Digital Commons Network^™

Social Engineering Through Shari’A: Islamic Law And State-Directed Da’Wa In Contemporary Aceh, R. Michael Feener

Indonesia Law Review

This study of the contemporary Islamic legal system in Aceh, Indonesia argues for new attention to be paid to the ways in which contemporary Muslim agendas for the implementation of Islamic law can be read as projects for future oriented social transformation—rather than as a series of reactive measures to perceived ‘crises of modernity’ and/or the political machinations of rival elites in contesting control of state power. In doing so it highlights the ways in which the ideals of, and institutional formations developed by, proponents of Islamic law are configured in relation to a broad range of non-Muslim modernist projects, …

Scaling Impact In The Health Sector, Al Hammond

Journal of Management for Global Sustainability

This essay examines possible routes to achieving significant health improvements in the underserved populations of developing countries. It argues that unconventional strategies, largely outside the health sector as conventionally defined, have the greatest potential to scale sustainably. The essay describes two such strategies—nutrition and safe drinking water. In particular, the essay argues that impact investors focused on social enterprises can best maximize their health impact by looking closely at the strategies described herein.

Recovery Of A Temperate Reef Assemblage In A Marine Protected Area Following The Exclusion Of Towed Demersal Fishing, Emma V. Sheehan, Timothy F. Stevens, Sarah C. Gall, Sophie L. Cousens, Martin J. Attrill

School of Biological and Marine Sciences

No abstract provided.

Why Do Small Dogs Have So Many Psychological Problems?, Harold Herzog

'Animals and Us' Blog Posts

Do little dogs suffer from the Napoleon Complex?

Microwave-Assisted Synthesis Of Carbon Supported Metal/Metal Oxide Nanocomposites And Their Application In Water Purification, Gunawan Gunawan

Theses and Dissertations

A novel, easy, and cost effective method for synthesizing carbon supported metal/metal oxide nanocomposites has been studied. Carbon supported metal/metal oxide nanocomposites have niche applications in the area of catalysis, fuel cells, electrodes, and more. The method utilizes a commercial microwave and features the addition of a developed graphite-jacket technique with renewable carbon resources, tannin and lignin. The method has been successfully used to synthesize carbon/nickel, carbon/iron oxide, and carbon/nickel phosphide nanocomposites. The method has shown its versatility in the synthesis of carbon nanocomposites. The process is much simpler when compared with the available methods for synthesizing carbon nanocomposites. The …

Study Of Surface Modification Of Tungsten Nanostructures For Superhydrophobic Applications, Richard Alletru

Theses and Dissertations

In this work, we studied the impact of the modification of the structure of tungsten surfaces through physical vapor deposition (magnetron sputtering), electrochemical (anodization and electropolishing), and thermal (annealing) processes on the wettability of the designed surfaces. We observed static contact angle values ranging from around 10° to above 150° showing the importance of the techniques used to produce the surfaces. We noticed that the annealing process tends to increase the wettability, transforming hydrophobic surfaces into hydrophilic surfaces. We also observed that electropolishing affects the wettability in such a way that the contact angles of pre-chemically treated tungsten foils tend …

The Osh Family Of Proteins And Their Role In Caloric Restriction-Mediated Lifespan Extension In The Budding Yeast Saccharomyces Cerevisiae, William Douglas Craft

Theses and Dissertations

Oxysterol-binding protein homolouges (OSH) have been implicated in mediating non-vesicular sterol transport. Caloric restriction (CR) down-regulates sterol synthesis in a variety of organisms, including the budding yeast Saccharomyces cerevisiae. OSH6, when up-regulated, extends replicative lifespan. In contrast, OSH5 up-regulation shortens replicative lifespan. In this thesis I obtained evidence to show that the deletion of OSH5 extends replicative lifespan in normal media. Deletion of OSH5 in the presence of caloric restriction blocks the lifespan-extending properties of the CR media. My data demonstrate that the total cellular sterol levels of the longevity mutants are indistinguishable from that of wild type. This suggests …

Infrared Vibrational Spectroscopy Analysis Of Selected Biomolecules, Busra Ergul

Theses and Dissertations

Fourier transform infrared (FTIR) spectroscopy is a useful tool to examine biological molecules for noninvasive measurements. This research has focused on the determination of concentrations of four important biomolecules, glucose, gluconic acid, hydrogen peroxide (H2O2), and dopamine by FTIR. It is crucial to determine blood glucose levels for diabetes diagnosis. H2O2 is an important biomolecule having implications in aging and aging related diseases. Gluconic acid is important in food and pharmaceutical industries, and dopamine plays a key role in brain activity. In this work, first, glucose, gluconic acid, and H2O2 in aqueous solutions have been studied by using FTIR. Standard …

