Digital Commons Network^™

Hunter-Gatherers In Southeast Asia: From Prehistory To The Present, Charles Higham

Human Biology

Anatomically modern hunter-gatherers expanded from Africa into Southeast Asia at least 50,000 years ago, where they probably encountered and interacted with populations of Homo erectus and Homo floresiensis and the recently discovered Denisovans. Simulation studies suggest that these hunter-gatherers may well have followed a coastal route that ultimately led to the settlement of Sahul, while archaeology confirms that they also crossed significant seas and explored well into the interior. They also adapted to marked environmental changes that alternated between relatively cool and dry conditions and warmer, wetter interludes. During the former, the sea fell by up to 120 m below …

Bosom Friends And The Sapphic Breasts Of Belinda, Ula E. Klein

ABO: Interactive Journal for Women in the Arts, 1640–1830

This article examines Maria Edgeworth’s 1801 novel Belinda in order to argue that the breast at the center of Lady Delacour’s narrative signifies not maternal failure but Sapphic feelings and connections. While previous studies of the novel have discussed the wounded breast of Lady Delacour as a punishment for her transgressions or as an emblem of her patriarchal oppression, this article claims that the wounded breast is both a sign of and a means to female same-sex desire and relationships. This article contrasts the wounded, festering breast with the tableau that ends the novel. The tableau, a constructed vision of …

The Elephants Of Gash-Barka, Eritrea: Nuclear And Mitochondrial Genetic Patterns, Adam L. Brandt, Yohannes Hagos, Yohannes Yacob, Victor David, Nicholas J. Georgiadis, Jeheskel Shoshani, Alfred L. Roca

Faculty Creative and Scholarly Works

Eritrea has one of the northernmost populations of African elephants. Only about 100 elephants persist in the Gash-Barka administrative zone. Elephants in Eritrea have become completely isolated, with no gene flow from other elephant populations. The conservation of Eritrean elephants would benefit from an understanding of their genetic affinities to elephants elsewhere on the continent and the degree to which genetic variation persists in the population. Using dung samples from Eritrean elephants, we examined 18 species-diagnostic single nucleotide polymorphisms in 3 nuclear genes, sequences of mitochondrial HVR1 and ND5, and genotyped 11 microsatellite loci. The sampled Eritrean elephants carried …

Characterization Of Plp, A Phosphatidylcholine-Specific Phospholipase And Hemolysin Of Vibrio Anguillarum, Ling Li, Xiangyu Mou, David R. Nelson

Cell and Molecular Biology Faculty Publications

Background: Vibrio anguillarum is the causative agent of vibriosis in fish. Several extracellular proteins secreted by V. anguillarum have been shown to contribute to virulence. While two hemolysin gene clusters, vah1-plp and rtxACHBDE, have been previously identified and described, the activities of the protein encoded by the plp gene were not known. Here we describe the biochemical activities of the plp-encoded protein and its role in pathogenesis.

Results: The plp gene, one of the components in vah1 cluster, encodes a 416-amino-acid protein (Plp), which has homology to lipolytic enzymes containing the catalytic site amino acid signature SGNH. Hemolytic …

Stress And Reproductive Hormones In Grizzly Bears Reflect Nutritional Benefits And Social Consequences Of A Salmon Foraging Niche, Heather M. Bryan, Chris T. Darimont, Paul C. Paquet, Katherine E. Wynne-Edwards, Judit E. G. Smits

Physiology Collection

Physiological indicators of social and nutritional stress can provide insight into the responses of species to changes in food availability. In coastal British Columbia, Canada, grizzly bears evolved with spawning salmon as an abundant but spatially and temporally constrained food source. Recent and dramatic declines in salmon might have negative consequences on bear health and ultimately fitness. To examine broadly the chronic endocrine effects of a salmon niche, we compared cortisol, progesterone, and testosterone levels in hair from salmon-eating bears from coastal BC (n = 75) with the levels in a reference population from interior BC lacking access to salmon …

The Anchor, Volume 127.12: November 27, 2013, Hope College

The Anchor: 2013

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Learning To Engage: How Positive Attitudes About The News, Media Literacy, And Video Production Contribute To Adolescent Civic Engagement, Renee Hobbs, Katie Donnelly, Jonathan Friesem, Mary Moen

