Digital Commons Network^™

Radiosensitization Of Head & Neck Carcinoma Cells By Linifanib, A Receptor Tyrosine Kinase Inhibitor, Heng-Wei Hsu

Loma Linda University Electronic Theses, Dissertations & Projects

Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop combination therapy to improve clinical outcome. The mechanisms between antiangiogenic agents and ionizing radiation are complicated and involve many interactions between the vasculature, tumor stroma and tumor cells. The proliferation and metastasis of tumor cells rely on angiogenesis/blood vessel formation. …

Titanic: Consuming The Myths And Meanings Of An Ambiguous Brand, Stephen Brown, Pierre Mcdonagh, Clifford J. Shultz

School of Business: Faculty Publications and Other Works

Myths have come of age in consumer research. In the 22 years since Levy’s inaugural article, the literature has grown at an impressive rate. Yet important questions remain unanswered: What makes some myths especially meaningful to consumers? Why are certain consumer myths more prevalent and less perishable than others? This article argues that ambiguity is an influential factor. Using the RMS Titanic as an empirical exemplar, it unpacks the principal forms of myth-informed ambiguity surrounding “the unsinkable brand.” Predicated on William Empson’s hitherto unsung principles of literary criticism, the article posits that ambiguity in its multifaceted forms is integral to …

Community Detection In Complex Networks, Yaojia Zhu

Computer Science ETDs

The stochastic block model is a powerful tool for inferring community structure from network topology. However, the simple block model considers community structure as the only underlying attribute for forming the relational interactions among the nodes, this makes it prefer a Poisson degree distribution within each community, while most real-world networks have a heavy-tailed degree distribution. This is essentially because the simple assumption under the traditional block model is not consistent with some real-world circumstances where factors other than the community memberships such as overall popularity also heavily affect the pattern of the relational interactions. The degree-corrected block model can …

Mathematical Modelling Of Blood Flow Through Catheterized Artery Under The Influence Of Body Acceleration With Slip Velocity, S. U. Siddiqui, Sapna Geeta

Applications and Applied Mathematics: An International Journal (AAM)

The flow of blood through stenosed catheterized artery with the effect of external body acceleration has been considered. The pulsatile flow behaviour of blood in an artery subjected to the pulsatile pressure gradient and slip velocity has been studied considering blood as a Newtonian fluid. The non-linear differential equations governing the fluid flow are solved using the perturbation method. The analytic expressions are derived for the velocity profile, flow rate, wall shear stress and effective viscosity. The computer codes are developed for the analysis of physiological parameters. The effects of various parameters on blood flow are discussed through graphs. It …

Generalized Fractional Integral Of The Product Of Two Aleph-Functions, R. K. Saxena, J. Ram, D. Kumar

Applications and Applied Mathematics: An International Journal (AAM)

This paper is devoted to the study and develops the generalized fractional integral operators for a new special function, which is called Aleph-function. The considered generalized fractional integration operators contain the Appell hypergeometric function F₃ as a kernel. We establish two results of the product of two Aleph-functions involving Saigo-Maeda operators. On account of the general nature of the Saigo-Maeda operators and the Aleph-function, some results involving Saigo, Riemann-Liouville and Erdélyi-Kober integral operators are obtained as special cases of the main result.

Organic Interfaces; Or, How Human Beings Augment Their Digital Devices, John Hunter

Faculty Journal Articles

It is a central premise of the advertising campaigns for nearly all digital communication devices that buying them augments the user: they give us a larger, better memory; make us more “creative” and “productive”; and/or empower us to access whatever information we desire from wherever we happen to be. This study is about how recent popular cinema represents the failure of these technological devices to inspire the enchantment that they once did and opens the question of what is causing this failure.

Using examples from the James Bond films, the essay analyzes the ways in which human users are frequently …

The Old Man Of The Internet: Thomas.Gov, Congress.Gov And The Promise Of Online Legislative Research Fulfilled, Kurt Metzmeier

Faculty and Staff Scholarship

The article discusses using U.S. Congressional resources on the Internet, in particular the Library of Congress' Congress.gov website. The paper focuses on how to use these tools to determine the legislative intent behind a statute.

