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2012

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Normative Data Of Needle Electromyography, What Is Different In Iraqi Patients, Hasan Azeez Al-Hamadani, Zainulabdeen Abdulsamad Mahdi, Farah Al-Saffar, Atheer Sabah Fayahd Dec 2012

Normative Data Of Needle Electromyography, What Is Different In Iraqi Patients, Hasan Azeez Al-Hamadani, Zainulabdeen Abdulsamad Mahdi, Farah Al-Saffar, Atheer Sabah Fayahd

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: The electrodiagnostic studies are useful adjuncts to the clinical examination of the peripheral nervous system. Electromyography (EMG) records the physiologic status of muscle function. Needle electromyography help localize abnormalities along peripheral nerves or lower motor neurons. OBJECTIVE: To establish the normal electrophysiological values of the common upper and lower limbs muscles in sample of healthy adult population in Iraq using standard temperature control, and to compare with those data published in other studies. MATERIAL AND METHODS: This is a cross sectional study conducted in Al-Kadhmiya Teaching Hospital during the period from July 2008 to December 2009. The study …


Predictors Of Outcome For Spontaneous Intracerebral Hemorrhage In Iraqi Stroke Patients, Zaki N. Al Mousawi, Kareem M. Al Tameemi, Ghazi Farhan Haji Dec 2012

Predictors Of Outcome For Spontaneous Intracerebral Hemorrhage In Iraqi Stroke Patients, Zaki N. Al Mousawi, Kareem M. Al Tameemi, Ghazi Farhan Haji

Iraqi Postgraduate Medical Journal

ABSTRACT: BACK GROUND: Primary intracerebral hemorrhage (ICH) is one of the common vascular insults with a relatively high rate of morbidity and mortality and there are many factors which influence the outcome. OBJECTIVE: The aim of this study is to determine potential early predictors of outcome within first six days of primary spontaneous supratentorial hemorrhage and to evaluate the influence of those various factors on the mortality and morbidity of patients with intracerebral hemorrhage (ICH). METHOD: 70 patients (48 men and 22 women) were admitted to Baghdad teaching hospital, for the period from January 2010 to January 2011. They were …


Fistulotomy Versus Fistulectomy As A Primary Treatment Of Low Fistula In Ano, Zuhair Bashir Kamal Dec 2012

Fistulotomy Versus Fistulectomy As A Primary Treatment Of Low Fistula In Ano, Zuhair Bashir Kamal

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Fistula in ano is common surgical condition that is treated by different surgical modalities. OBJECTIVE: Is to compare the outcome and complications of fistulotomy and fistulectomy as primary treatment of low fistula in ano. PATIENTS AND METHODS: A prospective randomized study was done on 76 patients of low fistulae in ano who were admitted to the surgical department at Alkindy teaching hospital from January 2009-January 2010. Fistulotomy was done in 32 patients, and fistulectomy was done in 44 patients. Patients were followed up post operatively for one year and the healing time was estimated in both groups and …


Management Of Choledochal Cysts In Gastroenterology And Hepatology Teaching Hospital, Mohamed H Suadi, Wesam Shakir Hameed, Laith. R. Alhadad Dec 2012

Management Of Choledochal Cysts In Gastroenterology And Hepatology Teaching Hospital, Mohamed H Suadi, Wesam Shakir Hameed, Laith. R. Alhadad

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: A Choledochal cyst is a rare biliary disease mostly presenting during childhood. Adult presentation is rare and associated diseases and complications are common. OBJECTIVE: This study aims to review the management of patients who presented to our hospital with choledochal cysts, focusing on their presentation, preoperative investigations, treatment given and postoperative course. METHODS: A prospective and retrospective review of all our choledochal cysts patients from April 2000 to November 2010 was performed RESULTS: There were twenty three patients, sixteen females and seven males the average age was 25.82 (range 4-70) years. The commonest presenting complaints were abdominal pain …


Evaluation Of Functional Outcome After Open Reduction And Internal Fixation Of Capitellar Fracture With K. Wires, Adnan Husain Hnoosh Dec 2012

Evaluation Of Functional Outcome After Open Reduction And Internal Fixation Of Capitellar Fracture With K. Wires, Adnan Husain Hnoosh

