Digital Commons Network^™

Toll-Like Receptors 2 And 9 Are Important For Innate Immune Cell Activation And Recruitment In Hypersensitivity Pneumonitis, Kelly J. Andrews

Theses and Dissertations (ETD)

Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of environmental antigens. The disease is characterized by alveolitis and granuloma formation; however, some patients develop chronic HP (CHP), a restrictive lung disease characterized by fibrosis. Previous studies revealed that neutrophils are recruited into the lung via a MyD88- dependent pathway and regulate disease severity through cytokine production. Toll-like receptors (TLRs) 2 and 9 recognize conserved molecular patterns present in bacteria, and signal through the adaptor molecule MyD88. The goal of my project is to investigate the role of TLRs 2 and 9 in the pathogenesis of HP …

Full-Gestational Exposure To Nicotine And Ethanol Results In Long-Term Dysregulation In The Ventral Tegmental Area, Emily Elizabeth Roguski

Theses and Dissertations (ETD)

Nicotine is considered a gateway drug for other drugs of abuse. The majority of smokers that begin smoking in adolescence, continue into adulthood. Multiple factors have been linked with smoking initiation, including maternal smoking. Drug exposure during pregnancy has long been suspected to exert deleterious effects on the fetal brain. Concurrent use of smoking and drinking alcohol throughout pregnancy is an all too frequent occurrence in the human population especially in disadvantaged and younger women.

The present study investigated the potential contributing factors for the enhanced nicotine selfadministration as seen in offspring with gestational exposure to nicotine and ethanol (Nic+EtOH).* …

Identification Of Novel Hif1a Target Genes That Regulate Tumor Progression And Metastasis, Danielle L. Peacock

Theses and Dissertations (ETD)

Hypoxia is a hallmark of most solid tumors. In response to hypoxic stress tumor cells adapt by regulating survival, metabolism and angiogenesis. The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic reprogramming, invasion, metastasis and resistance to radiation therapy and chemotherapy. Overexpression of HIF-1α and HIF-2α has been documented in multiple human cancers and HIF-1 protein is over-expressed in ~30% of primary breast tumors and ~70% of metastases, which independently correlates with poor prognosis and decreased survival in …

Synthesis Of Resveratrol Ester Derivatives, Daniel Ressler

Electronic Theses and Dissertations

The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted one of the hydroxyl groups on resveratrol to an ether with a methylene chain terminated by a carboxylic acid. By varying the lengths of the methylene chain we varied the water …

How Social Emotional Development Skills Gained In High Quality Public School Prekindergarten Impact Kindergarten Academic Readiness, Gale A. Collett

Electronic Theses and Dissertations

Longitudinal research has demonstrated that children’s emotional and social skills are linked to their early academic achievement (Wentzel & Asher, 1995). Children who have difficulty paying attention, following directions, getting along with others, and controlling negative emotions like anger and distress do not do as well in school (Arnokl et al., 1999; McClelland et al., 2000). Academic achievement in the early years of schooling appears to be built on a firm foundation of children’s social emotional skills (Ladd, Kochenderfer, & Coleman, 1997; O’Neil et al., 1997). Higher quality prekindergarten programs are associated with the early years of schooling and more …

Women, Feminism, And Aging In Appalachia, Sherry Kaye Ms.

Electronic Theses and Dissertations

Aging has become a problem for men and women in Western societies where youth is touted and revered as a standard of success by which individual value is measured and esteemed. Older women in particular find that as they age they face discrimination in the form of ageism and social diminution. The purpose of the study is to remedy a lack of scholarship on aging in Appalachia and to establish a precedent for future studies. A liberal, feminist approach is used to analyze the results of recorded interviews and to interpret transcripts of relevant data. The results of the analysis …

Natural Resource Management Newsletter, Dave Willis

NRM Newsletter

No abstract provided.

