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2012

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A Preliminary Study On The Use Of Alternative Chemicals For Treatment Of Wastewater In Coal Fired Power Generation / Gunasegran A/L Ramasamy, Gunasegran Ramasamy Jan 2012

A Preliminary Study On The Use Of Alternative Chemicals For Treatment Of Wastewater In Coal Fired Power Generation / Gunasegran A/L Ramasamy, Gunasegran Ramasamy

Student Works (2010-2019)

Hydrated lime is used for pH adjustment as part of the treatment process at the main wastewater treatment plant in Sultan Azlan Shah Power Station, Manjung. Many problems are encountered in usage of hydrated lime mainly in terms of handling. Manual labour is used to load hydrated lime into bag unloader and it is a messy job because some of the chemical spills and gets air borne. This is also a safety concern. The hydrated lime also frequently chokes the outlet of storage silo and is another manual job to clear the blockage. This study is important because replacement of …

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Peculiar Feed-Forward Loop Network Motifs In Escherichia Coli / Kok Eng Piew, Eng Piew Kok Jan 2012

Peculiar Feed-Forward Loop Network Motifs In Escherichia Coli / Kok Eng Piew, Eng Piew Kok

Student Works (2010-2019)

A feed-forward loop (FFL) is one type of transcription network motifs studied in systems biology. So far, eight types of FFL based on their regulatory patterns have been identified. The majority of FFL found in transcription networks of biological systems have been identified to belong to coherent and incoherent type 1 FFL. Nevertheless, six FFL types (coherent and incoherent type 2, 3 and 4 FFL) are present in low frequencies in Escherichia coli. The persistence and not elimination of these “peculiar” FFL through natural selection is perplexing. One way to understanding this conundrum is to study the dynamics of these …

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Solid Waste Debris Management On Selected Beaches In Malaysia / Khairunnisa Ahmad Kamil, Khairunnisa Ahmad Kamil Jan 2012

Solid Waste Debris Management On Selected Beaches In Malaysia / Khairunnisa Ahmad Kamil, Khairunnisa Ahmad Kamil

Student Works (2010-2019)

Solid waste debris on beaches had caused environmental, aesthetical, economic and social problems in Malaysian beaches. This study discussed solid waste debris management on selected Malaysian beaches namely, Teluk Kemang, Pasir Panjang, Batu Burok, Seberang Takir, Tanjung Aru and Teluk Likas. The objectives of the study are to determine the abundance, composition, rate of accumulation, and the sources of debris on these beaches. It also aims to investigate the current beach management in Malaysia and beach users’ opinion and attitude towards marine pollution issues. Debris from a total area of 60 m along each beach were collected, separated, counted, and …

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Detection Of Selected Resistance Genes, Integrons, Salmonella Genomic Island And Plasmids In Multidrug Resistant Salmonella / Lee Kong Hoe Lee, Kong Hoe., Kong Hoe Lee Jan 2012

Detection Of Selected Resistance Genes, Integrons, Salmonella Genomic Island And Plasmids In Multidrug Resistant Salmonella / Lee Kong Hoe Lee, Kong Hoe., Kong Hoe Lee

Student Works (2010-2019)

The study was to detect and characterize the selected antimicrobial resistance genes, class 1 integron, Salmonella Genomic Island 1 (SGI1) and plasmid profile of 41 selected multidrug resistant (MDR) Salmonella strains of human origin. Salmonella strains harbored blaCTX-M (33.3%) followed by blaTEM (25.0%), blaPSE-1 (13.9%), blaCMY-2 (8.3%) and blaSHV (2.8%) genes. Quinolone or fluoroquinolone-resistant strains harbored qnrB (75.0%) and qnrS (29.2%) genes. Concurrent presence of β-lactamase genes and qnr genes were detected in 9 strains, including S. Lagos (n=1), S. Enteritidis (n=2), S. Farsta (n=2) and S. Typhimurium (n=4). Class 1 integron was detected in 9 strains (S. Albany (n=2), …

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Study Of S-Band Optical Amplifiers And Its Applications / Mohd Zamani Zulkifli, Zulkifli Mohd Zamani Jan 2012

Study Of S-Band Optical Amplifiers And Its Applications / Mohd Zamani Zulkifli, Zulkifli Mohd Zamani

Student Works (2010-2019)

