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Beneath The Forest, Volume 6, No. 2, Fall 2013, Johanna L. Kovarik

Beneath the Forest

Contents: Sandy Glacier Cave Project: Mt. Hood, Oregon - MOU between the National Cave and Karst Research Institute and the Forest Service - C-23: New Discoveries in an Old Cave - Battle for Bats: New White-Nose Syndrome Video Available

Pages From Scholarly Life: The Snowman Melted, Phyllis Gimbel

Bridgewater Review

No abstract provided.

The Tacuinum Sanitatis: A Medieval Health Manual, Loren D. Mendelsohn

Publications and Research

No abstract provided.

Delegating Away The Unitary Executive: Reviewing Ina § 287(G) Agreements Through The Lens Of The Unitary Executive Theory, Matthew A. Smith

Duke Journal of Constitutional Law & Public Policy

No abstract provided.

Exploring The Native American Colonial Landscape Of The Central Savannah River Area, Late 17th -Early 18th Centuries, J. Christopher Gillam, Charles R. Cobb, Chester B. Depratter, Tammy F. Herron

Faculty & Staff Publications

No abstract provided.

A Photo Gallery Of Legume Content In Pastures, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

A Box Of Paradoxes: The Fascinating World Of Viruses, Boriana Marintcheva

Bridgewater Review

No abstract provided.

Filopodia As Sensors, Carol A. Heckman, H. K. Plummer

Biological Sciences Faculty Publications

Filopodia are sensors on both excitable and non-excitable cells. The sensing function is well documented in neurons and blood vessels of adult animals and is obvious during dorsal closure in embryonic development. Nerve cells extend neurites in a bidirectional fashion with growth cones at the tips where filopodia are concentrated. Their sensing of environmental cues underpins the axon's ability to "guide," bypassing non-target cells and moving toward the target to be innervated. This review focuses on the role of filopodia structure and dynamics in the detection of environmental cues, including both the extracellular matrix (ECM) and the surfaces of neighboring …

Soundings 2013-11-01, N/A N/A

Soundings

No abstract provided.

Lack Of Rbl1/P107 Effects On Cell Proliferation And Maturation In The Inner Ear, Sonia M. Rocha-Sanchez, Laura R. Scheetz, Sabrina Siddiqi, Michael W. Weston, Lynette M. Smith, Kate Dempsey, Hesham Ali, Joann Mcgee, Edward J. Walsh

Information Systems and Quantitative Analysis Faculty Publications

Loss of postnatal mammalian auditory hair cells (HCs) is irreversible. Earlier studies have highlighted the importance of the Retinoblastoma family of proteins (pRBs) (i.e., Rb1, Rbl1/p107, and Rbl2/p130) in the auditory cells’ proliferation and emphasized our lack of information on their specific roles in the auditory system. We have previously demonstrated that lack of Rbl2/p130 moderately affects HCs’ and supporting cells’ (SCs) proliferation. Here, we present evidence supporting multiple roles for Rbl1/p107 in the developing and mature mouse organ of Corti (OC). Like other pRBs, Rbl1/p107 is expressed in the OC, particularly in the Hensen’s and Deiters’ cells. Moreover, Rbl1/p107 …

Twelve Days Of Christmas Mechatronic Display, Michael Beltran, Christine Hagerman, Katie Ruhm

Mechanical Engineering

No abstract provided.

Making Sense: Rhetoric, Perception, And Materiality, Aaron P. Donaldson

Electronic Theses and Dissertations

This dissertation dwells on the intersections of language-use and perception. The premise is that language makes literal sense and this reality has profound implications for those Burke called "symbol-using/mis-using animals." Communication scholars have long accepted a model of communication that positions language as "constitutive articulate contact" as opposed to a discrete means of transmission (Stewart, 1994), but a great deal of work remains to be done in terms of developing the implications for individuals and their language-use.

