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Multicultural Training Of Clinical And Counseling Psychology Doctoral Students: Ideals Vs. Practice, Bryana F. C. White

Open Access Dissertations

The American Psychological Association (APA), which is the advocating body for the field of psychology, emphasizes the importance of multicultural competencies for researchers and clinicians (APA, 2003; 2010). Graduate students are the field’s future professionals. The multicultural training of doctoral level clinical and counseling psychology graduate students is integral to efforts to improve clinical services and the research that provides the foundation for those services. While the literature addresses issues of multicultural competence and training in a general way, few specifics regarding the methods employed by graduate programs to aid their students in the process of developing those competencies are …

Program Assessment: Enough Or Too Much?, Eric G. Boyce

School of Pharmacy Faculty Articles

No abstract provided.

Examination Of Hippocampal N-Methyl-D-Aspartate Receptors Following Chronic Intermittent Ethanol Exposure In Vitro, Anna R. Reynolds

Theses and Dissertations--Psychology

Chronic intermittent ethanol exposure (CIE) is associated with degeneration of hippocampal neurons. The present study used hippocampal cultures to examine the loss of NeuN immunoreactivity, a relaible marker or neuronal density, after 1, 2, or 3 cycles of 5 days EtOH exposure (50 mM), followed by a 24-hour period of EWD or continuous EtOH exposure. NeuN immunoreactivity was decreased by 13%, 19%, and 16% in the CA1, CA3, and dentate gyrus after 3 cycles of CIE respectively; thionine staining confirmed significant cellular losses within each hippocampal subregion. Two cycles of CIE in aged tissue cultures resulted in significant decreases in …

Wst 2309g : Women, Men, And Culture, Women's And Gender/Sexuality Studies

Approved Course Proposals

No abstract provided.

Joints Or The Joint: Colorado And Washington Square Off Against The United States, Michael Vitiello

McGeorge School of Law Scholarly Articles

No abstract provided.

Justice Kennedy’S “Gay Agenda”: Romer, Lawrence, And The Struggle For Marriage Equality, Lawrence C. Levine

McGeorge School of Law Scholarly Articles

No abstract provided.

The Property Jurisprudence Of Justice Kennedy, John G. Sprankling

McGeorge School of Law Scholarly Articles

No abstract provided.

Medicare Part D Roulette: Potential Implications Of Random Assignment And Plan Restrictions, Rajul A. Patel, Mark P. Walberg, Joseph A. Woelfel, Michelle M. Amaral, Paresh Varu

School of Pharmacy Faculty Articles

Background: Dual-eligible (Medicare/Medicaid) beneficiaries are randomly assigned to a benchmark plan, which provides prescription drug coverage under the Part D benefit without consideration of their prescription drug profile. To date, the potential for beneficiary assignment to a plan with poor formulary coverage has been minimally studied and the resultant financial impact to beneficiaries unknown.

Objective: We sought to determine cost variability and drug use restrictions under each available 2010 California benchmark plan.

Methods: Dual-eligible beneficiaries were provided Part D plan assistance during the 2010 annual election period. The Medicare Web site was used to determine benchmark plan costs and prescription …

Insulin Treatment Attenuates Renal Adam17 And Ace2 Shedding In Akita Diabetic Mice, Esam Said Busah Salem

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Diabetic patients have a 40%-50% lifetime chance of developing chronic kidney disease, which remains one of the leading causes of morbidity and mortality. Alterations within renin angiotensin system balance contribute to the pathogenesis of diabetic kidney disease. Angiotensin converting enzyme 2 (ACE2) has an endogenous renoprotective role due to its ability to form angiotensin (1-7) (Ang 1-7) by degrading angiotensin II (Ang II). We have shown previously that hyperglycemia increases urinary ACE2 and albumin excretion in db/db diabetic mice. The protease, disintegrin and metalloprotease (ADAM) 17, is involved in the shedding of several transmembrane proteins, including ACE2 in vitro. Tissue …