Currently, existing networks which utilizes Dense Wavelength Division Multiplexing (DWDM) have come to its limitation, with the increase of data traffic extending the operational bandwidth from the C- to the L-band. Although the L-band can sustain current demands, there is a pressing need to explore the S-band region for future needs. One of the important components for operation in the S-band region is the S-band optical amplifier, which requires in-depth investigation and is the scope and objective of this thesis. The work will undertake a nearly comprehensive evaluation of the different types of optical amplifiers such as Erbium Doped Fibers …

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Why Corporate Social Responsibility Will Emerge As A Driver Of Effective And Compelling Differentiation For Chinese Brands, Joseph Baladi Jan 2012

Why Corporate Social Responsibility Will Emerge As A Driver Of Effective And Compelling Differentiation For Chinese Brands, Joseph Baladi

Research Collection Lee Kong Chian School Of Business

Although the responsibility and role of business within society have evolved over the past two decades, they remain issues that retain conceptual dimensions. This means that instead of consensus over form and function, both are surrounded by a persistent cloud of disagreement and confusion. Too many people remain unsure about what they represent, the importance they play and the impact they have (or should have) on business as well as society. For one thing, different interpretations of what defines business responsibility to society exist. These range from concern over business’ environmental impact and contribution to climate change, to sustainability practices, …

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The Competitive Dynamics Of New Dvd Releases, Anirban Mukherjee, Vrinda Kadiyali Jan 2012

The Competitive Dynamics Of New Dvd Releases, Anirban Mukherjee, Vrinda Kadiyali

Research Collection Lee Kong Chian School Of Business

In the U.S. motion picture industry, DVDs are increasingly a major source of revenue for moviestudios. Two important strategic decisions for DVDs are the release date and price. Industry evidencesuggests studios consider various release options as evidenced by their pre-release announcements. Whendeciding DVD release dates and prices, studios must consider the following. First, weeks of high demandpotential, increase sales. Second, intense competition in weeks of peak demand might reduce marketshare, lower margins and lead to higher costs of release. Third, deferring a DVD release (e.g. to a nonpeakdemand week) after the movie’s theatrical run reduces the potential sales of the …

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What Are Analysts Really Good At?, Ohad Kadan, Leonardo Madureira, Rong Wang, Tzachi. Zach Jan 2012

What Are Analysts Really Good At?, Ohad Kadan, Leonardo Madureira, Rong Wang, Tzachi. Zach

Research Collection Lee Kong Chian School Of Business

Sell-side analysts employ different benchmarks when defining their stock recommendations. Forexample, a ‘buy’ for some brokers means the stock is expected to outperform its peers in the same sector(“industry benchmarkers”), while for other brokers it means the stock is expected to outperform themarket (“market benchmarkers”), or just some absolute return (“total benchmarkers”). We use thesebenchmarks to analyze the role of stock picking, industry picking and market timing in contributing to theperformance of stock recommendations. We are able to do so given that different benchmarks suggest theuse of different sets of abilities. Analysis of the relation between analysts’ recommendations and theirlong-term …

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Core Debates In Assessment Center Research: Dimensions ‘Versus’ Tasks, Neil D. Christiansen, Filip Lievens Jan 2012

Core Debates In Assessment Center Research: Dimensions ‘Versus’ Tasks, Neil D. Christiansen, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Although personality constructs are now widely accepted as being important for understanding work behavior, self-report personality tests as a method of assessment are not without their critics (e.g., Morgeson et al., 2007). Whether misguided or not, concerns persist regarding the validity of these measures and the issue of applicant faking has yet to be fully resolved (Tett & Christiansen, 2007). Moreover, applicant reactions tend to be less favorable for personality inventories than many other assessments commonly used in employment settings (Hausknecht, Day, & Thomas, 2004). To some, self-report inventories may be a poor way to assess personality traits, and yet …

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Pelaksanaan Kutipan Zakat Perniagaan Dalam Kalangan Usahawan Muslim Industri Kecil Dan Sederhana Di Madura, Jawa Timur, Indonesia / Mohammad Hamidi, Abdullah Mohammad Hamidi Jan 2012

Pelaksanaan Kutipan Zakat Perniagaan Dalam Kalangan Usahawan Muslim Industri Kecil Dan Sederhana Di Madura, Jawa Timur, Indonesia / Mohammad Hamidi, Abdullah Mohammad Hamidi

Student Works (2010-2019)

