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2013

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Commonwealth Times 2013-04-25 Apr 2013

Commonwealth Times 2013-04-25

Commonwealth Times, 1969-

No abstract provided.

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Microbial Community Structure Of A Leachfield Soil: Response To Intermittent Aeration And Tetracycline Addition, Janet A. Atoyan, Andrew M. Staroscik, David R. Nelson, Erika L. Patenaude, David A. Potts, José A. Amador Apr 2013

Microbial Community Structure Of A Leachfield Soil: Response To Intermittent Aeration And Tetracycline Addition, Janet A. Atoyan, Andrew M. Staroscik, David R. Nelson, Erika L. Patenaude, David A. Potts, José A. Amador

Cell and Molecular Biology Faculty Publications

Soil-based wastewater treatment systems, or leachfields, rely on microbial processes for improving the quality of wastewater before it reaches the groundwater. These processes are affected by physicochemical system properties, such as O2 availability, and disturbances, such as the presence of antimicrobial compounds in wastewater. We examined the microbial community structure of leachfield mesocosms containing native soil and receiving domestic wastewater under intermittently-aerated (AIR) and unaerated (LEACH) conditions before and after dosing with tetracycline (TET). Community structure was assessed using phospholipid fatty acid analysis (PLFA), analysis of dominant phylotypes using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR–DGGE), and cloning and sequencing …

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Relationship Of Cellular Topoisomerase Iiα Inhibition To Cytotoxicity And Published Genotoxicity Of Fluoroquinolone Antibiotics In V79 Cells, Gary M. Williams, Klaus D. Brunnemann, Daniel J. Smart, David Molina, Alan M. Jeffrey, Jian-Dong Duan, Niels Krebsfaenger, Andreas Kampkoetter, Gabriele Schmuck Apr 2013

Relationship Of Cellular Topoisomerase Iiα Inhibition To Cytotoxicity And Published Genotoxicity Of Fluoroquinolone Antibiotics In V79 Cells, Gary M. Williams, Klaus D. Brunnemann, Daniel J. Smart, David Molina, Alan M. Jeffrey, Jian-Dong Duan, Niels Krebsfaenger, Andreas Kampkoetter, Gabriele Schmuck

NYMC Faculty Publications

Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effects in mammalian systems through mechanisms not yet established, but which are postulated to involve inhibition of TOPO II enzymes. To assess the relationship of inhibition of cell nuclear TOPO II to cytotoxicity and reported genotoxicity, two FQ, clinafloxacin (CLFX) and lomefloxacin (LOFX), having available genotoxicity data showing substantial differences with CLFX being more potent than LOFX, were selected for study. The relative inhibitory activities of these …

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Otter Realm, April 25, 2013, California State University, Monterey Bay Apr 2013

Otter Realm, April 25, 2013, California State University, Monterey Bay

The Otter Realm

Marathon of Events: UPD Officer Participated in Boston Marathon -- What You Otter Be Doing April 25 - May 8 -- Disregard Media Acquire Knowledge -- Now What? Expectations of Next Year's Student Government: Expectations of Next Year's Student Government -- Housing Conversations: Interpersonal Solutions Event Held with Residential Life -- New Faculty Finds Her Home -- A Call Against Gender Violence: The MENding Monologues Makes its Way to Campus -- Race and Disability Panel Talks Tolerance, Oppression: Students Share Their Stories of Discrimination -- Chancellor Comes to Town: Chancellor White and Trustees Review Ochoa's Work -- Gobble, Gobble, Gobble …

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2013 - The Eighteenth Annual Symposium Of Student Scholars Apr 2013

2013 - The Eighteenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Eighteenth Annual Symposium of Student Scholars, held on April 25, 2013. Includes abstracts from the presentations and posters.

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Anthropology In The Real World: Year Vii, William Torres B.A., Nicole Benigno B.A. Apr 2013

Anthropology In The Real World: Year Vii, William Torres B.A., Nicole Benigno B.A.

Petersheim Academic Exposition

No abstract provided.