Chapter One explores the stances embraced by rhetorical materialists struggling to describe how language matters. The first chapter fields a series of critiques …

Cytochrome P450 Family 1 Inhibitors And Structure-Activity Relationships, Jiawang Liu, Jayalakshmi Sridhar, Maryam Foroozesh

Faculty and Staff Publications

With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied. Generally, planar polycyclic molecules such as polycyclic aromatic hydrocarbons, stilbenoids, and flavonoids are considered to potentially be effective inhibitors of these enzymes, however, the details of the structure-activity relationships and selectivity of these inhibitors are still ambiguous. In this review, we thoroughly discuss the selectivity of many representative P450 family 1 inhibitors reported in the past 20 years through a meta-analysis.

2013 November Newsletter, Nancy Rockey

Human Subject Research Archive

No abstract provided.

Slope Of Change Through D-Cycloserine Facilitation Of Exposure Therapy In A Social Anxiety Population, Christina M. Sheerin

Dissertations

The present study sought to add to a growing base of research investigating approaches that facilitate the therapeutic effects of exposure-based therapy for social anxiety disorders. In particular, the approach involves the use of medication adjuvants that work in conjunction with therapeutic learning. This work translates findings from preclinical work to further our understanding of the neurobiological mechanisms that impact extinction learning. Among others, a promising method has been found with the use of D-cycloserine (DCS), a partial NMDA receptor agonist. Evidence of its positive impact in preclinical work has led to its application to clinical populations who suffer from …

Cognitive Apprenticeship And The Supervision Of Science And Engineering Research Assistants, Michelle A. Maher, Joanna A. Gilmore, David F. Feldon, Telesia E. Davis

Instructional Technology and Learning Sciences Faculty Publications

We explore and critically reflect on the process of science and engineering research assistant skill development both within laboratory-based research teams and, when no team is present, whithin the faculty supervisor-research assistant interactions. Using a performance-based measure of research skill development, we identify research assistants who, over the course of an academic year of service as a researcher, markedly developed, modestly developed, or failed to develop their research skills. Interviews with these research assistants and their faculty supervisors, seen through the lens of cognitive apprenticeship, provide insight into this variation. We found that within the contours of supervisory relationships and …

Ct Angiography In The Detection Of Carotid Body Enlargement In Patients With Hypertension And Heart Failure, Sreejit Nair, Ajay Gupta, Marat Fudim, Christopher Robinson, Vinay Ravi, Sandra M. Hurtado Rua, Zoar Engelman, Kyungmouk S. Lee, C. Douglas Philips, Akhilesh K. Sista

Mathematics and Statistics Faculty Publications

Introduction: The carotid body (CB) has previously been found to be enlarged and hyperactive in various disease states such as heart failure (HF), hypertension (HTN), and respiratory disease. Evaluation of CB size in these disease states using imaging has not been performed. The purpose of this case–control study was to compare CB sizes in patients with HF and HTN with those of controls using CT angiography. Methods: A retrospective review was performed on 323 consecutive patients who had neck computed tomography angiography (CTA) exams in 2011. Following extensive review, 17 HF and HTN patients and 14 controls were identified. Two …

The Effects Of Diethylstilbestrol Administration On Rat Kidney. Ultrastructural Study, Adel M. Hussein, Mohamed H. Badawoud, Mustafa H. Noaman

Saudi Medical Journal

OBJECTIVE: To assess the histological and ultrastructural changes that can be induced by diethylstilbestrol (DES) on renal tissues using histological, immunohistochemical, and ultrastructural methods. METHODS: Thirty adult male Wistar rats were divided into 3 groups (10 rats each): Group 1 - control; Group 2 - received DES at a dose of 60 ug/kg/day, dissolved in 0.1 ml corn oil for 20 days; and Group 3 - received the same dose of DES for 50 days by oral gavage. The renal tissues were studied histologically, immunohistochemically (using an anti-BCL2-associated X protein [BAX protein] antibody), and ultrastructurally. This study was carried out …