Kajian ini bertujuan untuk menganalisis pelaksanaan kutipan zakat perniagaan dalam kalangan usahawan Muslim industri kecil sederhana (IKS) di Madura Provinsi Jawa Timur Indonesia. Kajian bermula daripada dalil al-Qur’an dan Hadis yang menyatakan wajibnya membayar zakat perniagaan, dan diteruskan dengan analisis bilangan IKS yang masuk kategori muzakki, potensi kutipan zakat, serta sumbangan kepada asnaf fakir miskin di Madura. Kajian ini juga menganalisis pengamalan zakat perniagaan IKS serta bilangan hasil kutipan zakat perniagaan IKS oleh amil zakat kerajaan di Madura. Manakala metode pengumpulan data dalam kajian ini adalah temu bual dengan pengurus amil zakat kerajaan, soal selidik yang disebarkan kepada usahawan Muslim …

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Pemilihan Perkataan Dan Struktur Morfologi Dalam Surah Al-Fatihah / Mat Taib Bin Pa, Pa Mat Taib Jan 2012

Pemilihan Perkataan Dan Struktur Morfologi Dalam Surah Al-Fatihah / Mat Taib Bin Pa, Pa Mat Taib

Student Works (2010-2019)

Kajian ini membincangkan mengenai pemilihan perkataan dan struktur morfologi dalam al-Quran al-Karim secara amnya dan surah al-Fatihah secara khasnya. Ini adalah kerana perkataan Arab boleh dilihat daripada beberapa sudut makna, iaitu makna tersurat, makna tersirat, makna majazi dan makna kinayah. Di samping itu, ia juga boleh dilihat dari sudut sinonim, polisemi dan taḍaadd. Dari aspek morfologi pula, perkataan Arab mempunyai banyak pola kata yang mempunyai perbezaan yang halus dan terperinci bukan sahaja antara kategori yang berlainan, malah antara kategori yang sama. Persoalan yang timbul ialah bagaimana pemilihan itu dilakukan? Justeru, kajian ini bertujuan untuk mengkaji sebab dan rahsia pemilihan perkataan …

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Topic Familiarization And Vocabulary Introduction In Second Language Reading / Mohsen Pornour, Mohsen Pornour Jan 2012

Topic Familiarization And Vocabulary Introduction In Second Language Reading / Mohsen Pornour, Mohsen Pornour

Student Works (2010-2019)

Although the field of second language teaching and learning has witnessed an enormous amount of research on reading skills, in general, and on topic familiarity and vocabulary teaching/learning, in particular, almost no attention has been paid to the teacher‟s role in topic familiarization and vocabulary introduction. In an attempt to fill this gap, and in an explanatory mixed methods design, the present study investigated the effects of the teacher‟s intervention in an L2 reading class by comparing the applicability of written topic familiarization with the effectiveness of teacher-directed topic familiarization in students‟ performance of comprehension tests. Furthermore, the adequacy of …

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Kaedah Psikoterapi Berasaskan Konsep Maqamat : Kajian Terhadap Kitab Qut Al-Qulub Abu Talib Al-Makki / Sharifah Basirah Binti Syed Muhsin, Sharifah Basirah Syed Muhsin Jan 2012

Kaedah Psikoterapi Berasaskan Konsep Maqamat : Kajian Terhadap Kitab Qut Al-Qulub Abu Talib Al-Makki / Sharifah Basirah Binti Syed Muhsin, Sharifah Basirah Syed Muhsin

Student Works (2010-2019)

Kajian ini yang berlandaskan kaedah penyelidikan perpustakaan menggunakan analisis kualitatif deskriptif adalah bertujuan membina kaedah psikoterapi Islam berasaskan perbahasan maqamat seorang tokoh sufi terkenal, Abu Talib al-Makki (m. 386H/966M) dalam karyanya yang terkenal, Qut al-Qulub. Secara khususnya, ia membincangkan latar belakang penulisan Qut al-Qulub dan idea-idea utamanya, dengan pemfokusan kepada al-maqamat dan kemudiannya merumuskan satu kaedah psikoterapi Islam. Bagi mencapai objektif tersebut, kajian ini dibahagi kepada enam bab iaitu bab pendahuluan, bab pertama mengenai latar belakang tokoh tasawuf Abu Talib al-Makki serta pengenalan kitab Qut al-Qulub, bab kedua membincangkan mengenai konsep maqamat dalam tasawuf dan hubungannya dengan psikoterapi Islam secara …

