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High Resolution X-Ray Diffraction Analysis Of Cb1 Receptor Antagonists As A Means To Explore Binding Affinity, Steven P. Fournet

LSU New Orleans Theses and Dissertations

Abstract

Charge density studies have been conducted on ten CB₁ cannabinoid receptor antagonists via high resolution x-ray crystallography. Bond critical point values and various other properties derived from these studies including the electrostatic potential were analyzed in correlation to the affinity of each compound with the CB₁ receptor. Correlation/anti-correlation was found between several properties and K_i. The data was also interpreted by principal component analysis with three principal components accounting for 85% of the data variation. Data mining was limit due to the low sample count and the requirements set for the inclusion of correlated/anti-correlated variables …

Hostile Attributional Bias In Aggression And Anxiety: The Role Of Perceived Provocateur Motivation, Melissa M. Kunimatsu

LSU New Orleans Theses and Dissertations

Although internalizing and externalizing problems are often considered in isolation from one another, the frequently co-occur in individuals leading to unique behavior profiles. The current study examined the associations between the forms, functions, and subtypes of aggression, anxiety, hostile attributional bias (HAB), and perceived (proactive or reactive) provocateur motivation in a sample of youth (mean age = 13.84 years, 51% male, 37.5% Caucasian). Results indicated that only reactive relational aggression significantly predicted anxiety, while relational and reactive aggression did not. HAB was not significantly associated with either anxiety or any type of aggression. Perceived proactive provocateur motivation was significantly associated …

Knights, Dudes, And Shadow Steeds: Late Victorian Culture And The Early Cycling Clubs Of New Orleans, 1881-1891, Lacar E. Musgrove

LSU New Orleans Theses and Dissertations

In the 1880s, two cycling clubs formed in New Orleans—the New Orleans Bicycle Club in 1881 and the Louisiana Cycling Club in 1887. These clubs were institutions of Victorian middle class culture that, like other athletic clubs, arose from the conditions of urban modernity and Victorian class anxieties. The NOBC, like other American cycling clubs, conformed to Victorian values of order and respectability. The attitudes and activities of the LCC, whose membership was younger, reflected instead a counter-Victorian ethos. This paper examines these two clubs in the context of late Victorian culture in New Orleans as it responded both to …

Wastewater Disinfection In Enclosed Recirculation Systems With Electromagnetic Waves, Luis G. Mosquera

LSU New Orleans Theses and Dissertations

Finding the most cost-effective and environmental friendly way to treat and disinfect wastewater has been raising concerns around the world. Failure in performing disinfection of wastewater before returning it to the environment could have terrible consequences to human health and the ecosystem. The risks associated to continue with current practices have led to the creation of stringent regulations.

In this research the HYDROPATH technology is tested while attaching a HydroFlow 60i unit to a reactor that works as a closed recirculation system. To determine the feasibility of the HydroFlow 60i unit as an alternative method to chlorine, the EPA method …

Am800, James Madison Roe

LSU New Orleans Theses and Dissertations

In this paper, I will detail the film making techniques that my crew and I employed while making AM800, my thesis film at the University of New Orleans. I will detail the creative and technical steps we took, from the earliest stages of idea conceptualization to the final phases of post-production and screening. During my recounting of this process, I will discuss our creative goals, the challenges that we faced while achieving these goals, and the resulting product's effectiveness as a narrative short film. The quality of the final product will be gauged through the results of test screenings …

The Runners Of Shawnee Road, Melissa Remark

LSU New Orleans Theses and Dissertations

No abstract provided.

Last Known Tomorrow, Larry J. Wormington

LSU New Orleans Theses and Dissertations

N/A

Missing Persons, Ho-Kyung Whang

LSU New Orleans Theses and Dissertations

No abstract provided.

Stories From A Golden State, Sara R. Paul

LSU New Orleans Theses and Dissertations

No abstract provided.