Communication Studies Faculty Publications

Many students enroll in video production courses in high school as part of a vocational, career, or technical program. While there has been an explosion of scholarly work in digital literacy in informal settings, less is known about how digital and media literacy competencies are developed through school-based video production courses. This study explores the relationship between civic engagement and the various multimedia instructional practices used in a high school video production course with a single-school convenience sample and an ethnically diverse population of students. Findings reveal that the best predictors of the intent to participate in civic engagement are …

The Guardian, November 27, 2013, Wright State University Student Body

The Guardian Student Newspaper

Twelve page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

Digital Inclusion, Learning, And Access At The Public Library, Melissa Morrone, Shanelle Witt

Urban Library Journal

New York City is not an easy place to live. Brooklynites who are just learning about the Internet in 2013—20 years after the development of the World Wide Web—likely have more challenges than simply needing someone to show them how to open up the computer's browser. Brooklyn Public Library has been engaged in a digital inclusion project that brings together issues of ability, access, and learning styles. By giving our patrons skills and confidence to navigate technology both online and off, we are laying the groundwork for them to have a voice in the city.

Personal And Household Hygiene, Environmental Contamination, And Health In Undergraduate Residence Halls In New York City, 2011, Benjamin A. Miko, Bevin Cohen, Katharine Haxall, Laurie Conway, Nicole Kelly, Dianne Stare, Christina Tropiano, Allan Gilman, Samuel L. Seward, Elaine Larson

Publications and Research

Background While several studies have documented the importance of hand washing in the university setting, the added role of environmental hygiene remains poorly understood. The purpose of this study was to characterize the personal and environmental hygiene habits of college students, define the determinants of hygiene in this population, and assess the relationship between reported hygiene behaviors, environmental contamination, and health status. Methods 501 undergraduate students completed a previously validated survey assessing baseline demographics, hygiene habits, determinants of hygiene, and health status. Sixty survey respondents had microbiological samples taken from eight standardized surfaces in their dormitory environment. Bacterial contamination was …

Design, Synthesis And Cytotoxic Evaluation Of O-Carboxamido Stilbene Analogues, Mohamad Nurul Azmi, Mohd Fadzli Md Din, Chin Hui Kee, Munirah Suhaimi, Kheng Ping Ang, Kartini Ahmad, Mohd Azlan Nafiah, Noel Francis Thomas, Kok Hoong Leong, Khalijah Awang

Research Publications (2011 to 2015)

Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 µM), colon cancer HT-29 (IC50 = 7.51 µM) and breast cancer MCF-7 (IC50 = 21.24 µM), respectively, which …

A Cell Permeable Peptide Targeting The Intracellular Loop 2 Of Endothelin B Receptor Reduces Pulmonary Hypertension In A Hypoxic Rat Model, Daniel S. Green, Chamila Rupasinghe, Rod Warburton, Jamie L. Wilson, Christine O. Sallum, Linda Taylor, Achan Yatawara, Dale Mierke, Peter Polgar, Nicholas Hill

Dartmouth Scholarship

Cell permeable peptides (CPP) aid cellular uptake of targeted cargo across the hydrophobic plasma membrane. CPP-mediated cargo delivery of receptor signaling motifs provides an opportunity to regulate specific receptor initiated signaling cascades. Both endothelin-1 receptors, ETA and ETB, have been targets of antagonist therapies for individuals with pulmonary arterial hypertension (PAH). These therapies have had success but have been accompanied by adverse reactions. Also, unlike the CPP which target specific signaling cascades, the antagonists target the entire function of the receptor. Using the CPP strategy of biased antagonism of the ETB receptor’s intracellular loop 2 (ICB2), we demonstrate blunting of …

Students Teaching Students: A Method For Collaborative Learning, Jean Halley, Courtney Heiserman, Victoria Felix, Amy Eshleman

Publications and Research

The Student Small Group Presentation (SSGP) model, a student-centered approach, is introduced and applied to learning communities. Similar to the jigsaw classroom, small groups of students in learning communities are responsible for teaching material to their peers. Unlike other jigsaw techniques, presentation groups in the SSGP teach an entire lesson based on collaborative work conducted outside of class. Presenters are responsible for thorough analysis of course material as they lead a discussion among a small group of peers. Students meet with the same small group throughout the semester, creating a feeling of intimate community within the larger learning community. By …

Dispatches From The Trenches Of America's Great Gun Trust Wars, Lee-Ford Tritt

NULR Online

No abstract provided.