Sympathetic Nerve Modulation Of Joint Pathology In Adjuvant-Induced Arthritis, Carlo Anthony Wood

Loma Linda University Electronic Theses, Dissertations & Projects

Background: There is increasing data suggesting a net increase in sympathetic tone plays an important role in rheumatoid arthritis. Several studies have reported altered distribution and density of autonomic nerves in patients with rheumatoid arthritis and animal models for the disease. This provides anatomical evidence that supports a neurally-mediated drive in inflammation and joint destruction. Methods: Adult rats were injected with complete Freund’s adjuvant. At 12 days post immunization, animals were randomly placed into a drug treatment group (SH1293, which interacts with - and ß2-ARs), an adjuvant arthritic group, or a control group. These animals were sacrificed at 14, 21, …

Caveolins And Njks Influence Brain Endothelial Permeability After Juvenile Tbi, David Olufemi Ajao

Loma Linda University Electronic Theses, Dissertations & Projects

Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, disrupted cerebral blood flow (CBF) autoregulation, long-term disabilities and death following TBI in young demographic. Unsurprisingly, BBB disruption and the resultant cerebral edema have emerged as therapeutic targets in juvenile TBI. It is therefore important to understand the molecular players and mechanisms involved in TBI-induced BBB disruption in the juvenile brain. To this end, the endothelial caveolins and …

The Value Of Precedent : Appellate Briefs And Judicial Opinions In The U.S. Courts Of Appeals., Laura P. Moyer, Todd A. Collins, Susan B. Haire

Faculty and Staff Scholarship

This study of appellate advocacy examines factors that affect judicial treatment of precedents identified in litigant briefs. Although we find some attorney and party characteristics influence whether a court addresses precedent cited by a party, legal resources are not as influential in determining whether the court adopts a party’s use of a precedent. At times, ideological congruence between the circuit panel and the litigant can increase the likelihood that the court’s opinion will use a precedent in the same way as presented by the litigants. There is also some support for the importance of attorney experience. Even when their clients …

Preparing Mental Health Professionals For Work In Collaborative Care Settings, Angela G. Hester

Loma Linda University Electronic Theses, Dissertations & Projects

There has been a significant shift regarding how health and illness are conceptualized. In decades past, the biomedical model predominated. Factors other than biological were not seen as important with regard to the diagnosis and treatment of illness; mind and body were viewed as separate. Engel’s 1977 article challenged the biomedical perspective with the biopsychosocial model, suggesting the reciprocal nature of biological, psychological and social factors on patients’ experience of health and illness, and responsiveness to treatment interventions. While viewing individuals holistically was not a new concept at that time, several factors led the biopsychosocial model to gain wide acceptance …

Expression And Function Of Ca2+-Activated K+ Channels In Uterine Arteries, Ronghui Zhu

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic hypoxia during pregnancy is one of the most common insults to the maternal cardiovascular system and fetal development, and is associated with increased uterine vascular tone and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested the hypothesis that calcium-activated potassium (KCa) channels play an essential role in uterine vascular adaptation to pregnancy, which is inhibited by chronic hypoxia during gestation. Uterine arteries (UAs) were isolated from nonpregnant ewes (NPUAs) and near-term pregnant ewes (PUAs) that had been maintained at sea level (~300 m) or exposed to high altitude (3,801 m) for 110 days. …

Abstract Models Of Molecular Walkers, Oleg Semenov

Computer Science ETDs

Recent advances in single-molecule chemistry have led to designs for artificial multi-pedal walkers that follow tracks of chemicals. The walkers, called molecular spiders, consist of a rigid chemically inert body and several flexible enzymatic legs. The legs can reversibly bind to chemical substrates on a surface, and through their enzymatic action convert them to products. We study abstract models of molecular spiders to evaluate how efficiently they can perform two tasks: molecular transport of cargo over tracks and search for targets on finite surfaces. For the single-spider model our simulations show a transient behavior wherein certain spiders move superdiffusively over …

