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2013

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Glutamine Supplementation Alleviates Vasculopathy And Corrects Metabolic Profile In An In Vivo Model Of Endothelial Cell Dysfunction., Francesco Addabbo, Qiuying Chen, Dhara P Patel, May Rabadi, Brian Ratliff, Frank Zhang, Jean-Francois Jasmin, Michael Wolin, Michael Lisanti, Steven S Gross, Michael S Goligorsky Jan 2013

Glutamine Supplementation Alleviates Vasculopathy And Corrects Metabolic Profile In An In Vivo Model Of Endothelial Cell Dysfunction., Francesco Addabbo, Qiuying Chen, Dhara P Patel, May Rabadi, Brian Ratliff, Frank Zhang, Jean-Francois Jasmin, Michael Wolin, Michael Lisanti, Steven S Gross, Michael S Goligorsky

Kimmel Cancer Center Faculty Papers

Endothelial Cell Dysfunction (ECD) is a recognized harbinger of a host of chronic cardiovascular diseases. Using a mouse model of ECD triggered by treatment with L-Nω-methylarginine (L-NMMA), we previously demonstrated that renal microvasculature displays a perturbed protein profile, including diminished expression of two key enzymes of the Krebs cycle associated with a Warburg-type suppression of mitochondrial metabolism. We hypothesized that supplementation with L-glutamine (GLN), that can enter the Krebs cycle downstream this enzymatic bottleneck, would normalize vascular function and alleviate mitochondrial dysfunction. To test this hypothesis, mice with chronic L-NMMA-induced ECD were co-treated with GLN at different concentrations for 2 …


A Phase 1b Study Of Humanized Ks-Interleukin-2 (Huks-Il2) Immunocytokine With Cyclophosphamide In Patients With Epcam-Positive Advanced Solid Tumors., Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, Roger Stupp Jan 2013

A Phase 1b Study Of Humanized Ks-Interleukin-2 (Huks-Il2) Immunocytokine With Cyclophosphamide In Patients With Epcam-Positive Advanced Solid Tumors., Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, Roger Stupp

Kimmel Cancer Center Faculty Papers

BACKGROUND: Humanized KS-interleukin-2 (huKS-IL2), an immunocytokine with specificity for epithelial cell adhesion molecule (EpCAM), has demonstrated favorable tolerability and immunologic activity as a single agent.

METHODS: Phase 1b study in patients with EpCAM-positive advanced solid tumors to determine the maximum tolerated dose (MTD) and safety profile of huKS-IL2 in combination with low-dose cyclophosphamide. Treatment consisted of cyclophosphamide (300 mg/m2 on day 1), and escalating doses of huKS-IL2 (0.5-4.0 mg/m2 IV continuous infusion over 4 hours) on days 2, 3, and 4 of each 21-day cycle. Safety, pharmacokinetic profile, immunogenicity, anti-tumor and biologic activity were evaluated.

RESULTS: Twenty-seven patients were treated …


Biodiversity, Biogeography, And Conservation Of Bats In The Lesser Antilles, Scott C. Pedersen, Hugh H. Genoways, Gary G. Kwiecinski, Peter A. Larsen, Roxanne J. Larsen Jan 2013

Biodiversity, Biogeography, And Conservation Of Bats In The Lesser Antilles, Scott C. Pedersen, Hugh H. Genoways, Gary G. Kwiecinski, Peter A. Larsen, Roxanne J. Larsen

University of Nebraska State Museum: Mammalogy Papers

The chiropteran fauna of the Lesser Antilles consists of 27 species. The diversity of this fauna is low when compared with Neotropical faunas of large continental islands or at sites on the adjacent mainland, however, the Lesser Antillean fauna contains 11 species endemic to these islands making it worthy of large-scale conservation efforts. At the southern end of the Lesser Antilles, the biological limit of the Lesser Antillean bat fauna is marked by Koopman’s Line. To the south of this line, the bat faunas of the Grenadines and Grenada are composed of South American and widespread species of bats. The …