Local Delivery Of Growth Stimulators For Diabetic Foot Ulcers: A Preliminary In Vitro Study, Jennifer Leigh Baldwin

Electronic Theses and Dissertations Archive

Diabetic foot ulcers affect approximately 15% of the almost 20.8 million people with diabetes mellitus, costing approximately $10.9 billion annually. Diabetic foot ulcers are particularly difficult to treat due to neuropathy and healing deficiencies. The objective of this in vitro study was to measure the effects of adenosine and glutathione on fibroblast proliferation and collagen synthesis while improving the availability of these compounds at the wound site with the use of a chitosan sponge as a localized delivery vehicle. This study found adenosine (500µM) and glutathione (250µM) enhanced fibroblast proliferation by approximately 100% and 46% increase as compared to untreated …

Contrast Adaptation In The Lateral Eye Of Limulus Polyphemus, Tchoudomira Valtcheva

USF Tampa Graduate Theses and Dissertations

Luminance and contrast adaptation are neuronal mechanisms that the retina applies for continuous adjustment to light sensitivity though a collection of cellular and synaptic mechanisms distributed across the retinal network, thus accommodating the wide input range of the visual system within the constricted output range of retinal ganglion cells. Luminance mean adaptation has been demonstrated in the output neurons of the invertebrate eye (eccentric cells), and the aim of the study was to investigate whether the homology in visual processing extends to luminance variance (contrast) adaptation as well. The spike trains of individual eccentric cells were recorded from live horseshoe …

Skeletal Muscle Contraction Simulation: A Comparison In Modeling, Jonathan M. Ford

USF Tampa Graduate Theses and Dissertations

Computer generated three-dimensional (3-D) models are being used at increasing rates in the fields of entertainment, education, research, and engineering. One of the aspects of interest includes the behavior and function of the musculoskeletal system. One such tool used by engineers is the finite element method (FEM) to simulate the physics behind muscle mechanics. There are several ways to represent 3-D muscle geometry, namely a bulk, a central line of action and a spline model. The purpose of this study is to exmine how these three representations affect the overall outcome of muscle movement. This is examined in a series …

The State Of Israel's Constitution; A Comparison Of Civilized Nations, Mark Goldfeder

Pace International Law Review

The art of constitution-making is never one-dimensional. In regard to the United States' model, it has recently been argued that “[d]espite the enormous literature on the critical period, including the foreign affairs imperatives behind the movement for reform, it is not fully understood that the animus behind the reform effort that culminated in the new Constitution was a desire to ensure that the United States would be in a position to meet its international commitments and thereby earn international recognition.” While there are obvious differences, and while this concept is perhaps of even greater importance and more poignantly felt for …

Ccr3 Inhibition For Ocular Angiogenesis And Macular Degeneration, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Patents

Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.

La Yeguada Volcanic Vomplex In The Republic Of Panama: An Assessment Of The Geologic Hazards Using 40ar/39ar Geochronology, Karinne L. Knutsen, William I. Rose, Brian Jicha

Department of Geological and Mining Engineering and Sciences Publications

La Yeguada volcanic complex is one of three Quaternary volcanic centers in Panama. To assess potential geologic hazards, new samples were analyzed using argon analysis (⁴⁰Ar/³⁹Ar), and obtained the following: the most recent eruption occurred approximately 32,000 years ago at the Media Luna cinder cone; the youngest dated eruption from the main dome complex occurred 357 ± 19 ka, producing the Castillo dome unit; Cerro Picacho, a separate dacite dome 1.5 km east of the main complex is 4.47 ± 0.23 Ma; and the El Satro Pyroclastic Flow unit surrounds the northern portion of the volcanic …

Functional And Structural Changes Throughout The Auditory System Following Congenital And Early-Onset Deafness: Implications For Hearing Restoration, Blake E. Butler, Stephen G. Lombar

Brain and Mind Institute Researchers' Publications

The absence of auditory input, particularly during development, causes widespread changes in the structure and function of the auditory system, extending from peripheral structures into auditory cortex. In humans, the consequences of these changes are far-reaching and often include detriments to language acquisition, and associated psychosocial issues.Much of what is currently known about the nature of deafness-related changes to auditory structures comes from studies of congenitally deaf or early-deafened animal models. Fortunately, the mammalian auditory system shows a high degree of preservation among species, allowing for generalization from these models to the human auditory system. This review begins with a …

The New Hampshire, Vol. 103 [104], No. 21 (Nov. 26, 2013), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 103, but it is the 104th volume in the series. This was corrected in pencil.

