Digital Commons Network^™

Investigating Potential Bioactive Compounds From Rhodococcus And Their Effects On Mcf7 Breast Cancer Cells, Megan N. Crabtree

Electronic Theses and Dissertations

Many drugs used in the treatment of various cancers are derived from or influenced by compounds from nature. The soil bacterium Rhodococcus is of interest because of its identified secondary metabolic pathways and the production of novel natural antibiotics from several strains. In this study, a solid agar extraction method was used to collect compounds from strains of Rhodococcus. These bacterial compound extracts were then tested using a MTT assay in order to evaluate their effectiveness in augmenting MCF7 breast cancer cell death. The results of two way ANOVA analyses revealed 18 compound extracts from 15 strains of Rhodococcus that …

Efficacy Of The Arvigo Techniques Of Maya Abdominal Therapy On Dysmenorrhea Symptoms In Women., Tabitha S. Burchett

Undergraduate Honors Theses

Dysmenorrhea is one of the most reported symptoms by women in OB/GYN departments with an effect on up to 95% of women. Because pain experienced during menstrual cycles influences the mental and physical health of women, it is important to find practical and effective relief.

Complementary and alternative medicine (CAM) is a new clinical and scientific field in the practice of Western medicine. The use of CAM by the public has increased dramatically in recent years and among the practiced modalities lies a fairly new massage technique aimed at treatment of uterine abnormalities attributed to misplacement. The Arvigo Techniques of …

Natural Law As Part Of International Law: The Case Of The Armenian Genocide, Fernando R. Tesón

San Diego Law Review

In this Article I argue that some norms are part of international law even if they have never been created by treaty or custom. Because such norms have never been posited, they are natural law norms, and my thesis is that these natural law norms are as much part of international law as the posited norms. By this I mean that these norms should figure in any catalog of what international law prescribes or permits.

A Chance To Be Heard: Thoughts About Schedules, Caps, And Collateral Source Deductions In The September 11th Victim Compensation Fund, Stephan Landsman

DePaul Law Review

No abstract provided.

A Psychological Perspective On Compensation For Harm: Examining The September 11th Victim Compensation Fund, Tom R. Tyler, Hulda Thorisdottir

DePaul Law Review

No abstract provided.

Grief, Procedure, And Justice: The September 11th Victim Compensation Fund, Elizabeth M. Schneider

DePaul Law Review

No abstract provided.

Money Talks: Searching For Justice Through Compensation For Personal Injury And Death, Deborah R. Hensler

DePaul Law Review

No abstract provided.

The Genie And The Bottle: Collateral Sources Under The September 11th Victim Compensation Fund, Kenneth S. Abraham, Kyle D. Logue

DePaul Law Review

No abstract provided.

Tort And Social Welfare Principles In The Victim Compensation Fund, Matthew Diller

DePaul Law Review

No abstract provided.

The September 11th Victim Compensation Fund: A Circumscribed Response Or An Auspicious Model?, Robert L. Rabin

DePaul Law Review

No abstract provided.

Radiating Effects Of Torts, Anne Bloom

DePaul Law Review

No abstract provided.

Litigation As A Measure Of Well-Being, Theodore Eisenberg, Sital Kalantry, Nick Robinson

DePaul Law Review

No abstract provided.

Perception And Decision At The Threshold Of Tort Law: Explaining The Infrequency Of Claims, David M. Engel

DePaul Law Review

No abstract provided.

Lawyers As "The Great Social Evil", Gowri Ramachandran

DePaul Law Review

No abstract provided.

How The "Haves" Come Out Ahead In The Twenty-First Century, Shauhin Talesh

DePaul Law Review

No abstract provided.

The Trials And Tribulations Of Counting "Trials", Herbert M. Kritzer

DePaul Law Review

No abstract provided.

Through A Glass Darkly: Law, Culture, And The Media, Lawrence M. Friedman

DePaul Law Review

No abstract provided.

Narcotics On Illinois's Roadways: Drugged Driving's Ill Effects After Martin, Darron J. Hubbard

DePaul Law Review

No abstract provided.