Development Of Frataxin Gene Expression Measures For The Evaluation Of Experimental Treatments In Friedreich's Ataxia., Heather L Plasterer, Eric C Deutsch, Matthew Belmonte, Elizabeth Egan, David R Lynch, James R Rusche Jan 2013

Development Of Frataxin Gene Expression Measures For The Evaluation Of Experimental Treatments In Friedreich's Ataxia., Heather L Plasterer, Eric C Deutsch, Matthew Belmonte, Elizabeth Egan, David R Lynch, James R Rusche

Department of Pediatrics Faculty Papers

BACKGROUND: Friedreich ataxia is a progressive neurodegenerative disorder caused by GAA triplet repeat expansions or point mutations in the FXN gene and, ultimately, a deficiency in the levels of functional frataxin protein. Heterozygous carriers of the expansion express approximately 50% of normal frataxin levels yet manifest no clinical symptoms, suggesting that therapeutic approaches that increase frataxin may be effective even if frataxin is raised only to carrier levels. Small molecule HDAC inhibitor compounds increase frataxin mRNA and protein levels, and have beneficial effects in animal models of FRDA.

METHODOLOGY/PRINCIPAL FINDINGS: To gather data supporting the use of frataxin as a …


Alpha 1-Antitrypsin. A Novel Biomarker For Obesity In Humans, Gong B. Xue, Wen L. Zheng, Lei H. Wang, Li Y. Lu Jan 2013

Alpha 1-Antitrypsin. A Novel Biomarker For Obesity In Humans, Gong B. Xue, Wen L. Zheng, Lei H. Wang, Li Y. Lu

Saudi Medical Journal

OBJECTIVE: To investigate the relationship between alpha 1-antitrypsin (A1AT), adiponectin, leptin, blood glucose, and insulin protein levels in human serum and obesity. METHODS: Forty-eight subjects with normal blood glucose levels and average age of 32.4+/-5.1 years were enrolled in this study. The study took place in the Reproductive Center, The Second Hospital of Jilin University, Changchun, China between June and July 2011. The height and weight were measured for calculating the body mass index (BMI) and grouped according to BMI. Fasting venous blood were drawn, and then serum levels of A1AT, adiponectin, leptin, blood glucose and insulin were measured by …


Efficacy And Safety Of Non-Penetrating Deep Sclerectomy Surgery In Saudi Patients With Uncontrolled Open Angle Glaucoma, Saleh A. Al-Obeidan, Ahmed Mousa, Abid Naseem, Khaled K. Abu-Amero, Essam A. Osman Jan 2013

Efficacy And Safety Of Non-Penetrating Deep Sclerectomy Surgery In Saudi Patients With Uncontrolled Open Angle Glaucoma, Saleh A. Al-Obeidan, Ahmed Mousa, Abid Naseem, Khaled K. Abu-Amero, Essam A. Osman

Saudi Medical Journal

OBJECTIVE: To investigate the efficacy and safety of deep sclerectomy (DS) in Saudi patients with primary and secondary open-angle glaucoma (OAG). METHODS: In this retrospective cohort study, a total of 194 eyes of 152 patients with OAG were consecutively enrolled to undergo DS with Mitomycin-C (MMC) at King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia between January 2002 and September 2010. Age at surgery, gender, type of glaucoma, operated eye, previous ocular surgery, type of implant, pre and final visit visual acuities, intraocular pressure (IOP), number of anti-glaucoma medications, optic nerve cup/disc ratio, and complications were recorded. RESULTS: Cases …


Assessment For “Digital First Language” Speakers: Online Video Assessment And Feedback In Higher Education, Will Turner, John West Jan 2013

Assessment For “Digital First Language” Speakers: Online Video Assessment And Feedback In Higher Education, Will Turner, John West

Research outputs 2013

While feedback has been highlighted as the most powerful influence on student achievement, Weaver (2006) noted that up to 40% of tertiary students lack confidence in their feedback and many students express dissatisfaction with this aspect of their student experience (Rodway-Dyer, Dunne, & Newcombe, 2009). Chasms remain between academic feedback and student feed forward outputs, as research suggests that feedback is undervalued by “unresponsive” tertiary students due to misunderstanding, inconsistencies and lack of clarity, and that feedback is not as effective as staff imagine. This paper explores student and staff perceptions of a video feedback model for tertiary institutions. Each …


