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Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma, Anthony Gebhard

USF Tampa Graduate Theses and Dissertations

Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma (MM) cell lines. Due to the intriguing biological activity and promising in vivo activity of HYD1, we pursued strategies for increasing the therapeutic efficacy of the parent linear peptide. These efforts led to the development of a cyclized peptidomimetic, MTI-101, with increased in vitro activity and robust in vivo activity as a single agent using two myeloma models that consider the bone marrow microenvironment. MTI-101 treatment resulted in mechanistically similar hallmarks of HYD1 induced cell death, namely the generation of …

Predictors Of The Incidence And Charges For Lumbar Spinal Fusion Surgery In Florida Hospitals During 2010, Anna Ialynychev

USF Tampa Graduate Theses and Dissertations

Over the past several decades rates of spine surgeries in the U.S. have increased dramatically. Spinal fusion surgery rates, in particular, have grown exponentially despite being one of the most costly, invasive, and controversial methods for treating patients suffering from back conditions. Furthermore, lumbar fusion surgeries continue to be performed at increasing rates despite a lack of scientific evidence and consensus that they are cost-effective and produce better clinical outcomes than less radical treatment of lower back pain. As a result, large amounts of healthcare dollars continue to be invested in these costly procedures which are potentially dangerous and have …

Subject Of Conscience: On The Relation Between Freedom And Discrimination In The Thought Of Heidegger, Foucault, And Butler, Aret Karademir

USF Tampa Graduate Theses and Dissertations

Martin Heidegger was not only one of the greatest philosophers of the twentieth century but also a supporter of and a contributor to one of the most discriminatory ideologies of the recent past. Thus, "the Heidegger's case" gives us philosophers an opportunity to work on discrimination from a philosophical perspective. My aim in this essay is to question the relationship between freedom and discrimination via Heidegger's philosophy. I will show that what bridges the gap between Heidegger's philosophy and a discriminatory ideology such as the National Socialist ideology is Heidegger's conceptualization of freedom with the aid of a monolithic understanding …

A Monte Carlo Approach To Change Point Detection In A Liver Transplant, Alexia Melissa Makris

USF Tampa Graduate Theses and Dissertations

Patient survival post liver transplant (LT) is important to both the patient and the center's accreditation, but over the years physicians have noticed that distant patients struggle with post LT care. I hypothesized that patient's distance from the transplant center had a detrimental effect on post LT survival. I suspected Hepatitis C (HCV) and Hepatocellular Carcinoma (HCC) patients would deteriorate due to their recurrent disease and there is a need for close monitoring post LT. From the current literature it was not clear if patients' distance from a transplant center affects outcomes post LT. Firozvi et al. (Firozvi AA, 2008) …

The Biomechanics Of The Tendu In Closing To The Traditional Position, Pli#233; And Relev#233;, Nyssa Catherine Masters

USF Tampa Graduate Theses and Dissertations

Dancers spend many years practicing repetitive movements in order for their bodies to gain flexibility, strength and muscle memory. This thesis investigated the biomechanics of a dance student's knee motion during a tendu to the front in first, third, and fifth positions. A dancer will often perform 75 or more tendu closing actions during one technique class - particularly in ballet technique. During a tendu the moving foot moves along the floor but the toes never leave the floor. The tendu is used to strengthen the leg muscles, particularly the quadriceps and gluteal muscles. Flexion/extension, abduction/adduction, and rotation angles of …

Community On The Menu: Seven-Courses To Cultivate Familial Bonds, Exchange Social Capital, And Nourish Community, David Franklin Purnell

USF Tampa Graduate Theses and Dissertations

This dissertation is an auto/ethnographic account, which examines food, close personal friendships, and community. The research combines autoethnography with ethnographic observations and personal/group interviews conducted within the Seminole Heights neighborhood of Tampa, Florida. The observations are of a weekly dinner event referred to by most attendees as Family Dinner. I am one of the founders of this event; the participants of this study are neighbors (or were at some point in time) as well as past and present attendees of the weekly dinner.

