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Articles 4621 - 4650 of 19626
Full-Text Articles in Entire DC Network
The Retina-Prosthesis Interface In Two Rat Models Of Retinitis Pigmentosa And Functional Changes Associated With Photoreceptor Loss., James William Fransen
The Retina-Prosthesis Interface In Two Rat Models Of Retinitis Pigmentosa And Functional Changes Associated With Photoreceptor Loss., James William Fransen
Electronic Theses and Dissertations
With increasingly successful clinical trials, the use of prosthetic devices to replace the function of photoreceptors has now become a viable option to treat degenerative diseases of the retina, including age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Using prosthetics, patients have demonstrated the ability to read large text, recognize small objects, and navigate. While promising, this represents coarse visual function, with the highest visual acuity equivalent to 20/560, still below the legal definition of blindness, 20/200. To investigate the benefit of more sophisticated designs, I implanted two types of photovoltaic prosthetic devices in two models of RP, Tg S334ter-3 …
6-Phosphofructo-2-Kinase Inhibition Induces Autophagy As A Survival Mechanism., Alden Klarer
6-Phosphofructo-2-Kinase Inhibition Induces Autophagy As A Survival Mechanism., Alden Klarer
Electronic Theses and Dissertations
Altered metabolism has long been recognized as a defining characteristic of tumor cells. The increased glycolytic phenotype, an observation credited to Otto Warburg in 1956, is almost universal for cancer cells, making metabolic enzymes attractive targets for cancer therapy. However, anti-metabolic drugs, thus far, have not lived up to expectations as stand-alone agents to treat this disease. Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from fructose-2,6-bisphosphate, a key regulator of the glycolytic enzyme phosphofructokinase-1 (PFK-1). One isoform, PFKFB3, has been shown to be highly expressed by …
Enhanced Penetration Of Lipid Functionalized Nanoparticles In 3d Cell Cultures., Christopher Gene England 1988-
Enhanced Penetration Of Lipid Functionalized Nanoparticles In 3d Cell Cultures., Christopher Gene England 1988-
Electronic Theses and Dissertations
Nanoparticle-based systems can alleviate systemic toxicity via surface functionalization to promote tissue-specific targeting as well as passive targeting abilities [1], such as the enhanced permeation and retention effect (EPR) [2]. The transport of nanoparticles is limited in hypoxic tumor regions due to the typically impaired tumor vasculature. To enhance diffusion of nanotherapeutics within tumor tissue; functionalized citrate gold nanoparticles and silica gold nanoshells with surface modifications of phosphatidylcholine (PC) and high density lipoprotein (HDL) were synthesized. 3D cell cultures were used as a representative model of portions of hypoxic tissue in liver, lung, and pancreatic solid tumors. Our results indicate …
Behavioral Rhythm, Sleep, And Mood Disturbances In Newly Admitted Nursing Home Residents., Irene M. Kostiwa
Behavioral Rhythm, Sleep, And Mood Disturbances In Newly Admitted Nursing Home Residents., Irene M. Kostiwa
Electronic Theses and Dissertations
Older adults entering a nursing home face many physical and psychosocial challenges, all at a point in life when their bodies may be least equipped to handle such adversity. Data for the present study were collected for 186 incoming residents from 6 nursing homes over the course of 1 year. Fifty-six participants were interviewed at the earliest possible time point following admission and rest-activity data were collected via actigraphy for 1 week, after which participants were interviewed a second time. Newly admitted residents in this sample were functionally dependent, highly medicated, and diagnosed with many conditions associated with sleep and/or …
Cytochrome B5 Reductase Encoded By Cbr1 Is Essential For A Functional Male Gametophyte In Arabidopsis, Laura L. Wayne, James G. Wallis, Rajesh Kumar, Jennifer E. Markham, John Browse
Cytochrome B5 Reductase Encoded By Cbr1 Is Essential For A Functional Male Gametophyte In Arabidopsis, Laura L. Wayne, James G. Wallis, Rajesh Kumar, Jennifer E. Markham, John Browse
Department of Biochemistry: Faculty Publications
