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2013

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Articles 18151 - 18180 of 19504

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Consumptive And Non-Consumptive Effects Of Predatory Fishes On Lobster In Southern Maine, Erin B. Wilkinson Jan 2013

Consumptive And Non-Consumptive Effects Of Predatory Fishes On Lobster In Southern Maine, Erin B. Wilkinson

All Theses And Dissertations

The American lobster, Homarus americanus, is an important consumer in the Gulf of Maine benthic community and supports the most valuable fishery in New England. Many fish predators that feed on juvenile lobster are found in the Gulf of Maine, but their abundance has varied over the previous decades. For example, striped bass, Morone saxatilis, have recovered from near extinction to become a viable recreational fishery on the east coast, and previous work examining the gut contents of striped bass found that juvenile lobsters were a large component of their diet during the summer in Massachusetts. However, striped …

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Kitten Has Claws: The Feminine, The Feline, And The Threat Of The New Woman In Cecilia Beaux's "Sita And Sarita", Alexa Hayes Jan 2013

Kitten Has Claws: The Feminine, The Feline, And The Threat Of The New Woman In Cecilia Beaux's "Sita And Sarita", Alexa Hayes

All ETDs from UAB

This thesis examines Cecilia Beaux's painting "Sita and Sarita" (1893-1894) as it expresses the conflicts of the women's rights movement, changing gender roles, and shifts in the perception of female sexuality and intellectualism in the late nineteenth century. The argument hinges on the quality of the woman's gaze and the anthropomorphic nature of the cat, which encompass growing interests in and fears of female mental capacity, sexuality, and animality. Examining how the portrait functions within three major traditions--depictions of young women in white dresses; women lost in thought or in reverie; and portraits of people with their pets, specifically women …

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The Role Of Autosomal Dominant Retinitis Pigmentosa Rhodopsin Mutant Ter349glu In Rod Cell Biogenesis And Retinal Inflammation, Tj Hollingsworth Jan 2013

The Role Of Autosomal Dominant Retinitis Pigmentosa Rhodopsin Mutant Ter349glu In Rod Cell Biogenesis And Retinal Inflammation, Tj Hollingsworth

All ETDs from UAB

Retinitis pigmentosa is one of the most common inherited blinding disorders, affecting 1 in 4000 individuals world-wide. Approximately 30% of retinitis pigmentosa cases are dominantly inherited and approximately 30% of these dominant mutations are found in rhodopsin. Most rhodopsin mutations result in misfolded protein aggregates and subsequent apoptosis while others have been shown to result in apoptosis associated with mislocalization, diminished/enhanced activity, or faulty protein-protein interactions. This work serves to test for mechanisms by which the naturally-occurring Ter349Glu rhodopsin mutation causes rod cell death. Ter349Glu rhodopsin was tested for the ability to bind the ligand 11-cis retinal, photoactivate, and activate …

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Identification And Biochemical Investigations Of Rhamnose And Glycoprotein In Mycoplasmas, David Jordan Jan 2013

Identification And Biochemical Investigations Of Rhamnose And Glycoprotein In Mycoplasmas, David Jordan

All ETDs from UAB

Mycoplasmas are host-specific human and animal pathogens within the class of wall-deficient bacteria named Mollicutes and have smaller sizes and genomes than the walled bacteria. Mycoplasma genome sequences reveal few if any genes for synthesis of a glycocalyx. Nevertheless, we find that mycoplasmas produce glycolipids, glycoprotein, and polysaccharides. Using gas chromatography and mass spectrometry, glucose, mannose, rhamnose, and galactose were detected in the glycolytic species Mycoplasma pneumoniae and Mycoplasma pulmonis. All of these sugars except galactose was found in Mycoplasma arthritidis. Rhamnose was in the rare D configuration in the glycolytic species and in both D and L forms in …

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Eight Days In Oak Lake, Cyndi Eubanks Jan 2013