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A Key New Ally In The Search For Huntington’S Disease Treatments, Kenneth P. Serbin Apr 2013

A Key New Ally In The Search For Huntington’S Disease Treatments, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

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The Utah Statesman, April 25, 2013, Utah State University Apr 2013

The Utah Statesman, April 25, 2013, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

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Sandspur, Vol 119, No 19, April 25, 2013, Rollins College Apr 2013

Sandspur, Vol 119, No 19, April 25, 2013, Rollins College

The Rollins Sandspur

Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.

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A Feedback Regulatory Loop Between G3p And Lipid Transfer Proteins Dir1 And Azi1 Mediates Azelaic-Acid-Induced Systemic Immunity, Keshun Yu, Juliana Moreira Soares, Mihir Kumar Mandal, Caixia Wang, Bidisha Chanda, Andrew N. Gifford, Joanna S. Fowler, Duroy Navarre, Aardra Kachroo, Pradeep Kachroo Apr 2013

A Feedback Regulatory Loop Between G3p And Lipid Transfer Proteins Dir1 And Azi1 Mediates Azelaic-Acid-Induced Systemic Immunity, Keshun Yu, Juliana Moreira Soares, Mihir Kumar Mandal, Caixia Wang, Bidisha Chanda, Andrew N. Gifford, Joanna S. Fowler, Duroy Navarre, Aardra Kachroo, Pradeep Kachroo

Plant Pathology Faculty Publications

Systemic acquired resistance (SAR), a highly desirable form of plant defense, provides broad-spectrum immunity against diverse pathogens. The recent identification of seemingly unrelated chemical inducers of SAR warrants an investigation of their mutual interrelationships. We show that SAR induced by the dicarboxylic acid azelaic acid (AA) requires the phosphorylated sugar derivative glycerol-3-phosphate (G3P). Pathogen inoculation induced the release of free unsaturated fatty acids (FAs) and thereby triggered AA accumulation, because these FAs serve as precursors for AA. AA accumulation in turn increased the levels of G3P, which is required for AA-conferred SAR. The lipid transfer proteins DIR1 and AZI1, both …

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The Pan American (2013-04-25), Karen Antonacci, Daniella Diaz Apr 2013

The Pan American (2013-04-25), Karen Antonacci, Daniella Diaz

UTPA Archives - The Pan American Newspaper

Vol. 69, No. 26

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Effects Of Age On Induced Glaucoma In An In Vivo Rat Model, Robert Cox Apr 2013

Effects Of Age On Induced Glaucoma In An In Vivo Rat Model, Robert Cox

Honors Theses

Previous in vitro studies from this lab have demonstrated that injection of a hypertonic saline solution into the episcleral vein of the rat’s eye mimics the effect of glaucoma. However, the age of the rat related to the amount of cell loss in the retina ganglion cell (RGC) layer is unknown. To address this issue, we propose to analyze the correlation of age and cell loss between 3-6 month and 1-year-old Long Evan rats. When inducing glaucoma in the Long Evan rats, the left eye in each rat was left untreated and used as an internal control. In the right …

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Camk-Ii: An Integral Protein In Cell Migration, Jamie Josephine Avila Mcleod Apr 2013

Camk-Ii: An Integral Protein In Cell Migration, Jamie Josephine Avila Mcleod

Theses and Dissertations

Coordinated inductive and morphogenetic processes of gastrulation establish the zebrafish body plan. Gastrulation includes massive cell rearrangements to generate the three germ layers and shape the embryonic body. Three modes of cell migration must occur during vertebrate gastrulation and include: epiboly, internalization of the presumptive mesendoderm and convergent extension (C&E). C&E movements narrow the germ layers mediolaterally (convergence) and elongate them anteroposteriorly (extension) to define the embryonic axis. The molecular mechanisms regulating coordinated cell migrations remain poorly understand and studying these has become of great interest to researchers. Understanding cell migration during development is highly relevant to a number of …

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The Daily Egyptian, April 25, 2013, Daily Egyptian Staff Apr 2013

The Daily Egyptian, April 25, 2013, Daily Egyptian Staff

April 2013

No abstract provided.