The purpose of this research is to illustrate how food can be a tool to build …

The Determinants Of Antiretroviral Therapy Adherence And The Relationship Of Healthcare Expenditures To Adherence Among Florida Medicaid-Insured Patients Diagnosed With Hiv Or Aids, Zachary Pruitt

USF Tampa Graduate Theses and Dissertations

Research supports the clinical and societal benefits of antiretroviral treatment (ART) for people living with HIV or AIDS (PLWHA). However, factors associated with ART adherence and the relationship of ART adherence to total healthcare expenditures are not well understood.

The research data included Florida Medicaid claims for five years (July 2006 through June 2011). All subjects (n=514) were HIV-positive, adult, non-pregnant, and ART naïve for at least 12 months prior to their 24 month measurement period. Each subject was categorized as adherent (>90%#37;) or non-adherent (<90%#37;) based upon medication possession ratios (MPR). Total expenditures were payments Medicaid made to providers and pharmacies.

Objective 1 modeled the logit probability of a subject being non-adherent to ART …

Evaluating Cfrp-Masonry Bond Using Thermal Imaging, Joseph Christopher Ross

USF Tampa Graduate Theses and Dissertations

This study presents results from non-destructive testing to evaluate the degradation of the CFRP-masonry bond using thermal imaging. The goal of the research was to identify locations where there was evidence of bond deterioration that could subsequently be verified through destructive pull-off testing.

Four full-scale masonry walls were built outdoors at the University of South Florida in 1995 to evaluate the effectiveness of CFRP for repairing settlement damage. Two of the settlement-damaged walls were repaired using single layer, commercially available unidirectional CFRP systems that used Tonen (wall 3) and Henkel (wall 2) epoxies. These two walls were the subject of …

Science Informational Trade Books: An Exploration Of Text-Based Practices And Interactions In A First-Grade Classroom, Virginia Anne Schreier

USF Tampa Graduate Theses and Dissertations

Although scholars have long advocated the use of informational texts in the primary grades, gaps and inconsistencies in research have produced conflicting reports on how teachers used these texts in the primary curriculum, and how primary students dealt with them during instruction and on their own (e.g., Saul & Dieckman, 2005). Thus, to add to research on informational texts in the primary grades, the purpose of this study was to examine: (a) a first-grade teacher's use of science informational trade books (SITBs) in her classroom, (b) the ways students responded to her instruction, and (c) how students interacted with these …

Continuing Attachment Bonds To The Deceased: A Study Of Bereaved Youth And Their Caregivers, Erica Hill Sirrine

USF Tampa Graduate Theses and Dissertations

Although grief is a universal experience impacting the lives of many children and adolescents each year, not much study has been afforded to this population. In addition, the concept of a continuing attachment bond (CAB) or ongoing relationship to the deceased and its role as adaptive or maladaptive in the bereavement process is in its infancy of research among adult populations and is largely unstudied among bereaved youth. This mixed-methods study attempted to bridge the gap by examining the relationship between CABs among a sample of 50 bereaved youth (ages 11-17) and their bereaved adult caregivers. In addition, the study …

Colors And Mapping: The Right To Receive Information, Kathryn Stephanie Skupien

USF Tampa Graduate Theses and Dissertations

Color is used in everything we see and do and it often can be used for effect and representation, particularly on maps and transportation signage. This study explores the issues that the color blind population exhibits when viewing these maps and signs. Seeing that 8%#37; of the male population is afflicted with some form of color blindness, it is pertinent that research reflect these issues and take into consideration the Right to Receive Information for this population. A qualitative method using Photovoice and interviews was used to determine whether this population considers itself having a disability and what solutions can …

Guanxi, Networks And Economic Development: The Impact Of Cultural Connections, Patricia Anne Weeks

USF Tampa Graduate Theses and Dissertations

The purpose of this study is to explore the mechanics of guanxi in an organizational setting, focusing on the use of interpersonal relationships within Chinese firms to discover how firms initiate, build and use guanxi networks. Two richly detailed case studies document changes that take place over time in two distinct networks with respect to key actors and their contacts. This research also investigates patterns of social structure that emerge over time in these two distinct cases looking at brokerage relationships, network density, and dyadic redundancy in three waves at six month intervals. The cases are dissimilar in all aspects …

When Celebrity Women Tweet: Examining Authenticity, Empowerment, And Responsibility In The Surveillance Of Celebrity Twitter, Megan M. Wood