Students With Disabilities: Perspectives Of Regular Education Teachers Of Increased Inclusion, Mindy D. Myers Mrs.

Electronic Theses and Dissertations

The purpose of this study was to explore regular education teachers’ perceptions of inclusion. The participants of this study were K-12 regular education teachers located in Tennessee’s First region. Specifically, this research explored (1) perceptions of the impact of inclusion on instructional strategies, (2) perceived level of preparedness to effectively teach students with disabilities (3) professional development needs of regular education teachers instructing students with disabilities, and (4) collaborative relationships between regular and special educators. The data sources analyzed consisted of a survey design using a 4-point Likert scale. Each research question had a corresponding null hypothesis. Each research question …

Student Retention And First-Year Programs: A Comparison Of Students In Liberal Arts Colleges In The Mountain South, Jeff S. Howard

Electronic Theses and Dissertations

The purpose of this study was to examine the association between the retention rate and 9 firstyear student programs at Liberal Arts Colleges in the Mountain South, a region in the southern Appalachian Mountains of the United States. Nine first-year programs were studied: Summer Bridge Programs, Preterm Orientation, Outdoor Adventure Orientation, Targeted Seminars, Learning Communities, Early Warning/Early Alert Systems, Service Learning, Undergraduate Research, and Assessment. The data for this study were accessed via the college database of The National Center for Education Statistics (NCES, 2013). Chi Square tests were used for analysis to identify associations between first-year student retention and …

Framing Of Business In China: East Vs. West, Xueyi Li

Electronic Theses and Dissertations

China is one of the largest and most promising markets for new global business ventures. This exploratory research investigates the current news-related themes regarding business in China by comparing news originating from eastern countries to western countries. This study applied agenda-setting and framing theoretical frameworks. A mixed-method approach of both qualitative and quantitative content analyses was used to generate key themes and their related concepts. The results indicate some thematic similarities as well as differences in agenda and news framing between eastern and western news samples. This exploratory study contributes to agenda-setting and framing literature as well as by creating …

Identification And Characterization Of Genetic Factors Involved In Candida-Bacterial Interactions, Sean J. Fox

Electronic Theses and Dissertations

Throughout existence, fungi and bacteria have long shared ecological niches and thus engage in numerous interactions to mutually enhance survival or antagonistically gain competitive advantages. Of importance to human health are those interactions that involve bacteria with the opportunistic fungi, Candida albicans. An important virulence factor of C. albicans is the ability to control morphology, which allows the transition between yeast, pseudohyphal, and hyphal phenotypes. Morphological control in C. albicans is governed by quorum sensing and the secreted autoregulatory molecule farnesol. Quorum sensing allows individual cells to sense the environment and respond as a group. Bacteria also use quorum …

The Effects Of Family Structure On Juvenile Delinquency, Alisha B. Parks

Electronic Theses and Dissertations

Studies show that family structure is an important factor in explaining delinquency among adolescents (Price & Kunz, 2003). There is a lack of research, however, pertaining to cohabitation. The main goals of this study are to determine if there are variations in delinquency between cohabitating and other family types, and to examine the extent to which parental social control measures account for the variation in delinquency by family structure. Data from the National Longitudinal Study of Adolescent Health (Add Health) are used for the purposes of this study (n = 4,389). While there are no significant differences in violent delinquency …

Physical Security Assessment Of A Regional University Computer Network, Nathan H. Timbs

Electronic Theses and Dissertations

Assessing a network's physical security is an essential step in securing its data. This document describes the design, implementation, and validation of PSATool, a prototype application for assessing the physical security of a network's intermediate distribution frames, or IDFs (a.k.a. "wiring closets"). PSATool was created to address a lack of tools for IDF assessment. It implements a checklist-based protocol for assessing compliance with 52 security requirements compiled from federal and international standards. This checklist can be extended according to organizational needs.