Physical Exercise Training But Not Metformin Attenuates Albuminuria And Shedding Of Ace2 In Type 2 Diabetic Db/Db Mice, Hari Krishna Somineni

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Angiotensin II (Ang II), a potent vasoconstrictor cleaved from Ang I, is responsible for renal damage in diabetes. Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and has been shown to be renoprotective by degrading Ang II to Ang-(1-7). A Disintegrin and Metalloproteinases (ADAMs) were recently identified as an ectodomain sheddases of transmembrane proteins. ADAM17 mediated shedding of renal ACE2 could contribute to the pathogenesis of diabetic nephropathy. In our previous study, rosiglitazone treatment normalized hyperglycemia and improved renal injury by preventing ACE2 shedding. The aim of this study is to test the hypothesis that improved glucose …

Bioaccumulation And Neuroinflammation Of Gold Nanoparticles In The Central Nervous System, Fahimeh Fallahi

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Gold nanoparticles (GNPs) possess unique physicochemical properties that may facilitate entry into the central nervous system (CNS) where they may act therapeutically. There is little information on biodistribution or inflammatory effects of GNPs in specific brain regions. Brain Localization and neuroinflammatory response to citrate-capped spherical GNP (10 nm) was determined 24 hours after intravenous (IV) injection in male C57Bl mice. A known inflammogen, lipopolysaccharide (LPS, 2 mg kg-1, SC), was tested as a positive control supplement. Aggregation of GNPs was measured using various Phosphate-Buffered Saline (PBS) concentrations (10, 1, 0.1, 0.01 X) to determine the optimal buffer concentration to maintain …

Amp-Activated Protein Kinase Knockdown In Labyrinthine Trophoblast Cells Results In Altered Morphology And Function, Erica Ashton Kayleigh Carey

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The placenta is a transient organ that develops upon initiation of pregnancy and is essential for fetal development and survival. The rodent placenta consists of three layers with predominantly analogous cell types in the human placenta. The labyrinth layer, which lies closest to the fetus, facilitates nutrient and waste exchange between mother and baby. Abnormalities of the placenta may occur as a result of cellular stress and have been associated with the pregnancy-associated disorders, intrauterine growth restriction and placental insufficiency. AMP-activated protein kinase (AMPK) is a master sensor of cellular stress and changes in AMPK expression or activation could be …

C-Bouton Coverage Of Alpha-Motoneurons Following Peripheral Nerve Injury, Esra Salah Shermadou

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Peripheral nerve injuries (PNI) cause alternations in central synapses leading to loss of function. The C-bouton synapses onto a-motoneurons in the ventral horn, and has a role in regulating motor output. Following tibial nerve ligation, the somatic C-bouton coverage is depleted (Alvarez et al., 2011), however, it is unknown what happens following crush type injuries. PNI causes neuroglia activation and proliferation that contribute to synaptic alterations, a response that has not been well-characterized in the ventral horn, where motoneurons are located. Therefore, I hypothesize that glia activation following peripheral nerve injury correlates to the degree of depletion of synaptic coverage …

K-Cl Cotransport: Role Of Kcc3 In Cellular Potassium (K) Homeostasis In Kcc3- Transfected Hek-293 Cells, Nagendra Babu Ravilla

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K-Cl cotransport (KCC) mediated by four protein isoforms, KCC1 to KCC4, plays a significant role in cell volume regulation, and in K and Cl homeostasis. In this study, we demonstrate the importance of KCC3 and its two threonine (T) phosphorylation sites T991 and T1048 in cellular K homeostasis in isogenic human embryonic kidney (HEK-293) cells transfected with KCC3 wild type (WT) or constitutively active double mutant KCC3 (AA) expressed under tetracycline or doxycycline control. In both WT and AA cells, under baseline conditions, the Na-K-2Cl cotransport (NKCC) (55 %- 60 %) was the major contributor of Rb influx followed by …