USF Tampa Graduate Theses and Dissertations

This thesis is a textual analysis of stories in online celebrity news articles about celebrity women and their use of Twitter. It adds to the burgeoning discussion about gendered and racialized bodies online using scholarship from critical feminist, surveillance, and digital media studies. Throughout, my work attends to notions of authenticity and surveillance, examining how what I term a "call to authenticity"--the use of technologies of self-surveillance to verify "authentic" displays of the self--serves to animate contradictory post-feminist paradigms of femininity which function together to discipline and subjugate femininity. I ask: How do post-feminist questions of empowerment and responsibility become …

Development Of A Novel Method For Deriving Thresholds Of Toxicological Concern (Ttcs) For Vaccine Constituents, Jennifer Jessica White

USF Tampa Graduate Theses and Dissertations

Abstract

Safety assessment relating to the presence of impurities, residual materials and contaminants in vaccines is a focus area of research at the United States Food and Drug Administration (FDA). Sponsors who submit Investigational New Drug (IND) applications for new vaccine products must report the results of safety assessments to the Division of Vaccines and Related Products Applications (DVRPA). Scientifically defining thresholds of toxicological concern (TTCs) as they apply to vaccine constituents will provide a useful aid to the sponsors and public regarding safety assessments of compounds for which there is little or no toxicity data. TTCs are mathematically modeled …

Development Of Nanostructured Graphene/Conducting Polymer Composite Materials For Supercapacitor Applications, Punya A. Basnayaka

USF Tampa Graduate Theses and Dissertations

The developments in mobile/portable electronics and alternative energy vehicles prompted engineers and researchers to develop electrochemical energy storage devices called supercapacitors, as the third generation type capacitors. Most of the research and development on supercapacitors focus on electrode materials, electrolytes and hybridization. Some attempts have been directed towards increasing the energy density by employing electroactive materials, such as metal oxides and conducting polymers (CPs). However, the high cost and toxicity of applicable metal oxides and poor long term stability of CPs paved the way to alternative electrode materials. The electroactive materials with carbon particles in composites have been used substantially …

Reading Assessment Practices Of Elementary General Education Teachers: A Descriptive Study, Sarah Mirlenbrink Bombly

USF Tampa Graduate Theses and Dissertations

In this descriptive study, I researched five elementary general education teachers' reading assessment practices as they worked within the context of IDEA (2004), NCLB (2002) and Response to Intervention (RTI). My own connection to the classroom and reading assessment practices brought me to this research. I presented my personal and professional connection through vignettes about my own classroom assessment practices. Relevant literature on both the context and culture of assessment were pertinent to this research.

I used a qualitative design, specifically, Colaizzi's (1978) method of phenomenological analysis. Data were three in-depth phenomenological interviews, relevant documents and artifacts, and use of …

Effect Of Localized Corrosion Of Steel On Chloride-Induced Concrete Cover Cracking In Reinforced Concrete Structures, Ezeddin Rafaa Busba

USF Tampa Graduate Theses and Dissertations

Abstract: Concrete cover cracking due to reinforcement corrosion is widely accepted as a limit-state indicator in defining the end of functional service life for existing reinforced concrete (RC) structures undergoing corrosion. Many of the currently available durability prediction models are incapable of providing realistic estimates of remaining service lives of RC structures beyond the corrosion initiation point. Therefore, the need to incorporate the length of the corrosion propagation stage in a comprehensive durability prediction approach has recently received much research attention. Previous research focus however was mostly limited to the case of uniformly corroding reinforcement with only few studies addressing …

Application And Characterization Of Self-Assembled Monolayers In Hybrid Electronic Systems, Michael Enoch Celesin

USF Tampa Graduate Theses and Dissertations

In this study, we explore ultra-thin insulators of organic and inorganic composition and their potential role as high-speed rectifiers. Typical applications for these structures include IR sensing, chemical detection, high speed logic circuits, and MEMS enhancements. While there are many elements in the functional group required to create a rectifying antenna (rectenna), the primary thrust of this work is on the rectifier element itself.

