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Articles 6121 - 6150 of 124711
Full-Text Articles in Entire DC Network
Life History Variation Of Common Terns In The Gulf Of Maine, Jeffery Bryant Kimmons
Life History Variation Of Common Terns In The Gulf Of Maine, Jeffery Bryant Kimmons
Graduate Theses and Dissertations
Life history is the inheritable rules that determine energy and time allocation towards different competing functions in the energy budget of an organism. Reproductive effort varies as organisms make reproductive decisions based on available energy. Factors influencing life histories are those that change energy and time budgets such as diet, competition, and environmental conditions.
Common tern (Sterna hirundo) life history phenotypes vary between islands in the Gulf of Maine. Common terns on offshore islands (>10km from mainland) and nearshore islands (5 to 10km from mainland) lay smaller clutches, hatching chicks with slower growth rates than common terns …
New Applications Of Mass Spectrometry For Drug And Lipid Analysis, Elizabeth Lauren Emerson
New Applications Of Mass Spectrometry For Drug And Lipid Analysis, Elizabeth Lauren Emerson
Graduate Theses and Dissertations
Mass spectrometry is an important tool used in many different disciplines and settings that include forensics, drug discovery, environmental analysis, and proteomics. Gas chromatography - mass spectrometry (GC-MS) and matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI - TOF MS) are two of the most important instruments used for analysis of compounds. Chapters 1 and 2 of this discussion use GC-MS for the investigation of synthetic cannabinoids in `K2' incense products and the detection of metabolites in urine samples from individuals suspected of consuming these mixtures. Analytical standards were synthesized and used for identification and confirmation of structures. Detection of …
Meta-Analysis Of Wheat Qtl Regions Associated With Heat And Drought Stress, Marlovi Andrea Acuna Galindo
Meta-Analysis Of Wheat Qtl Regions Associated With Heat And Drought Stress, Marlovi Andrea Acuna Galindo
Graduate Theses and Dissertations
Heat and drought are the two most important environmental constraints to wheat production globally, are often present simultaneously and will become more severe with global climate change. This presents a unique challenge to wheat scientists who must work to develop wheat cultivars that are productive and adapted to future environmental conditions. A number of recent studies have reported quantitative trait loci (QTL) associated with heat and drought tolerance, as well as QTL for stress adaptive traits such as the availability of stem carbohydrates or crop canopy temperature. The objective of this study was to perform a meta-analysis of these QTL …
Analytical Research Topics In Sport Management, Gi-Yong Koo
Analytical Research Topics In Sport Management, Gi-Yong Koo
Graduate Theses and Dissertations
The field of sport management has grown tremendously as an academic discipline. Researchers have continuously discussed the scope and direction of research and the importance of the diversity of research design. There have been a significant number of studies examining the scope and direction of research over the past few decades such as: the lack of diversity in methodology; the lack of diversity in research focus; the lack of importance of power analysis; and the lack of diversity in topic areas. Embracing a variety of research designs is an absolutely necessary condition for the growth and credibility of sport management …
Study Of Current Optocoupler Techniques And Applications For Isolation Of Sensing And Control Signals In Dc-Dc Converters, Jake Williams
Study Of Current Optocoupler Techniques And Applications For Isolation Of Sensing And Control Signals In Dc-Dc Converters, Jake Williams
Graduate Theses and Dissertations
There is a need for power switches that can operate at high voltage, high temperature, and high switching frequencies with low losses. Power switches fabricated from wide bandgap materials such as silicon carbide (SiC) or gallium nitride (GaN) can outperform conventional silicon switches due to material property advantages. Another common problem in grid-connected applications is the need for high voltage-isolation of gate drivers and control circuitry while operating efficiently at the high switching frequencies, high power density, and high temperatures made possible by wide bandgap devices. Transformers cannot operate at the temperatures of these wide bandgap devices and a new …