Factual Precedents, Allison Orr Larsen

Faculty Publications

Lawyers and judges speak to each other in a language of precedents—decisions from cases that have come before. The most persuasive precedent to cite, of course, is an on-point decision of the U.S. Supreme Court. But Supreme Court opinions are changing. They contain more factual claims about the world than ever before, and those claims are now rich with empirical data. This Supreme Court factfinding is also highly accessible; fast digital research leads directly to factual language in old cases that is perfect for arguments in new ones. An unacknowledged consequence of all this is the rise of what I …

Promising Protection: 911 Call Records As Foundation For Family Violence Intervention, James G. Dwyer

Faculty Publications

No abstract provided.

The Resilience Of Property, Lynda L. Butler

Faculty Publications

Resilience is essential to the ability of property to face transforming social and environmental change. For centuries, property has responded to such change through a dialectical process that identifies emerging disciplinary perspectives and debates conflicting values and norms. This dialectic promotes the resilience of property, allowing it to adapt to changing conditions and needs. Today the mainstream economic theory dominating common law property is progressively being intertwined with constitutionally protected property, undermining its long-term resilience. The coupling of the economic vision of ordinary property with constitutional property embeds the assumptions, choices, and values of the economic theory into both realms …

Hierarchically Variable Deference To Agency Interpretations, Aaron-Andrew P. Bruhl

Faculty Publications

When courts review agency action, they typically accord agency decisions a degree of deference. As many courts and commentators have recognized, the law in this area is complicated because it features numerous standards of review, including several distinct regimes for evaluating agencies’ legal interpretations. There is, however, at least one important respect in which uniformity rather than variety prevails: the applicable standards of review do not vary depending on which court is reviewing the agency. Whichever standard governs a particular case—Chevron, Skidmore, or something else—all courts in the judicial hierarchy are supposed to apply that same standard.

This Article proposes …

Do Market Incentives Crowd Out Charitable Giving?, Cary Deck, Erik O. Kimbrough

Economics Faculty Articles and Research

Donations and volunteerism can be conceived as market transactions with a zero explicit price. However, evidence suggests people may not view zero as just another price when it comes to pro-social behavior. Thus, while markets might be expected to increase the supply of assets available to those in need, some worry such financial incentives will crowd out altruistic giving. This paper reports laboratory experiments directly investigating the degree to which market incentives crowd out large, discrete charitable donations in a setting related to deceased organ donation. The results suggest markets increase the supply of assets available to those in need. …

Invisible Minority: People Incarcerated With Mental Illness, Developmental Disabilities, And Traumatic Brain Injury In Washington's Jails And Prisons, Bette Michelle Fleishman

Seattle Journal for Social Justice

No abstract provided.

Filling In The Holes In Whistleblower Protection Systems: Lessons From The Hanford Council Experience, Jonathan Brock

Seattle Journal for Social Justice

No abstract provided.

The Money Or The Media? Lessons From Contrasting Developments In Us And Australian Whistleblowing Laws, Terry Morehead Dworkin, A.J. Brown

Seattle Journal for Social Justice

No abstract provided.

An Inconsistent Invitation: Am I Invited To Be A Party? How Not Affording Party Status To Youth In Washington Dependency Hearings Can Be A Violation Of Due Process, Laura Baird

Seattle Journal for Social Justice

No abstract provided.

Stymieing Controversy Over Generic Top-Level Domains (Gtlds) And Other Internet Governance Decisions With Content Neutrality, Nafees Uddin

Seattle Journal for Social Justice

No abstract provided.

The Future Of Transit In West Virginia, Diana Long, Benjamin L. Blandford, Peter J. Dailey, Sinaya Dayan, Justin Matthews, Kent Sowards

Reports with Contribution from KTC Researchers

No abstract provided.