Eight Days In Oak Lake, Cyndi Eubanks

All ETDs from UAB

Eight Days in Oak Lake is an incomplete fictional novel about teenage Laine Reardon, who finds her life in turmoil after her family embarks on a trip to Oak Lake, Mississippi, for a family reunion. On the trip, Laine learns a disturbing secret about her father, and she is reunited with her childhood friend, Jake Donnelly. With sisters she often does not understand and parents who have their own problems, Laine seeks solace in the now-grown boy she grew up with. As she struggles to understand her feelings for Jake and deal with the revelation about her father, Laine is …

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Regulation Of Capsule By Cpsa And Global Regulatory Networks In Streptococcus Pneumoniae Type 2, Kanupriya Gupta Jan 2013

Regulation Of Capsule By Cpsa And Global Regulatory Networks In Streptococcus Pneumoniae Type 2, Kanupriya Gupta

All ETDs from UAB

Streptococcus pneumoniae is a major human pathogen that can reside asymptomatically in the nasopharynx before causing invasive disease by entering systemic sites. This involves regulation of colonization and virulence factors including capsule. cps2A, the first gene of the capsule (cps) locus has been proposed to regulate capsule, however its exact role and mechanism is not well understood. A complete deletion of cps2A resulted in enhanced capsule levels, with no alteration in the transcription levels of cps genes. Complementation of Cps2A restored wild type levels of capsule. Expression of the C-terminal tail alone was able to partially complement the deletion strain, …

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Comparison Of The Lenstar Optical Biometer And A-Scan Ultrasonography To Measure Ocular Components, Drew W. Gann Jan 2013

Comparison Of The Lenstar Optical Biometer And A-Scan Ultrasonography To Measure Ocular Components, Drew W. Gann

All ETDs from UAB

The purpose of this study was to compare ocular component dimensions and treated minus control eye differences measured with the Lenstar optical biometer to those measured with A-scan ultrasound in the tree shrew model of refractive development and induced myopia. A-scan ultrasonographic measures (A-scan) were taken with a 15 MHz focused pulser/receiver and compared with measures made with the Lenstar LS900 optical biometer (Haag-Streit, Basel, Switzerland). Anterior segment depth (ASD), lens thickness (LT), vitreous chamber depth (VCD), and axial length (AL) were measured in treated eyes (30), fellow control eyes (30), and normal eyes (86) in tree shrews (n=146), between …

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Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston Jan 2013

Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston

All ETDs from UAB

Malignant gliomas are the most frequently diagnosed and the most fatal primary brain tumors. Innovative therapeutic approaches are necessary to combat these devastating cancers, and oncolytic herpes simplex virus type-1 (oHSV) deleted of the γ134.5 neurovirulence gene is a promising adjunctive therapy. The primary mechanism of tumor clearance by oHSV is lytic replication specifically within malignant cells. oHSV also stimulates tumor infiltration of cytotoxic immune effector cells that can participate in tumor clearance. However, cytotoxic immune cells target oHSV as well as tumor, which may limit therapeutic efficacy. Further knowledge regarding the nature of these interactions and how the interactions …

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Virus-Induced Inflammation And Central Nervous System Development, Kate Kosmac Jan 2013

Virus-Induced Inflammation And Central Nervous System Development, Kate Kosmac

All ETDs from UAB

Congenital human cytomegalovirus (HCMV) infection is a complex cause of central nervous system (CNS) disease. Infection with HCMV during pregnancy results in virus transmission across the placenta and infection of the fetus. With a seroconversion rate in pregnant women between 1% and 4%, HCMV is the most frequently transmitted virus from mother to developing child. Each year between 2,000 and 4,000 infants will suffer from long-term neurologic deficits as a result of congenital infection. The well documented CNS sequelae resulting from congenital HCMV infection have described a wide range of damage without a specific set of pathologic markers for disease. …

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The Influence Of Socioeconomic Status And System Design On Child Passenger Safety, Donald Scott Burke Jan 2013

The Influence Of Socioeconomic Status And System Design On Child Passenger Safety, Donald Scott Burke

