kentucky Streams, Bob Hawley and others, Sustainable Streams, LLC, Louisville, KY
• The Gunpowder and Woolper Creek Watershed Initiatives, Local Cases of a National Problem, Mark Jacobs and others, Boone County Conservation District, Burlington, KY
• Watershed-Scale Model of Carbon and Nitrogen Cycles in Streams, William Ford and Jimmy Fox, Dept of Civil Engineering, UK
• Sensor Network for Suspended Sediment Monitoring, Robert Stewart and others, Dept of Civil Engineering, UK

Session 2c, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Mercury Bioaccumulation and the Impact of Stream Basin Characteristics on Susceptible Populations: Policy Implications for Kentucky, Caroline Chan, Kentucky Division of Water, Frankfort, KY
• Asian Carp in Kentucky Waters: An Ecological Disaster? Ron Brooks, Kentucky Dept of Fish and Wildlife Resources, Frankfort, KY
• Effects of Streambed Sediments on the Fate of Selenium in Eastern Kentucky Watersheds Contaminated with Surface Coal Mining Operations, Edward Fisher and Yi-Tin Wang, Dept of Civil Engineering, UK
• Thermal Dependence of Solvation Geometries in Aqueous Nitrate Ion Solutions, Matthew Nee, Dept of Chemistry, WKU, Bowling Green, KY
• The Combined Effects of Atrazine and …

Session 2b, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Developing a Vegetation-Based Index of Biotic Integrity for Assessing the Ecological Condition of Wetlands in Kentucky, Tanner Morris and others, Dept of Biological Sciences, EKU, Richmond, KY
• Using Vegetation and Landscape Analysis to Validate a Wetland Rapid Assessment Method for Kentucky's Forested Riparian Wetlands, JohnRyan Polascik and others, Dept of Biological Sciences, EKU, Richmond, KY
• Improving Overall Stream Function Beyond the Channel (Opportunity Meets Necessity), Oakes Routt and Wanda Lawson, Stantec Consulting Services Inc., Louisville, KY
• The Effects of Prescribed Fire Restoration on Amphibian and Reptile Diversity, Robert Knopp and others, Murray State University, Murray, KY …

Rock Creek Alliance V. U.S. Forest Service, Matt Pugh

Public Land & Resources Law Review

A coalition of environmental advocacy groups challenged the U.S. Forest Service, U.S. Fish and Wildlife Service, and the U.S. Department of Agriculture‟s approval of a mining project near Noxon, Montana. The proposed mine would operate partially on national forest land and involve tunneling beneath the Cabinet Mountains Wilderness to extract copper and silver. The plaintiffs challenged the mine approval by advancing claims under the Endangered Species Act, National Environmental Policy Act, Clean Water Act, Organic Administration Act, and the National Forest Management Act. The court entered summary judgment for the defendants on all but two counts. Minor changes must be …