Digital Commons Network^™

Characterization Of Ovine Nectin-4, A Novel Peste Des Petits Ruminants Virus Receptor, Jamie Birch, Nicholas Juleff, Michael P. Heaton, Ted Kalbfleisch, James Kijas, Dalan Bailey

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.

A Primer On The 2011 Corrections Realignment: Why California Placed Felons Under County Control, Steven Thomas Fazzi

McGeorge Law Review

No abstract provided.

Endangered Status And Designation Of Critical Habitat For Gunnison Sage-Grouse: Literature Cited

United States Fish and Wildlife Service: Publications

Literature Cited A-Z

Aldridge, C.L. 1998. Status of the sage grouse (Centrocercus urophasianus urophasianus) in Alberta. Alberta Environmental Protection, Wildlife Management Division, and Alberta Conservation Association, Wildlife Status Report No. 13, Edmonton, AB. 23 pp.

Aldridge, C.L. and M.S. Boyce. 2007. Linking occurrence and fitness to persistence: a habitat-based approach for endangered greater sage-grouse. Ecological Applications 17:508-526.

Aldridge, C.L. and R.M. Brigham. 2003. Distribution, abundance, and status of the greater sage-grouse, Centrocercus urophasianus, in Canada. Canadian Field-Naturalist 117:25-34.

Aldridge, C.L., S.E. Nielsen, H.L. Beyer, M.S. Boyce, J.W. Connelly, S.T. Knick, and M.A. Schroeder. 2008. Range-wide patterns of …

Antigenicity And Immunogenicity Of Rv144 Vaccine Aidsvax Clade E Envelope Immunogen Is Enhanced By A Gp120 N-Terminal Deletion, S. Munir Alam, Hua-Xin Liao, Georgia D. Tomaras, Mattia Bonsignori, Chun-Yen Tsao, Kwan-Ki Hwang, Hiayan Chen, Krissey E. Lloyd, Cindy Bowman, Laura Sutherland, Thomas L. Jeffries Jr., Daniel M. Kozink, Shelley Stewart, Kara Anasti, Frederick H. Jaeger, Robert Parks, Nicole L. Yates, R. Glenn Overman, Faruk Sinangil, Phillip W. Berman, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Nicos Karasavva, Supachai Rerks-Ngarm, Jerome H. Kim, Nelson L. Michael, Susan Zolla-Pazner, Sampa Santra, Norman L. Letvin, Stephen C. Harrison, Barton F. Haynes

United States Army: Publications

An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Δ11) and addition of a herpes simplex virus (HSV) gD protein-derived tag (gD). We investigated the effects of these modifications on gp120 expression, antigenicity, and immunogenicity by comparing unmodified A244 gp120 with both Δ11 deletion and gD tag and with Δ11 only. Analysis of A244 gp120, with or without Δ11 or gD, demonstrated that the Δ11 deletion, without the addition of gD, …

Novel 16s Rrna Methyltransferase Rmth Produced By Klebsiella Pneumoniae Associated With War-Related Trauma, Jessica A. O'Hara, Patrick Mcgann, Erik C. Snesrud, Robert J. Clifford, Paige E. Waterman, Emil P. Lesho, Yohei Doi

United States Army: Publications

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

Adaptive Evolution Of The Streptococcus Pyogenes Regulatory Aldolase Lacd.1, Zachary Cusumano, Michael Caparon

Open Access Publications

No abstract provided.

Clostridium Difficile Ribotype Diversity At Six Health Care Institutions In The United States, Sheila Waslawski, Eugene S. Lo, Sarah A. Ewing, Vincent B. Young, David M. Aronoff, Susan E. Sharp, Susan M. Novak-Weekley, Arthur E. Crist Jr, W. Michael Dunne, Joan Hoppe-Bauer, Michelle Johnson, Stephen M. Brecher, Duane W. Newton, Seth T. Walk

Open Access Publications

No abstract provided.

