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Cytotoxicity Study Of Iron Oxide Nanoparticles, Single-Wall Carbon Nanotubes And Their Complexes Applied To Mcf7 Breast Cancer Cells, Karine Mege

Theses and Dissertations

Reactive Oxygen Species (ROS) are radicals of great concern to biologists. Their role in several diseases--such as neurodegenerative disease, diabetes, premature aging and cancer--has been intensively investigated during the last decade. Since a major focus in cancer research is to better understand how it is induced and therefore how it can be cured, the study of the cytotoxic effects of ROS production within cancer cells is vital. Nanotechnology is an emerging field of science that promises great improvements in a number of disciplines. Nano medicine is one of its daughter fields. Various nanomaterials are used for diagnosis and disease detection, …

Emu Today, August 20, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Methods And Products For Biasing Cellular Development, Kiminobu Sugaya, Angel Alvarez, Amelia Marutle

UCF Patents

Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.

Fecal Transplantation Does Not Transfer Either Susceptibility Or Resistance To Food Borne Listeriosis In C57bl/6 And Balb/C/By Mice, Tanya Myers-Morales, Kate M. Bussell, Sarah E. F. D'Orazio

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The composition of the intestinal microbiota has wide reaching effects on the health of an individual, including the development of protective innate immune responses. In this report, a fecal transplantation approach was used to determine whether resistance to food borne listeriosis was dependent on the murine gut microbiota. Transplantation of BALB/c/By feces did not increase the susceptibility of C57BL/6 mice to Listeria monocytogenes infection. Likewise, transplantation of C57BL/6 fecal matter did not enhance the resistance of BALB/c/By mice. Thus, intestinal microbiota composition is not a key factor that confers either susceptibility or resistance to food borne listeriosis in mice.

Can Acartia Spp. Adapt To Climatic Warming? Heritable Within-Population Genetic Variation In Life History Traits, Benjamin L. Cournoyer

Master's Theses

To predict the response of the biota to environmental change requires information on intrapopulation variation in life history traits and the proportion of phenotypic variation attributable to genes, heritability. Yet, knowledge of these parameters in marine populations is very limited. In the present study, I consider phenotypic plasticity and heritability of temperature-dependent, fitness-related life history traits in two coastal copepod species, Acartia tonsa and Acartia hudsonica, from Long Island Sound, a temperate estuary on the east coast of the USA. Acartia hudsonica is a purportedly cold-adapted species and A. tonsa a warm-adapted one. I used a full-sibling, split family design …

Crisis Communication Strategies Used During The 2008 Chinese Milk Scandal: A Content Analysis Of Press Releases From Four Major Chinese Milk Companies, Lijie Zhou

Student Theses and Dissertations

This study examined how the press releases from the four major Chinese milk companies, namely Mengniu, Yili, the Bright Group and Sanlu responded to the 2008 Chinese milk scandal from September 8, 2008 to December 25, 2011. Four hundred and ten press releases were considered as the crisis responding announcements for the 2008 Chinese milk scandal from the four Chinese milk companies, with 55 from Sanlu, 124 from Mengniu, 106 from Yili and 125 from the Bright Group. By dividing the milk scandal into the three stages, the findings revealed that during the pre-crisis stage, the four companies displayed considerable …

The Infected Organization: “Corpz” Exposure, Bobby G. Martin

Publications

Max Brooks’ 2006 novel, World War Z: An oral history of the zombie war presents an account of life in a post-apocalyptic world, from the perspective of those who lived through the experience. In the world [earth] of which Brooks speaks, there are people who, whether by personal preparedness, or pure chance, survived the apocalypse unscathed, and there are also those less fortunate, who were infected. The infected are in effect, reanimated corpses; referred to as Zed Heads (Zed, British for the letter Z), or, perhaps more familiar, ZOMBIES! The term zombie according to Brooks (2003) is “an animated corpse …

Regulation Of Cell Death By Transfer Rna., Ya-Ming Hou, Xiaolu Yang

Department of Biochemistry and Molecular Biology Faculty Papers

SIGNIFICANCE: Both transfer RNA (tRNA) and cytochrome c are essential molecules for the survival of cells. tRNA decodes mRNA codons into amino-acid-building blocks in protein in all organisms, whereas cytochrome c functions in the electron transport chain that powers ATP synthesis in mitochondrion-containing eukaryotes. Additionally, in vertebrates, cytochrome c that is released from mitochondria is a potent inducer of apoptosis, activating apoptotic proteins (caspases) in the cytoplasm to dismantle cells. A better understanding of both tRNA and cytochrome c is essential for an insight into the regulation of cell life and death.