Multicenter Study Comparing Shunt Type In The Norwood Procedure For Single-Ventricle Lesions: Three-Dimensional Echocardiographic Analysis., Gerald R. Marx, Girish S. Shirali, Jami C. Levine, Lin T. Guey, James F. Cnota, Jeanne M. Baffa, William L. Border, Steve Colan, Gregory Ensing, Mark K. Friedberg, David J. Goldberg, Salim F. Idriss, J Blaine John, Wyman W. Lai, Minmin Lu, Shaji C. Menon, Richard G. Ohye, David Saudek, Pierre C. Wong, Gail D. Pearson, Pediatric Heart Network Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The Pediatric Heart Network's Single Ventricle Reconstruction (SVR) trial randomized infants with single right ventricles (RVs) undergoing a Norwood procedure to a modified Blalock-Taussig or RV-to-pulmonary artery shunt. This report compares RV parameters in the 2 groups using 3-dimensional echocardiography.

METHODS AND RESULTS: Three-dimensional echocardiography studies were obtained at 10 of 15 SVR centers. Of the 549 subjects, 314 underwent 3-dimensional echocardiography studies at 1 to 4 time points (pre-Norwood, post-Norwood, pre-stage II, and 14 months) for a total of 757 3-dimensional echocardiography studies. Of these, 565 (75%) were acceptable for analysis. RV volume, mass, mass:volume ratio, ejection fraction, …

Novel Neuroprotective Function Of Apical-Basal Polarity Genecrumbs In Amyloid Beta 42 (Aβ42) Mediated Neurodegeneration, Andrew Steffensmeier, Meghana Tare, Oorvashi Roy Puli, Rohan Modi, Jaison Nainaparampil, Madhuri Kango-Singh, Amit Singh

Biology Faculty Publications

Alzheimer's disease (AD, OMIM: 104300), a progressive neurodegenerative disorder with no cure to date, is caused by the generation of amyloid-beta-42 (Aβ42) aggregates that trigger neuronal cell death by unknown mechanism(s). We have developed a transgenic Drosophilaeye model where misexpression of human Aβ42 results in AD-like neuropathology in the neural retina. We have identified an apical-basal polarity gene crumbs (crb) as a genetic modifier of Aβ42-mediated-neuropathology. Misexpression of Aβ42 caused upregulation of Crb expression, whereas downregulation of Crb either by RNAi or null allele approach rescued the Aβ42-mediated-neurodegeneration. Co-expression of full length Crb with Aβ42 increased severity of Aβ42-mediated-neurodegeneration, …

Bilingual And Esl Pre-Service Teachers Learn About Effective Instruction For Ells Through Meaningful Collaboration, Alma D. Rodríguez

Bilingual and Literacy Studies Faculty Publications

This article presents the results of a study conducted to identify the perceptions of bilingual and ESL pre-service teachers regarding the integration of a collaborative service learning project in a key course of their teacher preparation program. Pre-, process, and final reflective essays were written by participants as they engaged in the development of an ESL unit to teach language through content to ELLs. The analysis of participants’ reflections revealed that preservice teachers connect the learning they acquire in their teacher education program with their life experiences, which contributes to their identity formation as prospective teachers of ELLs. In addition, …

The Grapes Of Wrath: Encouraging Fruitful Collaborations Between Local Governments And Farm Wineries In The Commonwealth, Philip Carter Strother, Andrew E. Tarney

University of Richmond Law Review

No abstract provided.

Homeotic Gene Teashirt (Tsh) Has A Neuroprotective Function In Amyloid-Beta 42 Mediated Neurodegeneration, Michael T. Moran, Meghana Tare, Madhuri Kango-Singh, Amit Singh

Biology Faculty Publications

Background: Alzheimer's disease (AD) is a debilitating age related progressive neurodegenerative disorder characterized by the loss of cognition, and eventual death of the affected individual. One of the major causes of AD is the accumulation of Amyloid-beta 42 (Aβ42) polypeptides formed by the improper cleavage of amyloid precursor protein (APP) in the brain. These plaques disrupt normal cellular processes through oxidative stress and aberrant signaling resulting in the loss of synaptic activity and death of the neurons. However, the detailed genetic mechanism(s) responsible for this neurodegeneration still remain elusive.

