Digital Commons Network^™

Reality And Imagination: The Authorial Decisions Of May Welland Archer And Emma Woodhouse, Melinda R. Vetter

EWU Masters Thesis Collection

The ideal woman of the eighteenth and nineteenth centuries was the "Angel in the House"-a woman who was sweet, shy, and modest. She lived to please the men in her life. She was also the child-woman who was sheltered from the knowledge of the world because it would be too painful and heavy for her fragile shoulders to endure. Edith Wharton, in The Age of Innocence, and Jane Austen, in Emma challenge this ideal picture by creating their respective heroines, May and Emma, to be the exact opposite of it. Though May constantly acts like the ideal woman mentioned earlier, …

Detection And Characterization Of Antibiotic Resistance Plasmids In Cheney Biosolids, Gaayathiri Paramasivam

EWU Masters Thesis Collection

"Biosolids are organic matter produced at the end of sewage treatment process. It has been shown that during sewage treatment, resistant bacteria are selected because of the presence of antibiotics and their byproducts. These resistant bacteria are more likely to transfer resistance genes to other bacteria. In the current study, we examined Cheney biosolids for the presence of drug resistant bacteria and the role of these bacteria in transfer of resistance genes to others. We screened 100 bacteria for drug resistance and found that 68% of the isolates were resistant to two or more drugs tested. Plasmids were separated from …

West Virginia Physical Education Teacher Perceptions Of State Mandated Fitnessgram® Testing And Application Of Results, William M. Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background/Purpose: In response to concerns with increasing rates of childhood obesity, many states have enacted policies that affect physical education. A commonly used approach is state mandated fitness test administration in school-based settings. While this approach is widely debated throughout the literature, one area that lacks research is teachers attitudes toward this fitness testing and the application of results in their professional practice. The purpose of this study was to examine the perceptions of West Virginia physical education teachers toward the mandated use of the FITNESSGRAM® and to gain a better understanding of how the resultant data are employed to …

Reading The Gospel Of Philip As A Temple Text, Gaye Strathearn

Faculty Publications

For many Latter-day Saints, their introduction to studies on Latter-day Saint ritual was in reading the works of Hugh Nibley, who specifically focused on the rites of the temple. Nibley was the first to point out the parallels between the religious behavior of earlier cultures, especially the ritual experiences of early Christianity, and our own. In this paper, Gaye continues this tradition as she introduces us to the Gnostic text the Gospel of Philip and points out intriguing similarities between this text and our own temple experience

Judicial Gatekeeping Of Suspect Evidence: Due Process And Evidentiary Rules In The Age Of Innocence, Keith A. Findley

Georgia Law Review

The growing number of wrongful convictions exposed
over the past two-and-a-half decades, and the research
that points to a few recurring types of flawed evidence in
those cases, raise questions about the effectiveness of the
rules of evidence and the constitutional admissibility
standards that are designed to guard against unreliable
evidence. Drawing on emerging empirical data, this
Article concludes that the system can and should be

adjusted to do a better job of guarding against undue
reliance on flawed evidence. The Article first considers the
role of reliability screening as a constitutional concern.
The wrongful convictions data identify what might …

Gettysburg Historical Journal 2013

The Gettysburg Historical Journal

No abstract provided.

The One That Got Away, Jeremiah D. Johnston

The Mercury

No abstract provided.

Management Options For Patients With Chronic Back Pain Without An Etiology, Lenny D. Salzberg, Eron G. Manusov

School of Medicine Publications

The treatment and management of low back pain is complex when there is no specific etiology such as cancer, fracture, or herniated disc. An organized approach to management that follows evidence based guidelines will facilitate care in a problem that reflects a lifetime prevalence of over 70 percent. The purpose of this review is to present a guideline to care for a common disabling process with a very heterogeneous etiology.

Cqarank: Jointly Model Topics And Expertise In Community Question Answering, Liu Yang, Minghui Qiu, Swapna Gottopati, Feida Zhu, Jing Jiang, Huiping Sun, Zhong Chen

Research Collection School Of Computing and Information Systems

Community Question Answering (CQA) websites, where people share expertise on open platforms, have become large repositories of valuable knowledge. To bring the best value out of these knowledge repositories, it is critically important for CQA services to know how to find the right experts, retrieve archived similar questions and recommend best answers to new questions. To tackle this cluster of closely related problems in a principled approach, we proposed Topic Expertise Model (TEM), a novel probabilistic generative model with GMM hybrid, to jointly model topics and expertise by integrating textual content model and link structure analysis. Based on TEM results, …