Local Policy Scan On Climate Change Adaptation, Adrienne I. Greve, Michael R. Boswell

City and Regional Planning

The Climate Change Adaptation Policy Scan provides a snapshot of the current state of community-level activities in the United States and Canada for addressing climate change impacts on public health. The report was developed using a combination of literature review, expert interviews, and case studies to identify best practices, common challenges, and keys to success. This report is intended to be useful to public health officials and community organizations; city and county public agencies, especially those involved in city planning and sustainability; and scholars in these fields. The information provided for the emerging area of climate adaptation policy development is …

South Dakota Animal Disease Research & Diagnostic Laboratory: Annual Report 2013, Animal Disease Research And Diagnostic Laboratory, South Dakota State University

South Dakota Animal Disease Research and Diagnostic Laboratory (ADRDL)

This document is the 2013 annual report of the South Dakota Veterinary and Biomedical Science Department Animal Disease Research and Diagnostic Laboratory.

What Are Parents' Perceptions On Immunizations Causing Autism Spectrum Disorders?, Shanae Nicole Blake

Theses Digitization Project

The purpose of this study was to identify parental perceptions on immunizations causing Autism Spectrum Disorders (ASDs), and identify whether or not these perceptions influenced whether or not a parent vaccinated their child. If parents are educated on vaccinations, and understand that numerous studies have been conducted proving immunizations do not cause autism, it may prevent a host of possible problems that may arise in the future.

A Mind-Body Approach To Promote Health And Enhance Healing, Lisa Dionne Meyering

Theses Digitization Project

The purpose of this project was to create for the public a research-based user-friendly booklet that provides guidance with regard to psychological considerations that may be employed to enhance, or accelerate, the process of healing from illness.

University Of Texas Health Science Center At Tyler Graduate Bulletin, 2013 - 2014, University Of Texas Health Science Center At Tyler

Catalogs

No abstract provided.

Role Of Trem1-Dap12 In Renal Inflammation During Obstructive Nephropathy, Alessandra Tammaro, Ingrid Stroo, Elena Rampanelli, Froilan Blank, Loes M. Butter, Nike Claessen, Toshiyuki Takai, Marco Colonna, Jaklien C. Leemans, Sandrine Florquin, Mark C. Dessing

Open Access Publications

No abstract provided.

Short Report: Semi-Quantitative Scoring Of An Immunochromatographic Test For Circulating Filarial Antigen, Cedric B. Chesnais, Francois Missamou, Sebastien D.S. Pion, Jean Bopda, Frederic Louya, Andrew C. Majewski, Gary J. Weil, Michel Boussinesq

Open Access Publications

No abstract provided.

Changing Behavior Among Nurses To Track Indwelling Urinary Catheters In Hospitalized Patients, Bona Yoon, Samantha D. Mcintosh, Leslie Rodriguez, Alma Holley, Charles Faselis, Angelike P. Liappis

Medicine Faculty Publications

Catheter-associated urinary tract infections (CAUTIs) are preventable complications of hospitalization. An interdisciplinary team developed a curriculum to increase awareness of the presence of indwelling urinary catheters (IUCs) in hospitalized patients, addressed practical, primarily nurse-controlled inpatient risk-reduction interventions, and promoted the use of the IUC labels (“tags”). Five thirty-minute educational sessions were cycled over three daily nursing shifts on two inpatient medical floors over a 1-year period; participants were surveyed to elicit feedback and provide real-time insight on the learning objectives. Nurse self-reported IUC tagging was early and sustained; after the IUC tag was introduced, there was a significant increase in …

The Curious Case Of Trent Arsenault: Questioning Fda Regulatory Authority Over Private Sperm Donation, Amber D. Abbasi

Annals of Health Law and Life Sciences

No abstract provided.

Complementarity In Public Health Systems: Using Redundancy As A Tool Of Public Health Governance, Lance Gable, Benjamin Mason Meier

Annals of Health Law and Life Sciences

No abstract provided.

A Randomized, Controlled Trial Of Catheter-Related Infectious Event Rates Using Antibiotic-Impregnated Catheters Versus Conventional Catheters In Pediatric Cardiovascular Surgery Patients, Elaine G. Cox, Chad A. Knoderer, Aimee Jennings, John W. Brown, Mark D. Rodefeld, Scott G. Walker, Mark W. Turrentine

Scholarship and Professional Work – COPHS

We conducted a randomized, controlled clinical trial to determine whether a difference in catheter-associated blood stream infection (CABSI) incidence existed between children who underwent cardiac surgery and had a central venous catheter impregnated with minocycline and rifampin versus those who had a conventional, nonimpregnated catheter after cardiac surgery. Due to a lower number of infections than expected, the study was terminated early. Among 288 evaluable patients, the rates of CABSI and line-related complications were similar between the 2 groups.