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The Weekly Challenger, April 25, 2013, The Weekly Challenger, Et Al Apr 2013

The Weekly Challenger, April 25, 2013, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The April 25, 2013, issue of The Weekly Challenger.

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The Cowl - V.77 - N.22 - Apr 25, 2013 Apr 2013

The Cowl - V.77 - N.22 - Apr 25, 2013

The Cowl

The Cowl - student newspaper of Providence College. Vol 77 - No. 22 - April 25, 2013. 24 pages.

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The Parthenon, April 25, 2013, John Gibb, Tyler Kes Apr 2013

The Parthenon, April 25, 2013, John Gibb, Tyler Kes

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

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Cavin1; A Regulator Of Lung Function And Macrophage Phenotype., Praveen Govender, Freddy Romero, Dilip Shah, Jesus Paez, Shi-Ying Ding, Libin Liu, Adam Gower, Elizabeth Baez, Sherif Shawky Aly, Paul Pilch, Ross Summer Apr 2013

Cavin1; A Regulator Of Lung Function And Macrophage Phenotype., Praveen Govender, Freddy Romero, Dilip Shah, Jesus Paez, Shi-Ying Ding, Libin Liu, Adam Gower, Elizabeth Baez, Sherif Shawky Aly, Paul Pilch, Ross Summer

Center for Translational Medicine Faculty Papers

Caveolae are cell membrane invaginations that are highly abundant in adipose tissue, endothelial cells and the lung. The formation of caveolae is dependent on the expression of various structural proteins that serve as scaffolding for these membrane invaginations. Cavin1 is a newly identified structural protein whose deficiency in mice leads to loss of caveolae formation and to development of a lipodystrophic phenotype. In this study, we sought to investigate the functional role of Cavin1 in the lung. Cavin1 deficient mice possessed dramatically altered distal lung morphology and exhibited significant physiological alterations, notably, increased lung elastance. The changes in distal lung …

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Student Research Engages The Community, Sarah Earle Apr 2013

Student Research Engages The Community, Sarah Earle

UNH Today Archive

No abstract provided.

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Crizotinib: A Tyrosine Kinase Inhibitor, Graham Mclaren Apr 2013

Crizotinib: A Tyrosine Kinase Inhibitor, Graham Mclaren

Honors Theses

Crizotinib is a small molecule tyrosine kinase inhibitor that is currently being marketed by Pfizer under the trade name Xalkori®. After its development in 2005, an appropriate target was discovered in 2007. By 2011 the FDA had approved crizotinib for use in patients with ALK+ non small cell lung cancer (NSCLC). ALK+ NSCLC is caused by a genetic mutation that truncates and flips a section of the EML4 gene and attaches it to a section of the ALK gene. The result is the EML4-ALK oncogene. The resulting protein from this mutation is capable of undergoing ligand independent dimerization, …

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Characterization Of Human Gut Microbiota Dynamics Using Model Communities In Gnotobiotic Mice, Nathaniel Patrick Mcnulty Apr 2013

Characterization Of Human Gut Microbiota Dynamics Using Model Communities In Gnotobiotic Mice, Nathaniel Patrick Mcnulty

All Theses and Dissertations (ETDs)

The human gut is colonized by a diverse array of microbes, collectively referred to as the microbiota. The microbiota's complexity poses significant challenges in characterizing the rules dictating its assembly, inferring the functional roles of its component species, and understanding how communities sense and respond to changes in their habitat. We developed defined, representative model communities comprised of sequenced human gut bacteria that could be characterized in a highly controlled manner in gnotobiotic mice, plus a suite of scalable molecular tools for assaying community properties. These tools were first used to evaluate how the microbiota is impacted by probiotic bacterial …

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Mammalian Mucosal Α-Glucosidases Coordinate With Α-Amylase In The Initial Starch Hydrolysis Stage To Have A Role In Starch Digestion Beyond Glucogenesis., Sushil Dhital, Amy Hui-Mei Lin, Bruce R. Hamaker, Michael J. Gidley, Anbunkani Muniandy Apr 2013