Reactive Oxygen Modulates B Lymphocyte Function Via The Nfκb/Rel Pathway, Eric J. Romer

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Reactive Oxygen Intermediates (ROI) can significantly affect B Lymphocyte function, but the effects on key signaling pathways and gene expression in activated and non-activated B lymphocytes are largely undefined. This study demonstrates a concentration dependent effect of exogenous hydrogen peroxide on the transcriptional regulation of a 3' regulatory region of the Immunoglobulin heavy chain gene (3'IghRR). Specifically, low μM hydrogen peroxide induces an enhancing effect while higher μM hydrogen peroxide (greater than or equal to 100 μM) is suppressive. The enhancing effects of hydrogen peroxide on 3'IghRR activity are dependent on the NFκB/Rel pathway, and appear to be most prominent …

Copper And Nickel Partitioning With Nanoscale Goethite, Kelsey Marie Danner

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Goethite is an ideal sorbent for investigations of metal partitioning with iron oxyhydroxides because it is the most abundant iron oxyhydroxide in sediments (Langmuir, 1997; van der Zee et al., 2003), and cations have a strong affinity for goethite (Coughlin and Stone, 1995). Steady-state partitioning of nickel (Ni) and copper (Cu) to nanoscale goethite (a-FeOOH) was investigated experimentally under conditions intended to be representative of those in natural waters. Manipulated conditions included i) sorbent mass, ii) solute metal concentration, iii) reaction time, iv) pH, v) ionic strength (I), and vi) humate concentration (competitive ligand) to examine how these factors influenced …

Cyclic Voltammetric And Square Wave Anodic Stripping Voltammetric Analysis Of Lead And Cadmium Utilizing The Novel Titanium Dioxide/ Zirconium Dioxide/ Tween 80 Carbon Paste Composite Electrode, Phuong Khanh Quoc Nguyen

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Heavy metals, particularly Lead (Pb) and Cadmium (Cd), had been long identified as hazardous pollutants in the environment. Joining the continuous effort to alleviate this dilemma, a new electro-chemical sensor has been developed to assess the level of Pb and Cd in aqueous environment. The current work describes the utilization of two different electro-analytical techniques, cyclic voltammetry (CV) and square wave anodic stripping voltammetry (SWASV), in conjunction with the novel Titanium Dioxide/ Zirconium Dioxide/ Tween 80 (TiO2/ ZrO2/ Tween 80) carbon paste composite electrode to qualitatively and quantitatively analyze Pb and Cd. In this dissertation, along with a comprehensive literature …

A Comprehensive Tool And Analytical Pathway For Differential Molecular Profiling And Biomarker Discovery, Claude Curtis Grigsby

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The key requirements to any empirically based study are to: (1) accurately measure and then compare the collected results in determining the result of the hypothesis being tested; and (2) collect a sample representative of the entities being studied. To demonstrate that an informatics tool can be designed that provides spectral registration, spectral and chromatographic alignment, visualization, and comparative analysis for data generated from multiple analytical platforms, e.g., LC-MS and GC-MS, the results and data analysis of five unique sets of experiments using a suite of novel informatics tools are presented. Comprehensive and reproducible sample collection techniques were developed concomitantly …

A Semantics-Based Approach To Machine Perception, Cory Andrew Henson

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Machine perception can be formalized using semantic web technologies in order to derive abstractions from sensor data using background knowledge on the Web, and efficiently executed on resource-constrained devices. Advances in sensing technology hold the promise to revolutionize our ability to observe and understand the world around us. Yet the gap between observation and understanding is vast. As sensors are becoming more advanced and cost-effective, the result is an avalanche of data of high volume, velocity, and of varied type, leading to the problem of too much data and not enough knowledge (i.e., insights leading to actions). Current estimates predict …

Simulating Hemodynamics In In Vitro Culture Models: Implications On Nano-Biointeractions, Monita Sharma