Inge Revsbech Wins The Journal Of Experimental Biology’S Outstanding Paper Prize 2013, Nicola Stead, Inge G. Revsbech, Hideaki Moriyama, Jay F. Storz, Angela Fago Jan 2013

Inge Revsbech Wins The Journal Of Experimental Biology’S Outstanding Paper Prize 2013, Nicola Stead, Inge G. Revsbech, Hideaki Moriyama, Jay F. Storz, Angela Fago

School of Biological Sciences: Faculty Publications

The Editors of The Journal of Experimental Biology are pleased to announce that Inge Revsbech from Aarhus University, Denmark, is the winner of this year’s JEB Outstanding paper prize. The prize is awarded in memory of Bob Boutillier (JEB Editor-in-Chief 1994–2003) to a junior author who has made the most significant contribution to an outstanding paper. ‘The prize aims to promote and reward the hard work that individual young scientists have put into solving different riddles of any particular species using ingenuity, perseverance and sound technology and methodology’, explains Hans Hoppeler, Editor-In-Chief.

Revsbech was the first author on the paper …


Effects Of Nitrogen Availability On The Fate Of Litter-Carbon And Soil Organic Matter Decomposition, Amy Kochsiek, Johannes Knops Jan 2013

Effects Of Nitrogen Availability On The Fate Of Litter-Carbon And Soil Organic Matter Decomposition, Amy Kochsiek, Johannes Knops

School of Biological Sciences: Faculty Publications

Aims: To determine whether addition of inorganic nitrogen (N) directly to maize litter (stalk and leaf) with differing tissue quality impacts litter and soil organic matter (SOM) decomposition. We tested whether N addition leads to 1) faster litter decomposition, 2) less SOM-C decomposition and 3) increased incorporation of organic-C into soil-C fractions thereby increasing C sequestration potential in maize-based systems.

Methodology: We investigated decomposition of two types of maize litter (stalk and leaf) with differing tissue quality both in the field and in a laboratory incubation experiment. In the field, litter was placed on the soil surface and at …


Bile-Acid-Mediated Decrease In Endoplasmic Reticulum Stress: A Potential Contributor To The Metabolic Benefits Of Ileal Interposition Surgery In Ucd-T2dm Rats, Bethany P. Cummings, Ahmed Bettaieb, James L. Graham, Jaehyoung Kim, Fangrui Ma, Noreene Shibata, Kimber L. Stanhope, Cecilia Giulivi, Frederik Hansen, Jacob Jelsing, Niels Vrang, Mark Kowala, Michael L. Chouinard, Fawaz G. Haj, Peter J. Havel Jan 2013

Bile-Acid-Mediated Decrease In Endoplasmic Reticulum Stress: A Potential Contributor To The Metabolic Benefits Of Ileal Interposition Surgery In Ucd-T2dm Rats, Bethany P. Cummings, Ahmed Bettaieb, James L. Graham, Jaehyoung Kim, Fangrui Ma, Noreene Shibata, Kimber L. Stanhope, Cecilia Giulivi, Frederik Hansen, Jacob Jelsing, Niels Vrang, Mark Kowala, Michael L. Chouinard, Fawaz G. Haj, Peter J. Havel

Nebraska Center for Biotechnology: Faculty and Staff Publications

Post-operative increases in circulating bile acids have been suggested to contribute to the metabolic benefits of bariatric surgery; however, their mechanistic contributions remain undefined. We have previously reported that ileal interposition (IT) surgery delays the onset of type 2 diabetes in UCD-T2DM rats and increases circulating bile acids, independently of effects on energy intake or body weight. Therefore, we investigated potential mechanisms by which post-operative increases in circulating bile acids improve glucose homeostasis after IT surgery. IT, sham or no surgery was performed on 2-month-old weight-matched male UCD-T2DM rats. Animals underwent an oral fat tolerance test (OFTT) and serial oral …


Plant Mitochondrial Genome Evolution Can Be Explained By Dna Repair Mechanisms, Alan C. Christensen Jan 2013