To achieve these research goals, a very good understanding of quantum tunneling was required to model the underlying phenomenon of charge conduction. The development of a multi-variable optimization routine for tunneling prediction was required. MATLAB was …

Magnetization Dynamics And Related Phenomena In Nanostructures, Sayan Chandra

USF Tampa Graduate Theses and Dissertations

Collective magnetic behavior in nanostructures is a phenomenon commonly observed in various magnetic systems. It arises due to competing inter/intra–particle interactions and size distribution and can manifest in phenomena like magnetic freezing, magnetic aging, and exchange bias (EB) effect. In order to probe these rather complex phenomena, conventional DC and AC magnetic measurements have been performed along with radio–frequency transverse susceptibility (TS) measurements. We also demonstrate the magnetic entropy change as a parameter sensitive to subtle changes in the magnetization dynamics of nanostructures. The focus of this dissertation is to study the collective magnetic behavior in core-shell nanostructures of Fe/γ–Fe …

Predictors Of Student Enrollment Patterns In High School Career Academies, E. Daniel Cox

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to describe participation patterns at the district level of students enrolled in career academies and determine whether participation in career academies is a function of demographic and/or prior learning experience and prior performance variables. Ex-post facto data was used to determine six-year enrollment trends. In addition, both binary logistic regression and multinomial logistic regression methods were employed to determine the extent demographic along with prior learning experience and prior performance variables could be used to predict participation within career academies. Trend data results indicated slight increases in the proportions of students of color (including …

Alliance And Mechanisms Of Medication Adherence In Pediatric Psychiatric Practice, Alessandro Stevens De Nadai

USF Tampa Graduate Theses and Dissertations

Psychiatric medications have been established as an efficacious treatment for pediatric psychopathology (Comer, Olfson, & Mojtabai, 2010), with approximately 3.9% of American children receiving psychotropic medication in a given year (Olfson, Marcus, Weissman, & Jensen, 2002). However, medication adherence for these conditions is suboptimal, with over 50% of children discontinuing treatment before the period recommended for full therapeutic benefit (e.g., Gau et al., 2006; Murray, de Vries, & Wong, 2004). This is highly problematic because pediatric psychopathology is associated with substantial functional impairment and reduced quality of life, as well as increased risk for suicidality (e.g., Bridge, Goldstein, & Brent, …

The Political Economy Of Maternal Health In A Medically Pluralistic Environment: A Case Study In The Callejón De Huaylas, Isabella Chan

USF Tampa Graduate Theses and Dissertations

This thesis examines maternal decision-making regarding prenatal care and childbirth in the rural, north-central Andes in the province of Carhuaz. Semi-structured interviews (n=30) and participatory action research workshops (n=7) were conducted with local women to elucidate how they conceptualize, experience, and negotiate the shifting landscape of prenatal care and childbirth practices and providers. Semi-structured interviews with obstetricians, midwives, and social workers (n=9) were also conducted to compare perspectives and identify disconnects in knowledge and practices existing between these two groups in order to facilitate an open conversation on how to jointly improve the maternal experience and reduce maternal mortality and …

Polysemy, Plurality, & Paradigms: The Quixotic Quest For Commensurability Of Ethics And Professionalism In The Practices Of Law, Eric Paul Engel

USF Tampa Graduate Theses and Dissertations

According to many, the legal industry is currently suffering from a professionalism problem. The following dissertation is a response to the question, "What can be done about incivility in the practice of law in Florida?" It begins by exploring the literature examining ethics and professionalism, specifically focusing on the role communication plays in the production and reification of patterns of meaning and action. After contextualizing the professionalism problem socio-culturally and historically, the dissertation next provides an overview of some relevant aspects of the Coordinated Management of Meaning (a theoretical communication framework employed to help make sense of the existing state …

Immobilization And Characterization Of Physisorbed Antibody Films Using Pneumatic Spray As Deposition Technique, Jhon J. Figueroa

USF Tampa Graduate Theses and Dissertations

The immobilization of antibodies on silica surfaces has been a wide and common practice via cross-linking with the formation of covalent bonds between surface and antibody. The formation of antibody thin films on solid surfaces using pneumatic spray (PS) as the deposition technique and the analysis of the surface morphology of these films were investigated during this study. The pneumatic spray method was compared with the covalent bonding method Avidin-Biotin Bridge (ABB). The intensities and capture efficiency tests showed similar results for both techniques with a lower signal-to-noise ratio (SNR) for the PS deposited films. Specificity tests suggested that the …