In all eukaryotes, NADH:cytochrome b5 reductase provides electrons, via cytochrome b5, for a range of biochemical reactions in cellular metabolism, including for fatty acid desaturation in the endoplasmic reticulum. Studies in mammals, yeast, and in vitro plant systems have shown that cytochrome b5 can, at least in some circumstances, also accept electrons from NADPH:cytochrome P450 reductase, potentially allowing for redundancy in reductase function. Here, we report characterization of three T-DNA insertional mutants of the gene encoding cytochrome b5 reductase in Arabidopsis thaliana, CBR1. The progeny of plants heterozygous for the cbr1-2 allele segregated 6% homozygous mutants, while cbr1-3 and cbr1-4 …
Preventative Behavioral Parent Training In A Primary Care Context: Initial Evaluation Of A Universal Prevention Program For Disruptive Behavior Disorders, Jessica L. Malmberg
Preventative Behavioral Parent Training In A Primary Care Context: Initial Evaluation Of A Universal Prevention Program For Disruptive Behavior Disorders, Jessica L. Malmberg
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
One of the biggest challenges parents face is effectively managing their child’s engagement in various disruptive behaviors including noncompliance, tantrums, and aggression. Typically when children begin exhibiting disruptive behaviors, parents will express their concerns to their pediatricians; however, there are significant barriers to parents gaining adequate guidance due to clinic time constraints, insurance reimbursement issues, and the limited training pediatricians receive in addressing these concerns. As such, children are generally referred to outside mental health clinics where additional barriers arise including waitlist delays and mental health stigmatization. The treatment for conduct problems (CP) that has proven most effective is referred …
Sodium (Na) Levels In Drinking Water (H20) And Development Of Hypertension In Children, Sara Schiffman
Sodium (Na) Levels In Drinking Water (H20) And Development Of Hypertension In Children, Sara Schiffman
HIM 1990-2015
This integrative review of the literature focused on sodium (Na) content in drinking water (H?O) supplies and the subsequent effect on blood pressure levels in children. Studies for this review were drawn from the Cumulative Index of Nursing and Allied Health, PubMED, Science and Technology Databases, PsychInfo, United States (US) Environmental Protection Agency (EPA) and EPA in Florida websites. Criterion for inclusion in the data base searches were hypertension, high blood pressure, sodium in drinking water, drinking water salinity, children or preg'. Subsequently, further article selection criteria included children (under 18 years of age) and published in the English language …
Running Among Thorns : Perspectives On Ethiopian/United States Educational Experiences., Bruce Whearty 1952-
Running Among Thorns : Perspectives On Ethiopian/United States Educational Experiences., Bruce Whearty 1952-
Electronic Theses and Dissertations
This dissertation is a qualitative exploration of the perspectives of Ethiopian immigrants to the United States who have educational experience in both cultures. By interviewing five respondents and asking them to reflect on the role that their education played in their acculturation to the United States, a series of case histories was developed. The case histories were analyzed using the Differentiated Multi-Dimensional Model of Acculturation to determine if they upheld the two predictions made by this model: 1) acculturation for any particular individual proceeds independently at different rates across three different dimensions: language, behavior, and cultural identity; and 2) acculturation …
Preclinical Safety Assessment Of Griffithsin-Based Vaginal Microbicides., Amanda Lasnik
Preclinical Safety Assessment Of Griffithsin-Based Vaginal Microbicides., Amanda Lasnik
Electronic Theses and Dissertations
Griffithsin (GRFT) is a protein derived from the red alga Griffithsia sp. off the coast of New Zealand. It binds and inactivates number of enveloped viruses including HIV-1. For a product to be developed as a microbicide, it must be safe and effective after repeated use. For initial in vivo safety testing we exposed mice repeatedly to various vaginal products and found that increased concentration of mouse serum albumin (MSA) in the vaginal lumen is predictive of epithelial damage. Repeated intravaginal administration of GRFT did not result in increased amounts of MSA, but the known epithelial disrupters nonoxynol-9 and benzylkonium …
Scitech Book News Reviews, Susan Fingerman
Faculty Handbook, 2013-2014, University Of Arkansas, Fayetteville
Faculty Handbook, 2013-2014, University Of Arkansas, Fayetteville
Faculty Handbook
No abstract provided.