Plant Mitochondrial Genome Evolution Can Be Explained By Dna Repair Mechanisms, Alan C. Christensen

School of Biological Sciences: Faculty Publications

Plant mitochondrial genomes are notorious for their large and variable size, nonconserved open reading frames of unknown function, and high rates of rearrangement. Paradoxically, the mutation rates are very low. However, mutation rates can only be measured in sequences that can be aligned—a very small part of plant mitochondrial genomes. Comparison of the complete mitochondrial genome sequences of two ecotypes of Arabidopsis thaliana allows the alignment of noncoding as well as coding DNA and estimation of the mutation rates in both. A recent chimeric duplication is also analyzed. A hypothesis is proposed that the mechanisms of plant mitochondrial DNA repair …


Nitrogen Uptake Strategies Of Edaphically Specialized Bornean Tree Species, Sabrina E. Russo, Amy Kochsiek, Jocelyn Olney, Lauren Thompson, Amy E. Miller, Sylvester Tan Jan 2013

Nitrogen Uptake Strategies Of Edaphically Specialized Bornean Tree Species, Sabrina E. Russo, Amy Kochsiek, Jocelyn Olney, Lauren Thompson, Amy E. Miller, Sylvester Tan

School of Biological Sciences: Faculty Publications

The association of tree species with particular soil types contributes to high b diversity in forests, but the mechanisms producing such distributions are still debated. Soil nitrogen (N) often limits growth and occurs in differentially available chemical forms. In a Bornean forest where tree species composition changes dramatically along a soil gradient varying in supplies of different N-forms, we investigated whether tree species’ N-uptake and soil specialization strategies covaried. We analyzed foliar 15N natural abundance for a total of 216 tree species on clay or sandy loam (the soils at the gradient’s extremes) and conducted a 15N-tracer experiment …


Paleoparasitology: The Origin Of Human Parasites; Paleoparasitologia: A Origem Dos Parasitas Humanos, Adauto Araújo, Karl Reinhard, Luis Fernando Ferreira, Elisa Pucu, Pedro Paulo Chieffi Jan 2013

Paleoparasitology: The Origin Of Human Parasites; Paleoparasitologia: A Origem Dos Parasitas Humanos, Adauto Araújo, Karl Reinhard, Luis Fernando Ferreira, Elisa Pucu, Pedro Paulo Chieffi

Karl Reinhard Publications

Parasitism is composed by three subsystems: the parasite, the host, and the environment. There are no organisms that cannot be parasitized. The relationship between a parasite and its host species most of the time do not result in damage or disease to the host. However, in a parasitic disease the presence of a given parasite is always necessary, at least in a given moment of the infection. Some parasite species that infect humans were inherited from pre-hominids, and were shared with other phylogenetically close host species, but other parasite species were acquired from the environment as humans evolved. Human migration …


Climatic Niche, Ecological Genetics, And Impact Of Climate Change On Eastern White Pine (Pinus Strobus L.): Guidelines For Land Managers, Dennis G. Joyce, Gerald E. Rehfeldt Jan 2013

Climatic Niche, Ecological Genetics, And Impact Of Climate Change On Eastern White Pine (Pinus Strobus L.): Guidelines For Land Managers, Dennis G. Joyce, Gerald E. Rehfeldt

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Approximately, 123,500 forest inventory and ecological ground plots representing eastern North America were used to predict the contemporary distribution of eastern white pine (Pinus strobus L.) from climate. The random forests classification tree procedures produced an 8-variable algorithm that had an 8% overall error rate. Erroneous predictions of presence, or errors of commission, were 13%, while falsely predicting absence, or errors of omission were 1%. Climate-based multiple regression models were developed to describe patterns of genetic variation among 112 populations representing the range of P. strobus in Ontario, Canada east of Lake Superior. Degree days >5°C was the best …


Carbon Storage And Sequestration By Trees In Urban And Community Areas Of The United States, David J. Nowak, Eric J. Greenfield, Robert E. Hoehn, Elizabeth Lapoint Jan 2013

Carbon Storage And Sequestration By Trees In Urban And Community Areas Of The United States, David J. Nowak, Eric J. Greenfield, Robert E. Hoehn, Elizabeth Lapoint

