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2012

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Conditional Over-Expression Of Pitx1 Causes Skeletal Muscle Dystrophy In Mice, Sachchida Nand Pandey, Jennifer Cabotage, Rongye Shi, Manjusha Dixit, Margaret L. Sutherland, Jian Liu, Stephanie Muger, Scott Q. Harper, Kanneboyina Nagaraju, Yi-Wen Chen Jul 2012

Conditional Over-Expression Of Pitx1 Causes Skeletal Muscle Dystrophy In Mice, Sachchida Nand Pandey, Jennifer Cabotage, Rongye Shi, Manjusha Dixit, Margaret L. Sutherland, Jian Liu, Stephanie Muger, Scott Q. Harper, Kanneboyina Nagaraju, Yi-Wen Chen

Genomics and Precision Medicine Faculty Publications

Paired-like homeodomain transcription factor 1 (PITX1) was specifically up-regulated in patients with facioscapulohumeral muscular dystrophy (FSHD) by comparing the genome-wide mRNA expression profiles of 12 neuromuscular disorders. In addition, it is the only known direct transcriptional target of the double homeobox protein 4 (DUX4) of which aberrant expression has been shown to be the cause of FSHD. To test the hypothesis that up-regulation of PITX1 contributes to the skeletal muscle atrophy seen in patients with FSHD, we generated a tet-repressible muscle-specific Pitx1 transgenic mouse model in which expression of PITX1 in skeletal muscle can be controlled by oral administration of …

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Secretome Survey Of Human Plexiform Neurofibroma Derived Schwann Cells Reveals A Secreted Form Of The Rarres1 Protein., Hui-Ling Chen, Haeri Seol, Kristy J. Brown, Heather Gordish-Dressman, D. Ashley Hill, Vittorio Gallo, Roger J. Packer, Yetrib Hathout Jul 2012

Secretome Survey Of Human Plexiform Neurofibroma Derived Schwann Cells Reveals A Secreted Form Of The Rarres1 Protein., Hui-Ling Chen, Haeri Seol, Kristy J. Brown, Heather Gordish-Dressman, D. Ashley Hill, Vittorio Gallo, Roger J. Packer, Yetrib Hathout

Pediatrics Faculty Publications

To bring insights into neurofibroma biochemistry, a comprehensive secretome analysis was performed on cultured human primary Schwann cells isolated from surgically resected plexiform neurofibroma and from normal nerve tissue. Using a combination of SDS-PAGE and high precision LC-MS/MS, 907 proteins were confidently identified in the conditioned media of Schwann cell cultures combined. Label free proteome profiling revealed consistent release of high levels of 22 proteins by the four biological replicates of NF1 Schwann cell cultures relative to the two normal Schwann cell cultures. Inversely, 9 proteins displayed decreased levels in the conditioned media of NF1 relative to normal Schwann cells. …

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Nor'easter News Volume 5 Issue 13.5, Nor'easter News Staff Jul 2012

Nor'easter News Volume 5 Issue 13.5, Nor'easter News Staff

Nor'easter News

The fifty-third issue of the University of New England's student-run newspaper, Nor'easter News.

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How To Use New Online Monitoring Techniques To Improve River Water Quality Modeling At The River Reach Scale, Michael Rode, Uwe Kiwel Jul 2012

How To Use New Online Monitoring Techniques To Improve River Water Quality Modeling At The River Reach Scale, Michael Rode, Uwe Kiwel

International Congress on Environmental Modelling and Software

High spatial and temporal resolution monitoring systems are needed to improve our knowledge on flow and matter transport pathways and substance transformation. The presentation will introduce a new online water quality monitoring system as part of the UFZ TERENO Hydrological Observatory “Bode” and show how this new information can improve river water quality modelling. Additional low flow measurement campaigns including delta 18O and delta 15N isotope analyses of nitrate have been used to identify denitrification processes on a selected lower river reach. It will be demonstrated how high resolution data can be used in combination with a process based river …

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Perceptual Modelling Of Environmental Indicators To Assess Land Uses Impacts On Water Quality, Nathalie Lalande, Flavie Cernesson, Marie-George Tournoud Jul 2012