Molecular Epidemiology Of Early And Acute Hiv Type 1 Infections In The United States Navy And Marine Corps, 2005–2010, Richard A. Heipertz, Eric Sanders-Buell, Gustavo Kijak, Shana Howell, Michelle Lazzaro, Linda L. Jagodzinski, John Eggleston, Sheila Peel, Jennifer Malia, Adam Armstrong, Nelson L. Michael, Jerome H. Kim, Robert J. O'Connell, Paul T. Scott, David Brett-Major, Sodsai Tovanabutra

Journal Articles: Epidemiology

The U.S. military represents a unique population within the human immunodeficiency virus 1 (HIV-1) pandemic. The last comprehensive study of HIV-1 in members of the U.S. Navy and Marine Corps (Sea Services) was completed in 2000, before large-scale combat operations were taking place. Here, we present molecular characterization of HIV-1 from 40 Sea Services personnel who were identified during their seroconversion window and initially classified as HIV-1 negative during screening. Protease/reverse transcriptase (pro/rt) and envelope (env) sequences were obtained from each member of the cohort. Phylogenetic analyses were carried out on these regions to determine relatedness within the cohort and …

Combating Sti Epidemic: Community Perspectives Learned From Mixed-Gender Focus Group Study, K. M. M. Islam, Laura C. Vinson, Sherri Nared, Ira Combs, Melissa Tibbits, Shinobu Watanabe-Galloway, Ruth Margalit

Journal Articles: Epidemiology

Background. Since 2004, Douglas County in Nebraska has been experiencing higher rates of sexually transmitted infections (STIs) than the rest of the state. Northern Omaha has been considered to be one of the “hot spots” for STIs in the county. In 2011-2012, a focus group study was conducted to investigate the community’s perception of STIs and to identify strategies to increase the testing and treatment of STIs. Methods. Fourteen young adults were recruited to participate in two mixed-gender focus group sessions, each lasting 1.5 hours. Sessions covered various topics on STIs. Audio-recorded sessions were transcribed and analyzed by …

Documentation Of Hiv Prevention Research And Programmatic Learnings From India—Selected Peer-Reviewed Journal Publications From The Knowledge Network Project (Volume 1), Population Council

HIV and AIDS

Over the past decade (2000–11), India has achieved dramatic successes in reversing the HIV epidemic. These successes are largely due to the implementation of upscaled HIV-prevention interventions by the National AIDS Control Organization, two other donors, and nongovernmental organizations, under the National AIDS Control Program III. As the epidemic in India is concentrated in vulnerable subpopulations, these interventions were focused on high-risk groups. It is important to understand the lessons learned from the implementation of HIV-prevention programs and the vulnerabilities that need to be addressed to reach the goal of zero new infections. To support this understanding, the Population Council …

Blue Light Rescues Mice From Potentially Fatal Pseudomonas Aeruginosa Burn Infection: Efficacy, Safety, And Mechanism Of Action, Tianhong Dai, Asheesh Gupta, Ying-Ying Huang, Rui Yin, Clinton K. Murray, Mark S. Vrahas, Margaret E. Sherwood, George P. Tegos, Michael R. Hamblin

United States Army: Publications

Blue light has attracted increasing attention due to its intrinsic antimicrobial effect without the addition of exogenous photosensitizers. However, the use of blue light for wound infections has not been established yet. In this study, we demonstrated the efficacy of blue light at 415 nm for the treatment of acute, potentially lethal Pseudomonas aeruginosa burn infections in mice. Our in vitro studies demonstrated that the inactivation rate of P. aeruginosa cells by blue light was approximately 35-fold higher than that of keratinocytes (P=0.0014). Transmission electron microscopy revealed blue light-mediated intracellular damage to P. aeruginosa cells. Fluorescence spectroscopy suggested that coproporphyrin …

Childhood Cancer In The Cinema: How The Celluloid Mirror Reflects Psychosocial Care, Jovana Pavisic

Yale Medicine Thesis Digital Library

Film is a powerful medium for sharing illness narratives, and can exert a significant influence on public medical discourse. The childhood cancer narrative has more recently emerged on the screen, and these images have yet to be analyzed. This study aims to evaluate the childhood cancer experience in commercially produced, readily available films with a character with childhood cancer, with a particular focus on psychosocial care. Twenty-nine films were reviewed, using quantitative and qualitative content analysis to identify the medical and psychosocial characteristics of the cinematic childhood cancer experience. Psychosocial support was rated on a five-point scale (0-4) based on …