PSATool was validated by using it to assess physical security at 135 IDFs at East Tennessee State University. …

Youth And Family Based In-Home Services Program In Tennessee: Factors For Success, Craig S. Hall

Electronic Theses and Dissertations

Intensive in-home services is a family-centered, strength-based intervention program offering comprehensive treatment that includes family therapy, mental health treatment and parenting skills for caregivers, development of positive social systems, and assistance with accessing community resources for long-term support (Youth Villages, 2013b). Framed on family system theory, Intensive-In Home Services (IIHS) was developed from Cognitive Behavioral Therapy, Functional Family Therapy, Social Development, and Crisis Intervention models as a means to modify behaviors that place youth at risk for out-of-home placement. The socio-historical development of these models is examined in the literature review.

Intensive in-home services is a family-centered, strength-based intervention program …

An Examination Of The Inhibitory Effects Of Antibiotic Combinations On Ribosome Biosynthesis In Staphylococcus Aureus, Justin Beach

Electronic Theses and Dissertations

Bacteremia initiated by Staphylococcus aureus infections can be a serious medical problem. Although a number of different antibiotics are used to combat staphylococcal infections, resistance has continued to develop. Combination therapy for certain infections has been used to reduce the emergence of resistance when a single agent has become ineffective. We hypothesize that the use of rifampicin and ciprofloxacin in combination with azithromycin, known for its inhibitory effects on the bacterial ribosome, can create potential synergistic effects resulting from indirect effects on ribosomal subunit synthesis.

To determine this we measured the effects of single and multiple antibiotics on cell growth …

Methylphenidate Conditioned Place Preference In Juvenile And Adolescent Male And Female Rats, Elizabeth D. Freeman

Electronic Theses and Dissertations

This investigation was an analysis of the effects of methylphenidate (MPH; trade name: Ritalin) on drug reward using the conditioned place preference (CPP) behavioral paradigm in a rodent model and underlying mechanisms of this effect. Animals were conditioned in adolescence from postnatal day (P)33-39) or P44-49 with saline, 1 or 5 mg/kg MPH. Rats administered 5 mg/kg but not 1 mg/kg MPH, resulted in a significant preference that was more robust in younger male adolescent rats. The 5 mg/kg dose of MPH also resulted in a significant decrease of the dopamine transporter in both the nucleus accumbens and striatum, revealing …

Technology Use In Rural Appalachia: A Pilot Study Of The Implications For Pediatric Behavioral Health, Courtney E. Lilly

Electronic Theses and Dissertations

Technology is a promising means for increasing rural individuals’ access to behavioral healthcare. However, the range of technology use in rural areas is currently unknown. The aims of this study were to examine the use of technology in rural areas, the relationship between technology use and willingness to access pediatric mental health services via videoconferencing, and this relationship within the context of other critical variables linked to service uptake. Data were collected at 2 pediatric primary care clinics. While no significant relationship was found between technology use and willingness to use videoconferencing, a significant relationship emerged between previous service seeking …

Who Done It? Rurality Vs. Ses As Critical Factors In Evaluating The Prevalence Of Child Psychosocial Concerns In Primary Care, Robert M. Tolliver

Electronic Theses and Dissertations

The purpose of this study was to evaluate the prevalence of child psychosocial concerns in rural primary care, hypothesized to be greater than national averages due to lacking mental health services in rural areas. This study was an examination of the role of SES, various definitions of “rural,” and the interaction of SES and rurality, in predicting parent-reported child psychosocial concerns in Appalachian primary care clinics. Caregivers presenting with their child at one of 8 pediatric primary care sites (n=2,672) were recruited to complete a measure assessing demographics and the Pediatric Symptom Checklist (PSC). Results showed that while rural status …

“Between The Dream And Reality”: Divination In The Novels Of Cormac Mccarthy, Robert A. Kottage

Electronic Theses and Dissertations

Divination is a trope Cormac McCarthy employs time and again in his work. Augury, haruspicy, cartomancy, voodoo, sortition and oneiromancy all take their places in the texts, overtly or otherwise, as well as divination by bloodshed (a practice so ubiquitous as to have no formal name). But mantic practices which aim at an understanding of the divine mind prove problematic in a universe that often appears godless—or worse.