Perceptual Modelling Of Environmental Indicators To Assess Land Uses Impacts On Water Quality, Nathalie Lalande, Flavie Cernesson, Marie-George Tournoud

International Congress on Environmental Modelling and Software

The stream functioning is closely influenced by land uses, along thestream itself and throughout the catchment. Land uses can be seen as both theexpression of the natural environment and the result of increasing human activities.Land uses generate various (in kind and intensity) pressures (positive or negative)that alter river water quality at different scales of time and space. The objective ofthis research is to conceptualize and quantify the interactions between river waterquality and land use through spatial modelling. Our methodology is based on (i) thedesign of a system of indicators using the DPSIR framework and (ii) thedevelopment of the relevant environmental …

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Pepperdine Magazine - Vol. 4, Iss. 2 (Summer 2012), Office Of Public Affairs, Pepperdine University Jul 2012

Pepperdine Magazine - Vol. 4, Iss. 2 (Summer 2012), Office Of Public Affairs, Pepperdine University

Pepperdine Magazine

Megan Huard Boyle, editor.

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Museu.M. News, No. 34, University Of Montana--Missoula. Philip L. Wright Zoological Museum Jul 2012

Museu.M. News, No. 34, University Of Montana--Missoula. Philip L. Wright Zoological Museum

Philip L. Wright Zoological Museum (UMZM) Newsletters

Recent Accessions -- Museum Art Show -- Follow the Museum's Blog! -- The Museum in the News -- Friends of Museum Dues are DUE!

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2012/2013 University Of The Pacific [Stockton] Graduate Catalog, University Of The Pacific Jul 2012

2012/2013 University Of The Pacific [Stockton] Graduate Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

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Quantifying Trade-Offs Between Bioenergy Production, Food Production, Water Quality And Water Quantity Aspects In A German Case Study, Sven Lautenbach, Martin Volk, Michael Strauch, Gerald Whittaker, Ralf Seppelt Jul 2012

Quantifying Trade-Offs Between Bioenergy Production, Food Production, Water Quality And Water Quantity Aspects In A German Case Study, Sven Lautenbach, Martin Volk, Michael Strauch, Gerald Whittaker, Ralf Seppelt

International Congress on Environmental Modelling and Software

Worldwide increasing bioenergy production is on the political agenda. It is well known that bioenergy production comes at a cost – several trade-offs with food production, water quality and quantity issues, biodiversity and ecosystem services are known but a quantification of these trade-offs is missing. Hence, we show in this study an analysis of trade-offs between bioenergy production, food production, water quality and water quantity aspects in the Parthe catchment in Central Germany. The analysis is based on using SWAT and a multi-objective genetic algorithm (NSGA II). The genetic algorithm is used to find Pareto-optimal configurations of crop rotation schemes. …

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Impact Of Species Parameter Uncertainty In Simulations Of Tree Species Migration With A Spatially Linked Dynamic Model, Julia E M S Nabel, Natalie Zurbriggen, Heike Lischke Jul 2012

Impact Of Species Parameter Uncertainty In Simulations Of Tree Species Migration With A Spatially Linked Dynamic Model, Julia E M S Nabel, Natalie Zurbriggen, Heike Lischke

International Congress on Environmental Modelling and Software

The simulation of tree species migration suffers from many sources of uncertainty.In our study we examined the influence of species parameter uncertainty on simulatedtree species migration, using the spatially linked dynamic forest landscape modelTreeMig. The impact of uncertainty becomes especially apparent under critical conditionsarising from the interaction of species sensitivities to climate, species competitionand spatial fragmentation. Therefore we examined the differences in migration successand speed in a realistic scenario including these critical conditions. The south-north migrationof the submediterranean tree species Ostrya carpinifolia through the highly fragmentedand climatically heterogeneous landscape of the Swiss Alps was simulated for27 different species parameter sets …

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Overview On Data Sources For Modeling Epidemiological Effects Of Environmental Pollution, Ralf Kusmierz, Hagen Scherb, Kristina Voigt Jul 2012

Overview On Data Sources For Modeling Epidemiological Effects Of Environmental Pollution, Ralf Kusmierz, Hagen Scherb, Kristina Voigt