RECENT ADVANCES: A recent study showed that the …

Synthesis And Characterization Of Polypyrrole-Metal Complexes As Electrocatalysts, Nandan K. Peddi

Theses and Dissertations

Modern fuel cells convert chemical energy to electrical energy due to the reaction between hydrogen and oxygen to produce water using a platinum electrocatalyst. The scarcity and high cost of platinum have led to the development of various less expensive and efficient electrocatalysts. Polypyrrole-cobalt (CoPPy) complex has been developed as a nonplatinum electrocatalyst for oxygen reduction reaction (ORR) and potential application as a cathode in fuel cells. The complex was synthesized by refluxing pyrrole monomer and cobalt acetate tetrahydrate in dimethylformamide (DMF) for two hours followed by vacuum distillation to collect the solid electrocatalyst. Cyclic voltammetry, rotating disk electrode voltammetry …

Breastfeeding: An Analysis And Community-Based Curriculum For The Contemporary Central Arkansas Audience, Jennifer Susan Atkins-Gordeeva

Theses and Dissertations

Contemporary society includes many features that impede women's decision-making about infant feeding. The Central Arkansas community is particularly affected by those features. Because informed decision-making involves an acknowledgment of the risks of formula use, breastfeeding advocates must talk about risk. This curriculum offers one way to discuss risks of formula and challenges and supports within the community, to create a supportive environment for making informed decisions, and to commit to a lactation plan, inside a supportive, community-based setting.

Alexander Volkov And The Dancing Bacha: Uzbek Motifs In Motion, Rachel S. Golden

Theses and Dissertations

Alexander Volkov (1886-1957), an Uzbek artist identified by his expressive style, vibrant palette, and devotion to folk subjects, was a leading figure in the movement known as the Uzbek avant-garde. Volkov's influence is still at work among artists in Uzbekistan, though his legacy remains largely unexplored by Western scholars. The Arkansas Arts Center owns one drawing by Volkov depicting the tradition of dancing boys or bachas, a subject the artist also painted among his reflections on Uzbek culture. Work from the same period by fellow artist Alexander Nikolaev (Usto Mumin, 1897-1957), who was better known for his attachment to bachas, …

Effect Of Phytoestrogens On Brain Development And Function, Jacob C. Ong, Dr. Edwin D. Lephart

Journal of Undergraduate Research

Phytoestrogens are estrogen-like compounds derived from plants such as the soy plant and can mimic the function of the human estrogen hormone by binding to estrogen receptors. Estrogen plays a major role in the prevention of osteoperosis and cardiovascular disease in woman. Evidence also suggests that estrogen influences various parts of the memory process and that its impact on an organism is dependent on the developmental stage at which exposure occurs [1].

New Galleries Season Focuses On Narrative And Story, Winthrop University

Winthrop News 2013

• All artist talks, receptions and exhibitions are free and open to the public.
• Galleries hours are 9 a.m.-5 p.m. Monday-Friday. It is closed on weekends and university holidays.

Rome, 1571: A Body And A Murder Investigation In The Ghetto, Serena Di Nepi

Early Modern Workshop: Resources in Jewish History

The 1571 story of Sabato del Corsetto tells about violence in the Roman ghetto in the second half of Sixteenth Century. It concerns many issues related to violence: family violence; verbal violence; physical violence; violence among women; violence arisen both for economic and personal reasons and even attempt made by the Jewish community to manage violence and violent people.

August 19, 2013: If Materialism Goes, What Goes With It?, Bruce Ledewitz

Hallowed Secularism

Blog post, “If Materialism Goes, What Goes With It?“ discusses politics, theology and the law in relation to religion and public life in the democratic United States of America.

