Digital Commons Network^™

Do You Hear What I Hear?: The Right Of Prospective Parents To Use Pgd To Intentionally Implant An Embryo Containing The Gene For Deafness, Sarah Aviles

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Cross Practitioner Inter-Rater Variability: Grading Of Adverse Skin Reactions After Radiation Therapy, Carleen A. Evans

Education Doctoral

This study estimated the inter-rater variability for adverse event grades for skin reactions related to radiation therapy among nurses and physicians. Currently, there appears to be a gap in literature on the reliability of severity grades across grading systems. Physicians and nurses conducted a retrospective review of photographs of skin reactions of patients with a diagnosis of breast cancer who received cancer therapy. Rater participants rated the condition(s) seen in each photograph on a scale of Grade 0 to Grade 5. This inter-rater reliability study used quantitative methods to estimate initer-rater agreement and inter-rater reliability of severity grades by comparing …

Assessing The Impacts Of Dams On Nutrient And Sediment Loading In The Kalamazoo River Using The Soil And Water Assessment Tool (Swat), Daniel Henry Serfas

Masters Theses

The Soil and Water Assessment Tool (SWAT) was applied to the Kalamazoo River Watershed in order to evaluate the impacts that several dams within a superfund site "Area of Concern" have on the sediment, nutrients, and streamflow of the system. It was hypothesized that the SWAT model could be used to recreate the watershed in hopes of estimating the amounts of nitrogen, phosphorus, and sediment that would result from the removal of the dams. The model would then be used to evaluate dam removal scenarios to come up with a best management practice (BMP).

The model was calibrated, however, during …

The Rise And Fall Of Kin Structure In The Neotropical, Family-Living Buff-Breasted Wren (Cantorchilus Leucotis) In Gamboa, Panama, Sarah C. Alessi

Masters Theses

Family-living species provide an exciting model to examine how natal dispersal and kin structure influence genetic structuring within local populations. Juvenile buff-breasted wrens (Cantorchilus leucotis) of both sexes delay dispersal and exhibit short-distance natal dispersal, which should lead to kin-structured populations in which relatives of both sexes occupy neighboring territories. Blood samples collected from juvenile and adult wrens in Gamboa, Panama were analyzed using microsatellite markers to determine whether related individuals are spatially clustered on neighboring territories, spatial clusters of relatives change over time, and if kin structure is sex-specific. Global and local spatial autocorrelation analyses detected genetic …

Laboratory Measures Of Aggression In Methadone Patients, Catherine M. Gayman

Masters Theses

Research suggests that current heroin users and individuals with a prior history of heroin dependence tend to be more aggressive than nonusers. No study has yet investigated whether opioid withdrawal affects aggressive responses on a laboratory task. The present study investigates whether mild opioid withdrawal affects aggression in six males and six females (N=12) undergoing methadone maintenance therapy. Aggressive behavior is measured using the Point Subtraction Aggression Paradigm (Cherek, 1981) computer task. Participants press buttons to earn money towards gift certificates. Money subtractions occur periodically and these are attributed to the behavior of a partner who is actually fictitious. Participants …

Early Arrest Mutant Ogre: A Defect In Cytokineis Caused By A Mutation In The Gene Racgap1, April Wicklund

Masters Theses

The early arrest mutant ogre, isolated in the Tübingen screen, has a block in cytokinesis (Kane et al., 1996). Here I use genetic and molecular techniques to demonstrate that the ogre phenotype is caused by a lesion in the gene encoding Racgap1. I performed fine mapping studies using microsatellite markers to a 0.15 cM region containing the ogre locus. DNA sequence data revealed a nonsense mutation in the Racgap1 gene of ogre mutants, and in situ hybridization experiments showed a loss of racgap1 mRNA at later stages of development, likely by nonsense mediated decay. This evidence supports the abolishment …

“A Key Area Of Knowledge Delivered By Someone Knowledgeable”: Feminist Expectations And Explorations Of A One-Off Economics Lecture On Gender, Emily Henderson

Journal of International Women's Studies

This paper explores the action of attending a visiting academic’s one-off lecture, whether in the lecture theatre or on the Internet, in order to gain knowledge from a recognised expert of an unfamiliar but relevant field of research. The actions of entering the theatre and sitting for an hour, or of clicking “play,” appear to be simple gestures for the acquisition of knowledge; this paper explores the complexity of the processes surrounding the lecture, and the way in which the lecture constructs a passive listening position for the audience. The exploration takes place in the frame of one such lecture: …

Non-Binary Gender Concepts And The Evolving Legal Treatment Of Uk Transsexed Individuals: A Practical Consideration Of The Possibilities Of Butler, Alex Harris

