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2012

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Age-Related Differences In Corpus Callosum Area Of Capuchin Monkeys, Kimberley A. Phillips, Chet C. Sherwood Jan 2012

Age-Related Differences In Corpus Callosum Area Of Capuchin Monkeys, Kimberley A. Phillips, Chet C. Sherwood

Psychology Faculty Research

Capuchin monkeys (Cebus apella) are New World primates with relatively large brains for their body size. The developmental trajectories of several brain regions-including cortical white matter, frontal lobe white matter, and basal ganglia nuclei-are similar to humans. Additionally, capuchins have independently evolved several behavioral and anatomical characteristics in common with humans and chimpanzees-including complex manipulative abilities, use of tools, and the use of precision grips-making them interesting species for studies of comparative brain morphology and organization. Here, we report the first investigation into the development of the corpus callosum (CC) and its regional subdivisions in capuchins. CC development …


Structural Insight Into Mr1-Mediated Recognition Of The Mucosal Associated Invariant T Cell Receptor, Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T. Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H. Hansen, Dale I. Godfrey, Jamie Rossjohn, James Mccluskey Jan 2012

Structural Insight Into Mr1-Mediated Recognition Of The Mucosal Associated Invariant T Cell Receptor, Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T. Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H. Hansen, Dale I. Godfrey, Jamie Rossjohn, James Mccluskey

Open Access Publications

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I-like molecule (MR1). However, the molecular basis for MAIT TCR recognition by MR1 is unknown. In this study, we present the crystal structure of a human Vα7.2Jα33-Vβ2 MAIT TCR. Mutagenesis revealed highly conserved requirements for the MAIT TCR-MR1 interaction across different human MAIT TCRs stimulated by distinct microbial sources. Individual residues within the MAIT TCR β chain were dispensable for the interaction with MR1, whereas the invariant MAIT TCR α chain controlled specificity through a small number of residues, which are conserved across …


Micrornas Are Exported From Malignant Cells In Customized Particles, Jaime Palma, Scree C. Yaddanapudi, Lucy Pigati, Mallory A. Havens, Sarah Jeong, Geoffrey A. Weiner, Kristina Mary Ellen Weimer, Brittany Stern, Michelle L. Hastings, Dominik M. Duelli Jan 2012

Micrornas Are Exported From Malignant Cells In Customized Particles, Jaime Palma, Scree C. Yaddanapudi, Lucy Pigati, Mallory A. Havens, Sarah Jeong, Geoffrey A. Weiner, Kristina Mary Ellen Weimer, Brittany Stern, Michelle L. Hastings, Dominik M. Duelli

Open Access Publications

No abstract provided.


Wormbase 2012: More Genomes, More Data, New Website, Karen Yook, Tamberlyn Bieri, Bill Nash, Philip Ozersky, John Spieth Jan 2012

Wormbase 2012: More Genomes, More Data, New Website, Karen Yook, Tamberlyn Bieri, Bill Nash, Philip Ozersky, John Spieth

Open Access Publications

No abstract provided.


Scertf: A Comprehensive Database Of Benchmarked Position Weight Matrices For Saccharomyces Species, Aaron T. Spivak, Gary D. Stormo Jan 2012

Scertf: A Comprehensive Database Of Benchmarked Position Weight Matrices For Saccharomyces Species, Aaron T. Spivak, Gary D. Stormo

Open Access Publications

No abstract provided.


Acute Respiratory Distress Syndrome: Pathophysiology And Therapeutic Options, Charalampos Pierrakos, Menelaos Karanikolas, Sabino Scolletta, Vasilios Karamouzos, Dimitrios Velissaris Jan 2012

Acute Respiratory Distress Syndrome: Pathophysiology And Therapeutic Options, Charalampos Pierrakos, Menelaos Karanikolas, Sabino Scolletta, Vasilios Karamouzos, Dimitrios Velissaris

Open Access Publications

No abstract provided.