Nicotine Exploits A Copi-Mediated Process For Chaperone-Mediated Up-Regulation Of Its Receptors, Brandon J. Henderson, Rahul Srinivasan, Weston A. Nichols, Crystal N. Dilworth, Diana F. Gutierrez, Elisha D. W. Mackey, Sheri Mckinney, Ryan M. Drenan, Christopher I. Richards, Henry A. Lester

Chemistry Faculty Publications

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this …

Interactive Virtual Suturing Simulations: Enhancement Of Student Learning In Veterinary Medicine, Charles B. Boyd, Amy J. Staton

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the College of Education at Morehead State University by Christine B. Boyd and Amy J. Staton on December 29, 2013.

Sphingosine-1-Phosphate-Mediated Mobilization Of Hematopoietic Stem/Progenitor Cells During Intravascular Hemolysis Requires Attenuation Of Sdf-1-Cxcr4 Retention Signaling In Bone Marrow, Kasia Mierzejewska, Yuri M. Klyachkin, Janina Ratajczak, Ahmed Abdel-Latif, Magda Kucia, Mariusz Z. Ratajczak

Saha Cardiovascular Research Center Faculty Publications

Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM). Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the plasma S1P level, the hemolysis of red blood cells would induce mobilization of HSPCs. To test this assumption, we induced hemolysis in mice by employing phenylhydrazine (PHZ). We observed that doubling the S1P level in PB from damaged erythrocytes induced only a marginally increased level of mobilization. However, if mice were exposed to PHZ together with the …

The Murray Ledger And Times, December 28, 2013, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Intrathecal Ketamine Versus Bupivacaine For Inguinal Hernia Surgery, Aimen Hameed Latef

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Ketamine shows beside its general anesthetic effect, a local anesthetic - like action; that is due to blocking of Na+ channels mainly with other proposed mechanisms. OBJECTIVE: Comparison of ketamine local anesthetic action with that of bupivacaine in neuraxial blockage (spinal anesthesia) was done. PATIENTS AND METHODS: Hundred patients were scheduled according to American Society of Anesthesiologists (ASA) physical status classification I-II for elective inguinal hernia surgery under spinal anaesthesia, divided into 2 equal groups, the first group received 2 ml (0.5%) bupivacaine, second group received 2 ml [75 mg preservative free Ketamine (1.5 ml) mixed with 0.5 …

Spatial Analysis Of Factors Influencing Long-Term Stress In The Grizzly Bear (Ursus Arctos) Population Of Alberta, Canada, Mathieu Bourbonnais, Trisalyn Nelson, Mark Cattet, Chris T. Darimont, Gordon Stenhouse

Physiology Collection

Non-invasive measures for assessing long-term stress in free ranging mammals are an increasingly important approach for understanding physiological responses to landscape conditions. Using a spatially and temporally expansive dataset of hair cortisol concentrations (HCC) generated from a threatened grizzly bear (Ursus arctos) population in Alberta, Canada, we quantified how variables representing habitat conditions and anthropogenic disturbance impact long-term stress in grizzly bears. We characterized spatial variability in male and female HCC point data using kernel density estimation and quantified variable influence on spatial patterns of male and female HCC stress surfaces using random forests. Separate models were developed for regions …

Beyond Perceptual Expertise: Revisiting The Neural Substrates Of Expert Object Recognition, Assaf Harel, Dwight J. Kravitz, Chris I. Baker

Psychology Faculty Publications

Real-world expertise provides a valuable opportunity to understand how experience shapes human behavior and neural function. In the visual domain, the study of expert object recognition, such as in car enthusiasts or bird watchers, has produced a large, growing, and often-controversial literature. Here, we synthesize this literature, focusing primarily on results from functional brain imaging, and propose an interactive framework that incorporates the impact of high-level factors, such as attention and conceptual knowledge, in supporting expertise. This framework contrasts with the perceptual view of object expertise that has concentrated largely on stimulus-driven processing in visual cortex. One prominent version of …

Effects Of Understory Vegetation And Litter On Plant Nitrogen (N), Phosphorus (P), N∶P Ratio And Their Relationships With Growth Rate Of Indigenous Seedlings In Subtropical Plantations, Jun Wang, Dafeng Hui, Hai Ren, Zhanfeng Liu, Long Yang