International Congress on Environmental Modelling and Software

We focus on German population based data, which are routinely available in German statistical databases for the evaluation of the human sex odds at birth in the vicinity of nuclear facilities as well as around chemical sites. In this respect we have to distinguish between the statistical offices of the German states (Bundesländer) and the Federal statistical office of the FRG (Federal Republic of Germany). A specific difficulty arising from the German reunification in 1991 concerns data availability and data formats from the former GDR (German Democratic Republic). These offices collect data on birth statistics which are the basis of …

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A Methodology For The Characterization Of Intelligent Environmental Decision Support Systems, Miquel Sànchez-Marrè, Karina Gibert, A. Cabello, F. Sem Jul 2012

A Methodology For The Characterization Of Intelligent Environmental Decision Support Systems, Miquel Sànchez-Marrè, Karina Gibert, A. Cabello, F. Sem

International Congress on Environmental Modelling and Software

The issue of the paper is to propose a methodology to characterize and describe any Intelligent Environmental Decision Support System (IEDSS). This characterization is necessary to analyse the IEDSSs built until now, to improve their abilities and their current output information. The methodology proposes a selection of a set of features to characterize all IEDSS, and in general, IDSS. The main characteristics of Intelligent Decision Support Systems have been identified through an accurate analysis of cognitive tasks, and several layers involved in this kind of systems. The resulting analysis has been implemented in a form. This form takes into account …

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Integration Of Bayesian Inference Techniques With Mathematical Modelling, George B. Arhonditsis Jul 2012

Integration Of Bayesian Inference Techniques With Mathematical Modelling, George B. Arhonditsis

International Congress on Environmental Modelling and Software

Skeptical views of the scientific value of modelling argue that there is no true model of an ecological system, but rather several adequate descriptions of different conceptual basis and structure. My study addresses this question using a complex ecosystem model, developed to guide the water quality criteria setting process in the Hamilton Harbour (Ontario, Canada), along with a simpler plankton model that considers the interplay among phosphate, detritus, and generic phytoplankton and zooplankton state variables. Predictions from the two models are combined using the respective standard error estimates as weights in a weighted model average. The two eutrophication models are …

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A Variable-Structure Catchment Model As The Engine For A Water Quality Decision Support Tool Facilitating Scientific Debate And Collaboration., M. Bruen, E. Mockler Jul 2012

A Variable-Structure Catchment Model As The Engine For A Water Quality Decision Support Tool Facilitating Scientific Debate And Collaboration., M. Bruen, E. Mockler

International Congress on Environmental Modelling and Software

Distributed or semi-distributed models are usually cascades of lumped models, each with an identical structure. This, classical, approach has a number of drawbacks; (i) each lumped model must be sufficiently general and thus complex to cope with the range of hydrological situations possible and (ii) it precludes debate and discussion between scientists about the most appropriate model conceptualisation and in particular it precludes using different conceptualisations in different areas to adapt the model to different hydrologic regimes, perhaps even in the same catchment. Both of these lead to distributed models that are unnecessarily complex and over-parameterised with consequent implications for …

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Use Of Integrated Models To Minimize The Impact Of Urban Wastewater Systems On A Mediterranean Stream, P. Prat, Corominas Ll, Lorenzo Benedetti, Joaquim Comas Jul 2012

Use Of Integrated Models To Minimize The Impact Of Urban Wastewater Systems On A Mediterranean Stream, P. Prat, Corominas Ll, Lorenzo Benedetti, Joaquim Comas

International Congress on Environmental Modelling and Software

In some regions, like in the Mediterranean area, streams are characterized by harsh hydrological fluctuations, with very low flow rates in summer and high in autumn. During low river flow conditions, wastewater treatment plant (WWTP) discharges contribute significantly to the total river flow and hence their impact is higher. The objective of this paper is to find solutions to confront this typical problematic situation by means of integrated modelling. The benefits of modelling the whole urban wastewater system (UWS) to evaluate multiple operational strategies are shown. The model includes two sewer systems, two WWTPs, a connection channel between the two …

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Image Assimilation And Motion Estimation Of Geophysical Fluids, Isabelle Herlin, Dominique Bereziat, Etienne Huot Jul 2012

Image Assimilation And Motion Estimation Of Geophysical Fluids, Isabelle Herlin, Dominique Bereziat, Etienne Huot

