Digital Commons Network^™

The Legacy, November 26, 2013, Lindenwood University

The Legacy (2007-2018)

Student Newspaper of Lindenwood University

Mice With Deficient Bk Channel Function Show Impaired Prepulse Inhibition And Spatial Learning, But Normal Working And Spatial Reference Memory, Marei Typlt, Magdalena Mirkowski, Erin Azzopardi, Lukas Ruettiger, Peter Ruth, Susanne Schmid

Anatomy and Cell Biology Publications

Genetic variations in the large-conductance, voltage- and calcium activated potassium channels (BK channels) have been recently implicated in mental retardation, autism and schizophrenia which all come along with severe cognitive impairments. In the present study we investigate the effects of functional BK channel deletion on cognition using a genetic mouse model with a knock-out of the gene for the pore forming α-subunit of the channel. We tested the F1 generation of a hybrid SV129/C57BL6 mouse line in which the slo1 gene was deleted in both parent strains.

We first evaluated hearing and motor function to establish the suitability of this …

Functional And Structural Changes Throughout The Auditory System Following Congenital And Early-Onset Deafness: Implications For Hearing Restoration, Blake E. Butler, Stephen G. Lombar

Brain and Mind Institute Researchers' Publications

The absence of auditory input, particularly during development, causes widespread changes in the structure and function of the auditory system, extending from peripheral structures into auditory cortex. In humans, the consequences of these changes are far-reaching and often include detriments to language acquisition, and associated psychosocial issues.Much of what is currently known about the nature of deafness-related changes to auditory structures comes from studies of congenitally deaf or early-deafened animal models. Fortunately, the mammalian auditory system shows a high degree of preservation among species, allowing for generalization from these models to the human auditory system. This review begins with a …

Minimum Wage. Increase. Initiative Statute.

Initiatives

Under existing law, California's minimum wage will increase from $8.00 per hour to $9.00 per hour, effective July 1, 2014. This measure would increase California's minimum wage to $10.00 per hour, effective March 1, 2015, and then to $12.00 per hour, effective March 1, 2016. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on state and local government: Increase or decrease in state and local tax revenues of uncertain magnitude, potentially totaling hundreds of millions of dollars per year. Changes in state revenues would affect the amount of required state funding for schools and community …

Minimum Wage. Increase. Initiative Statute.

Initiatives

Under existing law, California's minimum wage will increase from $8.00 per hour to $9.00 per hour, effective July 1, 2014. This measure would increase California's minimum wage to $10.00 per hour, effective March 1, 2015, and then to $12.00 per hour, effective March 1, 2016. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on state and local government: Increase or decrease in state and local tax revenues of uncertain magnitude, potentially totaling hundreds of millions of dollars per year. Changes in state revenues would affect the amount of required state funding for schools and community …

The New Hampshire, Vol. 103 [104], No. 21 (Nov. 26, 2013), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 103, but it is the 104th volume in the series. This was corrected in pencil.

High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang, Lin Xue, Shurong Hou

Pharmaceutical Sciences Faculty Patents

Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.

The Advocate, November 26, 2013, Minnesota State University Moorhead

The Advocate

No abstract provided.

State V. Hawkins Clerk's Record Dckt. 41621

Idaho Supreme Court Records & Briefs, All

No abstract provided.

A Huntington’S Thanksgiving Message: Gratitude For Health And The Ability To Work, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Daily Egyptian, November 26, 2013, Daily Egyptian Staff

November 2013

No abstract provided.

November 26, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

2013-November-26-Moorman Nih Grant, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

You Can Write!

News Releases

No abstract provided.

Emu Today, November 26, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Jak/Stat Inhibitors And Mapk/Erk Inhibitors For Rsv Infection, Shyam S. Mohapatra

USF Patents

The present invention concerns a method for treating or reducing the likelihood of developing a respiratory syncytial virus (RSV) infection in a subject by administering an effective amount of an inhibitor of the janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway or the mitogen-activated kinase (MAPK)/extracellular signal-regulated kinase (ERK1/2) signaling pathway to the subject. Another aspect of the invention concerns a pharmaceutical composition that includes an inhibitor of JAK/STAT or MAPK/ERK signaling to the subject; and a pharmaceutically acceptable carrier. Another aspect of the invention concerns a method for identifying agents useful for treating or reducing the …

Transdisciplinary Perspectives On Pathways To Citizenship Behaviors In Mutual-Help Addiction Recovery Housing, Christopher Beasley

College of Science and Health Theses and Dissertations

Substance abuse and dependence is a social problem in the U .S. that continues to be difficult to adequately address (Dutra et al.. 2008; Harwood. 2000; 0 DCP, 2004; SAMHSA,2010). Services such as inpatient treatment, outpatient treatment, mutual-help addiction support groups and recovery housing have attempted to redress the issue with limited effect (Jason eta l2001 ). Obviously, additional research is needed for these serv ices. In particular, additional research is needed for mechanisms by which mutual-help and recovery housing influence behavior. For example, research suggests that members who engage in helping behaviors have more favorable outcomes (Crape. Latkin, Laris. …

Time Resloved Saxs Analysis Of Fusion Protein, Matthew Andorf

College of Science and Health Theses and Dissertations

The structural dynamics of the fusion protein (F protein) of parainfluenza virus 5 (PIV 5) was studied using time resolved Small Angle X-ray Scattering (SAXS). Conformational changes of the F protein, equivalent to the conformational changes the protein must undergo while infecting a host cell, are triggered by temperature jump to the protein in solution. The time and temperature dependence of the rate of the protein changing state is then determined through standard SAXS analysis. Thermodynamic transition state theory is then used to calculate the activation energy, enthalpy and entropy of the transition which is independent of any particular model. …