Introduction: The Politics Of Hate, Robert L. Tsai Jan 2012

Introduction: The Politics Of Hate, Robert L. Tsai

Faculty Scholarship

This is a special issue dedicated to the topic of hate and political discourse. Collectively, the peer-reviewed articles in this volume are concerned with the political aspects of hatred, i.e., psychology, motivations, organization, tactics, and ends. The articles approach the problem from a variety of disciplines, including anthropology, history, law, literature, philosophy, political science, psychology, and sociology. Among the subjects analyzed: group hatred as a heritable trait; hate as an irrational system of thought; Italian fascism's construction of the Communist other; the rise of the English Defence League and its anti-Islam activities; the persistent myth of blood libel; judicial handling …


Quantitative Trait Loci Affecting Liver Fat Content In Mice, Olga Minkina, James M. Cheverud, Gloria Fawcett, Clay F. Semenkovich, Jane P. Kenney-Hunt Jan 2012

Quantitative Trait Loci Affecting Liver Fat Content In Mice, Olga Minkina, James M. Cheverud, Gloria Fawcett, Clay F. Semenkovich, Jane P. Kenney-Hunt

Open Access Publications

No abstract provided.


Conserved Motifs And Prediction Of Regulatory Modules In Caenorhabditis Elegans, Guoyan Zhao, Nnamdi Ihuegbu, Mo Lee, Larry Schriefer, Ting Wang, Gary D. Stormo Jan 2012

Conserved Motifs And Prediction Of Regulatory Modules In Caenorhabditis Elegans, Guoyan Zhao, Nnamdi Ihuegbu, Mo Lee, Larry Schriefer, Ting Wang, Gary D. Stormo

Open Access Publications

No abstract provided.


Whole-Genome Sequencing To Identify Mutants And Polymorphisms In Chlamydomonas Reinhardtii, Susan K. Dutcher, Linya Li, Huawen Lin, Leslie Meyer, Thomas H. Giddings Jr., Alan L. Kwan, Brian L. Lewis Jan 2012

Whole-Genome Sequencing To Identify Mutants And Polymorphisms In Chlamydomonas Reinhardtii, Susan K. Dutcher, Linya Li, Huawen Lin, Leslie Meyer, Thomas H. Giddings Jr., Alan L. Kwan, Brian L. Lewis

Open Access Publications

No abstract provided.


A Noncomplementation Screen For Quantitative Trait Alleles In Saccharomyces Cerevisiae, Hyun Seok Kim, Juyoung Huh, Linda Riles, Alejandro Reyes, Justin C. Fay Jan 2012

A Noncomplementation Screen For Quantitative Trait Alleles In Saccharomyces Cerevisiae, Hyun Seok Kim, Juyoung Huh, Linda Riles, Alejandro Reyes, Justin C. Fay

Open Access Publications

No abstract provided.


Schistosome-Derived Omega-1 Drives Th2 Polarization By Suppressing Protein Synthesis Following Internalization By The Mannose Receptor, Bart Everts, Leonie Hussaarts, Nicole N. Driessen, Moniek H.J. Meevissen, Gabriele Schramm, Alwin J. Van Der Ham, Barbara Van Der Hoeven, Thomas Scholzen, Sven Burgdorf, Markus Mohrs, Edward J. Pearce, Cornelis H. Hokke, Helmut Haas, Hermelijn H. Smits, Maria Yazdanbakhsh Jan 2012

Schistosome-Derived Omega-1 Drives Th2 Polarization By Suppressing Protein Synthesis Following Internalization By The Mannose Receptor, Bart Everts, Leonie Hussaarts, Nicole N. Driessen, Moniek H.J. Meevissen, Gabriele Schramm, Alwin J. Van Der Ham, Barbara Van Der Hoeven, Thomas Scholzen, Sven Burgdorf, Markus Mohrs, Edward J. Pearce, Cornelis H. Hokke, Helmut Haas, Hermelijn H. Smits, Maria Yazdanbakhsh

Open Access Publications

Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime Th2 responses. However, the molecular mechanisms underlying this effect remain unknown. We show in this study by site-directed mutagenesis of omega-1 that both the glycosylation and the RNase activity are essential to condition DCs for Th2 polarization. Mechanistically, we demonstrate that omega-1 is bound and internalized via its glycans by the mannose receptor (MR) and subsequently impairs protein synthesis by degrading both ribosomal and messenger RNA. These experiments reveal an unrecognized …


Zbtb46 Expression Distinguishes Classical Dendritic Cells And Their Committed Progenitors From Other Immune Lineages, Ansuman T. Satpathy, Wumesh Kc, Jörn C. Albring, Brian T. Edelson, Nicole M. Kretzer, Deepta Bhattacharya, Theresa L. Murphy, Kenneth M. Murphy Jan 2012

Zbtb46 Expression Distinguishes Classical Dendritic Cells And Their Committed Progenitors From Other Immune Lineages, Ansuman T. Satpathy, Wumesh Kc, Jörn C. Albring, Brian T. Edelson, Nicole M. Kretzer, Deepta Bhattacharya, Theresa L. Murphy, Kenneth M. Murphy