All ETDs from UAB

Motor vehicle collisions remain the number one cause of death for children in the United States, despite decades of prevention efforts led by safety experts and numerous private and government organizations. The overarching purpose of this research was to examine and compare the system safety factors that influence child passenger safety (CPS) with a particular focus on children living in poverty. The NASS-CDS and U.S. Census national databases were utilized to determine the effect of socioeconomic status on child occupant morbidity and mortality. The results of this analysis revealed for the first time, the disproportionate vulnerability of poor children in …

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The Molecular Mechanisms Underlying Cardiac Hypertrophy Due To Volume Overload., Justin Andrew Barnes Jan 2013

The Molecular Mechanisms Underlying Cardiac Hypertrophy Due To Volume Overload., Justin Andrew Barnes

All ETDs from UAB

Mitral regurgitation (MR) is a common form of heart disease, but there are no approved medical therapies for MR or other cardiovascular conditions associated with hemodynamic volume overload (VO) and eccentric remodeling. We have previously shown that a standard heart failure treatment, ß-adrenergic system blockade (ß-RB), improves function in animal models of VO and in MR patients without attenuating the adverse eccentric hypertrophy that occurs in conjunction with VO. This paradox highlights how poorly we understand eccentric remodeling of the heart, and a better understanding of the molecular mechanisms at work in VO must be obtained before we can develop …

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The Interactional Effects Of Incentive Value And Task Difficulty: A Partial Explanation For Gender Differences In Cardiovascular Response To A Performance Challange., Patricia Barreto Jan 2013

The Interactional Effects Of Incentive Value And Task Difficulty: A Partial Explanation For Gender Differences In Cardiovascular Response To A Performance Challange., Patricia Barreto

All ETDs from UAB

Participants were presented an impossible or moderately difficult mental addition task; half of them were led to believe that they could win a traditionally masculine incentive by meeting a certain performance standard and half of them were led to believe that they could win a traditionally feminine incentive if they met the same performance standard. In the feminine incentive group, Systolic Blood Pressure (SBP) during the work period was stronger under difficult than impossible conditions among women, but low under both difficulty conditions among men. In the masculine incentive group, blood pressure measures (SBP, diastolic blood pressure, and mean arterial …

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Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty Jan 2013

Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty

All ETDs from UAB

Adenoviruses are the most commonly used gene therapy vector for cancer therapy clinical trials. While adenovirus has shown a great track record in a variety of cancer therapeutics it has not progressed as a vector system for the modification of T lymphocytes. One of the major roadblocks towards utilizing adenovirus for T cell therapy is the lack of coxsackie virus and adenovirus receptor on the cell surface of T cell lineages. Exploitation of alternative receptors has allowed adenovirus vectors to be utilized in a variety of cell types that native adenovirus type 5 cannot infect. Thus, retargeting adenovirus to an …

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In-Vivo Characterization Of Cone Photoreceptor Packing Density With Adaptive Optics Scanning Laser Ophthalmoscopy In Different Racial Groups, Ernesto Blanco Rivero Jan 2013

In-Vivo Characterization Of Cone Photoreceptor Packing Density With Adaptive Optics Scanning Laser Ophthalmoscopy In Different Racial Groups, Ernesto Blanco Rivero

All ETDs from UAB

Cone photoreceptors are one of the two types of essential light sensitive cells that initiate the visual process in the human retina. A normal database of the cone density of healthy eyes may provide an important measure for diagnosing retinal diseases that cause photoreceptor loss, for monitoring disease progression, and for evaluating treatment out-come. Recent studies revealed that the foveal pit morphology, retina thickness, retinal nerve fiber layer (RNFL) thickness, and optic nerve head structure significantly correlated with racial background. We hypothesize that the cone density may be also modified by racial background. To test this hypothesis, I used a …

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Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi Jan 2013

Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi

All ETDs from UAB

Astrocytes are the most numerous cells in the brain and play a critical role in maintaining homeostatic extracellular potassium ([K+]e). This process is mediated, in part, by a glial-specific, inwardly rectifying potassium channel, Kir4.1. Pharmacological inhibition, knock down, or complete knock out of this channel results in astrocytes with increased membrane resistance, depolarized resting membrane potential, and altered extracellular potassium dynamics. Subsequent to the dysregulation of [K+]e, Kir4.1 knockout (KO) animals suffer from ataxia, seizures, and early postnatal death. Interestingly, Kir4.1 has long been characterized as a seizure susceptibility gene. The importance of Kir4.1 is further underscored by recent studies …

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New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor Jan 2013

New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor

All ETDs from UAB

Hedgehog (Hh) signaling is required for many developmental processes, and causes several diseases and cancers. Described in chapter one below, vertebrate Hh sig-naling is dependent on the primary cilium (PC), a small organelle that extends from the surface of most mammalian cell types. A better understanding of how the PC modulates Hh signaling is important, as defects in the structure or function of PC result in severe human disorders termed the ciliopathies. For example, patients with Meckel-Gruber Syndrome have extra digits and neural tube defects, which are Hh both related pheno-types. In chapter two we sought to further understand the …

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Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy Jan 2013

Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy

All ETDs from UAB

Estrogen replacement therapy (ERT) has been shown to improve memory function in menopausal women, but increases hormone sensitive cancers, prompting a more targeted investigation of estrogen's action in learning and memory to develop more targeted therapeutics. Estrogen improves performance on the novel object recognition task by increasing phosphorylation of extracellular signal-regulated kinase (pERK) within minutes in the hippocampus. Dr. Lori McMahon's lab showed that the improvement in novel object recognition can be seen 24 hours after subcutaneous injection of proestrous levels of estrogen (referred to as E24). Whether a corresponding increase in pERK occurs at the E24 time point had …

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Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith Jan 2013

Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith

All ETDs from UAB

Acetylcholine receptors (AChRs) are involved in visual processing and are expressed by inner retinal neurons in all species studied to date (Keyser et al., 2000; Dmitrieva et al., 2007; Liu et al., 2009), but their distribution in the mouse retina remains unknown. Reductions in alpha 7 nicotinic AChRs (nAChRs) are thought to contribute to memory and visual deficits observed in Alzheimer's and schizophrenia (Coyle et al., 1983; Nordberg et al., 1999; Leonard et al., 2006). However, the alpha 7 nAChR knockout (KO) mouse has a mild phenotype (Paylor et al., 1998; Fernandes et al., 2006; Young et al., 2007; Origlia …

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Biocomposite Material Evaluation And Processing For Automotive Interior Components, Theresa Lee Sullins Jan 2013

Biocomposite Material Evaluation And Processing For Automotive Interior Components, Theresa Lee Sullins

All ETDs from UAB

There is growing demand for materials that are environmentally friendly and sustainable. One of the areas of focus right now is the transportation/automotive field where more energy efficient vehicles are needed to meet growing government regulations and to reduce the negative impacts on global air quality, human health and global climate. Several researchers are focusing on bio-based composites with natural fibers being the prime choice for fiber reinforced composites. The processing and characterization of 30 wt. % industrial hemp fiber reinforced PP composites for automotive interior components are discussed. The material was compounded by a twin screw and then processed …

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The Effect Of Incentive Strategy On Health Behaviors And Outcomes In The Workplace, Lindsay M. Sutton Jan 2013

The Effect Of Incentive Strategy On Health Behaviors And Outcomes In The Workplace, Lindsay M. Sutton

All ETDs from UAB

This study examined participation, engagement, and achievement of health-related targets under two sequentially administered wellness programs for approximately 2,000 full-time city personnel of a Southern municipal government. Program A utilized paper fliers and community posters as the primary communication strategy and incented employees for achieving 3 health outcomes only by a lump-sum, one-time monetary reward distributed at the end of the year. Program B subsequently utilized a web-based site where employees logged into individualized accounts and received points that accrued for both completing behaviors and achieving health outcomes. Both electronic and paper communication strategies were utilized to as primary mediums …