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Carbon storage and sequestration by urban trees in the United States was quantified to assess the magnitude and role of urban forests in relation to climate change. Urban tree field data from 28 cities and 6 states were used to determine the average carbon density per unit of tree cover. These data were applied to statewide urban tree cover measurements to determine total urban forest carbon storage and annual sequestration by state and nationally. Urban whole tree carbon storage densities average 7.69 kg C m‒2 of tree cover and sequestration densities average 0.28 kg C m‒2 of tree …


Evaluating Population Connectivity For Species Of Conservation Concern In The American Great Plains, Samuel A. Cushman, Erin L. Landguth, Curtis H. Flather Jan 2013

Evaluating Population Connectivity For Species Of Conservation Concern In The American Great Plains, Samuel A. Cushman, Erin L. Landguth, Curtis H. Flather

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Habitat loss and fragmentation are widely recognized as among the most important threats to global biodiversity. New analytical approaches are providing an improved ability to predict the effects of landscape change on population connectivity at vast spatial extents. This paper presents an analysis of population connectivity for three species of conservation concern [swift fox (Vulpes velox); lesser prairie-chicken (Tympanuchus pallidicinctus); massasuaga (Sistrurus catenatus)] across the American Great Plains region. We used factorial least-cost path and resistant kernel analyses to predict effects of landscape conditions on corridor network connectivity. Our predictions of population connectivity provide …


Small Geographic Range But Not Panmictic: How Forests Structure The Endangered Point Arena Mountain Beaver (Aplodontia Rufa Nigra), William J. Zielinski, Fredrick V. Schlexer, Sean A. Parks, Kristine L. Pilgrim, Michael K. Schwartz Jan 2013

Small Geographic Range But Not Panmictic: How Forests Structure The Endangered Point Arena Mountain Beaver (Aplodontia Rufa Nigra), William J. Zielinski, Fredrick V. Schlexer, Sean A. Parks, Kristine L. Pilgrim, Michael K. Schwartz

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The landscape genetics framework is typically applied to broad regions that occupy only small portions of a species’ range. Rarely is the entire range of a taxon the subject of study. We examined the landscape genetic structure of the endangered Point Arena mountain beaver (Aplodontia rufa nigra), whose isolated geographic range is found in a restricted (85 km2) but heterogenous region in California. Based on its diminutive range we may predict widespread gene flow and a relatively weak role for landscape variation in defining genetic structure. We used skin, bone, tissue and noninvasively collected hair samples …


Stand- And Landscape-Scale Selection Of Large Trees By Fishers In The Rocky Mountains Of Montana And Idaho, Michael K. Schwartz, Nicholas J. Decesare, Benjamin S. Jimenez, Jeffrey P. Copeland, Wayne E. Melquist Jan 2013

Stand- And Landscape-Scale Selection Of Large Trees By Fishers In The Rocky Mountains Of Montana And Idaho, Michael K. Schwartz, Nicholas J. Decesare, Benjamin S. Jimenez, Jeffrey P. Copeland, Wayne E. Melquist

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The fisher (Pekania pennanti; formerly known as Martes pennanti) is a North American endemic mustelid with a geographic distribution that spans much of the boreal forests of North America. In the Northern Rocky Mountain (NRM) fishers have been the focus of Endangered Species Act (ESA) listing decisions. Habitat studies of West Coast fishers in California have consistently identified late-successional forests as important, providing direct implications for forest management and fisher conservation. In the NRM range very little is known about the habitat selection patterns of fishers relative to forest age and species composition, yet ESA petitioners have repeatedly listed habitat …


The Influence Of Vertical And Horizontal Habitat Structure On Nationwide Patterns Of Avian Biodiversity, Patrick D. Culbert, Volker C. Radeloff, Curtis H. Flather, Josef M. Kellndorfer, Chadwick D. Rittenhouse, Anna M. Pidgeon Jan 2013

The Influence Of Vertical And Horizontal Habitat Structure On Nationwide Patterns Of Avian Biodiversity, Patrick D. Culbert, Volker C. Radeloff, Curtis H. Flather, Josef M. Kellndorfer, Chadwick D. Rittenhouse, Anna M. Pidgeon