Iraqi Postgraduate Medical Journal

ABSTRACT : BACKGROUND : Isolated capitellar fractures are uncommon. Authors continue to differ about the preferred method of treatments and it's results on the post operative outcome. OBJECTIVE: Of This study: Is to evaluate the clinical and functional out come of operatively treated capitellar fracture with K.Wire , and furthermore to define the impact of fracture type on the out come. PATIENTS AND METHOD: A retrospective study carried out on 15 patients Sustaind closed capitellar fracture , 11 females , 4 males. The main age (16 – 58 years). the Operative treatment performed at a mean of 10 days, by …


Prevalence Of Pressure Ulcers In Orthopaedic Patients, Ali M. Al-Shadedi Dec 2012

Prevalence Of Pressure Ulcers In Orthopaedic Patients, Ali M. Al-Shadedi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Pressure sore in orthopedic patients is a common problem with high expectation of occurrence on the ward, it should be watched for in any admitted patient having high liability for its development like, old age particularly those patients with dementia, patient with malnutrition or anemia and long stay in bed or complicated multiple surgeries. Orthopedic staff should be familiar with measures required to prevent and reduce its occurrence. OBJECTIVE: To highlight the prevalence, onset, types and number and the most common sites of pressure sores, length of stay in hospital with various types of treatment delivered to these …


The Correlation Between Insulin ,Il-6 And Crp In Acute Myocardial Infarction, Lmmma Esmaeel Ibrahim, Hadef Dhafer El-Yassin, Hamid Kareem Sachit Al-Janabi Dec 2012

The Correlation Between Insulin ,Il-6 And Crp In Acute Myocardial Infarction, Lmmma Esmaeel Ibrahim, Hadef Dhafer El-Yassin, Hamid Kareem Sachit Al-Janabi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Insulin is a hormone produced by the beta cells of the pancreas. Insulin is necessary for the uptake of glucose into all cells in the body other than the Brain. C reactive protein (CRP) is a main inflammatory factor that is produced by the liver during acute infection or inflammation and its concentration in plasma can increase as much as 1000-fold during injury and infection. Interleukin-6 (IL-6), a major regulatory proinflammatory cytokine, is produced by a variety of cells, including leukocytes, adipocytes, and endothelial cells, and acts on the liver to stimulate the production of a number of …


Evaluation Of Postnatal Prophylactic Program For Rhesus Isoimmunization, Taghreed K. Alhaidari, Murooge Abdul-Razza Dec 2012

Evaluation Of Postnatal Prophylactic Program For Rhesus Isoimmunization, Taghreed K. Alhaidari, Murooge Abdul-Razza

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Since the introduction of routine postpartum prophylaxis in the 1960s, the crude incidence of Rhesus isoimmunization has been declined all over the world. Iraq and due to many years of sanctions and wars had many occasions where there was a limited supply of this valuable injection. OBJECTIVE To evaluate the effectiveness of our preventive postnatal prophylactic protocol for Rhesus isoimmunization. METHODS: A Cohort observational study conducted at a private clinic and AL-Elwyia Maternity Teaching Hospital between the start of April 2010 till the end of June 2011. A total of 500 women were enrolled in the study; who …


Left Ventricular Remodeling Patterns In Chronic Heart Failure, Muataz Fawzi Hussein Dec 2012

Left Ventricular Remodeling Patterns In Chronic Heart Failure, Muataz Fawzi Hussein

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Patients with heart failure show a wide spectrum of changes in left ventricular volume, mass, and function. OBJECTIVE: The aims of this study were to define the patterns of left ventricular structural and functional remodeling and consider their clinical implications in patients with chronic heart failure. PATIENTS AND METHODS: Two-dimensional echocardiograms were obtained for patients with chronic heart failure in Baghdad teaching hospital during the period from February 2009 to February 2011 and were used to calculate left ventricular volume, mass, geometry, and ejection fraction. Inclusion required the diagnosis of heart failure in symptomatic patients on medical therapy. …


Echocardiographic Parameters Of Left Ventricle Systolic And Diastolic Function In Patients With Β-Thalassemia Major, Asaad Abdullah Abbas, Basil Najeb, Alaa Abdulhussein, Jassim Hanoon Jassim, Majid Abdulmuhsin Falih, Hussein Jubiaer, Qasim Mudalal Ubaid Dec 2012