The Influence Of Ubiquitin-Related Modifier Protein Urm1 On Prion Formation, Jacob Beaver

Bridges: A Journal of Student Research

Prions are infectious proteins that are autocatalyzing (formed by altering a regular protein into the structurally different prion form), and are associated with many neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Bovine Spongiform encephalopathy (or Mad Cow disease). This experiment tested the effect of three different plasmids—pH317, pER62, and pMP46—on prion formation in both wild-type and Urm1 deletion mutants in the yeast Saccharomyces cerevisiae. The proposed hypothesis was over-expression of the Ure2 prion forming protein would increase the frequency of prion formation, as well as yield less sustainable prion amyloids (or prion aggregations) that are easier to cure. Another …

Comparing Two-Year Community College And Four-Year University Student Social And Behavioral Sexually Transmitted Infection Risk Factors, Oswald M. Attin

Faculty Dissertations

Sexually transmitted infections (STIs) could cause ectopic, cervical cancer, infertility, and organ damage to the heart, kidneys, and brain. This study compared several behavioral risk factors of STIs (condom use, number of sexual partners, type of sex (anal or vaginal) and drinking habits) between two distinct educational settings and their association with socioeconomic risk factors such as low income and parent’s lower level of education that are known to increase the incidence of STIs among college-aged students. This study was based on the precautionary-health-behavior model, where individuals act regardless of consequences, and the health-behavior-change model, where individual behaviors either increase …

Factors Affecting Uptake Of, And Adherence To, Treatment For Latent Tuberculosis Infection In Ventanilla, Peru, Mariano Matias Iberico Lozada

Master of Public Health Program Student Publications

In Peru, treatment for latent tuberculosis infection (LTBI) with isoniazid is free for all people younger than 20 who have been in close contact with a person with active pulmonary tuberculosis (TB). Despite the availability of this drug therapy within the context of a TB control program that exceeds the international standards for TB care, very few children access, and even fewer complete a full course of treatment. This study was done in order to understand which factors contribute to latent tuberculosis infection treatment uptake and adherence, and whether a socio-economic intervention could improve uptake and adherence of treatment for …

Icipe Demonstrating Excellence 2007-2012, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Food For Thought … Mechanistic Validation, Thomas Hartung, Sebastian Hoffman, Martin Stephens

Experimentation Collection

Validation of new approaches in regulatory toxicology is commonly defined as the independent assessment of the reproducibility and relevance (the scientific basis and predictive capacity) of a test for a particular purpose. In large ring trials, the emphasis to date has been mainly on reproducibility and predictive capacity (comparison to the traditional test) with less attention given to the scientific or mechanistic basis. Assessing predictive capacity is difficult for novel approaches (which are based on mechanism), such as pathways of toxicity or the complex networks within the organism (systems toxicology). This is highly relevant for implementing Toxicology for the 21st …

The Study On The Impact Of The Fukushima Nuclear Accident On Animals, Ito Nobuhiko

Disasters and Disaster Response

After the 2011 earthquake that produced a tsunami devastating the coastal regions north of Tokyo and that led to three nuclear reactor meltdowns at the Daiichi Nuclear Power Plant in the Fukushima Prefecture of Japan, the national government required inhabitants in a zone around the nuclear plant to evacuate. Eventually, 154,000 evacuated but many left their animals behind. This report prepared by faculty at the Kitasato School of Veterinary Medicine documented what happened to the animals left in the exclusion zone. It is one of the only published reports looking at how one might deal with animals that have been …

Fox In The Henhouse: A Study Of Police Officers Arrested For Crimes Associated With Domestic And/Or Family Violence, Philip M. Stinson, John Liederbach

Criminal Justice Faculty Publications

The problem of violence within police families has been increasingly recognized as an important socio-legal issue, but there is a lack of empirical data on what has commonly been referred to as officer-involved domestic violence (OIDV). There are no comprehensive statistics available on OIDV and no government entity collects data on the criminal conviction of police officers for crimes associated with domestic and/or family violence. Prior self-report officer surveys are limited by the tendency to conceal instances of family violence and the interests of officers to maintain a "code of silence" to protect their careers. The purpose of the current …