Multi Scale Interactions In Biological Motion Perception, Zsolt Palatinus

Doctoral Dissertations

This dissertation investigates the potential contribution of fractal fluctuations of head sway in the time evolution of visual recognition in biological motion perception. The first experiment found no difference in recognition times when point light display (PLD) activities are shown either from a fixed or a moving point of observation. The second experiment, using head tracking, multifractal analyses, and geometrical manipulations in the PLDs found that (1) the multi-scale fractality of head sway is different before and after recognition, and (2) the time-evolution of the multifractal spectra predicts recognition. The third experiment manipulated both the geometrical qualities of PLDs and …

Azzan, Edward Anthony Belly Iii

Student Theses and Dissertations

In an endeavor to improve my writing skills, I chose to write a full-length fantasy novel. The editing of which, as well as the critical feedback from my committee, would allow me to more fully understand the writing process and more accurately evaluate my abilities as a writer. The piece is meant as an entertaining work, though it also exhibits multiple themes that lend themselves toward a deeper meaning. The story explores oppression, parental abandonment, religious persecution, and the dangers of blind devotion to creed. The writing of this work was both fulfilling and affirming for me. I received valuable …

Prevalence Of Shiga-Toxin Producing E. Coli On Cattle Farms Located In The Arkansas Delta Region, Monica Nicole Yarbrough

Student Theses and Dissertations

The objective of this study was to determine the prevalence of E. coli STEC on small (30- 40 head) cattle farms in the Arkansas Delta. Samples were collected between 6 September and 25 November 2012 (average air temperature = 16.9oC) from 180 randomly selected beef cows located on 18 farms in five counties (Clay, Craighead, Greene, Poinsett and St. Francis). Samples collected included: 30 rectal swabs from ten cows per farm (3 samples from each cow), three soil samples, three water samples, and when available, three feed samples. The rectal swabs were transferred to 5 ml sterile modified Trypticase Soy …

Determining Homology Of Turkey Round Heart Disease Marker Sequences: A Computer-Based Study, Ryan D. Mcallister, Dr. David Kooyman

Journal of Undergraduate Research

Round heart disease (RHD) is a spontaneous occurring cardiomyopathy in turkeys. The domestic turkey Meleagris gallopavo is affected by low body weight and premature death due to congestive heart failure from RHD (1). RHD results in decreased profitability for the animal agriculturists and higher prices for turkey products. DNA markers have been identified for both normal turkeys and for turkeys affected by RHD. These genetic markers have been amplified using Random Amplified Polymorphic DNA (RAPD) analysis (2). 16 DNA marker sequences amplified by RAPD have now been determined (3). Basic Local Alignment Search Tool (BLAST) is a computer program designed …

Amino Acids And Mtor Mediate Distinct Metabolic Checkpoints In Mammalian G1 Cell Cycle, Mahesh Saqcena, Deepak Menon, Deven Patel, Suman Mukhopadhyay, Victor Chow, David A. Foster

Publications and Research

Objective In multicellular organisms, cell division is regulated by growth factors (GFs). In the absence of GFs, cells exit the cell cycle at a site in G1 referred to as the restriction point (R) and enter a state of quiescence known as G0. Additionally, nutrient availability impacts on G1 cell cycle progression. While there is a vast literature on G1 cell cycle progression, confusion remains – especially with regard to the temporal location of R relative to nutrient-mediated checkpoints. In this report, we have investigated the relationship between R and a series of metabolic cell cycle checkpoints that regulate passage …

Calpain-2 Compensation Promotes Angiotensin Ii-Induced Ascending And Abdominal Aortic Aneurysms In Calpain-1 Deficient Mice, Venkateswaran Subramanian, Jessica J. Moorleghen, Anju Balakrishnan, Deborah A. Howatt, Athar H. Chishti, Haruhito A. Uchida

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND AND OBJECTIVE: Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice. In addition, pharmacological inhibition of calpain attenuated AngII-induced abdominal aortic aneurysm (AA) in mice. Recent studies have shown that AngII infusion into mice leads to aneurysmal formation localized to the ascending aorta. However, the precise functional contribution of calpain isoforms (-1 or -2) in AngII-induced abdominal AA formation is not known. Similarly, a functional role of calpain in AngII-induced ascending AA remains to be defined. Using BDA-410, an inhibitor of calpains, and calpain-1 genetic deficient mice, …

Microdevices For Isolating Single Axons For The Study Of Axonal Transport In Dopaminergic Neurons, Xi Lu

All Theses and Dissertations (ETDs)

Axonal degeneration plays an important role in the etiology of major central nervous system: CNS) neurodegenerative disorders such as Parkinson's disease: PD) but investigations into the mechanisms underlying this important process has been limited. The goal of this dissertation was to design and demonstrate the use of a compartmented microdevice which allows for the isolation and study of axonal processes such as mitochondrial transport away from cell neuronal bodies. To achieve this goal, a PDMS microdevice comprised of two large chambers connected by a parallel array of microchannels successfully achieved separation of axons from the soma and allows tracking of …

Bjc Today

BJC Today

No abstract provided.