My thesis uses divination as the starting point for a close reading of each of McCarthy’s novels. Research into Babylonian, Greek, Roman and African soothsaying practices is included, as well as the …

The Sustainability Of Agriculture In Nigeria Using Rubber As A Case Study, Owen Osahon Ogbebor

Electronic Theses and Dissertations

The study is an investigation of the sustainability of agriculture in Nigeria using Rubber as case study. Edo and Abia states were sampled for the study with 300 questionnaires administered in 10 communities among rubber farmers. The study is an investigation of the socio-demographic distribution of the rubber farmers, perception of rubber farmers, and influence of government activities. Sources of information and the data were cumulated for Nigeria as a whole. The data were analyzed using statistical analysis.

Findings indicated the distribution of rubber farmers on socio-demographic distribution, sources of funds, and the effects on agricultural sustainability in Nigeria. Farmers’ …

Plasma Antibodies To Oral Bacteria And Risk Of Pancreatic Cancer In A Large European Prospective Cohort Study, Dominique S. Michaud, Jacques Izard, Charlotte S. Wilhelm-Benartzi, Doo-Ho You, Verena A. Grote, Anne Tjønneland, Christina C. Dahm, Kim Overvad, Mazda Jenab, Veronika Fedirko, Marie Christine Boutron-Ruault, Françoise Clavel- Chapelon, Antoine Racine, Rudolf Kaaks, Heiner Boeing, Jana Foerster, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Carlotta Sacerdote, Sabina Sieri, Domenico Palli, Rosario Tumino, Salvatore Panico, Peter Siersema, Petra Hm Peeters, Eiliv Lund, Aurelio Barricarte, José-María Huerta, Esther Molina-Montes, Miren Dorronsoro, J. Ramón Quirós, Eric J. Duell, Weimin Ye, Malin Sund, Björn Lindkvist, Dorthe Johansen, Kay-Tee Khaw, Nick Wareham, Ruth C. Travis, Paolo Vineis, H. Bas Bueno-De-Mesquita, Elio Riboli

Department of Food Science and Technology: Faculty Publications

Objective: Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study.

Design: We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study (EPIC). Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index.

Results: Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a 2-fold higher risk of pancreatic cancer than individuals lower levels of …

Assessments Of Student-Teacher Relationships In Residential Treatment Center Schools, Kathleen Moritz Rudasill, Amy B. Gonshak, Patrick Pössel, Andrew Nichols, Natalie Stipanovic

Department of Educational Psychology: Faculty Publications

Students in residential treatment center (RTC) schools are likely to have histories of extreme or ongoing relational trauma (e.g., abuse and neglect by primary caregivers), have substantial interpersonal and relationship problems, and exhibit many high-risk behaviors. Accordingly, these students may have particular difficulty forming positive relationships with teachers, yet student-teacher relationship quality in RTC schools has not been empirically studied. This study examines links between RTC school students’ assessments of their relationships with teachers and their perceptions of self and others. Participants were 113 students in 2 RTC schools from 5th to 12th grade. Results indicate that male and female …

The Mir-17/92 Cluster: A Comprehensive Update On Its Genomics, Genetics, Functions And Increasingly Important And Numerous Roles In Health And Disease., Elena Mogilyansky, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in …

Repeated Elevational Transitions In Hemoglobin Function During The Evolution Of Andean Hummingbirds, Joana Projecto-Garcia, Chandrasekhar Natarajan, Hideaki Moriyama, Roy E. Weber, Angela Fago, Zachary A. Cheviron, Robert Dudley, Jimmy A. Mcguire, Christopher C. Witt, Jay F. Storz