Flexibility In Food Extraction Techniques In Urban Free-Ranging Bonnet Macaques, Macaca Radiata, Madhur Mangalam, Mewa Singh

Journal Articles

Non-human primate populations, other than responding appropriately to naturally occurring challenges, also need to cope with anthropogenic factors such as environmental pollution, resource depletion, and habitat destruction. Populations and individuals are likely to show considerable variations in food extraction abilities, with some populations and individuals more efficient than others at exploiting a set of resources. In this study, we examined among urban free-ranging bonnet macaques, Macaca radiata (a) local differences in food extraction abilities, (b) between-individual variation and within-individual consistency in problem-solving success and the underlying problem-solving characteristics, and (c) behavioral patterns associated with higher efficiency in food extraction. When …

Categorization Of Large Corpora Of Malicious Software, Deekshit Kura

LSU New Orleans Theses and Dissertations

Malware is computer software written by someone with mischievous or, more usually, malicious and/or criminal intent and specifically designed to damage data, hosts or networks. The variety of malware is increasing proportionally with the increase in computers and we are not aware of newly emerging malware. Tools are needed to categorize families of malware, so that analysts can compare new malware samples to ones that have been previously analyzed and determine steps to detect and prevent malware infections.

In this thesis, I developed a technique to catalog and characterize the behavior of malware, so that malware families, the level of …

The Effects Of Ecological Context And Individual Characteristics On Stereotyped Displays In Male Anolis Carolinensis, Catherine Policastro

LSU New Orleans Theses and Dissertations

Displays are ubiquitous throughout the animal kingdom. While many have been thoroughly documented, the factors affecting the expression of such displays are still not fully understood. We tested the hypotheses that display production would be affected by ecological context (i.e. the identity of the receiver) and intrinsic qualities of the signaler (i.e. heavyweight and lightweight size class) in the green anole lizard, Anolis carolinensis. Our results supported these predictions and show that a) ecological context, specifically displaying to conspecifics, has the greatest impact on display production; b) size class influenced display rate with heavyweight males displaying more to green …

Llave, Brenda M. Reagan

LSU New Orleans Theses and Dissertations

No abstract provided.

The Effects Of Chronic Simvastatin Treatment On The Expression Of Behavioral Symptoms In A Transgenic Mouse Model Of Huntington’S Disease, Ashley Whitmarsh

LSU New Orleans Theses and Dissertations

Huntington’s disease (HD) is a heritable, neurodegenerative disorder characterized by motor, cognitive, and psychiatric disturbances. An unstable CAG expansion within the gene normally encoding for the Huntingtin protein is responsible. The expanded mutant form of Huntingtin and the putative protein co-factor Rhes interact and cause cell death within the striatum. We hypothesized chronic treatment with simvastatin, a cholesterol lowering drug, would disrupt the biosynthetical pathway which gives both Rhes and its target cells binding sites and render Rhes inactive. Healthy and HD mice were treated with simvastatin or a vehicle. Animals’ motor behavior was assessed with three separate tests over …

Effects Of Prescribed Burns On Grassland Breeding Birds At Mississippi Sandhill Crane National Wildlife Refuge, Elizabeth A. Ruffman

LSU New Orleans Theses and Dissertations

There has been a critical decline in grassland bird populations due to habitat fragmentation and deterioration, and suppression of natural fires. Alteration of the disturbance cycle may lead to changes in vegetation structure and thus habitat suitability for breeding grassland birds. Management practices at the Mississippi Sandhill Crane National Wildlife Refuge, including the use of prescribed fire, are in need of evaluation. My study asked what frequency of prescribed burns is necessary to support breeding grassland birds and whether vegetation structure varies among burn units. In this study, bird abundance and species richness did not differ significantly among burn units …

Statistical And Comparative Phylogeography Of Mexican Freshwater Taxa In Extreme Aquatic Environments, Lyndon M. Coghill

LSU New Orleans Theses and Dissertations

Phylogeography aims to understand the processes that underlie the distribution of genetic variation within and among closely related species. Although the means by which this goal might be achieved differ considerably from those that spawned the field some thirty years ago, the foundation and conceptual breakthroughs made by Avise are nonetheless the same and are as relevant today as they were two decades ago. Namely, patterns of neutral genetic variation among individuals carry the signature of a species’ demographic past, and the spatial and temporal environmental heterogeneity across a species’ geographic range can influence patterns of evolutionary change. Aquatic systems …