One-Dimensional Compressibility Of Intermediate Non-Plastic Soil Mixtures, Sean E. Salazar

Civil Engineering Undergraduate Honors Theses

The results of high stress, one-dimensional compression testing on intermediate soils are presented. Nevada Sand and silica silt mixtures were subjected to very high vertical stresses (140 MPa) in one-dimensional, monotonic compression. Each soil mixture was tested in a nominally loose condition. A specially designed mold with an integrated sensor array was fabricated to contain the soil during pre-consolidation and loading. The 1-D compression curve was plotted for each mixture in the double-logarithmic void ratio (e), and vertical effective stress (σ’v) space and characteristics of the Limiting Compression Curve (LCC) were identified. Initial and post test grain size distribution curves …

Attenuation Of Parenteral Nutritionassociated Liver Disease By Omega-3 Long-Chain Polyunsaturated Fatty Acids, Emma Monique Tillman

Theses and Dissertations (ETD)

No abstract provided.

Signal Transduction And Transcriptional Regulation Pathways Essential For Azole Resistance In Candida Albicans, Erin M. Vasicek

Theses and Dissertations (ETD)

Candida albicans is the most prevalent human fungal pathogen, found as a commensal organism in the mucosa, gastrointestinal, and urogenital tracts of humans. This pathogenic fungus causes a wide spectrum of diseases, including the mucosal infection oropharyngeal candidiasis (OPC) which frequently effects patients with human immunodeficiency virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore have limited efficacy against this organism, especially for immunocompromised patients. In C. albicans, the transcription factor Upc2 …

Erg11-Mediated Azole Resistance In Candida Albicans, Stephanie Ann Flowers

Theses and Dissertations (ETD)

Although many medically important Candida species are commensal to the gut or colonizers of the skin, these organisms have the propensity to cause disease in the event of a waning immune system. Clinical manifestations of infections with Candida species can range from superficial mucosal infections to deep organ involvement usually resulting from haematogenous spread of infection. Despite significant progress made in the management of patients with fungal infections, the emergence of antifungal resistant clinical isolates creates significant problem in regards to antifungal prophylaxis and empirical treatment strategies. Antifungal resistance is associated with high mortality rates and hefty medical costs. The …

Stimulant Use, Associated Psychopathology, And Eating Disordered Symptomatology, Tiffany Ann Hopkins

Master's Theses

The current study developed profiles of eating disorder, personality, and other psychopathological symptoms related to the use of central nervous system stimulants versus other types of drug use. Participants included 124 women in residential treatment for substance use with and without comorbid eating disorders. Symptomatology was measured by the Eating Disorders lnventory-3 (EDI-3), Millon Multiaxial Inventory-III (MCMI-III), and Personality Assessment Inventory (PAl). The current study utilized a series of six multivariate analyses of variance (MANOVAs) and discriminant analyses to determine patterns of psychopathology separating stimulant use from other drug use. Results indicated that women who used stimulants were primarily separated …

Melancholia & Metaphor In Kazuo Ishiguro's The Remains Of The Day, Kristin Lasheaú Teston

Master's Theses

Critics widely acknowledge the psychological grounding of Kazuo Ishiguro's writing. His 1989 novel The Remains of the Day presents a central character deeply afflicted by his inability to acknowledge his condition. Both literal and figurative loss proliferates throughout the novel, and turning to Sigmund Freud's influential essay, "Mourning and Melancholia," allows us to understand how loss influences Stevens's narrative. In this essay, Freud explores conditions that result after the loss of person or an ideal. For Stevens, the lost object is the myth of pre-war English traditions. Freud's theories regarding melancholia provide a crucial insight to Stevens's inability to acknowledge …

Corpus Callosal Microstructure Influences Intermanual Transfer In Chimpanzees, Kimberley A. Phillips, J. Schaeffer, William D. Hopkins

Psychology Faculty Research

Learning a new motor skill with one hand typically results in performance improvements in the alternate hand. The neural substrates involved with this skill acquisition are poorly understood. We combined behavioral testing and non-invasive brain imaging to study how the organization of the corpus callosum was related to intermanual transfer performance in chimpanzees. Fifty-three chimpanzees were tested for intermanual transfer of learning using a bent-wire task. Magnetic resonance and diffusion tensor images were collected from 39 of these subjects. The dominant hand showed greater performance benefits than the nondominant hand. Further, performance was associated with structural integrity of the motor …