Mitigating The Problem Of Vulture Holdout: International Certification Boards For Sovereign Debt Restructurings, John A. E. Pottow
Mitigating The Problem Of Vulture Holdout: International Certification Boards For Sovereign Debt Restructurings, John A. E. Pottow
Law & Economics Working Papers
The Great Recession has brought greater sovereign debt defaults, which in turn has brought a surfeit of academic explorations and policy discussions of sovereign debt restructuring. The purpose of this article is to offer yet one more idea for the hopper of what to do with the seemingly intractable problem of restructuring sovereign bond debt. The field does not lack for statutory and contractual proposals, from SDRM to CACs, but it is not yet sufficiently saturated that another proposal cannot join the mix. The proposal is for the establishment of international certification boards that can give a stamp of approval …
Authorized Access Points In Rda, Julene L. Jones
Authorized Access Points In Rda, Julene L. Jones
Library Faculty and Staff Publications
Describes changes to authorities for personal name, family name, and corporate body headings due to RDA implementation. Includes examples and references to guidelines in RDA Toolkit.
Expression Of C-Fos In Hilar Mossy Cells Of The Dentate Gyrus In Vivo., Aine M Duffy, Michael J Schaner, Jeannie Chin, Helen E Scharfman
Expression Of C-Fos In Hilar Mossy Cells Of The Dentate Gyrus In Vivo., Aine M Duffy, Michael J Schaner, Jeannie Chin, Helen E Scharfman
Department of Neuroscience Faculty Papers
Granule cells (GCs) of the dentate gyrus (DG) are considered to be quiescent--they rarely fire action potentials. In contrast, the other glutamatergic cell type in the DG, hilar mossy cells (MCs) often have a high level of spontaneous activity based on recordings in hippocampal slices. MCs project to GCs, so activity in MCs could play an important role in activating GCs. Therefore, we investigated whether MCs were active under basal conditions in vivo, using the immediate early gene c-fos as a tool. We hypothesized that MCs would exhibit c-fos expression even if rats were examined randomly, under normal housing conditions. …
Image And Multimedia Resources In An Academic Environment: A Qualitative Study Of Students’ Experiences And Literacy Practices, Krystyna K. Matusiak
Image And Multimedia Resources In An Academic Environment: A Qualitative Study Of Students’ Experiences And Literacy Practices, Krystyna K. Matusiak
Library and Information Science: Faculty Scholarship
The digital environment provides an abundance of images and multimedia and offers a new potential for using resources in multiple modes of representation for teaching and learning. This paper reports the findings of a case study that investigated the use of image and multimedia resources in an undergraduate classroom. The study assumed a contextual approach and focused on different class contexts and students’ literacy practices. The class, which took place in a resource-rich, multimodal environment, was perceived by students as a positive learning experience. The distribution of resources and their role in teaching and learning varied and depended on the …
Vascular Reactivity Of Immature Arterialized Capillaries, Sara Hellstrom
Vascular Reactivity Of Immature Arterialized Capillaries, Sara Hellstrom
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) is a globally prevalent cardiovascular disease in which atherosclerotic plaques narrow arterial lumen diameters and restrict blood flow to down stream tissues. The impact of these occlusions can be mitigated by collateral vessels that connect parallel arterial branches and act as natural bypasses to maintain perfusion. Some patients with PAOD may not have robust collateral networks to accommodate ischemic tissues in the event of an occlusion and, therefore, may be more susceptible to hypoxia and tissue necrosis. In animal models that lack collateral arterioles, capillaries can arterialize and form functional collaterals; however, in the early …
2013 Tsu Undergraduate Research Program, David Owerbach
2013 Tsu Undergraduate Research Program, David Owerbach
Office of Research Institutional Research and Scholarship
No abstract provided.