Short-Term International Service-Learning: Faculty Perceptions Of And Pedagogical Strategies For The Design And Implementation Of Successful Learning Experiences, Thomas Jacob Van Cleave

Dissertations and Theses

Faculty-led short-term international service-learning (STISL) experiences are thought to have great potential in developing students' global citizenship through combining study abroad and community service pedagogies. However, thorough investigation of the pedagogical strategies employed in STISL courses to achieve such outcomes has yet to be conducted. This qualitative narrative inquiry of STISL faculty at 7 different institutions across multiple academic disciplines and country service sites sought to fill that void. Data reveal a new conceptualization of STISL teaching, learning, and service success that involves culturally contextualized solidarity, global civic engagement, and global competence, which culminate into students' global agency. Emerging from …

How I Saved My Horses' Hooves: An "Old School" Cowboy Goes Natural, James Karl Dawson

Theses and Dissertations

How I Saved My Horses' Hooves: An "Old School" Cowboy Goes Natural is an essay written to persuade horse owners to choose natural hoof care over traditional shoeing. It is an argument against nailing iron shoes on the hooves of horses. My intent is to persuade horse owners to provide their horses with every means possible to allow them to shape their hooves naturally. Doing so will strengthen their hooves to the point where they will no longer need shoes. Domestic horses cannot live normal lives, therefore, they cannot grow and naturally shape their hooves unless we offer what nature …

Early Innate Immunity Determines Outcome Of Mycobacterium Tuberculosis Pulmonary Infection In Rabbits, Selvakumar Subbian, Nirmalya Bandyopadhyay, Liana Tsenova, Paul O'Brien, Viraj Khetani, Nicole L. Kushner, Blas Peixoto, Patricia Soteropoulos, Joel S. Bader, Petros C. Karakousis, Dorothy Fallows, Gilla Kaplan

Publications and Research

Background: Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while asymptomatic latent Mtb infection (LTBI) is established in the remainder. The host immune responses that determine this differential outcome following Mtb infection are not fully understood. Using a rabbit model of pulmonary TB, we have shown that infection with the Mtb clinical isolate HN878 (a hyper-virulent W-Beijing lineage strain) leads to progressive cavitary disease similar to what is seen in humans with active TB. In contrast, infection with Mtb CDC1551 (a hyper-immunogenic clinical isolate) is efficiently …

August 17, 2013 (Pages 4693-4830), Pennsylvania Legislative Reference Bureau

Volume 43 (2013)

No abstract provided.

The Life History Of Effie Kokrine Through Personal Recordings, Annette J. Freiburger

Arctic and Northern Studies

This thesis is a combination of tape transcriptions and research to document the life history of Athabascan leader Effie Folger Kokrine. Effie Kokrine was well known in the Interior of Alaska, but her impact reached much farther, and in many directions, as she loved to travel and share her stories with people in many different states and in several other countries. Sharing stories was only one of her many talents. She was an Alaska Native culture educator, a champion dog musher, an expert seamstress, skin sewer and beader, hunter, fisher, cook and bottle washer. Effie stayed active and busy right …

Local Trapping As Predator Control In Rural Alaska: Limiting Factors In Allakaket And Alatna And The Potential For Increased Community Involvement In Wildlife Management, Heidi L. Hatcher

Natural Resources

For a community to be involved in natural resources management that community must have the capacity to make management actions. The capacity for a community to be involved in natural resources management or to take management action might be dependent on a wide variety of factors, largely based upon the resource and asset base available to a community. Aerial wolf control as a wildlife management strategy in the state of Alaska is a controversial endeavor. In the rural villages of Allakaket and Alatna wolf trapping was traditionally a commonly practiced subsistence activity but local levels of wolf trapping are currently …

Zinc Oxide Nanoparticles And Sh-Sy5y Cell Line, Jinghui Zheng, 静慧 郑

Chemistry and Biochemistry

The Arctic and sub-arctic regions are impacted by the growth of the global nanotechnology industry. Nanomaterials have unique chemical and physical properties that may lead to toxicological effects that interfere with normal cellular metabolism. Zinc oxide nanoparticles (ZnO NPs) are now very common and widely used in daily life. In industry, ZnO NPs are used to protect different materials from damage caused by UV exposure. The scientific literature suggests that ZnO NPs can have negative impacts on both living organisms and plants. However, there is a paucity of research on the mechanisms by which ZnO NPs may affect the neuronal …