Effects Of Associated Subcortical Beetles On Oviposition Behavior And Early-Stage Survival Of Sirex Nigricornis F. (Hymenoptera: Siricidae), Ace J. Lynn-Miller
Effects Of Associated Subcortical Beetles On Oviposition Behavior And Early-Stage Survival Of Sirex Nigricornis F. (Hymenoptera: Siricidae), Ace J. Lynn-Miller
Graduate Theses and Dissertations
Sirex (Hymenoptera: Siricidae) woodwasps develop within xylem of host conifers. Sirex females drill through the bark, phloem and into xylem tissues where they deposit eggs along with a symbiotic Amylostereum fungus. The presence of Amylostereum is necessary for successful development of Sirex immatures as the larvae are unable to derive adequate nutrition from xylem in the absence of the fungus. The Eurasian woodwasp, Sirex noctilio F., was discovered in northeastern North America in 2004. Sirex noctilio has caused significant economic damage in Pinus radiata D. Don plantations of the southern hemisphere, but is of little economic significance in its native …
Design And Analysis Of An Adaptive Asynchronous System Architecture For Energy Efficiency, Brent Michael Hollosi
Design And Analysis Of An Adaptive Asynchronous System Architecture For Energy Efficiency, Brent Michael Hollosi
Graduate Theses and Dissertations
Power has become a critical design parameter for digital CMOS integrated circuits. With performance still garnering much concern, a central idea has emerged: minimizing power consumption while maintaining performance. The use of dynamic voltage scaling (DVS) with parallelism has shown to be an effective way of saving power while maintaining performance. However, the potency of DVS and parallelism in traditional, clocked synchronous systems is limited because of the strict timing requirements such systems must comply with. Delay-insensitive (DI) asynchronous systems have the potential to benefit more from these techniques due to their flexible timing requirements and high modularity. This dissertation …
The Role Of Centromeric Chromatin And Kinetochore-Associated Factors In Chromosome Segregation, Wesley Williamson
The Role Of Centromeric Chromatin And Kinetochore-Associated Factors In Chromosome Segregation, Wesley Williamson
Graduate Theses and Dissertations
Previous work in our lab has identified a point mutation in HTA1, one of the genes encoding histone H2A, which causes an increase-in-ploidy phenotype in Saccharomyces cerevisiae. This histone mutant strain was used to carry out a transposon insertion screen to identify suppressors of the increase-in-ploidy phenotype. This screen identified all three subunits of the Hda histone deacetylase complex, HDA1, HDA2, and HDA3. This study aims to elucidate the function of the Hda complex in chromosome segregation by exploring interactions among the members of the complex, as well as interactions between Hda complex and kinetochore components. …
Refractive Index Chemical Sensing With Noble Metal Nanoparticles, Phillip Blake
Refractive Index Chemical Sensing With Noble Metal Nanoparticles, Phillip Blake
Graduate Theses and Dissertations
Chemical sensing is a key component in modern society, especially in engineering applications. Because of their widespread impact, improvements to chemical sensors are a significant area of research. One class of sensors, plasmonic sensors, is being heavily researched because of their ability to detect low levels of analyte in near real time without destroying the analyte. This work studies a new class of plasmonic sensor that utilizes diffractive coupling to improve sensor performance. Specifically, this work outlines the first study of diffractive coupling sensors with typical nanoparticle shapes. Sensitivity of this new class of sensor is directly compared to typical …
The Lived Experience Of The Parents Of High School Dropouts: A Phenomenological Study, Christine Ann Silano
The Lived Experience Of The Parents Of High School Dropouts: A Phenomenological Study, Christine Ann Silano
Graduate Theses and Dissertations
The purpose of this study is to describe the experiences and perceptions of parents whose children did not receive a high school diploma. This subpopulation has been rarely studied. The central question is, "What are the perceptions and experiences of the parents of public high school dropouts as they pertain to schools, their children, and themselves?"