Mammalian Mucosal Α-Glucosidases Coordinate With Α-Amylase In The Initial Starch Hydrolysis Stage To Have A Role In Starch Digestion Beyond Glucogenesis., Sushil Dhital, Amy Hui-Mei Lin, Bruce R. Hamaker, Michael J. Gidley, Anbunkani Muniandy

Department of Food Science Faculty Publications

Starch digestion in the human body is typically viewed in a sequential manner beginning with α-amylase and followed by α-glucosidase to produce glucose. This report indicates that the two enzyme types can act synergistically to digest granular starch structure. The aim of this study was to investigate how the mucosal α-glucosidases act with α-amylase to digest granular starch. Two types of enzyme extracts, pancreatic and intestinal extracts, were applied. The pancreatic extract containing predominantly α-amylase, and intestinal extract containing a combination of α-amylase and mucosal α-glucosidase activities, were applied to three granular maize starches with different amylose contents in an …

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The Mechanotransduction Of Primary Cilia In Tumor Progression Of Lung Adenocarcinoma, Sagar Patel Apr 2013

The Mechanotransduction Of Primary Cilia In Tumor Progression Of Lung Adenocarcinoma, Sagar Patel

Theses and Dissertations

The objective of this study was to investigate primary cilia and their mechanotransduction role in lung adenocarcinoma tumor progression. The main focus investigated the effect of primary cilia on cell cycle progression, survival, adhesion and migration analysis of these cells and the role of sonic hedgehog signaling pathway in mechanotransduction. Human Non-Small Cell Lung Cancer (NSCLC) adenocarcinoma biopsies contain more primary cilia than non-tumor lung sections. To observe the effects of primary cilia presence in lung cancer cells in-vitro, formation of primary cilia is inhibited using small interfering RNA. A549 cells with intact primary cilia observe less cell cycle progression …

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The Inflammasome In Acute Myocarditis, Harsha Kannan Apr 2013

The Inflammasome In Acute Myocarditis, Harsha Kannan

Theses and Dissertations

Acute myocarditis is an acute inflammatory syndrome characterized by myocardial damage and dysfunction often due to a viral infection followed by a variable development over time. There are currently no specific treatments and standard treatments for heart failure are generally applied. The inflammasome is a recently identified macromolecular structure that occupies a central role in the amplification of the inflammatory response and promotion of cell death during acute and chronic infections. We hypothesized the formation of the inflammasome in acute myocarditis. To investigate, samples of patients were collected from the Cardiomyopathy Registry in Trieste, with 12 cases of biopsy-proven myocarditis …

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Actual Entities: A Control Method For Unmanned Aerial Vehicles, Erica Absetz Apr 2013

Actual Entities: A Control Method For Unmanned Aerial Vehicles, Erica Absetz

Theses and Dissertations

The focus of this thesis is on Actual Entities, a concept created by the philosopher Alfred North Whitehead, and how the concept can be applied to Unmanned Aerial Vehicles as a behavioral control method. Actual Entities are vector based, atomic units that use a method called prehension to observe their environment and react with various actions. When combining multiple Actual Entities a Colony of Prehending Entities is created; when observing their prehensions an intelligent behavior emerges. By applying the characteristics of Actual Entities to Unmanned Aerial Vehicles, specifically in a situation where they are searching for targets, this emergent, intelligent …

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Choosing The Cut Point For A Restricted Mean In Survival Analysis, A Data Driven Method, Emily H. Sheldon Apr 2013

Choosing The Cut Point For A Restricted Mean In Survival Analysis, A Data Driven Method, Emily H. Sheldon

Theses and Dissertations

Survival Analysis generally uses the median survival time as a common summary statistic. While the median possesses the desirable characteristic of being unbiased, there are times when it is not the best statistic to describe the data at hand. Royston and Parmar (2011) provide an argument that the restricted mean survival time should be the summary statistic used when the proportional hazards assumption is in doubt. Work in Restricted Means dates back to 1949 when J.O. Irwin developed a calculation for the standard error of the restricted mean using Greenwood’s formula. Since then the development of the restricted mean has …

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Undergraduate Research Shines At Illinois Wesleyan Conference, Kim Hill Apr 2013

Undergraduate Research Shines At Illinois Wesleyan Conference, Kim Hill

News and Events (Discontinued Series)

No abstract provided.