Biology Faculty Research

Establishing seedlings in subtropical plantations is very important for forest health, succession and management. Information on seedling nutrient concentrations is essential for both the selection of suitable indigenous tree species to accelerate succession of the established plantation and sustainable forest management. In this study, we investigated the concentrations of nitrogen ([N]), phosphorus ([P]), and N∶P ratio in leaves, stems and roots of seedlings of three indigenous tree species (Castanopsis chinensis, Michelia chapensis and Psychotria rubra) transplanted with removing or retaining understory vegetation and litter at two typical subtropical forest plantations (Eucalyptus plantation and native species plantation). We also measured the …

The Role Of Astrocyte And Purinergic Signaling In Rtn Chemoreception, Ian C. Wenker

Doctoral Dissertations

Central chemoreception is the mechanism by which the brain regulates breathing in response to changes in tissue pH/CO2. It is particularly important during sleep and its disruption has been associated with certain pathologies, including central sleep apnea and central congenital hypoventilation syndrome. A region of the brainstem called the retrotrapezoid nucleus (RTN) is thought to be an important site of central chemoreception. Recent evidence suggests that RTN chemoreception involves two mechanisms. The first appears to be H+-mediated activation of neurons via inhibition of pH-sensitive potassium channels. More recently, a second sensing mechanism has been identified; paracrine release of ATP in …

Obit - June Marie Krutza, Journal Gazette-Times Courier

EIU in the News

Dr. Krutza joined the art faculty at Eastern Illinois State College in 1952. Hired to teach Art education and high school art at Buzzard Lab School, she later taught undergraduate and graduate courses in a variety of media including jewelry and textiles, but ceramics was her love. She was honored with a Distinguished Faculty Award in 1987. Professor Krutza retired from Eastern Illinois University in 1989.

Spinal Morphine But Not Ziconotide Or Gabapentin Analgesia Is Affected By Alternative Splicing Of Voltage-Gated Calcium Channel Cav2.2 Pre-Mrna, Yu-Qiu Jiang, Arturo Andrade, Diane Lipscombe

Publications and Research

Presynaptic voltage-gated calcium CaV2.2 channels play a privileged role in spinal level sensitization following peripheral nerve injury. Direct and indirect inhibitors of CaV2.2 channel activity in spinal dorsal horn are analgesic in chronic pain states. CaV2.2 channels represent a family of splice isoforms that are expressed in different combinations according to cell-type. A pair of mutually exclusive exons in the CaV2.2 encoding Cacna1b gene, e37a and e37b, differentially influence morphine analgesia. In mice that lack exon e37a, which is enriched in nociceptors, the analgesic efficacy of intrathecal morphine against noxious thermal stimuli is reduced. Here we ask if sequences unique …

The Weekly Challenger, December 26, 2013, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 26, 2013, issue of The Weekly Challenger.

The Toxoplasma Gondii Cyst Wall Protein Cst1 Is Critical For Cyst Wall Integrity And Promotes Bradyzoite Persistence, Tadakimi Tomita, David J. Bzik, Yan Fen Ma, Barbara A. Fox

Dartmouth Scholarship

Toxoplasma gondii infects up to one third of the world's population. A key to the success of T. gondii as a parasite is its ability to persist for the life of its host as bradyzoites within tissue cysts. The glycosylated cyst wall is the key structural feature that facilitates persistence and oral transmission of this parasite. Because most of the antibodies and reagents that recognize the cyst wall recognize carbohydrates, identification of the components of the cyst wall has been technically challenging. We have identified CST1 (TGME49_064660) as a 250 kDa SRS (SAG1 related sequence) domain protein with a large …

Real-Time, Multiple Pan/Tilt/Zoom Computer Vision Tracking And 3d Positioning System For Unmanned Aerial System Metrology, Daniel D. Doyle

Theses and Dissertations

The study of structural characteristics of Unmanned Aerial Systems (UASs) continues to be an important field of research for developing state of the art nano/micro systems. Development of a metrology system using computer vision (CV) tracking and 3D point extraction would provide an avenue for making these theoretical developments. This work provides a portable, scalable system capable of real-time tracking, zooming, and 3D position estimation of a UAS using multiple cameras. Current state-of-the-art photogrammetry systems use retro-reflective markers or single point lasers to obtain object poses and/or positions over time. Using a CV pan/tilt/zoom (PTZ) system has the potential to …

Inflammatory Cytokine Gene Expression In Mesenteric Adipose Tissue During Acute Experimental Colitis, William Conan Mustain, Marlene E. Starr, Joseph Daniel Valentino, Donald A. Cohen, Daiki Okamura, Chi Wang, B. Mark Evers, Hiroshi Saito

Markey Cancer Center Faculty Publications

BACKGROUND: Production of inflammatory cytokines by mesenteric adipose tissue (MAT) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Animal models of colitis have demonstrated inflammatory changes within MAT, but it is unclear if these changes occur in isolation or as part of a systemic adipose tissue response. It is also unknown what cell types are responsible for cytokine production within MAT. The present study was designed to determine whether cytokine production by MAT during experimental colitis is depot-specific, and also to identify the source of cytokine production within MAT.