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Investigating Information Seeking Anxiety Among Postgraduate Students : Development And Validation Of A Multidimensional Scale / Mohammadamin Erfanmanesh, Mohammadamin Erfanmanesh Jan 2012

Investigating Information Seeking Anxiety Among Postgraduate Students : Development And Validation Of A Multidimensional Scale / Mohammadamin Erfanmanesh, Mohammadamin Erfanmanesh

Student Works (2010-2019)

The current study aims to determine whether a valid and reliable instrument could be developed and validated to measure levels of anxiety experienced by postgraduate students during the information seeking process. It also attempts to determine the prevalence and correlates of the information seeking anxiety among postgraduate students at a research intensive university in Kuala Lumpur, Malaysia. Results of the study indicated that the newly developed scale, the Information Seeking Anxiety Scale (ISAS), had satisfactory face, content, and construct validity as well as internal reliability. The Information Seeking Anxiety Scale (ISAS) contains thirty-eight (38) 5-point Likert-format items that measures seven …

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Gerakan Dakwah Di Kota Kinabalu : Kajian Terhadap Pertubuhan Islam Seluruh Sabah (Usia) / Suzanah Binti Nilam, Suzanah Nilam Jan 2012

Gerakan Dakwah Di Kota Kinabalu : Kajian Terhadap Pertubuhan Islam Seluruh Sabah (Usia) / Suzanah Binti Nilam, Suzanah Nilam

Student Works (2010-2019)

Disertasi ini memberikan tumpuan kepada usaha yang dilakukan oleh Pertubuhan Islam Seluruh Sabah iaitu USIA dalam mengerakkan dakwah Islamiah. Usaha yang dilakukan memfokuskan kepada strategi yang digunakan dan diadaptasikan menerusi program dakwah yang dijalankan. Selain strategi dan program dakwah, cabaran dakwah juga menjadi tumpuan dalam kajian ini. Kajian yang dilakukan ini merupakan kajian lapangan dan perpustakaan. Pengkaji menggunakan metod historis, metod dokumentasi serta metod wawancara dalam proses pengumpulan data. Manakala metod induktif, metod deduktif dan metod komparatif digunakan dalam proses menganalisa data. Melalui kajian ini, pengkaji mengenal pasti program yang dijalankan oleh USIA disamping mengetahui strategi dakwah yang digunapakai serta …

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Pembentukan Model Keberkesanan Pengintegrasian Teknologi Dalam Pengajaran Dan Pembelajaran Di Sekolah Rendah Malaysia / Qhamariah Samu, Qhamariah Samu Jan 2012

Pembentukan Model Keberkesanan Pengintegrasian Teknologi Dalam Pengajaran Dan Pembelajaran Di Sekolah Rendah Malaysia / Qhamariah Samu, Qhamariah Samu

Student Works (2010-2019)

Kajian ini bertujuan menyelidik kepadanan model yang dicadangkan dengan data yang dikumpulkan daripada 1428 responden yang terdiri daripada guru besar, guru penolong kanan, guru mata pelajaran sains, matematik dan bahasa Inggeris di sekolah rendah seluruh Malayisa. Faktor-faktor yang dikaji adalah kekangan luaran atau kekangan tahap pertama seperti Kompetensi teknologi, infrastruktur teknologi, motivasi daripada pihak luar, kepimpinan teknologi dan perhubungan faktor-faktor ini dengan keberkesanan pengintegrasian teknologi. Pendekatan Model persamaan struktural (Structural Equation Modeling) digunakan untuk menerangkan perhubungan antara faktor. Kajian ini juga menyelidik kesan mediation faktor kepimpinan teknologi dan kesan moderation faktor demografi iaitu peranan, lokasi sekolah dan mata pelajaran. Dapatan …

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Disruption Of Mammalian Dream Complexes By Human Papilomavirus E7 Proteins / Nurshamimi Nor Rashid, Rashid Nurshamimi Nor Jan 2012

Disruption Of Mammalian Dream Complexes By Human Papilomavirus E7 Proteins / Nurshamimi Nor Rashid, Rashid Nurshamimi Nor

Student Works (2010-2019)