Echocardiographic Parameters Of Left Ventricle Systolic And Diastolic Function In Patients With Β-Thalassemia Major, Asaad Abdullah Abbas, Basil Najeb, Alaa Abdulhussein, Jassim Hanoon Jassim, Majid Abdulmuhsin Falih, Hussein Jubiaer, Qasim Mudalal Ubaid

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Advances in the current treatment of β-thalassemia major have contributed to improve prognosis, and nowadays, an increasing number of patients do survive up to the third or fourth, decade. Cardiac complications are still the most common cause of death in patients with major thalassemia. OBJECTIVE: Assessment of Left ventricular systolic and diastolic parameters in β-Thalassemia Major patients and its relation to ferritin level and to spleen status. PATIENT AND METHODS: A Cross -sectional descriptive study done at Ibn Al- Albalady Hospital for Children and Maternity Baghdad city from beginning of January 2011-to the end of July 2011,( 427) …


Correlations Between Preoperative Measurement Of Prostate Volume By Transabdominal And Transrectal Ultrasound With Open Prostatectomy, Auda Hassan Ali Al.Jabbiri, Mohanad M.H. Al-Saed, Usama S. Al.Nasiri Dec 2012

Correlations Between Preoperative Measurement Of Prostate Volume By Transabdominal And Transrectal Ultrasound With Open Prostatectomy, Auda Hassan Ali Al.Jabbiri, Mohanad M.H. Al-Saed, Usama S. Al.Nasiri

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Despite being formally included in the assessment of patients presenting with lower urinary tract symptoms (LUTS), transrectal ultrasonography (TRUS) is not routinely offered to these patients. Data exist on the superiority of TRUS over transabdominal ultrasound in accurately predicting prostate volume. OBJECTIVE: To evaluate which of these methods are more accurate in calculation of prostate volume. The volume is most commonly measured using the formula, prostate volume=height×width×length /6, which is derived considering the gland as ellipsoid, PATIENTS AND METHODS: Thirty five patients aged (60-75) years; with mean age (65.1±4.016) years and mean of serum prostate specific antigen (PSA) …


The Effect Of Intradetrusor Botulinum Toxin Injection In Patients With Idiopathic Detrosur Overactivity, Waleed Nassar Jaffal, Hassanain Farhan Hasan, Adil Hifdhi Al-Sufi Dec 2012

The Effect Of Intradetrusor Botulinum Toxin Injection In Patients With Idiopathic Detrosur Overactivity, Waleed Nassar Jaffal, Hassanain Farhan Hasan, Adil Hifdhi Al-Sufi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: The overactive bladder (OAB) is extremely common. The treatment of refractory overactive bladder conditions has changed radically over the last decade. The efficacy of OAB treatment protocols in improving patient symptoms are not satisfactory, so new agents such as botulinum-A toxin must be investigated. OBJECTIVE: To evaluate the safety and efficacy of intradetrusor botulinum -A toxin injection in patients with idiopathic detrusor overactivity resistant to anticholinergic drugs. METHODS: From March 2010 to September 2011, 38 women with refractory idiopathic detrusor overactivity (IDO), from the urologic consultation department in Baghdad Medical City and Al-Ramadi teaching hospital, were included in …


Prevalence Of Hymenolepis Nana Infections In Abu-Ghraib City /Baghdad/Iraq, Huda Thaher Al- Marsome Dec 2012

Prevalence Of Hymenolepis Nana Infections In Abu-Ghraib City /Baghdad/Iraq, Huda Thaher Al- Marsome

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Intestinal parasitic infestation represents a considerable medical and public health problem in the developing countries and up to 10% of the population of the developing world is infected with intestinal worms(1). OBJECTIVE: This study was initiated to investigate the prevalence of H. nana infection in rural environments in Baghdad and to determine if the prevalence could be linked to the availability of water and sanitation facilities. MATERIAL AND METHODS: This study included 300 patients in the Abu-Ghraib province. Stool smear were prepared for each sample stool culture for Shigella spp. . Hemoglobin estimation was evaluated by Cyanmethemoglobin method. …


Emphysematous Pyelonephritis, Hayder Mahdi Al-Ardi Dec 2012

Emphysematous Pyelonephritis, Hayder Mahdi Al-Ardi

Iraqi Postgraduate Medical Journal

No abstract provided.