METHODS: Experimental colitis was induced in 6-month-old C57BL/6 …

Carry On, Yatao Li

Theses

Carry On is my thesis project for a MFA in Film and Animation at Rochester Institute of Technology. The entire process took more than two years from start to finish. In November 2011, I wrote the first draft of the script. In April 2013, we finished filming. I did not wrap up editing and the final stages of production until December 2013. I ran into many difficulties and faced many challenges during this special experience, yet I also received more help than I had ever imagined in getting me through these hard times. Truthfully, there would be no way for …

The Murray Ledger And Times, December 24, 2013, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Pnmt As A Novel Marker For Progenitor Cells, Steven Ebert, Karl Pfeifer

UCF Patents

In certain aspects, the present invention provides methods and compositions relating to a Pnmt-positive progenitor cell. In certain aspects, the present invention relates to methods for isolating and transplanting the subject progenitor cells, and methods for treating diseases such as myocardiac injuries and neurodegenerative disorders.

Rna-Based System And Method To Differentiate Seafood, John H. Paul, David E. John

USF Patents

Substituting fish of lesser value for high priced fish such as grouper has become a major problem for restaurants, wholelsalers, and the general public. A method based upon nucleic acid amplification enables clear differentiation between grouper and potential substitutes. The nucleic acid is incubated with a molecular beacon probe thereby allowing detection of the hybridized molecular beacon probe. All grouper, including the fresh market sample, were successfully confirmed as grouper. Several non-grouper samples obtained fresh and frozen from the market were also tested; none were detected as grouper.

Effect Of Nanoparticles On The Biochemical And Behavioral Aging Phenotype Of The Nematode Caenorhabditis Elegans, Andrea Scharf, Annette Piechulek, Anna Von Mikecz

Biological Sciences Faculty Research & Creative Works

Invertebrate animal models such as the nematode Caenorhabditis elegans (C. elegans) are increasingly used in nanotechnological applications. Research in this area covers a wide range from remote control of worm behavior by nanoparticles (NPs) to evaluation of organismal nanomaterial safety. Despite of the broad spectrum of investigated NP-bio interactions, little is known about the role of nanomaterials with respect to aging processes in C. elegans. We trace NPs in single cells of adult C. elegans and correlate particle distribution with the worm's metabolism and organ function. By confocal microscopy analysis of fluorescently labeled NPs in living worms, we identify two …

A Mechanism Linking Id2-Tgfβ Crosstalk To Reversible Adaptive Plasticity In Neuroblastoma, Lina Chakrabarti, Bi-Dar Wang, Norman H. Lee, Anthony D. Sandler

Pharmacology and Physiology Faculty Publications

The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy has produced an elusive childhood cancer with remarkably poor prognosis. A novel phenomenon enabling neuroblastoma to survive selection pressure is its capacity for reversible adaptive plasticity. This plasticity allows cells to transition between highly proliferative anchorage dependent (AD) and slow growing, anoikis-resistant anchorage independent (AI) phenotypes. Both phenotypes are present in established mouse and human tumors. The differential gene expression profile of the two cellular phenotypes in the mouse Neuro2a cell line delineated pathways of proliferation in AD cells or tyrosine kinase activation/ apoptosis inhibition in AI …

Microfluidic Generated Egf-Gradients Induce Chemokinesis Of Transplantable Retinal Progenitor Cells Via The Jak/Stat And Pi3kinase Signaling Pathways., Uchenna J. Unachukwu, Moira Sauane, Maribel Vazquez, Stephen Redenti

Publications and Research

A growing number of studies are evaluating retinal progenitor cell (RPC) transplantation as an approach to repair retinal degeneration and restore visual function. To advance cell-replacement strategies for a practical retinal therapy, it is important to define the molecular and biochemical mechanisms guiding RPC motility. We have analyzed RPC expression of the epidermal growth factor receptor (EGFR) and evaluated whether exposure to epidermal growth factor (EGF) can coordinate motogenic activity in vitro. Using Boyden chamber analysis as an initial high-throughput screen, we determined that RPC motility was optimally stimulated by EGF concentrations in the range of 20-400 ng/ml, with decreased …