Open Access Publications

Distinguishing dendritic cells (DCs) from other cells of the mononuclear phagocyte system is complicated by the shared expression of cell surface markers such as CD11c. In this study, we identified Zbtb46 (BTBD4) as a transcription factor selectively expressed by classical DCs (cDCs) and their committed progenitors but not by plasmacytoid DCs (pDCs), monocytes, macrophages, or other lymphoid or myeloid lineages. Using homologous recombination, we replaced the first coding exon of Zbtb46 with GFP to inactivate the locus while allowing detection of Zbtb46 expression. GFP expression in Zbtb46(gfp/+) mice recapitulated the cDC-specific expression of the native locus, being restricted to cDC …


Student Masthead, Mjlst Editorial Board Jan 2012

Student Masthead, Mjlst Editorial Board

Minnesota Journal of Law, Science & Technology

No abstract provided.


Returning Individual Research Results: What Role Should People’S Preferences Play?, Lisa S. Parker Jan 2012

Returning Individual Research Results: What Role Should People’S Preferences Play?, Lisa S. Parker

Minnesota Journal of Law, Science & Technology

No abstract provided.


Deidentification And Reidentification In Returning Individual Findings From Biobank And Secondary Research: Regulatory Challenges And Models For Management, William Mcgeveran, Leili Fatehi, Pari Mcgarraugh Jan 2012

Deidentification And Reidentification In Returning Individual Findings From Biobank And Secondary Research: Regulatory Challenges And Models For Management, William Mcgeveran, Leili Fatehi, Pari Mcgarraugh

Minnesota Journal of Law, Science & Technology

No abstract provided.


Perspective On Biorepository Return Of Results And Incidental Findings, Scott D. Jewell Jan 2012

Perspective On Biorepository Return Of Results And Incidental Findings, Scott D. Jewell

Minnesota Journal of Law, Science & Technology

No abstract provided.


The Tension Between Policy And Practice In Returning Research Results And Incidental Findings In Genomic Biobank Research, Sharon F. Terry Jan 2012

The Tension Between Policy And Practice In Returning Research Results And Incidental Findings In Genomic Biobank Research, Sharon F. Terry

Minnesota Journal of Law, Science & Technology

No abstract provided.


Uvas Unidas: A Research Study And Campaign Design For Hispanic Millennials, Candace Margaret Rodriguez Jan 2012

Uvas Unidas: A Research Study And Campaign Design For Hispanic Millennials, Candace Margaret Rodriguez

Honors Theses

The Hispanic market is a fast growing demographic that has begun to drastically reshape the population composition of the United States. Many unique and different cultures and identities are represented under the label, “Hispanic." Many companies have started l recognizing the value and importance of the Hispanic demographic. Along with the rising Hispanic population, Millennials are becoming an increasingly significant market. Hispanics have a lower median age, 25.4, than both African Americans and Caucasians in the United States and play a vital role as members of the Millennial generation. Hispanic Millennials are a market segment that is often overlooked. A …


La Jurisprudence Américaine En Matière De “Class Arbitration”: Entre Débat Politique Et Technique Juridique, William W. Park Jan 2012

La Jurisprudence Américaine En Matière De “Class Arbitration”: Entre Débat Politique Et Technique Juridique, William W. Park

Faculty Scholarship

Arbitration law implicates a delicate equilibrium between respect for the bargain to arbitrate and protection of basic procedural fairness. The role of law thus remains intimately linked to the rule of law, in the sense of an impartial tribunal, the right to be heard, and respect for the arbitrator's mission. The legitimacy of the process depends on how arbitrators balance the often competing goals of due process and efficiency, and whether the authorities that review awards can monitor procedural integrity without infringing an arbitrator's prerogatives on a dispute's substantive merits. Two U.S. Supreme Court decisions on class arbitration serve as …


Hippocampal Shape And Volume Changes With Antipsychotics In Early Stage Psychotic Illness, Daniel Mamah, Michael P. Harms, Deanna Barch, Martin Styner, Jeffrey A. Lieberman, Lei Wang Jan 2012

Hippocampal Shape And Volume Changes With Antipsychotics In Early Stage Psychotic Illness, Daniel Mamah, Michael P. Harms, Deanna Barch, Martin Styner, Jeffrey A. Lieberman, Lei Wang

Open Access Publications

No abstract provided.