Spectral Analysis Of Nonstationary Heart Rate Of Neonates Receiving Therapeutic Hypothermia Treatment, Tareq Al-Shargabi

Theses and Dissertations

We studied Heart Rate Variability (HRV) evolution during therapeutic hypothermia in newborns with hypoxic ischemic encephalopathy (HIE) using spectral analysis. We hypothesized that HRV measures are predictive of neurological outcome in babies with HIE. Non-stationarity in the data causes inaccurate quantification of the spectral power. A modification was proposed to power spectral analysis approach to mitigate the effect of non-stationarity. The modified and the standard approaches were applied to cardiac beat-to-beat intervals of newborns receiving hypothermia treatment. The performance of the approaches in distinguishing the RRi dynamics of two groups of newborns was assessed using area under the receiver operating …

Single-Peaked Preferences Over Multidimensional Binary Alternatives, Jonathan K. Hodge, Lindsey Brown, Hoang Ha

Open Access Publishing Support Funded Articles

Single-peaked preferences are important throughout social choice theory. In this article, we consider single-peaked preferences over multidimensional binary alternative spaces—that is, alternative spaces of the form {0, 1}ⁿ for some integer n ≥ 2. We show that preferences that are single-peaked with respect to a normalized separable base order are nonseparable except in the most trivial cases. We establish that two distinct base orders can induce the same single-peaked preference order if any only if they differ by a transposition of their two central elements. We then use this result to enumerate single-peaked binary preference orders over a separable …

Independent - Nov. 26, 2013, Jacklyn Nowotnik

The Independent (1988-present)

No abstract provided.

The Prospector, November 26, 2013, Utep Student Publications

The Prospector

Headline: Catch 'Em If You Can!

Brain Mapping Of The Mismatch Negativity Response To Vowel Variances Of Natural And Synthetic Phonemes, Lyndsy Marie Smith

Theses and Dissertations

The mismatch negativity (MMN) is a specific event-related potential (ERP) component used frequently in the observation of auditory processing. The MMN is elicited by a deviant stimulus randomly presented in the presence of repeating stimuli. The current study utilized the MMN response in order to determine the temporal (timing) and linguistic processing of natural and synthetic vowel stimuli. It was hypothesized that a significant MMN response would be elicited by natural and synthetic vowel stimuli. Brain mapping of the MMN response was hypothesized to yield temporal resolution information, which would provide detail regarding the sequential processing differences between natural and …

Global Mortality Estimates For The 2009 Influenza Pandemic From The Glamor Project: A Modeling Study, Lone Simonsen, Peter Spreeuwenberg, Roger Lustig, Robert J. Taylor, Douglas M. Fleming, Madelon Kroneman, Maria D. Van Kerkhove, Anthony D. Mounts, W. John Paget

Global Health Faculty Publications

Background

Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estimated the 2009 pandemic mortality burden through statistical modeling of mortality data from multiple countries.

Methods and Findings

We obtained weekly virology and underlying cause-of-death mortality time series for 2005–2009 for 20 countries covering ~35% of the world population. We applied a multivariate linear regression model to estimate pandemic respiratory mortality in each collaborating country. We then used …

The Eps Matrix As An Adaptive Bastion For Biofilms: Introduction To Special Issue, Alan W. Decho

Faculty Publications

No abstract provided.

Evaluating The Effectiveness Of Design For The Environment Tools To Help Meet Sustainability And Design Goals, Ana Maria Leal-Yepes

Theses

Environmental impacts of electronics are a growing concern because the amount and type of materials used in production of the devices, the impacts to the environment from discarded

electronics and the early retirement of products due to rapidly evolving devices, changing design trends, and perceived technological obsolescence. Design for the Environment is a sustainability strategy that aims to reduce the environmental impacts through techniques that enable sustainability solutions during the design decision-making process. In order to suit the diverse

needs of sustainable design practitioners, there has been a large number of tools for Design for the Environment (DfE) developed, confusing …

Predeliberation Activity In Prefrontal Cortex And Striatum And The Prediction Of Subsequent Value Judgment, Uri Maoz, Ueli Rutishauser, Soyoun Kim, Xinying Cai, Christof Koch

Psychology Faculty Articles and Research

Rational, value-based decision-making mandates selecting the option with highest subjective expected value after appropriate deliberation. We examined activity in the dorsolateral prefrontal cortex (DLPFC) and striatum of monkeys deciding between smaller, immediate rewards and larger, delayed ones. We previously found neurons that modulated their activity in this task according to the animal's choice, while it deliberated (choice neurons). Here we found neurons whose spiking activities were predictive of the spatial location of the selected target (spatial-bias neurons) or the size of the chosen reward (reward-bias neurons) before the onset of the cue presenting the decision-alternatives, and thus before rational deliberation …

Sex Differences In Mother-Infant Interaction, Klaudia Kosiak

Seton Hall University Dissertations and Theses (ETDs)

Sex differences in human behavior have frequently been explored by researchers. Although there are numerous studies documenting sex differences between boys and girls from childhood into adulthood, few studies have adequately examined how genetics and environment interact in infancy to promote sex differences in infant behavior. Therefore, the present study sought to examine how sex differences in maternal behavior interact with differences in infant behavior. Maternal and infant behaviors were analyzed within the still-face paradigm, a paradigm which allows for examination of mother-infant interaction in normal, stressful, and recovery situations. It was hypothesized that infant boys would react with more …

State V. Neff Respondent's Brief Dckt. 40534

Not Reported

No abstract provided.

State V. Ash Respondent's Brief Dckt. 40565

Not Reported

No abstract provided.