School of Biological Sciences: Faculty Publications

Animals that sustain high levels of aerobic activity under hypoxic conditions (e.g., birds that fly at high altitude) face the physiological challenge of jointly optimizing blood-O₂ affinity for O₂ loading in the pulmonary circulation and O₂ unloading in the systemic circulation. At high altitude, this challenge is especially acute for small endotherms like hummingbirds that have exceedingly high mass-specific metabolic rates. Here we report an experimental analysis of hemoglobin (Hb) function in South American hummingbirds that revealed a positive correlation between Hb-O₂ affinity and native elevation. Protein engineering experiments and ancestral- state reconstructions revealed that this …

Making Advanced Trauma Life Support More Effective, Sanjay Meena, Amit Singla, Buddhadev Chowdhury

Saudi Medical Journal

No abstract provided.

Neonatal Hemochromatosis: Case Series From Bahrain, Hasan M. Isa, Afaf M. Mohamed

Saudi Medical Journal

OBJECTIVE: To review clinical presentations, diagnosis, response to treatment, and outcome of infants with neonatal hemochromatosis (NH). METHODS: This is a retrospective review of all cases admitted to the Pediatric Department at Salmaniya Medical Center, Manama, Bahrain between March 2008 and May 2011. The diagnosis was based on serum iron and ferritin, alpha-fetoprotein levels (AFP), liver and buccal biopsies, and abdominal MRI scan. RESULTS: Ten patients (8 males and 2 females) were diagnosed with NH. Two patients were intrauterine growth restriction (IUGR) and 6 were preterm. The median birth weight was 1.700 grams. The median age at presentation was 16 …

Quality Of Life Among Children With Beta-Thalassemia Major Treated In Western Saudi Arabia, Mohammed D. Ayoub, Suhaib A. Radi, Abdulrahman M. Azab, Abdulrahman A. Abulaban, Abdulrahman H. Balkhoyor, Seif-Eleslam W. Bedair, Soad K. Aljaouni, Jameela A. Kari

Saudi Medical Journal

OBJECTIVE: To assess the quality of life among children and adolescents with thalassemia major. METHODS: This cross-sectional study used the Pediatric Quality of Life Inventory (PedsQL). Children and adolescents with beta-thalassemia major who attended the Day Care Unit at King Abdulaziz University Hospital, Jeddah, Saudi Arabia from October 2012 to February 2013 were surveyed. The questions highlighted 4 health status scales, namely physical functioning (PF), emotional functioning (EF), school performance (SC), and social functioning (SF). Scores were calculated for each patient and data were analyzed using the Statistical Package for Social Sciences. RESULTS: We recruited 46 children (60.9% males). The …

Perceptions And Effects Of Antenatal Education, Mohammed A. Al-Ateeq, Amal A. Al-Rusaiess, Aida A. Al-Dughaither

Saudi Medical Journal

OBJECTIVE: To assess the quality and effect of antenatal health education on health-related issues during pregnancy, and the benefits to women during the peripartum period. METHODS: This is a descriptive study of 300 women attending the Postnatal Clinics and Women Health Clinics in 2 Family Medicine centers at King AbdulAziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia. The study was carried out between November 2009 and February 2010. A predesigned questionnaire was used. RESULTS: Three hundred women completed the questionnaire. Most women made their first antenatal visit during the fourth month of pregnancy, and most had 3-6 antenatal …

Diffusion Tensor Imaging Findings Associated With Cognitive Performance In Hydrocephalus Patients, Hongwei Cheng, Wenming Hong, Xiaojie Wang, Xiaopeng Hu

Saudi Medical Journal

No abstract provided.

Propylene Glycol Allergic Contact Dermatitis: A Quick Reference Guide For Propylene Glycol-Free Topical Corticosteroids In Saudi Arabia, Mohammed I. Aljasser, Ibrahim A. Al-Omair

Saudi Medical Journal

No abstract provided.