Chinese Consumers' Evaluation Of Domestic And Foreign Products: The Roles Of Country Of Origin And Product Usage Experience, Yuze Gao

USF Tampa Graduate Theses and Dissertations

Although COO has been a topic of central interest in international marketing research, most work has focused on consumers in western countries. The concept of product usage experience, though often implied in COO research, has yet to be investigated more directly and explicitly. The goal of the study is to examine the relationships among COO perceptions, product usage experience and purchase intention among Chinese consumers. The study examined two kinds of product usage experiences (usage variety and frequency) pertaining to products (products in general and laptop computers in specific) made in two countries (America and China). Empirical data gathered from …

Asbestos Exposure In The Research Laboratory, Ediberto D. Garcia

USF Tampa Graduate Theses and Dissertations

Introduction: Asbestos has been employed in a myriad of industrial applications for more than a century. Of the 181 Mt of asbestos produced worldwide, over 31 Mt was consumed in the U.S. The production and consumption of this mineral eventually was found to cause asbestosis, lung cancer and mesothelioma. While the brunt of the human exposure to asbestos occurred in insulation work, many more workers in other jobs were expose to asbestos fibers. Very little is known about the potential exposure to asbestos in research labs.

Goal: In order to investigate potential research lab work exposures, we simulated lab work …

Insights Into Reflection And Pre-Service Teacher Education: An Hermeneutic Phenomenology, Andrea M. Gelfuso

USF Tampa Graduate Theses and Dissertations

With recent calls for teacher education programs to increase both the quantity and quality of field experiences (NCATE, 2010), it is important for teacher educators to understand how pre-service teachers create meaning from those experiences. Reflection is a mode of thought historically associated with creating "warranted assertabilities" (Dewey, 1938, p.15) from experience. Therefore, reflection is a common component of many teacher education programs (Darling-Hammond, 2010). Despite the abundance of research that has been conducted about reflection and teacher education, little is understood about the process of supported reflection as it is experienced by pre-service teachers. In this hermeneutic phenomenology, I …

An(Other) Rhetoric: Rhetoric, Ethics, And The Rhetorical Tradition, Kathleen Sandell Hardesty

USF Tampa Graduate Theses and Dissertations

Rhetoric as a discipline is still touched by the shadow of ancient Greece. Rhetoric was defined famously by Aristotle as the "available means of persuasion," codified into five canons in classical Rome, and has since been a central part of Western education to train speakers and writers to effectively move their audiences. However, particularly beginning in the mid-20th Century, the discipline's understanding of rhetoric as a means of persuasion (or even manipulation) passed down from our ancient roots began to shift to a sense of rhetoric as matters of ethics and a concern for the other. It begs the question: …

Corrosion Of Post-Tensioning Strands In Ungrouted Ducts - Unstressed Condition, Michael John Hutchison

USF Tampa Graduate Theses and Dissertations

Recent failures and severe corrosion distress of post-tensioned (PT) bridges in Florida have revealed corrosion of the 7-wire strands in tendons. Post-tensioned duct assemblies are fitted with multiple 7-wire steel strands and ducts are subsequently filled with grout. During construction, the length of time from the moment in which the strands have been inserted into the ducts, until the ducts are grouted, is referred to as the `ungrouted' period. During this phase, the steel strands are vulnerable to corrosion and consequently the length of this period is restricted (typically to 7 days) by construction guidelines. This investigation focuses on determining …

The Perception Of Emergency Department Physicians Regarding Economic And Regulatory Factors Impacting Management Of Drug Seeking Patients, Sharon Susanne Kelley

USF Tampa Graduate Theses and Dissertations

Abstract

Physicians in the emergency department (ED) are facing a number of unique challenges in the currently changing healthcare and economic climates. Dramatic increases in ED patient volumes have been noted nationwide with visits related to prescription opioid abuse and misuse alone having increased by 111% between 2004 and 2008.

Ironically, several challenges ED physicians are facing arise from regulatory and economic initiatives which were originally designed for the protection of patients. Regulatory requirements to address pain as the fifth vital sign, along with entities utilizing patient satisfaction based reimbursement, have inadvertently created an environment conducive to exploitation by the …