Human papillomaviruses have been identified as the major aetiological factor in cervical cancer. Constitutive expression of the high risk HPV E6 and E7 oncoproteins are important for malignant transformation in infected keratinocytes. In particular, E6 and E7 bind to and inactivate the cellular tumor suppressors p53 and pRB, respectively, thus delaying differentiation and inducing proliferation in suprabasal keratinocytes to enable HPV replication. One member of the pRB family, p130 appears to be an important target for E7 in promoting S-phase entry. Recently, it has been discovered that p130 is part of a large protein complex termed DREAM. The composition of …

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Penguasaan Masdar : Satu Kajian Dalam Kalangan Pelajar Bahasa Arab Di Ipts Perak / Mohamad Faizal Bin Amat @ Mohd Yusoff, Amat @ Mohd Yusoff Mohamad Faizal Jan 2012

Penguasaan Masdar : Satu Kajian Dalam Kalangan Pelajar Bahasa Arab Di Ipts Perak / Mohamad Faizal Bin Amat @ Mohd Yusoff, Amat @ Mohd Yusoff Mohamad Faizal

Student Works (2010-2019)

Pengkaji menyiapkan sebuah disertasi yang bertajuk “Penguasaan Masdar : Satu Kajian Dalam Kalangan Pelajar Bahasa Arab Di IPTS Perak”. Kajian ini membicarakan tentang penguasaan pelajar-pelajar di IPTS Perak berkaitan dengan Masdar di dalam Nahu Bahasa Arab. Penguasaan ini meliputi kemahiran bertutur dan menulis di dalam Bahasa Arab. Kandungan disertasi ini juga menyentuh beberapa perkara berkaitan penguasaan Masdar di kalangan pelajar iaitu dari sudut pencapaian pemahaman tentang tajuk ini di samping menerangkan beberapa masalah yang mempengaruhi pencapaian pelajar. Pada peringkat permulaan pengkaji membuat kajian perpustakaan berkaitan masdar dan diterangkan di dalam sebuah bab disertasi ini. Ia meliputi beberapa bab masdar yang …

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A Scalable And Secure Position-Based Routing Protocol For Ad-Hoc Networks / Liana K. M. Qabajeh, Liana K. M. Qabajeh Jan 2012

A Scalable And Secure Position-Based Routing Protocol For Ad-Hoc Networks / Liana K. M. Qabajeh, Liana K. M. Qabajeh

Student Works (2010-2019)

Mobile Ad-Hoc NETworks (MANETs) are wireless multi-hop networks formed by a set of mobile nodes in a self-organizing way without requiring already established infrastructure. Along with their traditional uses such as disaster situations and military battlefields, MANETs are being increasingly used in daily applications such as conferences, personal area networking and meetings. Routing in MANETs is a challengeable task due to limited bandwidth of wireless links, highly dynamic topology, limited radio transmission range and limited nodes‟ energy. Though security issues could arise in numerous areas in MANETs such as physical security, key management and intrusion detection, routing is considered as …

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Life-Cycle Financial Planning In Malaysia: Investment Planning And Strategies For The Post-Retirement Period / Tan Hoe Kock, Hoe Kock Tan Jan 2012

Life-Cycle Financial Planning In Malaysia: Investment Planning And Strategies For The Post-Retirement Period / Tan Hoe Kock, Hoe Kock Tan

Student Works (2010-2019)

This study examines the extent Malaysians make financial preparations and their readiness for retirement and the predictors of retirement plans based on the life-cycle model that people seek to maintain their living standards by smoothing their consumption, as they age and face life’s various contingencies. The study delved into the concept of life-cycle financial planning, life-cycle theories of savings, consumption, and investing, and the critical issues surrounding the study of retirement, particularly investment planning strategies for financing consumption during the postretirement period. The three potential sources of post-retirement income for Malaysians are: a defined benefit (DB) pension for retired civil …

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An Artificial Co-Stimulation Classifier For Malicious Api Calls Classification In Portable Executable Malwares / Saman Mirza Abdulla, Saman Mirza Abdulla Jan 2012

An Artificial Co-Stimulation Classifier For Malicious Api Calls Classification In Portable Executable Malwares / Saman Mirza Abdulla, Saman Mirza Abdulla

Student Works (2010-2019)

Recently, most researchers have employed behaviour based detection systems to classify Portable Executable (PE) malwares. They usually tried to identify malicious Application Programming Interface (API) calls among the sequence of calls that made by a suspected application. They depended mostly on measuring the similarity or the distance between the suspected API calls with a set of predefined calls that collected from normal and malware applications. However, malwares always tried to keep their normality through hiding their malicious activities. Within such behaviours, calls that made by PE malwares become more similar to normal, which in turn, challenging most distinguishing models. Even …