Menthol Binding And Inhibition Of A7-Nicotinic Acetylcholine Receptors, Abrar Ashoor, Jacob C. Nordman, Daniel Veltri, Keun-Hang Susan Yang, Lina T. Al Kury, Yaroslav M. Shuba, Mohamed Magoub, Frank Christopher Howarth, Bassem Sadek, Amarda Shehu, Nadine Kabbani, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined. In this study we show an effect of menthol on the α7 subunit of the nicotinic acetylcholine (nACh) receptor function. Using a two-electrode voltage-clamp technique, menthol was found to reversibly inhibit α7-nACh receptors heterologously expressed in Xenopus oocytes. Inhibition by menthol was not dependent on the membrane potential and did not involve endogenous Ca2+-dependent Cl− channels, since menthol inhibition remained unchanged by intracellular injection of the Ca2+ chelator BAPTA and perfusion with Ca2+-free bathing solution containing …

Critical Thinking: Primary Concepts, James Digiovanna

Open Educational Resources

I’ve been teaching critical thinking for many years, and I’ve developed a short, free, Creative Commons-licensed text that’s useful for a brief (maybe 3 week?) critical thinking section in any intro philosophy or composition course (or really, just about any course; it’s been used at my college by professors from a number of departments.)

Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber

Psychology Faculty Research and Publications

Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …

Safety And Efficacy Of Ranolazine For The Treatment Of Chronic Angina Pectoris, Mohammed Aldakkak, David F. Stowe, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Coronary heart disease is a global malady and it is the leading cause of death in the United States. Chronic stable angina is the most common manifestation of coronary heart disease and it results from the imbalance between myocardial oxygen supply and demand due to reduction in coronary blood flow. Therefore, in addition to lifestyle changes, commonly used pharmaceutical treatments for angina (nitrates, ß-blockers, Ca2+ channel blockers) are aimed at increasing blood flow or decreasing O2 demand. However, patients may continue to experience symptoms of angina. Ranolazine is a relatively new drug with anti-anginal and anti-arrhythmic effects. Its anti-anginal mechanism …

Characterization Of Nano-Scale Aluminum Oxide Transport Through Porous Media, Sasha Norien Norwood

Dissertations and Theses

Land application of biosolids has become common practice in the United States as an alternative to industrial fertilizers. Although nutrient rich, biosolids have been found to contain high concentrations of emerging contaminants (e.g. pharmaceuticals, personal care products) while containing a significant fraction of inorganic nano-scale colloidal materials such as oxides of iron, titanium, and aluminum.

Given their reactivity and small size, there are many questions concerning the potential migration of these nano-sized colloidal materials through the soil column and into our surface and groundwater bodies. Transport of emerging pollutants of concern through the soil column, at minimum, is impacted by …

A Transgenic Minipig Model Of Huntington's Disease, Monika Baxa, Marian Hruska-Plochan, Stefan Juhas, Petr Vodicka, Antonin Pavlok, Jana Juhasova, Atsushi Miyanohara, Tetsuya Nejime, Jiri Klima, Monika Macakova, Silvia Marsala, Andreas Weiss, Svatava Kubickova, Petra Musilova, Radek Vrtel, Emily M. Sontag, Leslie Thompson, Jan Schier, Hana Hansikova, David S. Howland, Elena Cattaneo, Marian Difiglia, Martin Marsala, Jan Motlik

Biological Sciences Faculty Research and Publications

Background: Some promising treatments for Huntington's disease (HD) may require pre-clinical testing in large animals. Minipig is a suitable species because of its large gyrencephalic brain and long lifespan. Objective: To generate HD transgenic (TgHD) minipigs encoding huntingtin (HTT)1–548 under the control of human HTT promoter. Methods: Transgenesis was achieved by lentiviral infection of porcine embryos. PCR assessment of gene transfer, observations of behavior, and postmortem biochemical and immunohistochemical studies were conducted. Results: One copy of the human HTT transgene encoding 124 glutamines integrated into chromosome 1 q24-q25 and successful germ line transmission occurred through successive generations (F0, F1, F2 …

A Philosophy Of Hope And A Landscape Of Principle: The Legacy Of David Getches's Federal Indian Law Scholarship, Rebecca Tsosie

University of Colorado Law Review

In this essay, Professor Tsosie documents two important aspects of David Getches's work in the field of federal Indian law. First, Professor Tsosie observes that David Getches was a strong proponent of guiding principles and a consistent structure in the law. Consequently, he was one of the first scholars to observe the ways in which the contemporary Supreme Court was "remapping" the field of federal Indian law, apparently in service of the Court's commitment to states' rights and the protection of mainstream values. David noted the dangers of this "subjectivist" approach and urged a return to the foundational principles of …