Genome-Wide Prediction Of Age At Puberty And Reproductive Longevity In Sows, Julie Kathleen Tart, Rodger K. Johnson, Justin W. Bundy, N. N. Ferdinand, A. M. Mcknite, Jennifer R. Wood, Phillip S. Miller, M. F. Rothschild, Matthew L. Spangler, Dorian J. Garrick, Stephen D. Kachman, Daniel C. Ciobanu
Genome-Wide Prediction Of Age At Puberty And Reproductive Longevity In Sows, Julie Kathleen Tart, Rodger K. Johnson, Justin W. Bundy, N. N. Ferdinand, A. M. Mcknite, Jennifer R. Wood, Phillip S. Miller, M. F. Rothschild, Matthew L. Spangler, Dorian J. Garrick, Stephen D. Kachman, Daniel C. Ciobanu
Department of Animal Science: Faculty Publications
Traditional selection for sow reproductive longevity is ineffective due to low heritability and late expression of the trait. Incorporation of DNA markers into selection programs is potentially a more practical approach for improving sow lifetime productivity. Using a resource population of crossbred gilts, we explored pleiotropic sources of variation that influence age at puberty and reproductive longevity. Of the traits recorded before breeding, only age at puberty significantly affected the probability that females would produce a first parity litter. The genetic variance explained by 1-Mb windows of the sow genome, compared across traits, uncovered regions that influence both age at …
An Evaluation Of The Nontarget Effects Of Transgenic Bacillus Thuringiensis Maize On Arbuscular Mycorrhizal Fungi In The Soil Ecosystem, Tanya Elizabeth Amy Cheeke
An Evaluation Of The Nontarget Effects Of Transgenic Bacillus Thuringiensis Maize On Arbuscular Mycorrhizal Fungi In The Soil Ecosystem, Tanya Elizabeth Amy Cheeke
Dissertations and Theses
My dissertation research examined the effect of the cultivation of insect-resistant Bacillus thuringiensis (Bt) maize on the soil environment with a goal of understanding how to obtain a balance between technological advancement and maintenance of a healthy soil ecosystem. Although Bt plants may help to reduce pesticide use, conferring benefits to farm workers and the environment, there are still unresolved questions about how the cultivation of Bt plants affects soil organisms. For this dissertation project, I used 14 different genotypes of Bt maize and non-Bt maize (Zea mays) to investigate the effects of transgenic Bt plants on the colonization ability, …
Eagleville Times, Volume 11, Issue 8, Debbie Ryan
Eagleville Times, Volume 11, Issue 8, Debbie Ryan
Eagleville Times
No abstract provided.
Human Foraging In A Virtual World, Jose Luis Martinez
Human Foraging In A Virtual World, Jose Luis Martinez
Research Papers
Methods for using the Torque® game engine to test the predictions of three optimal foraging models of human behavior are proposed. Traditional tests of Charnov’s marginal value theorem, the diet breadth model and the effect of energy Budget manipulation on risky choice are translated into a virtual world programmable through Torque®. Use of immersive environments allows participants to interact with experimental conditions that bear a greater functional resemblance to extra-laboratory environments, thereby increasing the ecological validity of the research.