Journal of International Women's Studies

This essay seeks to bridge the gap between the UK legal system’s treatment of transsexuals and post-structuralist gender theory. It argues that whilst the greater representation of transsexuals in UK legal discourse embodied in the Gender Recognition Act is a positive move forward in terms of classic liberal notions of human rights and in its acceptance of transsexuals as proper subjects before the law, it nonetheless represents an essentialist conception of transsexuals; requiring them to ‘fit’ within binary categories of male and female. It is argued that post-structuralist thought regarding gender can illuminate some of the problems inherent within the …

Bereavement Among Urban University Students: The Role Of Meaning Making In Adjustment To Loss, Rebecca L. Norris-Bell

Graduate Doctoral Dissertations

Employing Neimeyer's theory of meaning reconstruction as a guiding framework, this study examined meaning making in a diverse sample of bereaved university students. The aims of this study were to 1) identify types of meanings made about loss, 2) examine socio-demographic and bereavement-related characteristics that might influence meaning making, and 3) investigate associations between types of meanings and post-loss psychological adjustment. Participants were 229 students from an urban commuter university. This was a cross-sectional study, employing self-report data collected on a secure, Web-based system. Participants were 18 years or older and had experienced the loss of a friend or family …

The Neuropsychological Functioning Of Older Adults Pre- And Post-Cognitive Training With A Brain Plasticity-Based Computerized Training Program, Shannon M. Sorenson

Graduate Masters Theses

The present study evaluates the effectiveness of Posit Science Cortex™ with Insight Drive Sharp™ as a tool for improving neuropsychological functioning in a normal aging sample. The purpose of the DriveSharp™ training program is to help an individual improve his or her visual attention and useful field of view. Each exercise continually adapts to the individual’s performance so that the training is always at an appropriate level for that specific person. Thirty-two healthy older adult participants were randomly assigned to either the active intervention group (DriveSharp™) or a waitlist control group. Participants in the intervention group were required to engage …

Model Stormwater Standards For Coastal Watershed Communities, University Of New Hampshire Stormwater Center (Unhsc), Rockingham Planning Commission

UNH Stormwater Center

No abstract provided.

2012 University Experience Survey National Report, Ali Radloff, Hamish Coates, Rebecca Taylor, Richard James, Kerri-Lee Krause

Higher education research

How students experience university plays a major role in their academic, personal and professional success. Over the last decade Australian universities and governments have placed considerable emphasis on key facets of the student experience ecology such as skills development, student engagement, quality teaching, student support, and learning resources. This report discusses a 2012 project that furnished a new national architecture for collecting feedback on understanding the improving the student experience. The University Experience Survey (UES) has been developed by the Australian Government to provide a new national platform for measuring the quality of teaching and learning in Australian higher education. …

Influence Of Nitrogen And Phosphorus On Ecosystem Co2 Exchange In A Restored Temperate Grassland, Lynn M. Socha

Biology Theses

Nitrogen (N) and phosphorus (P) affect the structure and function of grasslands by altering plant competitive interactions, shifting patterns of above- and belowground biomass allocation, and by increasing net primary production. However, the influence of N and P on net ecosystem productivity is poorly understood. In the context of a field-based factorial N- and P-addition experiment, I measured soil moisture, leaf area index and component fluxes of ecosystem CO₂ exchange throughout the growing season in a restored temperate grassland near Buffalo, New York. I predicted that N-addition would enhance ecosystem CO₂ uptake (GEE) while P-addition would stimulate ecosystem …

Rickettsia Felis In Cat Fleas, Ctenocephalides Felis Parasitizing Opossums, San Bernardino County, California, Kyle F. Abramowicz, J. W. Wekesa, C. N. Nwadike, Maria L. Zambrano, Sandor E. Karpathy, D. Cecil, J. Burns, R. Hu, Marina E. Eremeeva

Environmental Health Sciences: Faculty Publications

Los Angeles and Orange Counties are known endemic areas for murine typhus in California; however, no recent reports of flea-borne rickettsioses are known from adjacent San Bernardino County. Sixty-five opossums (Didelphis virginiana) were trapped in the suburban residential and industrial zones of the southwestern part of San Bernardino County in 2007. Sixty out of 65 opossums were infested with fleas, primarily cat fleas, Ctenocephalides felis (Bouché, 1835). The flea minimum infection rate with Rickettsia felis was 13.3% in pooled samples and the prevalence was 23.7% in single fleas, with two gltA genotypes detected. In spite of historic records of murine …