A Multi-Gene By Environment Perspective Of Adhd Symptomatology In Young Children, Amber L. Allison

LSU New Orleans Theses and Dissertations

Attention deficit hyperactivity disorder (ADHD) is a heritable disorder, which has detrimental effects on childhood development and is associated with maladaptive functioning in adulthood. Despite this, we are far from an understanding of the etiology and possible trajectories of ADHD, possibly due to investigations focusing on the contribution of single genes. In fact, single genes are likely not influential enough to alter behavior, but the additive effect of many genes may predispose an individual toward certain behaviors. Further, environmental input can activate or suppress genetic expression, thereby leading to vast individual differences in both normative behavior and psychopathological illness, including …

Assessing The Responses Of Adult, Juvenile, And Larval Fish Assemblages To The Closure Of The Mississippi River Gulf Outlet, An Artificial Tidal Pass In Southeastern Louisiana, Rebecca Weatherall Cope

LSU New Orleans Theses and Dissertations

The creation of the Mississippi River Gulf Outlet (MRGO) in 1963 by the U.S. Army Corps of Engineers (USACE) represents one of the most catastrophic, anthropogenic stressors ever to impact the Lake Pontchartrain estuary in southeastern Louisiana, USA. The artificial tidal pass provided a direct route from the Gulf of Mexico to New Orleans. It allowed for high saline waters to enter Lake Pontchartrain, resulting in detrimental changes to the biotic community of the Lake and surrounding wetland areas. In July 2009, the USACE closed the MRGO in hopes of restoring natural ecosystems. This study assesses changes in the adult, …

Pre - Service Teachers’ Perceptions Of Disability As Represented In Children’S Television Programs--Research, Laura S. Clarke, Dusty Columbia Embury, Anna Epperly, Jennifer Christensen

Journal of Excellence in College Teaching and Learning

As colleges and universities prepare pre-service teachers to teach in inclusive classrooms, it is important to understand college students’ schema of diversity. Part of creating an inclusive classroom culture is to understand how children view similarities and differences in others, and how to create a culture of acceptance. One way to create a culture of understanding is to use media representations and popular children’s television shows as a springboard for conversation and acceptance, but before pre-service teachers can use media, they have to first understand the characteristics and qualification criteria for students with disabilities, and also how the community at …

The Origins Of Trade Silver Among The Lenape: Pewter Objects From Southeastern Pennsylvania As Possible Precursors, Marshall Joseph Becker

Northeast Historical Archaeology

A reawakening of interest in material culture has stimulated the examination of some small pewter castings in use among northeastern Native American peoples during the 17th and early 18th centuries. Reports by 17thcentury explorers and colonists, ·who found Eastern Woodland natives to be disinterested in gold and silver artifacts, are now better understood. The period from 1720 to 1750 was critical to the Lenape and other peoples who had just become major players in the fur trade to the Allegheny and Ohio River areas. During this period various silver-colored white metal castings may have been the precursors of sterling-quality silver …

The General Hospital At Mount Independence: 18th-Century Health Care At A Revolutionary War Cantonment, David R. Starbuck

Northeast Historical Archaeology

The General Hospital at Mount Independence in Orwell, Vermont, has been examined in order to learn more about the configuration of an 18-century military hospital. Historical research combined with on-site excavation in 1990 exposed the foundation of a 250-foot-long building containing principally archicetural and kitchen debris. While physical remains did not reveal the layout of individual rooms, archaeological and historical evidence have nevertheless provided insights into the appearance and function of this important structure.

Beluga Whale Vocalizations, Michael T. Johnson

Dr. Dolittle Project: A Framework for Classification and Understanding of Animal Vocalizations

Sound files:

A Chirp; A Whistle ; B Chirp; B Whistle: Buzz; C Whistle; CH6 A Chirp; D Whistle; Down Warble; Down Whistle; E Whistle; Voca

Thunder And Powder: May They Never Meet! Lightning Conductors At The Esplanade Powder Magazine, Quebec City, Pierre Drouin

Northeast Historical Archaeology

Archaeological excavations carried out at the Esplanade powder magazine in Quebec City have revealed the remains of three successive lighting conductor systems. These 19th-century remains are closely examined in the light of contemporary literature and compared with the military instructions concerning the subject. Their presence highlights the efforts made by military engineers of the time to safeguard contents, buildings, and people from the hazards inherent to the storage of explosive materials in powder magazines.