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Gold nanoparticles (Au-NPs) have demonstrated great potential in the development of a variety of tools with applications ranging from biomedical to military fields. Consequently, there is increasing concern regarding the toxic potential of these nanomaterials. Biodistribution studies demonstrate clearance of Au-NPs from peripheral circulation and bulk localization primarily in the liver and spleen post- intravenous administration. Deposition of Au-NPs in spleen suggests the potential for direct exposure of immune cells to these foreign materials under relatively static conditions. Although much less, due to the Blood Brain Barrier (BBB), Au-NPs appear to also deposit in the brain, suggesting that the resident …

Chronic Swim Stress Attenuates Endocrine Response And Improves Cardiac Function In Mice Lacking The Angiotensin Ii Type 1a Receptor, Najat Khalifa Almahroug

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Stress is a stimulus that causes an often abrupt but always large change in autonomic activity and hormone secretion. Angiotensin II (AngII) is one of the main neurohormonal mediators that are stimulated by stress. AngII mediates most of its relevant biological effects via AngII type1 receptor (AT1R) activation. Stress increases tissue and circulating levels of Ang II which contributes to stimulation of adrenal AT1R, mediating stressinduced hormone release. Ang II through the activation of AT1R not only elevates blood pressure but also has a patho-physiological relevance in cardiac remodeling. The goal of this study was to assess the influence of …

Piezoelectric-Based, Self-Sustaining Artificial Cochlea, Jared Evans

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Hearing loss is a prevalent issue, affecting all ages in innumerable occupations. Cochlear implants are one solution to sensorineural hearing complications; and though they are commonly used, the electronic devices have limitations in power consumption and external equipment. Piezoelectric films emulate the relationship between the basilar membrane and inner hair cell structures of the human cochlear epithelium, inducing a potential difference in response to sound pressure. Through proper MEMS fabrication and material selection, an artificial cochlear can be developed utilizing piezoelectrics, which is self-sustainable and functions naturally with the mechanisms of the human ear. This research investigates the feasibility of …

Trace Metals In Sediments On The Continental Margin Of The Northwest Atlantic Ocean, Daniel L. Marsh

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Trace metals in the ocean are derived from natural and anthropogenic sources. Despite increased human impact on the marine environment and biological productivity of continental margins, trace metal studies in marine sediments have focused primarily on near-shore regions. I investigated 22 metals in sediments on the continental margin of the northwest Atlantic Ocean to calculate enrichment factors (EF) relative to upper continental crust and identify spatial variations with distance from shore and depth below the sediment-seawater interface. Metals were well correlated with Al, Fe, organic matter, or CaCO3. No clear trends in metal EFs with distance from shore were evident …

"Characterization Of Red Diamondback Rattlesnake Venom Proteins On Cell Death And Function", Venus Ebrahimian

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Snake venom is composed of many different toxins and protein components such as metalloproteases and phospholipase A2. Together, these proteins cause an up regulation in cell death pathways and disrupt the overall homeostasis of a living cell. The Red Diamondback Rattlesnake is abundantly available and well-known specie and has been used as a source for development of new drugs. It has been mainly used for the purposes of making anti-venom but it has also been therapeutically used for surgical purposes to act as an anti-aggregate. Integrins derived from RDB venom has been used for cancer cell treatment as well. Specifically …

Locating Chelerythrine, An Alkaloid, Within A Cytosolic Environment By Maldi-Tof Mass Spectrometry, Bradley Allen Williams

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The quaternary benzo-phenanthridine alkaloid (QBA) chelerythrine (CET) is a well-known inhibitor of PKC and cancer growth (Herbert et al., 1990). In human lens epithelial cells (HLECs), CET almost completely inhibits the Na+/K+ pump ATPase (NKA) without changes in phosphorylation (Lauf et al. 2013). Protein alignment studies revealed B-lymphocyte type 2 protein (Bcl-2) BH1- like motifs within the a1 subunit of the NKA to which CET, a drug mimicking Bcl-2 protein BH3-like motifs, might bind thus disrupting NKA function (Lauf et al, 2013). It is unknown by which mechanism CET crosses the plasma membrane to reach its intracellular targets, especially the …