Methodology/Principal Findings: We have generated a transgenic Drosophila eye model where …

2013 November Newsletter, Nancy Rockey

Life Renewal Archive

No abstract provided.

Microbial Natural Products: Molecular Blueprints For Antitumor Drugs, Lesley Ann Giddings, David J. Newman

Chemistry: Faculty Publications

Microbes from two of the three domains of life, the Prokarya, and Eukarya, continue to serve as rich sources of structurally complex chemical scaffolds that have proven to be essential for the development of anticancer therapeutics. This review describes only a handful of exemplary natural products and their derivatives as well as those that have served as elegant blueprints for the development of novel synthetic structures that are either currently in use or in clinical or preclinical trials together with some of their earlier analogs in some cases whose failure to proceed aided in the derivation of later compounds. In …

The New Hampshire, Vol. 103 [104], No. 15 (Nov. 1, 2013), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 103, but it is the 104th volume in the series. This was corrected in pencil.

Assessment And Recommendations For Using High-Resolution Weather Information To Improve Winter Maintenance Operations, Michael Baldwin, Kimberly Hoogewind, Derrick Snyder, Matthew Price, R. Jeffrey Trapp

JTRP Technical Reports

A variety of methods for obtaining detailed analyses regarding the timing and duration of winter weather across the state of Indiana for multiple seasons were compared and evaluated during this project. Meteorological information from sources such as surface reporting stations, National Weather Service radars, and three-dimensional weather analysis and prediction systems were utilized in this work. In addition, daily weather forecasts were provided by students at Purdue University during the 2012-13 winter season. These forecasts supplemented the weather forecast information already in use at INDOT. Purdue weather forecasts were systematically evaluated during this project. The results from these assessments are …

The Envenoming Pandemic And The Misguided Views Of Snakes: Developing Sustainable Relationships Between Native Poisonous Snakes Of India And The Citizens Of Maharashtra Through The Use Of The Irula Model., Destiny Villanueva

Animal Science

Due to its vast population and general negative consensus regarding snakes, India is notorious for having more snakebite incidents than any other country. Snakes are simultaneously revered and feared in Indian religion and culture. This stigma is perpetuated through propaganda, family beliefs, and innate fears of snakes.These stigmas are more pronounced within rural areas, such as the region of Mahad within the state of Maharshtra. Envenoming is endemic in these areas, and others like them. The World Health Organization identified envenoming as one of the most neglected tropical diseases of the 21st century (Nature India, 2013). Additionally, both nonvenomous and …

Roadway Striping Productivity Data Analysis For Indot Greenfield And Crawfordsville Districts, Dan Koo

JTRP Technical Reports

The main objective of the SPR-3650 research project is to provide an accurate overview of striping operation so that INDOT finds a way to effectively save significant investment for purchasing new striping trucks in near future without compromising roadway striping operation and maintenance. Telematics data collection technology was selected to collect 2012 striping season operation, from April 2012 to November 2012, in real-time via wireless network to analyze complete striping operation performance including four striping trucks and multiple supporting vehicles in Crawfordsville and Greenfield district. The performance analyses include productivity, utilization, idling, WMS, materials consumption, and fleet tracking. The research …

Dna Barcoding Distinguishes Pest Species Of The Black Fly Genus Cnephia (Diptera: Simuliidae), I. M. Confitti, K. P. Pruess, A. Cywinska, T. O. Powers, D. C. Currie

Department of Entomology: Faculty Publications

Accurate species identification is essential for cost-effective pest control strategies. We tested the utility of COI barcodes for identifying members of the black fly genus Cnephia Enderlein (Diptera: Simuliidae). Our efforts focus on four Nearctic Cnephia species—Cnephia dacotensis (Dyar & Shannon), Cnephia eremities Shewell, Cnephia ornithophilia (Davies, Peterson & Wood), and Cnephia pecuarum (Riley)—the latter two being current or potential targets of biological control programs. We also analyzed one Palearctic species, Cnephia pallipes (Fries). Although Cnephia adults can be identified anatomically to species, control programs target the larval stage, which is difficult or impossible to distinguish morphologically. By using …