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Reading Comprehension Difficulties Among Middle Eastern Students / Ihab A. Abdulaziz, A. Abdulaziz Ihab Jan 2012

Reading Comprehension Difficulties Among Middle Eastern Students / Ihab A. Abdulaziz, A. Abdulaziz Ihab

Student Works (2010-2019)

Reading is a process that requires effort on the readers’ part if they want to understand what they are reading. A vast amount of research has been devoted to understand processes that contribute to reading comprehension. As part of that research, this study was conducted to explore problems or difficulties faced by 30 Middle Eastern students in the University of Malaya when they read texts in English and the reading strategies used by them. Based on the hypotheses that the students lack of ability to identify main ideas, infer information, deduce meaning from context, elicit specific information or details, guess …

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Sokongan Organisasi Dan Konflik Kerja-Famili Terhadap Pengayaan Kerja-Famili Dalam Kalangan Wanita Profesional Di Sarawak / Surena Bt Sabil, Surena Sabil Jan 2012

Sokongan Organisasi Dan Konflik Kerja-Famili Terhadap Pengayaan Kerja-Famili Dalam Kalangan Wanita Profesional Di Sarawak / Surena Bt Sabil, Surena Sabil

Student Works (2010-2019)

Bagi merealisasikan visi negara ke arah negara maju pada tahun 2020, pelbagai usaha yang agresif telah dijalankan seperti wujudnya pelbagai program transformasi yang memerlukan komitmen daripada semua pihak tanpa mengira ideologi, latarbelakang, budaya dan gender. Seiring dengan visi negara, penghargaan terhadap penglibatan wanita bekerja perlu ditingkatkan kerana sumbangan berterusan mereka dalam pembangunan modal insan negara. Senario ini telah menyebabkan berlakunya transformasi terhadap tren demografi yang mempengaruhi komposisi tenaga kerja, peningkatan famili dwi-kerjaya, famili tunggal dan kekaburan peranan. Seterusnya, kepelbagaian peranan yang dialami oleh wanita bekerja turut menimbulkan implikasi negatif seperti tekanan, namun pada hakikatnya terdapat manfaat dan hikmah bagi wanita …

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Assessing Information Security Management In Malaysian Academic Libraries / Roesnita Binti Ismail, Roesnita Ismail Jan 2012

Assessing Information Security Management In Malaysian Academic Libraries / Roesnita Binti Ismail, Roesnita Ismail

Student Works (2010-2019)

This research aimed to study the perceived threats of information security, their frequency of occurrence and the perceived main source of information security threats in Malaysian academic libraries. Utilising the relevant literature, a possible list of information security threats were listed and investigated. In addition, the researcher also studied the levels of implementation of information security measures in these academic libraries. The information security measures were grouped into five (5) components that represent the proposed library information security assessment model (LISAM). The five (5) components included the technological measures, information security policies, security procedures, security methods and security awareness creation …

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Development, Expression And Characterization Of Humanized Anti-C2 Monoclonal Antibody / Suba Dharshanan A/L Panja Bernam, Panja Bernam Suba Dharshanan Jan 2012

Development, Expression And Characterization Of Humanized Anti-C2 Monoclonal Antibody / Suba Dharshanan A/L Panja Bernam, Panja Bernam Suba Dharshanan

Student Works (2010-2019)

Humanized monoclonal antibodies (mAbs) are widely used for diagnosis and treatment of cancer due to their reduced immunogenicity and high specificity. In this project, we aimed to develop procedures to produce, with high efficiency in terms continuity of production, lowered cost and increased speed, humanized mAbs against C2-antigen (hum-C2 mAbs), a marker specifically expressed in colorectal and ovarian cancer, from mAb of mouse origin. The resulting hum-C2 mAbs must still retain their original specificity and functionality, but possess reduced immunogenicity. Two methods of humanization were compared to identify potential immunogenic mouse amino acids in the variable regions: a deimmunization method …

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Gender Differences In The Reactivity Of Normoglycemic And Diabetic Rat Aorta And The Effects Of Quercetin And 17Β-Estradiol / Aloysius Umelo Iguegbe, Umelo Iguegbe Aloysius Jan 2012