The Normative Ethics Of Gandhian Nonviolence, Jacob N. Bauer

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This thesis examines Mahatma Gandhi's ethical views on nonviolence from the perspective of contemporary philosophical ethics. Gandhian nonviolence is situated in the field of contemporary ethics by using the concepts and terminology from Shelly Kagan's work, Normative Ethics. Three questions are asked that classify and clarify Gandhian nonviolence. First, is nonviolence primarily instrumentally or intrinsically significant? This question is closely tied to the second, does Gandhian nonviolence belong to which type of ethical theory, consequentialism or deontology? And third, is nonviolence an absolutist constraint or a high threshold that allows for exceptions? Gandhi views nonviolence as both instrumentally and …

Rwanda: (Limited) Effects Of The First Female Parliamentary Majority In The World, Charlene Anita Raman-Preston

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The case of Rwanda provides a laboratory to explore a unique set of circumstances. This thesis builds upon feminist theory, the literature on post-conflict situations and failed states. It finds that although Rwanda's post-conflict situation provided unexpected and historic opportunities for women to enter politics (a record 64 percent of the members of parliament are female), more women in parliament does not mean the end of patriarchy. Since 1994, Rwanda has experienced significant yet limited progress toward gender equality in employment and education. However, much remains to be done and gender dynamics have not changed substantively. Rather, increasing the numbers …

Effects Of Red Diamondback Rattlesnake Venom On Keloid Dermal Fibroblasts In Vitro, Mackenzie Shelby Newman

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Keloid scarring is an inflammatory healing response to physical injury such as incision or piercing in the dermis. It is characterized by aberrant extracellular matrix production, the overaccumulation of mature collagen, and excessive fibroblast proliferation and migration beyond the borders of the original wound site. This results in swelling, depigmentation, itchiness, and pain akin to a benign tumor. Although there are myriad treatments for the condition, most are invasive and exhibit a high recurrence rate. Previous studies have shown that rattlesnake venom stimulates apoptosis in the skin via multiple specific mechanisms, largely composed of extracellular matrix and its receptors' interactions. …

Being Ethically Minded: Practising The Scholarship Of Teaching And Learning In An Ethical Manner, Ruth L. Healey, Tina Bass, Johnette (Jay) Caulfield, Adam Hoffman, Michelle K. Mcginn, Janice Miller-Young, Martin Haigh

Management Faculty Research and Publications

The authors propose a working definition of ethical Scholarship of Teaching and Learning (SoTL), advance an ethical framework for SoTL inquiry, and present a case study that illustrates the complexity of ethical issues in SoTL. The Ethical SoTL Matrix is a flexible framework designed to support SoTL practitioners, particularly in the formative stages of their inquiries. Three dominant ethical traditions form the basis of the matrix: teleological or pragmatic, external, and deontological. The key message of the paper is that SoTL practitioners should reflect on different perspectives in their efforts to do what is right in any given situation. The …

Confronting The Myth Of State Court Class Action Abuses Through An Understanding Of Heuristics And A Plea For More Statistics, Patricia W. Moore

Faculty Articles

The Supreme Court heard six cases involving class actions this term. One of these cases, Standard Fire Insurance Company v. Knowles, brought the Class Action Fairness Act to the Court for the first time. Petitioner insurance company and its numerous business-interest amici repeatedly claimed before the Court that "state court class action abuses" justified removal of the case (which was based on state law and filed in state court) to federal court.

The charge of a "flood" of "abusive state court class actions" echoed the same rhetoric that CAFA's supporters used a decade ago in their ultimately successful efforts to …