Prefrontal And Striatal Activity Related To Values Of Objects And Locations, Soyoun Kim, Xinying Cai, Jaewon Hwang, Daeyeol Lee Jan 2012

Prefrontal And Striatal Activity Related To Values Of Objects And Locations, Soyoun Kim, Xinying Cai, Jaewon Hwang, Daeyeol Lee

Open Access Publications

No abstract provided.


Aptamers In Virology: Recent Advances And Challenges, Jennifer M. Binning, Daisy W. Leung, Gaya K. Amarasinghe Jan 2012

Aptamers In Virology: Recent Advances And Challenges, Jennifer M. Binning, Daisy W. Leung, Gaya K. Amarasinghe

Open Access Publications

No abstract provided.


Review Of The Bci Competition Iv, Gerwin Schalk, Et Al Jan 2012

Review Of The Bci Competition Iv, Gerwin Schalk, Et Al

Open Access Publications

No abstract provided.


Isolated Lymphoid Follicles Are Dynamic Reservoirs For The Induction Of Intestinal Iga, Kathryn A. Knoop, Rodney D. Newberry Jan 2012

Isolated Lymphoid Follicles Are Dynamic Reservoirs For The Induction Of Intestinal Iga, Kathryn A. Knoop, Rodney D. Newberry

Open Access Publications

No abstract provided.


Palmetto Area Council Boy Scouts Of America Records - Accession 213, Boy Scouts Of America, Palmetto Area Council Jan 2012

Palmetto Area Council Boy Scouts Of America Records - Accession 213, Boy Scouts Of America, Palmetto Area Council

Manuscript Collection

The Palmetto Area Council Boy Scouts of America Records is a source of boy scouting records in the upstate area of South Carolina during the twentieth century. While the Palmetto Area Council was organized in 1935, records of boy scouting in the area begin earlier and continue until the late 1960s. The collection consists of a brief history of the council, newspaper clippings, photographs, certificate of election, minutes of an organizational meeting, annual reports, a trust fund brochure and program for 1938 testimonial dinner. These records give a brief overview of the history of the Palmetto Area Council. They are …


Temporal Evolution Of Gamma Activity In Human Cortex During An Overt And Covert Word Repetition Task, Eric C. Leuthardt, Xiao-Mei Pei, Jonathan Breshears, Charles Gaona, Mohit Sharma, Zac Freudenberg, Dennis Barbour, Gerwin Schalk Jan 2012

Temporal Evolution Of Gamma Activity In Human Cortex During An Overt And Covert Word Repetition Task, Eric C. Leuthardt, Xiao-Mei Pei, Jonathan Breshears, Charles Gaona, Mohit Sharma, Zac Freudenberg, Dennis Barbour, Gerwin Schalk

Open Access Publications

No abstract provided.


Leishmania Rna Virus: When The Host Pays The Toll, Mary-Anne Hartley, Catherine Ronet, Haroun Zangger, Stephen M. Beverley, Nicolas Fasel Jan 2012

Leishmania Rna Virus: When The Host Pays The Toll, Mary-Anne Hartley, Catherine Ronet, Haroun Zangger, Stephen M. Beverley, Nicolas Fasel

Open Access Publications

No abstract provided.


An Enhancer From The 8q24 Prostate Cancer Risk Region Is Sufficient To Direct Reporter Gene Expression To A Subset Of Prostate Stem-Like Epithelial Cells In Transgenic Mice, Man-Chun Ting, Chun-Peng Liao, Chunli Yan, Li Jia, Susan Groshen, Baruch Frenkel, Pradip Roy-Burman, Gerhard A. Coetzee, Robert Maxson Jan 2012

An Enhancer From The 8q24 Prostate Cancer Risk Region Is Sufficient To Direct Reporter Gene Expression To A Subset Of Prostate Stem-Like Epithelial Cells In Transgenic Mice, Man-Chun Ting, Chun-Peng Liao, Chunli Yan, Li Jia, Susan Groshen, Baruch Frenkel, Pradip Roy-Burman, Gerhard A. Coetzee, Robert Maxson

Open Access Publications

No abstract provided.


Functional Consequences Of Subunit Diversity In Rna Polymerases Ii And V, Ek Han Tan, Todd Blevins, Thomas S. Ream, Craig S. Pikaard Jan 2012

Functional Consequences Of Subunit Diversity In Rna Polymerases Ii And V, Ek Han Tan, Todd Blevins, Thomas S. Ream, Craig S. Pikaard

Open Access Publications

No abstract provided.