Habitat Selection And Nesting Ecology Of Snowy Plover In The Great Basin, Kristen Sue Ellis

Theses and Dissertations

Snowy plovers (Charadrius nivosus) are small, ground-nesting shorebirds that are a species of conservation concern throughout North America. Despite increased efforts to understand factors contributing to the decline of snowy plover, little is known about habitat selection and breeding ecology of snowy plover for the large population found in the Great Basin. We tested hypotheses concerning the occupancy and nesting success of snowy plover. First, we identified factors influencing snowy plover nest survival at Great Salt Lake, Utah. We hypothesized that snowy plover would demonstrate differences in nest survival rates across years due to differences in habitat characteristics, predator abundance, …

High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang, Lin Xue, Shurong Hou

Pharmaceutical Sciences Faculty Patents

Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.

The Advocate, November 26, 2013, Minnesota State University Moorhead

The Advocate

No abstract provided.

Post Protein Hydrolysis Removal Of A Potent Ribonuclease Inhibitor And The Enzymatic Capture Of Dna, Matt Ewert

USF Patents

The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample.

Spectral Analysis Of Nonstationary Heart Rate Of Neonates Receiving Therapeutic Hypothermia Treatment, Tareq Al-Shargabi

Theses and Dissertations

We studied Heart Rate Variability (HRV) evolution during therapeutic hypothermia in newborns with hypoxic ischemic encephalopathy (HIE) using spectral analysis. We hypothesized that HRV measures are predictive of neurological outcome in babies with HIE. Non-stationarity in the data causes inaccurate quantification of the spectral power. A modification was proposed to power spectral analysis approach to mitigate the effect of non-stationarity. The modified and the standard approaches were applied to cardiac beat-to-beat intervals of newborns receiving hypothermia treatment. The performance of the approaches in distinguishing the RRi dynamics of two groups of newborns was assessed using area under the receiver operating …

Predeliberation Activity In Prefrontal Cortex And Striatum And The Prediction Of Subsequent Value Judgment, Uri Maoz, Ueli Rutishauser, Soyoun Kim, Xinying Cai, Christof Koch

Psychology Faculty Articles and Research

Rational, value-based decision-making mandates selecting the option with highest subjective expected value after appropriate deliberation. We examined activity in the dorsolateral prefrontal cortex (DLPFC) and striatum of monkeys deciding between smaller, immediate rewards and larger, delayed ones. We previously found neurons that modulated their activity in this task according to the animal's choice, while it deliberated (choice neurons). Here we found neurons whose spiking activities were predictive of the spatial location of the selected target (spatial-bias neurons) or the size of the chosen reward (reward-bias neurons) before the onset of the cue presenting the decision-alternatives, and thus before rational deliberation …

The Role Of Animacy In Russian Morphosyntax, Zhanna A. Glushan

Doctoral Dissertations

This dissertation investigates the effects of animacy in the syntax and morpho-syntax of language. More precisely, I examine cases in which minimal pairs, varying only in the animacy of the subject NP, show different morpho-syntactic behavior. This study suggests that a significant part of the explanation of these effects lies in the syntactic representation of argument structure—that animate and inanimate NPs, under certain conditions, receive different thematic roles, and thus occupy different structural positions at the syntactic level(s) where argument structure is represented. The findings of this project are shown to constitute a part of a broader generalization and find …

Enigmatic Allegory, Sara Virginia Kinsey

Theses and Dissertations

My artwork is autobiographical and shaped by my experiences. Collectively, it serves as a visual journal expressing a range of emotions honoring meaningful people, portraying important places, and commemorating significant events in my life. My art documents the progression from turmoil, despair, and isolation to growth, recovery, and gratitude. I utilize a recurring set of subjective symbols which hold personal significance. These symbols, which include robots, eggs, chairs, shoes, and trash cans, help me create narratives and visual continuity across my body of work. I purposefully omit some information to mask the entirety of the story being told. Typically, these …