Parenting Blog Coverage Of The Autism-Vaccine Controversy, Aidan Bryant

Media Studies - Theses

This study examines source type, citation accuracy, and anecdotal reliance in parenting blog articles about the autism/vaccine controversy. Existing literature on common errors and shortcomings of traditional health journalism, in conjunction with existing guidelines and suggestions for optimal health journalism practices, were used to synthesize a content analysis code structure. The code structure was used to examine 122 parenting blog posts from 18 different blogs, spanning a time period from June 22, 2005 to January 9, 2012, for details including the following:

• author demographics (gender, profession, parenthood, vaccination patterns)

• type of blog the article appeared in

• author stance of the …

Traditional Knowledge, Cultural Expression, And The Siren’S Call Of Property, Justin Hughes

San Diego Law Review

Discussions on international legal norms for the protection of TK/TCE have, in their contemporary form, been ongoing since the late 1990s. In that time, our understanding of key issues for a workable system—subject matter, beneficiaries, rights, or protections—have advanced little, if at all. Indeed, as Michael Brown has observed, “vexing questions of origins and boundaries . . . are commonly swept under the rug in public discussions.” Yet even if all those questions were settled, we also need a clear justification or justifications for a new form of intellectual property on the world stage.

Toward A Lockean Moral Justification Of Legal Protection Of Intellectual Property, Kenneth Einar Himma

San Diego Law Review

This Article attempts to provide the beginnings of a viable moral justification for recognizing and providing legal protection of intellectual property. The argument follows a line of arguments that is fairly characterized as “inspired” by John Locke’s attempt to justify legal protection of what he took to be a natural, objective, moral right to material property. That is to say, it is Lockean in spirit in the following sense: Locke grounds his argument for original acquisition in the idea that a person is justified in acquiring something from the commons in virtue of an investment he makes of something that …

The Impact Of Genetic Background On Body Temperature Regulation In Beef Cattle During Periods Of Heat And Cold Stress, Jeremy T. Howard

Department of Animal Science: Dissertations, Theses, and Student Research

Cattle are reared in environments that differ and vary greatly in climate, thus the ability to regulate body temperature across multiple environments is essential. However, inherent differences between animals do exist and can influence their response to extreme temperatures. The objectives of the current study were to model the impact of myostatin genotype (MG) on body temperature during heat and cold stress and conduct a genome-wide association study (GWAS) to better understand the genetic basis of body temperature regulation during extreme temperatures.

Crossbred steers and heifers (n= 239) with varying degrees of Piedmontese influence were fed in four groups over …

Spoilage Of Wet Distillers' Grains Plus Solubles When Stored In A Bunker, Jana L. Harding

Department of Animal Science: Dissertations, Theses, and Student Research

Five studies evaluated the impact of spoilage of wet distillers grains plus solubles (WDGS) on nutrient composition, nutrient losses, and cattle performance. Exp. 1 and Exp. 2 utilized barrels to evaluate the ability of various cover treatments to prevent nutrient changes and losses due to spoilage. In Exp. 3, a 140-d barrel study was conducted to mimic bunker storage under ambient temperature but with no precipitation. Barrels were weighed and sampled on 28 day intervals. In Exp. 4, a 130-d finishing study utilized 60 individually-fed steers fed 3 treatments: a dry-rolled corn based diet (control) and 2 diets containing 40% …

The Rhetoric Of Mom Blogs: A Study Of Mothering Made Public, Madeline Yonker

Writing Program – Dissertations

This dissertation examines the phenomenon of mom blogs to determine their handling of conventional motherhood and the rhetorical nature of their discourse. Unlike other prior studies of blogs and specifically of mom blogs, the dissertation examines both the blog entries themselves and the many comments such entries generate from readers.

In addition, it seeks to determine the values and rhetorical practices of any community that might be established through such blog commenting. To accomplish these aims, the dissertation focuses on the entries and comments from three particular blogs chosen to represent the network of mom bloggers.