This phenomenological study examined the lived experience of the parents of high school dropouts. Five women and one man participated in the study by sitting for interviews. The collected interview data was transcribed and analyzed using qualitative methodology including open and axial coding as …
Long-Term Effects Of Rice Rotation, Tillage, And Fertility On Near-Surface Soil Carbon And Nitrogen Cycling, Jill Marie Motschenbacher
Long-Term Effects Of Rice Rotation, Tillage, And Fertility On Near-Surface Soil Carbon And Nitrogen Cycling, Jill Marie Motschenbacher
Graduate Theses and Dissertations
Rice (Oryza sativa L.)-based cropping systems are different from other row crops due to the flood-irrigation scheme used from about one month after planting to a few weeks prior to harvest. The frequent cycling between anaerobic (i.e., flooding during the growing season) and aerobic (i.e., generally, the remainder of the year) conditions can influence the rate of soil organic matter (SOM) decomposition, which can greatly influence carbon (C) and nitrogen (N) storage and sequestration in the soil over time. Therefore, a study was conducted on a silt-loam soil (fine, smectitic, thermic, Typic Albaqualf) at the Rice Research and Extension Center …
Preparedness To Implement Wellness Strategies: Perceptions Of School Counselors, Tena Burnett
Preparedness To Implement Wellness Strategies: Perceptions Of School Counselors, Tena Burnett
Graduate Theses and Dissertations
The purpose of this study is to survey school counselors to determine their knowledge and perceived preparedness to implement wellness strategies in school counseling programs. Wellness plans are a requirement for thousands of public school districts in the United States. There are no established standards for the training of school counselors in the area of wellness. School counselors are in a unique position to positively impact students through the use of wellness programs and strategies. School counselors from a mid-south state (N = 156) completed an electronic survey to measure how they implement wellness strategies and their perceived preparedness in …
Laboratory And Field Performance Of The Biosand Point Of Use Water Filtration System In The Artibonite Valley, Haiti, Andrew John Sisson
Laboratory And Field Performance Of The Biosand Point Of Use Water Filtration System In The Artibonite Valley, Haiti, Andrew John Sisson
Masters Theses
The research presented here is summary two years of studying the Biosand filter (BSF) both in Haiti during March 2011 and in the laboratory. In Chapter 2, we examined the long term use and sustainability 55 BSF systems near Deschapelles, Haiti and 47% were found to be no longer in use. Interviews with BSF owners revealed problems related to intermittent filter use. A review of 17 BSF field studies also was included to compare and substantiate observations made in Haiti. Together, previous field studies and our observations point toward the importance of providing culturally appropriate technologies and education materials explaining …
The Role Of Saturated Fatty Acids In Connexin Expression On Endothelial Cells And Eosinophils, Kurt Anthony Ashack
The Role Of Saturated Fatty Acids In Connexin Expression On Endothelial Cells And Eosinophils, Kurt Anthony Ashack
Masters Theses
Eotaxin is a potent chemoattractant for eosinophils that becomes elevated in the tissues in response to inflammation and increased adiposity. Therefore, eosinophil migration into adipose tissue should increase in diet-induced obese individuals, yet it does not. This suggested to us that something within the cellular microenvironment of diet-induced obese individuals might be altering the endothelial leukocyte adhesion molecules (ELAM) such as VCAM-1 or selectins on the endothelial cells, thus preventing eosinophils from entering the inflamed tissue. Connexons are gap junctions in endothelial cells and on immune cells such as macrophages that are composed of connexins and have been shown to …
Successful Weight Loss, Weight Loss Maintenance And Psychological Characteristics In Minority Men And Women Attending An Inner-City Weight Loss Program, Julie Ann Hall
Masters Theses
Inner-city communities are disproportionately impacted by obesity and chronic disease. The LOSE BIG Challenge is a motivational physical activity and nutrition education program offered to inner-city Grand Rapids, Michigan residents with diabetes or hypertension. Twenty-eight participants (26 women, 2 men) in a 12-week culturallybased weight loss program were studied. Before and after the intervention, height, weight, lifestyle information, readiness to change, eating behaviors, depression scores, and quality of life scores were measured. Participants were followed 4 and 6 months post intervention. At baseline, 86% of the participants were obese (BMI >30 kg/m2), 54% watched more than ten hours …
Protecting The Hand: .Quantifying Pressures Involved In Daily Living Activities With Tools, Kelly Cotter, Trisha Thompson, Amanda Ward
Protecting The Hand: .Quantifying Pressures Involved In Daily Living Activities With Tools, Kelly Cotter, Trisha Thompson, Amanda Ward
Hand and Upper Extremity
This study utilized individuals with no known hand joint pathologies and analyzed the pressure exerted on varying spoon handle diameters during a simulated self-feeding exercise. This was done in an effort to determine which spoon handle diameter required the least amount of pressme. Individuals with no known hand joint pathologies were selected in order to prevent any inaccuracy of results due to underlying co-morbidities. Methods: The Novel Pliance-X hand sensor was wrapped around 15 mm, 25 IDDl, and 40 mm spoon handles. The participants were asked to complete a self-feeding exercise. The self-feeding exercise was simulated by scooping quarters from …
Effects Of Computer Assisted Tier Ii Interventions By Gender On Math And Reading Achievement For Remediated Students, Kathi (Lutz) Sweere
Effects Of Computer Assisted Tier Ii Interventions By Gender On Math And Reading Achievement For Remediated Students, Kathi (Lutz) Sweere
College of Education Dissertations
Response to Intervention (RtI) is a current reform initiative being examined by educators, politicians, and proponents of differentiated education. RtI has tiers of intervention designed to meet the various academic needs of all students. RtI has been developed as an educational methodology to increase student achievement through various problem-solving techniques, through the implementation of specific interventions based on each student’s individual needs, and through data-based decision making regarding the interventions used. The implementation of RtI requires schools to shift current educational paradigms of how services are delivered to students.