Exploring The Oncogenic Role Of P27 In Regulating Tumor Progression, Dekuang Zhao

Open Access Dissertations

p27 is a cell cycle regulator and an atypical tumor suppressor. However, p27 gene deletions or mutations are rarely observed in human cancers. Instead, p27 is frequently degraded or mislocalized to the cytoplasm in aggressive human cancers. Phosphorylation at T157 or T198 by different PI3K effector kinases leads to p27 cytoplasmic accumulation. However, the functional contribution of phosphorylated and cytoplasmic p27 to cancer progression remains unknown. By introducing a cell cycle defective (CK-) and double phosphomimetic p27 mutant (T157D/T198D or DD), we found that phosphorylation of p27 at T157 or T198 by PI3K/mTOR directly regulated tumor cell migration and invasion. …

Septins Of Platyhelminths: Identification, Phylogeny, Expression And Localization Among Developmental Stages Of Schistosoma Mansoni, Ana E. Zeraik, Gabriel Rinaldi, Victoria H. Mann, Anastas Popratiloff, Ana P.U. Araujo, Ricardo Demarco, Paul J. Brindley

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Septins are a family of eukaryotic GTP binding proteins conserved from yeasts to humans. Originally identified in mutants of budding yeast, septins participate in diverse cellular functions including cytokinesis, organization of actin networks, cell polarity, vesicle trafficking and many others. Septins assemble into heteroligomers to form filaments and rings. Here, four septins of Schistosoma mansoni are described, which appear to be conserved within the phylum Platyhelminthes. These orthologues were related to the SEPT5, SEPT10 and SEPT7 septins of humans, and hence we have termed the schistosome septins SmSEPT5, SmSEPT10, SmSEPT7.1 and SmSEPT7.2. Septin transcripts were detected throughout the developmental cycle …

Joe Bauer Presented "Enforcement Issues Under American Antitrust Laws" At The University Of Tilburg (Holland) Center For Law And Economics On December 19, 2013, Joseph P. Bauer

Faculty Lectures and Presentations

Joe Bauer presented a seminar at the University of Tilburg (Holland) Center for Law and Economics on December 19. His topic was Enforcement Issues under American Antitrust Laws. View PowerPoint slides of lecture by clicking pdf link.

Measuring Changes In Tactile Sensitivity In The Hind Paw Of Mice Using An Electronic Von Frey Apparatus, Tijana Martinov, Madison Mack, Akilah Sykes, Devavani Chatterjea

Faculty Publications

Measuring inflammation-induced changes in thresholds of hind paw withdrawal from mechanical pressure is a useful technique to assess changes in pain perception in rodents. Withdrawal thresholds can be measured first at baseline and then following drug, venom, injury, allergen, or otherwise evoked inflammation by applying an accurate force on very specific areas of the skin. An electronic von Frey apparatus allows precise assessment of mouse hind paw withdrawal thresholds that are not limited by the available filament sizes in contrast to classical von Frey measurements. The ease and rapidity of measurements allow for incorporation of assessment of tactile sensitivity outcomes …

The Weekly Challenger, December 19, 2013, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 19, 2013, issue of The Weekly Challenger.

Braese V. Stinker Stores Appellant's Brief Dckt. 41296

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Surgery For Post-Vitrectomy Cataract, Diana V. Do, Stephen Gichuhi, Satyanarayana S. Vedula, Barbara S. Hawkins

Journal Articles: Ophthalmology

BACKGROUND: Cataract formation or acceleration can occur after intraocular surgery, especially following vitrectomy, a surgical technique for removing the vitreous which is used in the treatment of disorders that affect the posterior segment of the eye. The underlying problem that led to vitrectomy may limit the benefit from cataract surgery.

OBJECTIVES: The objective of this review was to evaluate the effectiveness and safety of surgery for post-vitrectomy cataract with respect to visual acuity, quality of life, and other outcomes.

SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2013, Issue 4), …