The Effects Of Variation In Collagen D-Spacing On Compact Bone Viscoelasticity: A Finite Element Analysis, Miguel A. Mendoza
The Effects Of Variation In Collagen D-Spacing On Compact Bone Viscoelasticity: A Finite Element Analysis, Miguel A. Mendoza
Master's Theses
The D-spacing that is characteristic of collagen and its structural arrangement was previously thought to be a constant value. Much research is revealing that it is actually a distribution of values in biological tissues. Recent ovine experimentation has also shown that the D-spacing distribution is significantly altered following estrogen depletion. While ewes contain some major biological differences between their human counterparts, they are an economical and robust large animal model for postmenopausal osteoporosis. So, the exploration of the possible implications that D-spacing has on the mechanical properties of the whole bone utilizing animal models and computational methods is warranted. Six …
The Role Of Gnrh-Ii And Its Receptor In Testicular Function, Amy T. Desaulniers
The Role Of Gnrh-Ii And Its Receptor In Testicular Function, Amy T. Desaulniers
Department of Animal Science: Dissertations, Theses, and Student Research
The second mammalian isoform of GnRH (GnRH-II) has been linked to regulation of cell proliferation, feed intake, and the interaction between energy balance and reproductive behavior. In contrast to the native form of GnRH (GnRH-I), GnRH-II is an inefficient modulator of gonadotropin secretion. Unlike many species, a functional receptor (GnRHR-II) specific to this ligand has been discovered in the pig that may be directly involved in testosterone production. Therefore, our objective was to identify the role of GnRH-II and its receptor in testicular function. First, there was 6-fold more GnRHR-II protein in the testis than anterior pituitary gland of boars. …
Animal Science E-Newsletter, August 2013, University Of Arkansas, Fayetteville. Department Of Animal Sciences
Animal Science E-Newsletter, August 2013, University Of Arkansas, Fayetteville. Department Of Animal Sciences
Animal Science e-Newsletter
No abstract provided.
Malaria Kinase Inhibition: A Tool For Antimalarial Drug Discovery And Elucidation Of Cell Cycle Protein Expression Patterns, Kristen M. Bullard
Malaria Kinase Inhibition: A Tool For Antimalarial Drug Discovery And Elucidation Of Cell Cycle Protein Expression Patterns, Kristen M. Bullard
Dissertations
No abstract provided.
The Bayesian Estimation Of The Fractal Dimension Index Of Fractional Brownian Motion, Chen-Yueh Chen
The Bayesian Estimation Of The Fractal Dimension Index Of Fractional Brownian Motion, Chen-Yueh Chen
Dissertations
No abstract provided.
Teachers' Report Of Strategies Used To Facilitate Language Development In Students With Hearing Loss, Candace Michele Handley
Teachers' Report Of Strategies Used To Facilitate Language Development In Students With Hearing Loss, Candace Michele Handley
Dissertations
No abstract provided.
The Korean Traditional Elements In Young-Jo Lee's Choral Works, Taehyun Kim
The Korean Traditional Elements In Young-Jo Lee's Choral Works, Taehyun Kim
Dissertations
No abstract provided.
Cave Research Foundation Quarterly, Volume 41, No. 3, August 2013, Laura Lexander
Cave Research Foundation Quarterly, Volume 41, No. 3, August 2013, Laura Lexander
KIP Articles
Contents: President's Column / Charles Fox -- Protractors for Cave Surveying / Dave West -- Overview of 2012-2013 CRF Lava Beds Cave Survey Monitoring Projects / Liz Wolff, John Tinsley, Peri Frantz and Bill Devereaux -- Regional Expedition Reports -- 2013-14 Expedition Calendar
Empathy And Threatened Egotism In Men’S Use Of Violence In Intimate Relationships, Jessica H. Turner
Empathy And Threatened Egotism In Men’S Use Of Violence In Intimate Relationships, Jessica H. Turner
Electronic Theses and Dissertations
The current study was undertaken to explore the relationship between self-esteem, narcissism, and empathy with intimate partner violence perpetration among men in 2 samples: college students and inmates. The sample was analyzed both as an aggregate and separately. A negative relationship was hypothesized between intimate violence perpetration and both self-esteem and empathy. A positive relationship was expected between intimate violence perpetration and narcissism. A 2-way interaction was examined between self-esteem and narcissism as a test of threatened egotism, defined as high self-esteem coupled with high narcissism, which was not expected in the current study. Empathy was hypothesized to moderate the …