This quantitative causal comparative study compared the effectiveness of PLATO alone, …
Finding Unpredictable Behaviors Of Periodic Bouncing For Forced Nonlinear Spring Systems When Oscillating Time Is Large, Yanyue Ning
Honors Scholar Theses
The model of nonlinear spring systems can be applied to deal with different aspect of mechanical problems, such as oscillations in periodic flexing in bridges and ships. The concentration of this research is the bouncing behaviors of nonlinear spring system when the processing time is large, therefore nonlinear ordinary differential equations (ODE) are suitable since researchers can add different variables into the models and solve them by computational methods. Benefit from this, it is easy to check the oscillations or bouncing behaviors that each variable contributes to the model and find the relationship between some important factors: vibrating frequency, external …
Md Mouse: Integrated Blood Pressure Device, Anand Shah, Jamila Mckenzie, Rex Weinstein, Noelle Nelson, Clayton Goertemiller
Md Mouse: Integrated Blood Pressure Device, Anand Shah, Jamila Mckenzie, Rex Weinstein, Noelle Nelson, Clayton Goertemiller
Intersections Fall 2020
Hypertension, or high blood pressure, is a public health concern due to both its pervasiveness and the significant risk of disability, stroke, or heart attack that can occur years after high blood pressure is detected. Furthermore, new pandemic statistics suggest that patients with hypertension experience greater health consequences of COVID-19, indicating that the condition is more circumstantially deadly. Occasional visits to a doctor's office, the most common method to measure blood pressure, only provide a snapshot of a person's blood pressure and are not an accurate characterization. This is because blood pressure can fluctuate based on daily changes to the …
System For Enhanced Removal Of Gastrointestinal Clots, Neha Boinpally, Megan Buford, Emma Hammelef, Sharmila Iyer, Keyvon Rashidi
System For Enhanced Removal Of Gastrointestinal Clots, Neha Boinpally, Megan Buford, Emma Hammelef, Sharmila Iyer, Keyvon Rashidi
Intersections Fall 2020
Gastrointestinal (GI) bleeding is a hazardous clinical condition often resulting in morbidities and mortality in patients. After diagnosis, treatment options include administering proton pump inhibitors (PPIs), embolic agents to aid in the breakdown of the clots. At the same time, hemostasis can also be achieved using targeted endoscopic techniques and hemostatic forceps. During the procedure, the blood clots and other fibrous material are removed from the GI tract via suction from the endoscope instrument. However, this process is not overly effective with regard to removing the clots from the GI tract since the clots often cause blockages in the suction …
Stress Measurement Wearable Device Optimized For Use In The Clinical Icu, Jacob Baraz, Max Jesurum, Mason Jiang, Cierra Spriggs, Ryan Tatton
Stress Measurement Wearable Device Optimized For Use In The Clinical Icu, Jacob Baraz, Max Jesurum, Mason Jiang, Cierra Spriggs, Ryan Tatton
Intersections Fall 2020
The current benchmark for measuring stress in the intensive care unit (ICU) is the perceived stress questionnaire (PSQ). Validated by a large population of in-patients, the PSQ is a self-reported questionnaire used in clinical and laboratory settings for assessing stressful circumstances that typically exacerbate disease symptoms. However, clinicians and nurses operating in the ICU could benefit from a more efficient system for measuring the stress of admitted patients. Monitoring physiological markers for the degree of stress can aid clinicians in providing accurate and effective treatment methods to benefit the health condition and alleviate the stress of the patient. The proposed …
Accommodating Face Mask For Those With Hearing Impairments, Anushka Khanna, Emily Hauser, Rashi Shukla, David Yo, Adam Portugali
Accommodating Face Mask For Those With Hearing Impairments, Anushka Khanna, Emily Hauser, Rashi Shukla, David Yo, Adam Portugali
Intersections Fall 2020
As COVID-19 continues to spread in our society, wearing face masks have become an integral part of daily life. For users with disabilities, specifically those with hearing impairments, the utilization of face masks creates additional problems. The obstruction of facial and visual expressions from mask wearing poses an increased difficulty in communicating with individuals when lip reading is not accessible; additionally, the elastic straps that hold the mask in place can become entangled or dislodge hearing aids, creating more discomfort for the users. Further, blocking a majority of the face from view makes it harder to see critical vital and …