Application Of Linear Sequences To Cryptography, Amanda C. Yeates

Honors Theses

Cryptography is the study of a centuries–old technique of secretly transferring information between parties. Linear recurrences were the chosen method of encryption and decryption in the thesis. The Fibonacci sequence, with its Zeckendorf representation, allows for the flexibility of encoding any number desired based on a particular encoding technique used in the film Sherlock Holmes: A Game of Shadows. The main goal is to find other linear recurrences that possess characteristics similar to the Fibonacci sequence to use as suitable substitutes for encoding. Different sequences were analyzed based on a number of criteria. In order for a sequence to be …

Peregrination Of The Selectivity Filter Delineates The Pore Of The Human Voltage-Gated Proton Channel Hhv1, Deri Morgan, Boris Musset, Kethika Kulleperuma, Susan M. E. Smith, Sindhu Rajan, Vladimir V. Cherny, Régis Pomès, Thomas E. Decoursey

Faculty Articles

Extraordinary selectivity is crucial to all proton-conducting molecules, including the human voltage-gated proton channel (hH_v1), because the proton concentration is >10⁶ times lower than that of other cations. Here we use "selectivity filter scanning" to elucidate the molecular requirements for proton-specific conduction in hH_v1. Asp¹¹², in the middle of the S1 transmembrane helix, is an essential part of the selectivity filter in wild-type (WT) channels. After neutralizing Asp¹¹² by mutating it to Ala (D112A), we introduced Asp at each position along S1 from 108 to 118, searching for "second site suppressor" activity. …

Distinct Phenotypes In Zebrafish Models Of Human Startle Disease, Lisa R. Ganser, Qing Yan, Victoria M. James, Robert Kozol, Maya Topf, Robert J. Harvey, Julia E. Dallman

Faculty Articles

Startle disease is an inherited neurological disorder that causes affected individuals to suffer noise- or touch-induced non-epileptic seizures, excessive muscle stiffness and neonatal apnea episodes. Mutations known to cause startle disease have been identified in glycine receptor subunit (GLRA1 and GLRB) and glycine transporter (SLC6A5) genes, which serve essential functions at glycinergic synapses. Despite the significant successes in identifying startle disease mutations, many idiopathic cases remain unresolved. Exome sequencing in these individuals will identify new candidate genes. To validate these candidate disease genes, zebrafish is an ideal choice due to rapid knockdown strategies, accessible embryonic stages, and stereotyped behaviors. The …

Depleted Energy Charge And Increased Pulmonary Endothelial Permeability Induced By Mitochondrial Complex I Inhibition Are Mitigated By Coenzyme Q1 In The Isolated Perfused Rat Lung, Robert D. Bongard, Ke Yan, Raymond G. Hoffmann, Said H. Audi, Xiao Zhang, Brian J. Lindemer, Mary I. Townsley, Marilyn P. Merker

Biomedical Engineering Faculty Research and Publications

Mitochondrial dysfunction is associated with various forms of lung injury and disease that also involve alterations in pulmonary endothelial permeability, but the relationship, if any, between the two is not well understood. This question was addressed by perfusing isolated intact rat lung with a buffered physiological saline solution in the absence or presence of the mitochondrial complex I inhibitor rotenone (20 μM). Compared to control, rotenone depressed whole lung tissue ATP from 5.66±0.46 (SEM) to 2.34±0.15 µmol·g⁻¹ dry lung, with concomitant increases in the ADP:ATP and AMP:ATP ratios. Rotenone also increased lung perfusate lactate (from 12.36±1.64 to 38.62±3.14 µmol·15 …

Mode I Fracture Toughness Of Eight-Harness-Satin Carbon Cloth Weaves For Co-Cured And Post-Bonded Laminates, Josh E. Smith

Master's Theses

Mode I interlaminar fracture of 3k 8-Harness-Satin Carbon cloth, with identical fill and weft yarns, pre-impregnated with Newport 307 resin was investigated through the DCB test (ASTM D5528). Crack propagations along both the fill and weft yarns were considered for both post-bonded (co-bonded) and co-cured laminates. A patent-pending delamination insertion method was compared to the standard Teflon film option to assess its applicability to mode I fracture testing. The Modified Beam Theory, Compliance Calibration method, and Modified Compliance Calibration method were used for comparative purposes for these investigations and to evaluate the validity of the proposed Equivalent Stiffness (EQS) method. …