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Purification Of Biotransformation Products Of Cis-Isoflavan-4-Ol By Biphenyl Dioxygenase Of Pseudomonas Pseudoalcaligenes Kf707 Strain Expressed In Escherichia Coli, Tri Ratna Sulistiyani Apr 2013

Purification Of Biotransformation Products Of Cis-Isoflavan-4-Ol By Biphenyl Dioxygenase Of Pseudomonas Pseudoalcaligenes Kf707 Strain Expressed In Escherichia Coli, Tri Ratna Sulistiyani

Makara Journal of Science

Isoflavone has multiple beneficial effects on human health, especially through its antioxidant and anticancer activities. The biotransformation of isoflavone using byphenyl dioxygenase could be performed to extend the diversity of flavonoids and to improve their biological and physiological properties. Biotransformation of two enantiomers (3R, 4R)-cis-isoflavan-4-ol and (3S, 4S)-cis-isoflavan-4-ol by E. coli JM109 (pJHF108) carrying a biphenyl dioxygenase gene from P. pseudoalcaligenes KF707 produced two products, designated as CM1 and CM2. The products had a retention time of 11.9 and 14.6 min, respectively, and the same absorption peaks at 204, 220, and 275 nm. CM1 and CM2 had [M-H2O+H]+ at m/z …

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Dissolution Properties Of Silk Cocoon Shells And Degummed Fibers From African Wild Silkmoths, K. T. Addis, S. K. Raina Apr 2013

Dissolution Properties Of Silk Cocoon Shells And Degummed Fibers From African Wild Silkmoths, K. T. Addis, S. K. Raina

All Peer-Reviewed Publications

Silk cocoon shells and degummed fibers from four African wild silkmoth species were studied and compared with the industrial standard, Bombyx mori, for their dissolution properties. Nine M aqueous Lithium bromide, Calcium chloride and Sodium thiocyanate solution systems were used. Efficiency of the solvent systems was determined by the percentage of dissolved silk cocoon shells and degummed fibers after three hours of treatment. Degummed fibers were more readily soluble than the cocoon shells. B. mori cocoon shells (51.5%) and fibers (59.3%) had higher solubility than their wild counterparts. Among the wild species, Gonometa postica cocoon shells and degummed fibers had …

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Kromium, Timbal, Dan Merkuri Dalam Air Sumur Masyarakat Di Sekitar Tempat Pembuangan Akhir Sampah, Taufik Ashar, Devi Nuraini Santi, Evi Naria Apr 2013

Kromium, Timbal, Dan Merkuri Dalam Air Sumur Masyarakat Di Sekitar Tempat Pembuangan Akhir Sampah, Taufik Ashar, Devi Nuraini Santi, Evi Naria

Kesmas

Tempat pembuangan akhir (TPA) sampah domestik dengan sistem penampungan terbuka sangat berisiko mencemari air tanah milik warga yang bermukim di sekitarnya melalui proses perlindian. Untuk mengetahui kandungan logam berat dalam air tanah di sekitar TPA, sebanyak 68 sampel air sumur gali (45 sumur Dusun I dan 23 sumur Dusun IV) dari Desa Namobintang Kecamatan Pancurbatu Kabupaten Deli Serdang, Sumatera Utara, telah dianalisis dengan inductively couple plasma atomic emission spectroscopy. Hubungan jarak sumur dengan konsentrasi kromium, merkuri, dan timbal diuji dengan Mann-Whitney, Spearman’s Correlation dan analisis regresi linier sederhana. Hasil penelitian menunjukkan konsentrasi kromium, timbal, dan merkuri (rerata ± deviasi standar, …

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