Gender Differences In The Reactivity Of Normoglycemic And Diabetic Rat Aorta And The Effects Of Quercetin And 17Β-Estradiol / Aloysius Umelo Iguegbe, Umelo Iguegbe Aloysius

Student Works (2010-2019)

Background & objectives: Diabetes is a stronger risk factor in the development of cardiovascular diseases in the female than the male gender. Diabetes-induced reactive oxygen species (ROS) alters the function of endogenous vasoconstrictors for which the antioxidant, quercetin, has been shown to restore in diabetic male rats, which has not been proven in the female. The female hormone, estradiol (a potent antioxidant), combined with quercetin may offer greater protection against diabetes/ROS-induced vascular reactivity. Therefore, the influence of gender on the response of normoglycemic/diabetic aorta to vasoconstrictors in the presence/absence of quercetin/estradiol, including mechanisms underlying any differences in tissue responses was …

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The Role Of Gelam Honey In Modulating The Immune Reponse Of Sepsis In Animal Model / Mustafa Kassim, Mustafa Kassim Jan 2012

The Role Of Gelam Honey In Modulating The Immune Reponse Of Sepsis In Animal Model / Mustafa Kassim, Mustafa Kassim

Student Works (2010-2019)

Persistent systemic inflammatory response syndrome is a serious health condition that may lead to multiple organ dysfunction, organ failure, and ultimately death. It leads to both acute inflammation, caused by either infective (microbes or lipopolysaccharide [LPS]) or non-infective (chemicals) sources, and sepsis, an infection caused by a lethal dose of LPS (endotoxemia). These conditions have similar inflammatory mediators such as cytokines, nitric oxide (NO), high-mobility group box-1 (HMGB1), and heme oxygenase-1 (HO-1), suggesting that they may result from similar pathogenic mechanisms. Previous studies have investigated the applications of natural products in targeting these inflammatory mediators. Honey, for example, is used …

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Why Women Present With Advanced Breast Cancer - A Mixed Methods Study / Nur Aishah Binti Mohd Taib, Mohd Taib Nur Aishah Jan 2012

Why Women Present With Advanced Breast Cancer - A Mixed Methods Study / Nur Aishah Binti Mohd Taib, Mohd Taib Nur Aishah

Student Works (2010-2019)

No abstract provided.

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The Influence Of Simon Stevin (1548-1620) Principles On Dutch Towns And Buildings Outside The Netherlands: Case Study Of Melaka / Robert C.M. Weebers, Robert C.M. Weebers Jan 2012

The Influence Of Simon Stevin (1548-1620) Principles On Dutch Towns And Buildings Outside The Netherlands: Case Study Of Melaka / Robert C.M. Weebers, Robert C.M. Weebers

Student Works (2010-2019)

This research concentrates on the influence of the Dutch architect and mathematician Simon Stevin (1548-1620). Stevin's ideas on forts, town planning and buildings are laid down in treatises and have had a great influence on the construction of forts in the Netherlands and forts and outposts of the VOC/Dutch in Asia specifically in East Indies, India, Sri Lanka and Malaya (Melaka). The objectives of this research are: to study and clarify Dutch architectural principles to establish new towns (settlements) outside the Netherlands. Specifically in East Indies India, Sri Lanka, and Malaya (Melaka). To study the implementation of Dutch treatise principles …

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Virtual Screening And Biological Assay Of Compound Libraries For Anticholinesterase Activity / Sri Devi D/O Sukumaran, Sri Devi Sukumaran Jan 2012

Virtual Screening And Biological Assay Of Compound Libraries For Anticholinesterase Activity / Sri Devi D/O Sukumaran, Sri Devi Sukumaran

Student Works (2010-2019)

The current research was aimed at finding peripheral anionic site (PAS) binding acetylcholinesterase (AChE) inhibitors to be used in the treatment of Alzheimer’s disease (AD). The crystal structure of human acetylcholinesterase (hAChE) in complex with fasciculin II (2.76 Ǻ) (PDB ID: 1b41) was found to be the most suitable protein for identifying PAS binding ligands in docking studies and was used for virtual screening of about 830 unknown ligands. Twenty-one compounds with a lowest binding energy ranging from -8.7 kcal/mol to -5.6 kcal/mol were selected for testing for AChE inhibitory activity. Four of these compounds were found to inhibit AChE …

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