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Plga Nanospheres For Sustained Release Of Rifampicin, Alyssa Brianna Terry Jan 2013

Plga Nanospheres For Sustained Release Of Rifampicin, Alyssa Brianna Terry

All ETDs from UAB

Although Tuberculosis (TB) is often regarded as a disease of the past, it is still one of the leading killers of people worldwide. TB is caused by Mycobacterium tuberculosis, a bacterium that mostly infects the lungs but can also infect other organs throughout the body. One goal for TB treatment is to create a biocompatible, biodegradable drug delivery system that employs the use of multiple drugs while simultaneously relieving the patient from the burden of self-medicating. For this study, we optimized a procedure for making poly(lactic acid-co-glycolic acid) (PLGA) nanospheres and loading Rifampicin, one of the most potent and least …

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The Origin, Regulation, And Function Of Tbet In Effector Cd4 T Cells During Chronic Autoimmune Disease, Wen-I Yeh Jan 2013

The Origin, Regulation, And Function Of Tbet In Effector Cd4 T Cells During Chronic Autoimmune Disease, Wen-I Yeh

All ETDs from UAB

Multiple Sclerosis (MS) is an autoimmune disease resulting from aberrant immune cells causing demyelination. We utilize the well-studied mouse model, experimental autoimmune encephalomyelitis (EAE), to decipher the underlying pathogenesis of MS. Effector CD4 T-cells play a critical role during EAE because the disease is induced by adoptively transferring myelin-specific CD4 T-cells into naïve mice. Classically, effector CD4 T-cells have been divided into distinct subsets based on their functional properties: Th1 cells produce IFNγ, Th2 cells secrete IL-4, IL-5, and IL-13, Th17 cells make IL-17A, IL-17F, IL-21, and IL-22, and regulatory T cells produce IL-10. Th1 cells were originally identified as …

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Investigation Of Death Receptor-5 Mediated Apoptosis And Inhibition Of Wnt/Ss-Catenin Signaling In Basal-Like Breast Cancer Stem Cells, Angelina Ix-Ik' Londono-Joshi Jan 2013

Investigation Of Death Receptor-5 Mediated Apoptosis And Inhibition Of Wnt/Ss-Catenin Signaling In Basal-Like Breast Cancer Stem Cells, Angelina Ix-Ik' Londono-Joshi

All ETDs from UAB

Basal-like breast cancers (BLBC) display aggressive clinical behavior attributed to the presence of cancer stem cells (CSCs). TRA-8, a monoclonal antibody that binds specifically to TRAIL death receptor 5, preferentially induces apoptosis in BLBC subtype cells; however it is unknown if TRA-8 is also cytotoxic to the CSC population. Moreover, some BLBC cell lines are resistant to TRA-8, and overcoming resistance is critical for clinical translation of this therapy. One potential approach to overcome TRA- 8 resistance is to target the Wnt/ß-catenin pathway. LRP6 is a cell surface receptor that is an indispensable element of the Wnt/ß-catenin signaling pathway that …

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Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James Jan 2013

Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James

All ETDs from UAB

Human Immunodeficiency Virus (HIV) is one of the leading infectious diseases in the world. In spite of substantial progress in the advancement of antiretroviral therapy for HIV treatment, new infections outpace the number of infected persons initiating ART. Therefore, the prevention of HIV remains a crucial health issue. Pre-Exposure Prophylaxis, (PrEP), which involves using one or more antiretroviral agents to reduce the risk of HIV infection prior to potential exposure, has shown effectiveness at reducing HIV transmission in study volunteers with different sexual orientation around the world. The clinical pharmacology of antiretroviral drugs, specifically tenofovir (TFV) and emtricitabine (FTC), in …

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The Challenges “Facing” Copyright Protection For Tattoos, Yolanda M. King Jan 2013