Jury Instructions As Constitutional Education, Andrew Guthrie Ferguson

University of Colorado Law Review

Juries are central to the constitutional structure of America. This Article articulates a theory of the jury as a "constitutional teaching moment," establishing a historical and theoretical basis for reclaiming the educative value of jury service. This Article addresses the fundamental question of why, despite an unquestioned acceptance of a constitutional role of the jury, our criminal justice system does not explain this role to jurors on jury duty. This Article seeks to answer the question of how we can educate jurors about the jury's constitutional role, while at the same time exploring the larger theoretical concerns with using the …

Renewable Energy Through Agency Action, Amy L. Stein

University of Colorado Law Review

Despite the many societal benefits associated with renewable energy, it is used to generate only about 5 percent of our nation's electricity needs. The bulk of governmental efforts to rectify this situation have disproportionately impacted private actors. This Article argues that the federal government should expand its efforts to more fully capture the gains that can be achieved by targeting both private and public actors, particularly federal agencies. Federal agencies have enormous purchasing power that can be channeled toward using electricity and fuels derived from renewable energy. Federal agencies are some of the largest consumers of electricity. Federal agencies manage …

I'Ll Huff And I'Ll Puff And I'Ll Blow Your House Down: The Argument For The Ability To Purchase Your Neighbor's Wind, Emily J. Wasserman

University of Colorado Law Review

Wind power capacity has increased substantially over the past decade. This growth in capacity is partially attributable to the policies that federal and state governments have enacted to help developers overcome the economic barriers to building commercial-scale wind facilities. However, the existing economic policies have a limited ability to continue to incentivize development of new wind power capacity. Therefore, if wind power capacity is going to continue to grow so that wind power eventually supplies enough electricity to meet a significant amount of the United States' energy needs, states need to supplement the economic policies with other, noneconomic policies. Specifically, …

Law Clinics And Lobbying Restrictions, Kevin Barry, Marcy Karin

University of Colorado Law Review

"Can law school clinics lobby?" This question has plagued professors for decades but has gone unanswered, until now. This Article situates law school clinics within the labyrinthine law of lobbying restrictions and concludes that clinics may indeed lobby. For ethical, pedagogical, and, ultimately, practical reasons, it is critical that professors who teach in clinics understand these restrictions. This Article offers advice to professors and students on safely navigating this complicated terrain.

Topical Gene Electrotransfer To The Epidermis Of Hairless Guinea Pig By Non-Invasive Multielectrode Array, Sigi Guo, Annelise L. Israel, Gaurav Basu, Amy Donate, Richard Heller

Bioelectrics Publications

Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently delivered plasmid DNA and enhanced expression to the skin of several animal models by in vivo gene electrotransfer. Here, we characterized plasmid DNA delivery with the MEA in a hairless guinea pig model, which has a similar histology and structure to human skin. Significant elevation of gene expression up to 4 logs was achieved with intradermal DNA administration followed by topical non-invasive skin gene electrotransfer. …

Bioelectrics In Basic Science And Medicine: Impact Of Electric Fields On Cellular Structures And Functions, Stephen J. Beebe

Bioelectrics Publications

Bioelectrics is a new interdisciplinary field that investigates electric field effects on cell membranes and other cellular components. It incorporates four main technologies, including electroporation, nanosecond pulsed electric fields, picosecond pulsed electric fields and cold plasmas. The parent technology in Bioelectrics is electroporation, which uses milli- and/or micro-second electric pulses to permeabilize cells and tissues, for delivery of membrane impermeable molecules. It is now being used for electro-gene delivery, with vascular endothelial growth factor, for revascularization in wound healing and cardiovascular and peripheral vascular disease. Plasmids expressing IL-12 are being delivered for immune system activation in melanoma treatment, now in …

Characterization And Control Of Occupational Exposure To Nanoparticles And Ultrafine Particles, Maximilien Debia, Charles Beaudry, Scott Weichenthal, Robert Tardif, André Dufresne

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

De nombreux travailleurs sont exposés à un ensemble de particules présentes à une échelle nanométrique. En hygiène du travail, il est commun de différencier les nanoparticules (NP) manufacturées, des particules ultrafines (PUF) qui proviennent de sources naturelles, humaine ou industrielle. Étant donné qu’il existe des lacunes importantes dans les démarches usuelles d'évaluation du risque à ces particules, l’objectif de cette recherche était d’évaluer les expositions professionnelles à des PUF et des NP. L’objectif secondaire était de tester globalement les capacités d’évaluation des expositions professionnelles aux NP et aux PUF dans un …

Visualizing And Understanding Tectonism And Volcanism On Earth And Other Terrestrial Bodies, Mladen M. Dordevic