Faculty Senate Newsletter, December 2013, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: Discussion of higher education policy today takes place in the language or practicality: of productivity, of graduation targets, and of workforce development. Yet politics, even of the most pragmatic variety, is compounded as much of speculation and fantasy as of data, experience, or “reality.” Policy discussions quickly turn from what is to what should be. For decades—since the heyday of Margaret Thatcher—privatization has been heralded by “the silent majority” as the best way to increase efficiency. In academe, the twentieth-century dream of a lean, dynamic government has expressed itself in a faith in production line metrics such …

Ripples Against The Other Shore: The Impact Of Trauma Exposure On The Immigration Process Through Adjudicators, Kate Aschenbrenner

Michigan Journal of Race and Law

Immigration is currently a hot topic; discussion of immigration reform and the problems in our current system appear in the news virtually every day. There is widespread consensus that our current immigration system is “broken,” but there is little agreement on why and even less on what should be done to fix it. These are difficult and important questions, involving many complex interrelated factors. While I do not hope and cannot aim to answer them completely in this Article, I will argue that in doing so we must consider an often overlooked and generally understudied issue: the effects of trauma …

An Insurmountable Obstacle: Denying Deference To The Bia’S Social Visibility Requirement, Kathleen Kersh

Michigan Journal of Race and Law

In the last fifteen years, the Board of Immigration Appeals has imposed a requirement that persons seeking asylum based on membership in a particular social group must establish that the social group is “socially visible” throughout society. This Comment argues that the social visibility requirement should be denied administrative deference on several grounds. The requirement should be denied Chevron deference because Congress’s intent behind the Refugee Act of 1980 is clear and unambiguous and, alternatively, the requirement is an impermissible interpretation of the statute. The requirement is also arbitrary and capricious under the Administrative Procedures Act. This Comment argues that …

From Script To Screen To Syllabus: The Path To Curriculum Design For Undergraduate Film Production Programs, Peter J. Muir

Dissertations

Nothing has impacted western society more than media. Tibetan spiritual leader, the Dali Lama, wrote that “film and television, newspapers, books and radio together have an influence over individuals that was unimagined a hundred years ago.” The responsibility of creating these cultural artifacts, particularly within motion picture production, is a delicate balance between artistic vision and craft-oriented vocation; the contemplative mind skills of a wise citizen with the functional hand skills of a tradesperson. Undergraduate film production education provides the best avenue for development of this duality. However, within these programs, little is known regarding how curriculum is fashioned and …

Pathways To Cyber Bullying From Bystander To Participant: Secondary School Students’ Perspectives, Michele L. Siderman

Dissertations

The author conducted a qualitative analysis of student artifacts to explore the pathway and experiences of students who had never bullied in the traditional sense but had cyber bullied through the use of social networking sites. In addition, the author explored students’ understanding of the difference between traditional and cyber bullying and their perceptions of the victim receiving the online bullying messages. A transcendental phenomenological approach was employed. The student artifacts analyzed were assignments from a required ninth grade character education class, which included a self-reflective survey, journals, a six-paragraph paper, and an online photo story project.

Results indicated that …

Homoeopathic Management Of Attention Deficit Hyperactivity Disorder: A Randomised Placebo-Controlled Pilot Trial, Praveen Oberai, S Gopinadhan, Roja Varanasi, Alok Mishra, Vikram Singh, Chaturbhuja Nayak

Indian Journal of Research in Homoeopathy

Objective: To evaluate the usefulness of individualised homoeopathic medicines in treatment of Attention Deficit Hyperactivity Disorder (ADHD). Design: Randomised placebo-controlled single-blind pilot trial. Setting: Central Research Institute (Homoeopathy), Kottayam, Kerala, India from June 2009 to November 2011. Participants: Children aged 6-15 years meeting the Diagnostic Statistical Manual of mental disorders (DSM-IV) criteria for ADHD. Interventions: A total of 61 patients (Homoeopathy = 30, placebo = 31) were randomised to receive either individualised homoeopathic medicine in fifty millesimal (LM) potency or placebo for a period of one year. Outcome measures: Conner′s Parent Rating Scale-Revised: Short (CPRS-R (S)), Clinical Global Impression-Severity Scale …