The Challenges “Facing” Copyright Protection For Tattoos, Yolanda M. King

Faculty Articles, Papers, and Other Scholarship

This Article addresses the ambiguity regarding the legal protectability of tattoos and the negative impact such ambiguity has on the rights of tattoo artists and their clients/customers. Notwithstanding the lack of federal court decisions in this area of the law, this Article determines that tattoos meet the requirements of copyrightability in the United States—originality and fixation in a tangible medium of expression. This Article examines the challenges presented by providing copyright protection for tattoos. In particular, this Article responds to the expert testimony of Professor David Nimmer, the author of a treatise often cited in the field of copyright law, …

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Characterization And Aerosol Dispersion Performance Of Spray-Dried Chemotherapeutic Pegylated Phospholipid Particles For Dry Powder Inhalation Delivery In Lung Cancer, Samantha A. Meenach, Kimberly W. Anderson, J. Zach Hilt, Ronald J. Mcgarry, Heidi M. Mansour Jan 2013

Characterization And Aerosol Dispersion Performance Of Spray-Dried Chemotherapeutic Pegylated Phospholipid Particles For Dry Powder Inhalation Delivery In Lung Cancer, Samantha A. Meenach, Kimberly W. Anderson, J. Zach Hilt, Ronald J. Mcgarry, Heidi M. Mansour

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Pulmonary inhalation chemotherapeutic drug delivery offers many advantages for lung cancer patients in comparison to conventional systemic chemotherapy. Inhalable particles are advantageous in their ability to deliver drug deep in the lung by utilizing optimally sized particles and higher local drug dose delivery. In this work, spray-dried and co-spray dried inhalable lung surfactant-mimic PEGylated lipopolymers as microparticulate/nanoparticulate dry powders containing paclitaxel were rationally designed via organic solution advanced spray drying (no water) in closed-mode from dilute concentration feed solution. Dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) with varying PEG chain length were mixed with varying amounts of paclitaxel in methanol …

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Dynamic Microtubules And Endomembrane Cycling Contribute To Polarity Establishment And Early Development Of Ectocarpus Mitospores, Jeffrey Jack Green, Diego Cordero Cervantes, Nick T. Peters, Kyle O. Logan, Darryl L. Kropf Jan 2013

Dynamic Microtubules And Endomembrane Cycling Contribute To Polarity Establishment And Early Development Of Ectocarpus Mitospores, Jeffrey Jack Green, Diego Cordero Cervantes, Nick T. Peters, Kyle O. Logan, Darryl L. Kropf

Faculty Publications

Many zygotes and spores of brown algae are photosensitive and establish a developmental axis in accordance with directional light cues. Ectocarpus siliculosus is being advanced as a genetic and genomic model organism for investigating brown alga development, and this report investigates photopolarization of the growth axis of mitospores. When exposed to unidirectional light, mitospores photopolarized and established a growth axis such that germination was preferentially localized to the shaded hemisphere of the spore body. The roles of the microtubule cytoskeleton and endomembrane cycling in the photopolarization process were investigated using pharmacological agents. Disruption of microtubule dynamics progressively reduced the percentage …

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A Tragedy Of The Anticommons: The Economic Inefficiencies Of Space Law, Benjamin David Landry Jan 2013

A Tragedy Of The Anticommons: The Economic Inefficiencies Of Space Law, Benjamin David Landry

Brooklyn Journal of International Law

No abstract provided.

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The Devil's Advocate: Using Neuroscientific Evidence In International Criminal Trials?, Adam B. Shniderman Jan 2013

The Devil's Advocate: Using Neuroscientific Evidence In International Criminal Trials?, Adam B. Shniderman

Brooklyn Journal of International Law

No abstract provided.

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Establishing An International Organ Exchange Through The General Agreement On Trade In Services, Kiran Sheffrin Jan 2013

Establishing An International Organ Exchange Through The General Agreement On Trade In Services, Kiran Sheffrin

Brooklyn Journal of International Law

No abstract provided.

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