Models Of Experimental Competitive Intensities Predict Home And Away Differences In Invasive Impact And The Effects Of An Endophytic Mutualist, Sa Xiao, Ragan M. Callaway, George Newcombe, Erik T. Aschehoug
Models Of Experimental Competitive Intensities Predict Home And Away Differences In Invasive Impact And The Effects Of An Endophytic Mutualist, Sa Xiao, Ragan M. Callaway, George Newcombe, Erik T. Aschehoug
Biological Sciences Faculty Publications
Understanding the role of competition in the organization of communities is limited in part by the difficulty of extrapolating the outcomes of small-scale experiments to how such outcomes might affect the distribution and abundance of species. We modeled the community-level outcomes of competition, using experimentally derived competitive effects and responses between an exotic invasive plant, Centaurea stoebe, and species from both its native and nonnative ranges and using changes in these effects and responses elicited by experimentally establishing symbioses between C. stoebe and fungal endophytes. Using relative interaction intensities (RIIs) and holding other life-history factors constant, individual-based and spatially explicit …
Positive Relationships Between Association Strength And Phenotypic Similarity Characterize The Assembly Of Mixed-Species Bird Flocks Worldwide, Hari Sridhar, Umesh Srinivasan, Robert A. Askins, Julio Cesar Canales Delgadillo, Chao-Chieh Chen, David N. Ewert, George A. Gale, Eben Goodale, Wendy K. Gram, Patrick J. Hart, Keith A. Hobson, Richard L. Hutto, Sarath W. Kotagama, Jessie Knowlton, Tien Ming Lee, Charles A. Munn, Somchai Nimnuan, B. Z. Nizam, Gillaume Péron, V. V. Robin, Amanda D. Rodewald, Paul G. Rodewald, Robert L. Thomson, Pranav Trivedi, Steven L. Van Wilgenburg, Kartik Shanker
Positive Relationships Between Association Strength And Phenotypic Similarity Characterize The Assembly Of Mixed-Species Bird Flocks Worldwide, Hari Sridhar, Umesh Srinivasan, Robert A. Askins, Julio Cesar Canales Delgadillo, Chao-Chieh Chen, David N. Ewert, George A. Gale, Eben Goodale, Wendy K. Gram, Patrick J. Hart, Keith A. Hobson, Richard L. Hutto, Sarath W. Kotagama, Jessie Knowlton, Tien Ming Lee, Charles A. Munn, Somchai Nimnuan, B. Z. Nizam, Gillaume Péron, V. V. Robin, Amanda D. Rodewald, Paul G. Rodewald, Robert L. Thomson, Pranav Trivedi, Steven L. Van Wilgenburg, Kartik Shanker
Biological Sciences Faculty Publications
Competition theory predicts that local communities should consist of species that are more dissimilar than expected by chance. We find a strikingly different pattern in a multicontinent data set (55 presence-absence matrices from 24 locations) on the composition of mixed-species bird flocks, which are important sub-units of local bird communities the world over. By using null models and randomization tests followed by meta-analysis, we find the association strengths of species in flocks to be strongly related to similarity in body size and foraging behavior and higher for congeneric compared with noncongeneric species pairs. Given the local spatial scales of our …
Port Injection Site Sanitization (Pss) Dispenser Design, Ya Gao, Lindsey Greenwood, Rachel Mann, Katherine He
Port Injection Site Sanitization (Pss) Dispenser Design, Ya Gao, Lindsey Greenwood, Rachel Mann, Katherine He
Intersections Fall 2020
Peripheral venous catheters (PVCs) are the most used device in hospitals, used for intravenous medication and for drawing blood. It is estimated that over 150 million catheters are inserted into patients each year in the US. About 250,000 patients with PVCs get catheter-related bloodstream infections (CRBIs) which are estimated to have a $2.8 billion additional cost nationwide and a 12%-15% mortality rate. It is also estimated that a 1.6% decrease in the incidence of CRBIs would yield a cost savings of $113 per inserted catheter. These statistics denote a clinical need for a reduction of infections caused by PVCs, saving …
Episleeve: Multimodal Night-Time Seizure Detection, Jorge Mirabelli, Sophia Hall, Dylan Rasmussen, Luca Lin, Devin Lewis
Episleeve: Multimodal Night-Time Seizure Detection, Jorge Mirabelli, Sophia Hall, Dylan Rasmussen, Luca Lin, Devin Lewis
Intersections Fall 2020