The commonplaces or ideals …

Environmental Triggers Of Winter Annual Weed Emergence And Management To Reduce Soybean Cyst Nematode Reproduction On Winter Annual Weed Hosts, Rodrigo Werle

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Winter annual weeds are becoming more common in many row crop fields in the midwestern USA. The impact of winter annual weeds in cropping systems is often overlooked because these weeds complete their lifecycle near the time of crop sowing. However, delayed soil warming, competition for nutrients during initial establishment of the main crop, difficult planting operations, and yield loss are some of the problems caused by dense mats of winter annual weeds. Moreover, some of these weeds have been reported as alternative hosts for pests such as the soybean cyst nematode (Heterodera glycines, SCN), considered the most …

Building Envelope Wind Pressure Manipulation For Application In Streamlined High-Rise Buildings, Sivaramprasad Sivakumar

Mechanical and Aerospace Engineering - Dissertations

This research investigates methods of manipulating building envelope wind pressure distribution for application in the natural ventilation of high-rise buildings. CFD simulations are employed to predict the wind pressure distribution around the building envelope. First, a 2-D CFD study is conducted to explore various techniques of manipulating the building envelope wind pressure distribution. This study indicates that the use of externally mounted flow-resistance devices is an effective method of manipulating the wind pressure distribution. It is demonstrated that this technique is well suited for application to buildings of streamlined cross-section (e.g. elliptical planform). Next, a 3-D CFD study is conducted …

Nucleophilic Carbon-Carbon Bond-Forming Reactions Of 2-Methylenetetrahydropyrans, Laura Jean Bateman

Chemistry - Dissertations

Reactions with 2-methylenetetrahydropyrans are underutilized in the literature, especially with respect to general methods demonstrating their nucleophilic nature. This work provides three general methods toward the synthesis of 2-β-oxygenated pyranyl substrates, which are key structural components of many biologically active polyketides and natural products.

The use of exocyclic enol ethers as nucleophiles was first demonstrated as a general process in three-component coupling reactions with secondary nucleophiles. The 2-β-hydroxy tetrahydropyran products were obtained in good to excellent yields through promotion with stoichiometric levels of titanium(IV) chloride at reduced temperatures. Only activated aldehydes or ketones worked as efficient coupling partners for this …

Synthesis, Design, And Biological Evaluation Of Inhibitors And Activators Of Src Homology 2 Domain-Containing Inositol Phosphatase (Ship) And Synthetic Studies Of Apicularen A And Maoecrystal V, Dennis Racca Viernes

Chemistry - Dissertations

This dissertation involves work both on the syntheses of small molecules with potential therapeutic applications and synthetic studies on natural products with unusual core skeletons.

The first part of this work involves the synthesis, design, and biological evaluation of aminosteroids as inhibitors for the SH2-containing inositol phosphatase 1 (SHIP1). SHIP1, a 145 kDa protein, is involved in regulating the formation of new blood cells. High- throughput screening identified several SHIP inhibitors including NSC23922, a mixture of 3a- and 3β-aminocholestane. Both 3a- and 3β-aminocholestane were synthesized from dihdyrocholesterol and the 3a- form was verified as …

The Path To An Orally Administered Protein Therapeutic For The Treatment Of Diabetes Mellitus, Susan Clardy James

Chemistry - Dissertations

Protein therapeutics like insulin and glucagon-like peptide-1 analogues are currently used as injectable medications for the treatment of diabetes mellitus. An orally administered protein therapeutic is predicted to increase patient adherence to medication and bring a patient closer to metabolic norms through direct effects on hepatic glucose production. The major problem facing oral delivery of protein therapeutics is gastrointestinal tract hydrolysis/proteolysis and the inability to passage the enterocyte. Herein we report the potential use of vitamin B₁₂ for the oral delivery of protein therapeutics.

We first investigated the ability of insulin to accommodate the attachment of B₁₂ at …

On Love In The Realm Of Science, Vuk Uskoković

Pharmacy Faculty Articles and Research

In the first half of 2009 I organized a series of talks at University of California, San Francisco. The series was dedicated to observing science from a wider perspective and figuring out where its trains and we as scientists in it are heading to. The final presentation in the series I envisaged as the one drawing threads between love and science. However, my aim was neither for that particular talk to be the one of explaining sensations of love using scientific language nor to be based on pastoral and pathetic eruptions of love about science. What I had in mind …

The Deaf Catholic, Winter 2012

ICDA The Deaf Catholic

A newsletter published for Deaf Catholics in USA

ICDA The Deaf CatholicFinding Aid

Why Are There So Many Diverse Holocaust Museums?: A Journey Through The Holocaust Museums Of Five Nations, Marjorie E. Carignan

History Theses

Holocaust museums around the world are unique in their respective missions, funding, architecture and exhibitions. Some of these distinctions are extreme, leaving museums seemingly opposites of each other. To better understand these diversities, this thesis analyzes Holocaust museums in France, Germany, Poland, Israel and the United States. Through analysis, unique facets in many basic areas of the museums can be found, with many of these being affected by which country the museum is in. By seeing what museums choose to include and leave out, we are able to see what parts of the Holocaust could use more attention and how …

Statistical Weights Of Single Source Dna Profiles, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.

Generating Forensic Dna Profiles, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.