A Case Of Giant Uterine Fibroid In A Young Woman, Safa M.Al-Obaidi, Mohammed Abd-Zaid Akool Dec 2012

A Case Of Giant Uterine Fibroid In A Young Woman, Safa M.Al-Obaidi, Mohammed Abd-Zaid Akool

Iraqi Postgraduate Medical Journal

ABSTRACT: The incidence of uterine fibroid tumor increase as women grow older and they may occur in more than 30 percent of women 40 to 60 years of age. Risk factors include nulliparity, obesity, family history, black race, and hypertension. These neoplasms frequently cause abnormal period, pelvic pain, and pressure symptoms. We present a case report of a large leiomyoma in an adult woman


Morc2 Signaling Integrates Phosphorylation-Dependent, Atpase-Coupled Chromatin Remodeling During The Dna Damage Response, Da-Qiang Li, Sujit S. Nair, Kazufumi Ohshiro, Anupam Kumar, Vasudha S. Nair, Suresh B. Pakala, Sirigiri Divijendra Natha Reddy, Rajendra P. Gajula, Jeyanthy Eswaran, L. Aravind, Rakesh Kumar Dec 2012

Morc2 Signaling Integrates Phosphorylation-Dependent, Atpase-Coupled Chromatin Remodeling During The Dna Damage Response, Da-Qiang Li, Sujit S. Nair, Kazufumi Ohshiro, Anupam Kumar, Vasudha S. Nair, Suresh B. Pakala, Sirigiri Divijendra Natha Reddy, Rajendra P. Gajula, Jeyanthy Eswaran, L. Aravind, Rakesh Kumar

Biochemistry and Molecular Medicine Faculty Publications

Chromatin dynamics play a central role in maintaining genome integrity, but how this is achieved remains largely unknown. Here, we report that microrchidia CW-type zinc finger 2 (MORC2), an uncharacterized protein with a derived PHD finger domain and a conserved GHKL-type ATPase module, is a physiological substrate of p21-activated kinase 1 (PAK1), an important integrator of extracellular signals and nuclear processes. Following DNA damage, MORC2 is phosphorylated on serine 739 in a PAK1-dependent manner, and phosphorylated MORC2 regulates its DNA-dependent ATPase activity to facilitate chromatin remodeling. Moreover, MORC2 associates with chromatin and promotes gamma-H2AX induction in a PAK1 phosphorylation-dependent manner. …


Best Of 2012 ― #5: Physicists' Use Of Black Hole Studies To Measure Photon Mass Published In Physical Review Letters, Edwin Smith Dec 2012

Best Of 2012 ― #5: Physicists' Use Of Black Hole Studies To Measure Photon Mass Published In Physical Review Letters, Edwin Smith

University of Mississippi News

No abstract provided.


The Posterior Hypothalamus Exerts Opposing Effects On Nociception Via The A7 Catecholamine Cell Group In Rats, Y. Jeong, J. R. Moes, M. Wagner, J. E. Holden Dec 2012

The Posterior Hypothalamus Exerts Opposing Effects On Nociception Via The A7 Catecholamine Cell Group In Rats, Y. Jeong, J. R. Moes, M. Wagner, J. E. Holden

University Faculty Publications and Creative Works

Stimulation of the posterior hypothalamic area (PH) produces antinociception in rats and humans, but the precise mechanisms are unknown. The PH forms anatomical connections with the parabrachial area, which contains the pontine A7 catecholamine cell group, a group of spinally projecting noradrenergic neurons known to produce antinociception in the dorsal horn. The aim of the present study was to determine whether PH-induced antinociception is mediated in part through connections with the A7 cell group in female Sprague-Dawley rats, as measured by the tail flick and foot withdrawal latency. Stimulation of the PH with the cholinergic agonist carbachol (125nmol) produced antinociception …


Parallel Ngo Networks For Hiv Control: Risks And Opportunities For Ngo Contracting., Shehla Zaidi, Xaher Gul, Noureen Aleem Nishtar Dec 2012

Parallel Ngo Networks For Hiv Control: Risks And Opportunities For Ngo Contracting., Shehla Zaidi, Xaher Gul, Noureen Aleem Nishtar