This project involves the creation of a nighttime wearable device that can measure heart rate, blood oxygen saturation, temperature, motion, and skin resistivity using sensors placed on the upper and lower arm. Incorporating a wide variety of sensors allows for detection of focal and generalized epilepsy. These sensors will be used to collect data to wirelessly (via Bluetooth) transmit to a separate base station for processing to determine if a seizure has occurred. If a seizure is detected for a specified period of time, the base station can call (via cellular communications) for medical aid to prevent harm to users. …
Development Of Core Body Temperature (Cbt) And Heart Rate Wearable Device, Brenna Carbone, Madison Castellanos, Jonathan Chen, Jenna Wagner
Development Of Core Body Temperature (Cbt) And Heart Rate Wearable Device, Brenna Carbone, Madison Castellanos, Jonathan Chen, Jenna Wagner
Intersections Fall 2020
Hyperthermia is a condition when the body's heat-regulation system is overwhelmed and a person's core body temperature (CBT) is above 100.4°F (38°C). This is a major risk among athletes and occupational workers in the military, construction, manufacturing, and emergency response who engage in intense physical activity. Currently the gold standard to measure CBT is through a rectal thermometer. While rectal thermometers are accurate, they are quite invasive and do not provide a way for continuous monitoring. Other skin and oral thermometers which are considered noninvasive are not accurate because they only measure surface temperature and are easily influenced by other …
Novel Wearable System To Monitor, Predict, And Acutely Treat Epileptic Seizures, Jackie Kresic, Katherine Glaess, Sunayana Jampanaboyana, Cathy Tao
Novel Wearable System To Monitor, Predict, And Acutely Treat Epileptic Seizures, Jackie Kresic, Katherine Glaess, Sunayana Jampanaboyana, Cathy Tao
Intersections Fall 2020
Epilepsy, a chronic condition involving recurrent and unprovoked seizures, affects over 50 million individuals globally. Characterized by abnormalbrain activity, these seizures affect the daily functioning of individuals, and increase the risk of further physical, mental, and emotional harm.Traditional treatment options such as invasive brain surgery and anti-epileptic drugs (AEDs) do not fully prevent the occurrence of epileptic seizures,can remain ineffective for certain individuals, and can lead to severe adverse effects. To reduce the incidence of serious lifestyle complications, weare proposing a novel design for a daily-use wearable that involves biopotential monitoring, seizure prediction, and an automated acute interventionstrategy to reduce …
Best Practices To Make Online Learning An Advantageous Tool For Students With Specific Learning Disorder, Sanchi Kalra
Best Practices To Make Online Learning An Advantageous Tool For Students With Specific Learning Disorder, Sanchi Kalra
Intersections Fall 2020
Online education has been prevalent for years, but with the spread of the Covid-19, it became the most viable option for students all over the world. Out of these students, an estimated 15-20% of them show signs of what the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders describes as Specific Learning Disorder (SLD). Students with SLD experience difficulties with learning and using academic skills such as reading, writing, and mathematics. These difficulties are independent of intelligence. Over the past two decades, SLD has also been referred to as dyslexia or a learning disability. While adapting to …
Remarkable Sensitivity Of The Prospective Photodynamic Therapy Agent 6-Selenoguanine To Ph, Collin Merrick, Sean J. Hoehn, Luis A. Ortiz-Rodríguez, Sarah Krul, Carlos E. Crespo-Hernández
Remarkable Sensitivity Of The Prospective Photodynamic Therapy Agent 6-Selenoguanine To Ph, Collin Merrick, Sean J. Hoehn, Luis A. Ortiz-Rodríguez, Sarah Krul, Carlos E. Crespo-Hernández
Intersections Fall 2020
The photophysical properties of the canonical DNA/RNA nucleobases can be modified by selective functionalization. The carbonyl functional group at the C6 position of guanine or 2-amino-6-oxopurine, for example, can be removed to form 2-aminopurine, thus replacing the ultrafast internal conversion pathway to the ground state observed in guanine with slow internal conversion and intersystem crossing pathways in 2-aminopurine.1 Similarly, substitution of the carbonyl oxygen in guanine with a heavier atom results in a redshift of the absorption spectrum and a remarkable modulation of the electronic relaxation pathways of the DNA nucleobase. More specifically, sulfur substitution redshifts the absorption spectrum of …