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

With limited resources for habitat conservation, the accurate identification of high-value avian habitat is crucial. Habitat structure affects avian biodiversity but is difficult to quantify over broad extents. Our goal was to identify which measures of vertical and horizontal habitat structure are most strongly related to patterns of avian biodiversity across the conterminous United States and to determine whether new measures of vertical structure are complementary to existing, primarily horizontal, measures. For 2,546 North American Breeding Bird Survey routes across the conterminous United States, we calculated canopy height and biomass from the National Biomass and Carbon Dataset (NBCD) as measures …


Keeping It Wild: Mapping Wilderness Character In The United States, Steve Carver, James Tricker, Peter Landres Jan 2013

Keeping It Wild: Mapping Wilderness Character In The United States, Steve Carver, James Tricker, Peter Landres

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

A GIS-based approach is developed to identify the state of wilderness character in US wilderness areas using Death Valley National Park (DEVA) as a case study. A set of indicators and measures are identified by DEVA staff and used as the basis for developing a flexible and broadly applicable framework to map wilderness character using data inputs selected by park staff. Spatial data and GIS methods are used to map the condition of four qualities of wilderness character: natural, untrammelled, undeveloped, and solitude or primitive and unconfined recreation. These four qualities are derived from the US 1964 Wilderness Act and …


Effects Of Environmental Stimulation On Infant Vocalizations And Orofacial Dynamics At The Onset Of Canonical Babbling, Meredith Poore Harold, Steven M. Barlow Jan 2013

Effects Of Environmental Stimulation On Infant Vocalizations And Orofacial Dynamics At The Onset Of Canonical Babbling, Meredith Poore Harold, Steven M. Barlow

Department of Special Education and Communication Disorders: Faculty Publications

The vocalizations and jaw kinematics of 30 infants aged 6–8 months were recorded using a Motion Analysis System and audiovisual technologies. This study represents the first attempt to determine the effect of play environment on infants’ rate of vocalization and jaw movement. Four play conditions were compared: watching videos, social contingent reinforcement and vocal modeling with an adult, playing alone with small toys, and playing alone with large toys. The fewest vocalizations and spontaneous movement were observed when infants were watching videos or interacting with an adult. Infants vocalized most when playing with large toys. The small toys, which naturally …


An Analytical Framework For Quantifying And Testing Patterns Of Temporal Dynamics In Social Networks, Elizabeth A. Hobson, Michael L. Avery, Timothy F. Wright Jan 2013

An Analytical Framework For Quantifying And Testing Patterns Of Temporal Dynamics In Social Networks, Elizabeth A. Hobson, Michael L. Avery, Timothy F. Wright

United States Department of Agriculture Wildlife Services: Staff Publications

Change is fundamental to all social systems. Temporal dynamics are critical in understanding how relationships form and change over time but rarely are studied explicitly in animal groups. Social network approaches are useful in describing association patterns and provide promising tools for investigating the dynamics of change in social structure but have rarely been used to quantify how animal associations change over time. In this study, we describe and test a framework for temporal analysis of social structure. We propose an analytical framework of methods that integrates across social scales and comparatively analyses change in social structure across multiple types …


Comparison Of Two Models For Estimating Mortality From Baitings With Compound Drc-1339 Concentrate Avicide, Jeffrey H. Homan, Randal S. Stahl, George M. Linz Jan 2013

Comparison Of Two Models For Estimating Mortality From Baitings With Compound Drc-1339 Concentrate Avicide, Jeffrey H. Homan, Randal S. Stahl, George M. Linz

United States Department of Agriculture Wildlife Services: Staff Publications

In the U.S., DRC-1339 baitings for blackbirds (Icteridae) are generally done under the pesticide label, Compound DRC-1339 Concentrate e Staging Areas. DRC-1339 is a slow-acting avicide and gives the birds enough time to leave the baiting sites. Carcass searches and other forms of onsite counts are ineffective. Instead, linear models (LM) are used. The LM are based on esophageal analyses of several blackbird species collected while feeding at staging area bait sites. Biases and large variances can occur with this type of sampling. As an alternative to the LM, we developed a semi-mechanistic model (SM) that combined mechanistic modeling of …