Community Health Sciences

Policy measures for preventive and promotive services are increasingly reliant on contracting of NGOs. Contracting is a neo-liberal response relying on open market competition for service delivery tenders. In contracting of health services a common assumption is a monolithic NGO market. A case study of HIV control in Pakistan shows that in reality the NGO market comprises of parallel NGO networks having widely different service packages, approaches and agendas. These parallel networks had evolved over time due to vertical policy agendas. Contracting of NGOs for provision of HIV services was faced with uneven capacities and turf rivalries across both NGO …


Testing Diagnostics Of Nuclear Activity And Star Formation In Galaxies At Z > 1, Jonathan R. Trump, Nicholas P. Konidaris, Guillermo Barro, David C. Koo, Dale D. Kocevski, Stéphanie Juneau, Benjamin J. Weiner, S. M. Faber, Ian S. Mclean, Renbin Yan, Pablo G. Pérez-González, Victor Villar Dec 2012

Testing Diagnostics Of Nuclear Activity And Star Formation In Galaxies At Z > 1, Jonathan R. Trump, Nicholas P. Konidaris, Guillermo Barro, David C. Koo, Dale D. Kocevski, Stéphanie Juneau, Benjamin J. Weiner, S. M. Faber, Ian S. Mclean, Renbin Yan, Pablo G. Pérez-González, Victor Villar

Physics and Astronomy Faculty Publications

We present some of the first science data with the new Keck/MOSFIRE instrument to test the effectiveness of different AGN/SF diagnostics at z ~ 1.5. MOSFIRE spectra were obtained in three H-band multi-slit masks in the GOODS-S field, resulting in 2 hr exposures of 36 emission-line galaxies. We compare X-ray data with the traditional emission-line ratio diagnostics and the alternative mass-excitation and color-excitation diagrams, combining new MOSFIRE infrared data with previous HST/WFC3 infrared spectra (from the 3D-HST survey) and multiwavelength photometry. We demonstrate that a high [O III]/Hβ ratio is insufficient as an active galactic nucleus (AGN) indicator …


The Posterior Hypothalamus Exerts Opposing Effects On Nociception Via The A7 Catecholamine Cell Group In Rats, Y. Jeong, J. R. Moes, M. Wagner, J. E. Holden Dec 2012

The Posterior Hypothalamus Exerts Opposing Effects On Nociception Via The A7 Catecholamine Cell Group In Rats, Y. Jeong, J. R. Moes, M. Wagner, J. E. Holden

University Faculty Publications and Creative Works

Stimulation of the posterior hypothalamic area (PH) produces antinociception in rats and humans, but the precise mechanisms are unknown. The PH forms anatomical connections with the parabrachial area, which contains the pontine A7 catecholamine cell group, a group of spinally projecting noradrenergic neurons known to produce antinociception in the dorsal horn. The aim of the present study was to determine whether PH-induced antinociception is mediated in part through connections with the A7 cell group in female Sprague-Dawley rats, as measured by the tail flick and foot withdrawal latency. Stimulation of the PH with the cholinergic agonist carbachol (125nmol) produced antinociception …


On The Interplay Of Telomeres, Nevi And The Risk Of Melanoma, Clara Bodelon, Ruth M. Pfeiffer, Valentina Bollati, Julien Debbache, Donato Calista, Paola Ghiorzo, Maria Concetta Fargnoli, Giovanna Bianchi-Scarra, Ketty Peris, Mirjam Hoxha, Amy Hutchinson, Laura Burke, Shenying Fang, Margaret A. Tucker, Alisa M. Goldstein, Jeffrey E. Lee, Qingyi Wei, Sharon A. Savage, Xiaohong R. Yang, Christopher Amos, Maria Teresa Landi Dec 2012

On The Interplay Of Telomeres, Nevi And The Risk Of Melanoma, Clara Bodelon, Ruth M. Pfeiffer, Valentina Bollati, Julien Debbache, Donato Calista, Paola Ghiorzo, Maria Concetta Fargnoli, Giovanna Bianchi-Scarra, Ketty Peris, Mirjam Hoxha, Amy Hutchinson, Laura Burke, Shenying Fang, Margaret A. Tucker, Alisa M. Goldstein, Jeffrey E. Lee, Qingyi Wei, Sharon A. Savage, Xiaohong R. Yang, Christopher Amos, Maria Teresa Landi