Physics Theses & Dissertations

This dissertation presents new methods of visualizing, teaching, assessing, modeling, and understanding tectonics on Earth and other celestial bodies. Tectonics is the study of planetary lithospheres and includes impact, plate, plume, cryo- and gravitational mechanisms. This dissertation is concerned with plate tectonics and plate/mantle plume interactions. Plate tectonics describes the mainly horizontal motion of lithospheric plates over the asthenosphere. Lithosphere is created at ridges and consumed at subduction zones. In addition to the plate tectonic system, mantle plumes also contribute to mass motions in the subsurface Earth. Both plate tectonics and plume upwelling processes help shape the present form of …

New Tools For Real-Time Study Of Embryonic Development, Lauren M. Browning

Theses and Dissertations in Biomedical Sciences

Embryonic development represents one of the most complex and dynamic cellular processes in biology, and plays vital roles in understanding of functions of embryonic stem cells (ESCs) and design of ESC-based therapy. Conventional assays and fluorescence-based imaging methods have been widely used for the study of embryonic development. These conventional methods cannot effectively provide spatial and temporal resolutions with sufficient sensitivity and selectivity that are required to depict embryonic development in vivo in real-time at single-cell and single-molecule resolutions. In this dissertation, we have developed a wide range of innovative tools for real-time study of embryonic development. These new tools …

Watershed-Scale Hybrid Stochastic-Deterministic Modeling Framework And Diffused Sources Superpositioning, Ruby Juvah Damalie

Civil & Environmental Engineering Theses & Dissertations

Predicting hydrologic system behavior is imperative to planning and management of water resources. The study developed an integrated hybrid stochastic and deterministic framework to improve prediction accuracy for overland flow and diffused sources in a watershed. The methodology includes sampling input parameters at system level and contribution of nonpoint source from hydrologically disconnected areas (heretofore referred to as system-level approach and superpositioning respectively). System-level approach includes the integration of a topography-based sampling grid generalized linear model developed by the study and Monte Carlo methods. The superpositioning method adopts in-stream water quality equation for overland flow pollution estimation.

The system-level approach …

Creative Writing Thesis: Poetry, Desmond Bonhomme

CMC Senior Theses

The title of this compilation of my own creative writings is Trees, Breathe, Paper. This unique collection of poetry, short stories and prose contains a range of work, composed from 2002-2012. The thematic goal of this undertaking is to ballast as many implicit and explicit meanings as are comprehensible, and to extrapolate a distinct spectrum of latent and straightforward explanations with discernible psycho-analytical accuracy. We all know poetry is truly formless and based on springs of natural inspiration. Thus, we derive our purest inspiration from the natural world and we prune it in its unfiltered, raw state. Poetry is an …

Salvation: An Exploration, Kelsey Rose Weber

CMC Senior Theses

This thesis explores how women in different religious communities relate to the concept of Salvation. Focusing on Buddhism, Judaism, Islam, and Hinduism, this short experimental film, and supplement paper, seek to provide an alternative point of view that translates this unique experience for women in religions that use heavily gendered language and that are rooted in traditional patriarchal cultures. By using the experimental film medium, viewers are able to perceive religion and film in a new way that pushes the viewer to give their own interpretation of the imagery on screen. It also allows viewers to give the imagery meaning …

Identification Of Pleiotropic Genetic Effects On Obesity And Brain Anatomy, Joanne E. Curran, D Reese Mckay, Anderson M. Winkler, Rene L. Olvera, Thomas D. Dyer, Peter T. Fox, Laura Almasy, Ravi Duggirala, John Blangero, David C. Glahn

School of Medicine Publications

Background/aims: Obesity is a major contributor to the global burden of chronic disease and disability, though current knowledge of causal biologic underpinnings is lacking. Through the regulation of energy homeostasis and interactions with adiposity and gut signals, the brain is thought to play a significant role in the development of this disorder. While neuroanatomical variation has been associated with obesity, it is unclear if this relationship is influenced by common genetic mechanisms. In this study, we sought genetic components that influence both brain anatomy and body mass index (BMI) to provide further insight into the role of the brain in …

More Than A Bath: An Examination Of Japanese Bathing Culture, Adam M. Merry

CMC Senior Theses

Steeped in tradition for over a thousand years, bathing culture in Japan remains relevant due to the preservation of the traditional, innovative modernization of existing bathing structures, and the diversification therein. This thesis will examine the significance of bathing culture, focusing largely on onsen and sento, account for its historical evolution, analyze how it functions in modern society and forecast its future viability. More specifically, the concept that Japan's vibrant bathing culture was able to flourish due to mythological creation stories, politically motivated access to baths, propagated therapeutic value, and scientific reinforcement of the benefits of a hot bath …