The Use Of Diazacon™ To Limit Fertility By Reducing Serum Cholesterol In Female Grey Squirrels, Sciurus Carolinensis, Brenda A. Mayle, Mark Ferryman, Andrew Peace, Christi A. Yoder, Lowell A. Miller, David Cowan Jan 2013

The Use Of Diazacon™ To Limit Fertility By Reducing Serum Cholesterol In Female Grey Squirrels, Sciurus Carolinensis, Brenda A. Mayle, Mark Ferryman, Andrew Peace, Christi A. Yoder, Lowell A. Miller, David Cowan

United States Department of Agriculture Wildlife Services: Staff Publications

BACKGROUND: The grey squirrel, Sciurus carolinensis Gmelin, is an invasive alien species introduced into Great Britain in the late nineteenth century and into Northern Italy during the early twentieth century. Grey squirrels have displaced the native European red squirrel, Sciurus vulgaris L., throughout much of Great Britain and have a significant impact on trees and woodlands through bark-stripping activity. In Britain, eradication is no longer an option at a regional scale, but fertility control offers a non-lethal approach to reducing negative impacts. The cholesterol mimic DiazaCon™ has been successfully used to inhibit reproduction in some species. These studies aimed to …


Laboratory Efficacy Of An Anthraquinone-Based Repellent For Reducing Bird Damage To Ripening Corn, James C. Carlson, Shelagh K. Tupper, Scott J. Werner, Susan E. Pettit, Michele M. Santer, George M. Linz Jan 2013

Laboratory Efficacy Of An Anthraquinone-Based Repellent For Reducing Bird Damage To Ripening Corn, James C. Carlson, Shelagh K. Tupper, Scott J. Werner, Susan E. Pettit, Michele M. Santer, George M. Linz

United States Department of Agriculture Wildlife Services: Staff Publications

Wildlife repellents provide a non-lethal alternative for managing agricultural impacts associated with wildlife depredation. To evaluate a potential bird repellent for ripening corn, we conducted a feeding experiment at the United States Department of Agriculture, National Wildlife Research Center with 66 red-winged blackbirds (Agelaius phoeniceus). Using a two-choice experimental design we tested the efficacy of Avipel repellent (a.i. 50% 9,10-anthraquinone) on ripening sweet corn. Red-winged blackbirds consumed an average of 8.6% ± 0.9% of kernels from untreated ears and 5.3% ± 1.1% from ears treated with anthraquinone. The interaction between anthraquinone concentration and corn treatment suggests a positive …


Experimental Infection Of White-Tailed Deer (Odocoileus Virginianus) With Northern European Bluetongue Virus Serotype 8, Barbara S. Drolet, Lindsey M. Reister, Tara D. Rigg, Pauline Nol, Brendan K. Podell, James O. Mecham, Kurt C. Vercauteren, Piet A. Van Rijn, William C. Wilson, Richard Bowen Jan 2013

Experimental Infection Of White-Tailed Deer (Odocoileus Virginianus) With Northern European Bluetongue Virus Serotype 8, Barbara S. Drolet, Lindsey M. Reister, Tara D. Rigg, Pauline Nol, Brendan K. Podell, James O. Mecham, Kurt C. Vercauteren, Piet A. Van Rijn, William C. Wilson, Richard Bowen

United States Department of Agriculture Wildlife Services: Staff Publications

Bluetongue (BT) is an insect-transmitted, economically important disease of domestic and wild ruminants. Although only five of the 26 reported bluetongue virus (BTV) serotypes are considered endemic to the USA, 10 exotic serotypes have been isolated primarily in the southeastern region of the country since 1999. For an exotic BTV serotype to become endemic there must be susceptible animal species and competent vectors. In the USA, sheep and white-tailed deer (WTD) are the primary sentinel livestock and wildlife species, respectively. In 2006, BTV-8 was introduced into Northern Europe and subsequently overwintered, causing unprecedented livestock disease and mortality during the 2006– …