Dartmouth Scholarship

The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease melanoma risk. We performed a systematic analysis of telomere-related genes and tagSNPs within these genes, in relation to the risk of melanoma, dysplastic nevi, and nevus count combining data from four studies conducted in Italy. In addition, we examined whether telomere length measured in peripheral blood leukocytes is related to the risk of melanoma, dysplastic nevi, number of nevi, or …


Hyperosmolar Therapy For Raised Intracranial Pressure., Ethan A Benardete Dec 2012

Hyperosmolar Therapy For Raised Intracranial Pressure., Ethan A Benardete

Department of Neurosurgery Faculty Papers

No abstract provided.


Summary Of Beazer Homes Holding Corp. V. Dist. Ct., 128 Nev. Adv. Op. 66, Jamie Stilz-Outlaw Dec 2012

Summary Of Beazer Homes Holding Corp. V. Dist. Ct., 128 Nev. Adv. Op. 66, Jamie Stilz-Outlaw

Nevada Supreme Court Summaries

The Court considered the ability of a homeowners’ association (HOA) to litigate construction-defect claims on behalf of its members’ homes under NRS 116.3102(1)(d) without fulfilling NRCP 23 class action requirements.


Summary Of Butwinick V. Hepner, 128 Nev. Adv. Op. 65, Robert Stewart Dec 2012

Summary Of Butwinick V. Hepner, 128 Nev. Adv. Op. 65, Robert Stewart

Nevada Supreme Court Summaries

The Court considered Respondents’ motion to substitute themselves as the real parties in interest after acquiring Appellants’ rights and interests in the underlying district court action at a judgment execution sale, and to dismiss Appellants’ appeal from a district court order.


Summary Of Howard V. State, 128 Nev. Adv. Op. 67, Priscilla Baker Dec 2012

Summary Of Howard V. State, 128 Nev. Adv. Op. 67, Priscilla Baker

Nevada Supreme Court Summaries

The Court considered the State’s motion to reconsider and other various motions regarding the sealing of the ex parte motion to substitute counsel. It further deliberated whether documents and records could be filed under seal in a pending criminal case before the Court. In addition, the Court also addressed the requirements and procedures for sealing such documents and records.


Percy Shelley’S Prose Fiction: Zastrozzi, St. Irvyne, The Assassins, The Coliseum, Diane Hoeveler Dec 2012

Percy Shelley’S Prose Fiction: Zastrozzi, St. Irvyne, The Assassins, The Coliseum, Diane Hoeveler

English Faculty Research and Publications

No abstract provided.


4-Aryl-4h-Naphthopyrans Derivatives: One-Pot Synthesis, Evaluation Of Src Kinase Inhibitory And Anti-Proliferative Activities, Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari, Amir Nasrolahi Shirazi, Deendayal Mandal, Abbas Shafiee, Keykavous Parang, Alireza Foroumadi, Tahmineh Akbarzadeh Dec 2012

4-Aryl-4h-Naphthopyrans Derivatives: One-Pot Synthesis, Evaluation Of Src Kinase Inhibitory And Anti-Proliferative Activities, Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari, Amir Nasrolahi Shirazi, Deendayal Mandal, Abbas Shafiee, Keykavous Parang, Alireza Foroumadi, Tahmineh Akbarzadeh

Biomedical and Pharmaceutical Sciences Faculty Publications

Background:

A series of 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives were synthesized and evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.

Methods:

The one-pot, three-component reaction of α or β-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the corresponding 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives, All target compounds were evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.

Results:

Among all tested compounds, unsubstituted 4-phenyl analog 4a showed Src kinas inhibitory effect with IC50 value of 28.1 μM and …


Where To Begin Researching International Sports Law, Rebecca Mattson Dec 2012

Where To Begin Researching International Sports Law, Rebecca Mattson

Law Library Faculty Works

In this article, the author discusses selected sources for researching international sports law.


Quakers, Culture, And The Transforming Power Of Love, Ellen M. Ross Dec 2012

Quakers, Culture, And The Transforming Power Of Love, Ellen M. Ross

Religion Faculty Works

No abstract provided.