Use Of Stormwater Impoundments Near Airports By Birds Recognizedas Hazardous To Aviation Safety, Brian J. Fox, Wesley B. Holland, Frank L. Boyd, Bradley F. Blackwell, James B. Armstrong Jan 2013

Use Of Stormwater Impoundments Near Airports By Birds Recognizedas Hazardous To Aviation Safety, Brian J. Fox, Wesley B. Holland, Frank L. Boyd, Bradley F. Blackwell, James B. Armstrong

United States Department of Agriculture Wildlife Services: Staff Publications

Design of privately-owned stormwater impoundments within or near airport siting criteria has received little attention with regard to potential hazards posed to aviation safety. In particular, minimizing use of these impoundments by bird species recognized as hazardous to aviation poses an important challenge. Emergent vegetation, shoreline irregularity, and proximity of other water resources are linked to avian richness and diversity within wetlands, as well as bird use of stormwater impoundments on airports. We predicted also that impoundments with bank slope >20% and those functioning as detention facilities, where water is periodically drawn down, would negatively influence use by birds; and …


The Safety Of Onrab® In Select Non-Target Wildlife, Tricia L. Fry, Kaci K. Vandalen, Colleen Duncan, Kurt C. Vercauteren Jan 2013

The Safety Of Onrab® In Select Non-Target Wildlife, Tricia L. Fry, Kaci K. Vandalen, Colleen Duncan, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

ONRAB® is a recombinant human adenovirus type 5 (HAd5) with the rabies glycoprotein gene incorporated into its genome. ONRAB® has been used in Canada as an oral rabies vaccine in target wildlife species such as: red fox (Vulpes vulpes), raccoon (Procyon lotor), and striped skunk (Mepthis mephitis). We evaluated the safety of ONRAB® in non-target wildlife species likely to contact the vaccine baits during oral rabies vaccine campaigns in the United States. We investigated the effects of oral inoculation of hightiter ONRAB®, approximately ten times the dose given to target …


Use Of Dairies By Postreproductive Flocks Of European Starlings, H. Jeffrey Homan, Jeffrey T. Lejeune, D. L. Pearl, T. W. Seamans, Thomas W. Seamans, A.A. Slowik, Mark R. Morasch, George M. Linz Jan 2013

Use Of Dairies By Postreproductive Flocks Of European Starlings, H. Jeffrey Homan, Jeffrey T. Lejeune, D. L. Pearl, T. W. Seamans, Thomas W. Seamans, A.A. Slowik, Mark R. Morasch, George M. Linz

United States Department of Agriculture Wildlife Services: Staff Publications

Knowledge of the behavior and movement patterns of European starlings (Sturnus vulgaris L.) is important to wildlife managers that seek to resolve conflicts at livestock facilities. We captured and radio tagged 10 starlings at each of 5 dairies in northeastern Ohio. From September 19 to October 31, 2007, we obtained sufficient data from 40 birds to study their behavior and movements. The birds visited the dairies where they were initially captured (home sites) on 85% of the days, spending 58% of each day at the dairies. Onsite arrival and departure times were 2.5 h after sunrise and 3.1 h …


Comparisons Between Blackbird Damage To Corn And Sunflower In North Dakota, Megan E. Klosterman, George M. Linz, Anthony Slowik, H. Jeffrey Homan Jan 2013

Comparisons Between Blackbird Damage To Corn And Sunflower In North Dakota, Megan E. Klosterman, George M. Linz, Anthony Slowik, H. Jeffrey Homan

United States Department of Agriculture Wildlife Services: Staff Publications

For sunflower producers in North Dakota, blackbird (Icterinae) damage is a chronic problem costing millions of dollars annually. Sunflower damage surveys were last completed in the state in 1979-1980. Since the last surveys, corn plantings have increased 6-fold to 1500 X 103 ha, whereas sunflower hectarage has declined by >75% to 310 × 103 ha. Blackbirds forage on both crops, and this rapid change in North Dakota’s agricultural landscape was a sound inducement for reassessing crop damage. Field surveys are an important step in damage methods development because they are used for measuring efficacy, as well as assessing …