International Congress on Environmental Modelling and Software

Simulation models and image data are simultaneously available for numerousscientific domains, such as oceanography and meteorology. They are indeed two complementarydescriptions of the same complex system. Data Assimilation is a well-knownmathematical technique used, in environmental sciences, to improve forecasts obtainedfrom the simulation models, thanks to the observation data. One class of data assimilationalgorithms, named 4D-Var, globally adjusts the model output to the observations, thatare available over a period of time. The question of how to derive accurate characteristicfeatures from images, with an optimal use of the simulation model, is of major interestfor the image processing community. In this article, we …

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Modelling Ecosystem Services Using Bayesian Belief Networks: Burggravenstroom Case Study, Dries Landuyt, Elina Bennetsen, Rob D. Hondt, Guy Engelen, Steven Broekx, Peter L. M. Goethals Jul 2012

Modelling Ecosystem Services Using Bayesian Belief Networks: Burggravenstroom Case Study, Dries Landuyt, Elina Bennetsen, Rob D. Hondt, Guy Engelen, Steven Broekx, Peter L. M. Goethals

International Congress on Environmental Modelling and Software

While being studied by scientists for decades, the term ecosystem services was only recently introduced to the general public. This introduction intended broad-scale recognition of ecosystems and their value for human well-being. Both quantitative and qualitative research on ecosystem services became emerging topics in scientific research. Ecosystem service prediction models were developed varying from basic qualitative models to complex mechanistic models which enable quantification of ecosystem services. The introduction of Bayesian belief networks in ecosystem service modelling has led to an intermediate approach between both methods. Major advantages of this Bayesian network modelling approach are the model transparency which enables …

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Dynamic Modelling Of Silvopastoral Landscape Structure: Scenarios For Future Climate And Land Use, François Gillet, Alexander Peringer Jul 2012

Dynamic Modelling Of Silvopastoral Landscape Structure: Scenarios For Future Climate And Land Use, François Gillet, Alexander Peringer

International Congress on Environmental Modelling and Software

Pasture-woodland landscapes result from a long history ofsilvopastoralism in mountain regions and provide valuable ecosystem services.They include a mosaic of grasslands, forests and wood-pastures, which is theheritage of a multipurpose management in the variable socio-economic andbiophysical context of the last millennium. In the perspective of ongoing climateand land-use changes, it is crucial to assess the resilience and the adaptivecapacity of such socio-ecological systems at different spatial and temporal scales.For this purpose, we developed a hierarchical, process-based, dynamic model,WoodPaM, and we simulated six scenarios of climate change and management ina real landscape of the Swiss Jura Mountains. Realistic climatic scenarios for …

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Integrated Ecological Modelling For Decision Support In The Integrated Urban Water System Modelling Of The Drava River (Varazdin, Croatia), Javier E. Holguin, Gert Everaert, Lorenzo Benedetti, Youri Amerlinck, Peter L. M. Goethals Jul 2012

Integrated Ecological Modelling For Decision Support In The Integrated Urban Water System Modelling Of The Drava River (Varazdin, Croatia), Javier E. Holguin, Gert Everaert, Lorenzo Benedetti, Youri Amerlinck, Peter L. M. Goethals

International Congress on Environmental Modelling and Software

Legal physical-chemical emission limits are traditionally used forassessing the effectiveness of urban sanitation infrastructure. However, thereceiving water’s ecological aspects are disregarded with this conventionalapproach. European legislation (i.e. Water Framework Directive-WFD) now has anintegrated approach of river management, which considers the concept ofecological status. Furthermore, the WFD urges the adoption of a combined analysisof emission limits values and physical-chemical and ecological aspects of thereceiving waters and encourage the availability and use of decision support tools forwater management such as simulation models. Croatia has signed agreements tojoin the European Union (EU) and thus taken up the obligation to coordinate itslegislation with EU …

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Probabilistic Risk Assessment And Decision Support Tools For The Evaluation Of Oil Transport In The Gulf Of Finland, North-Eastern Baltic Sea, Annukka Lehikoinen, Emilia Luoma, Maria Hänninen, Jenni Storgård, Sakari Kuikka Jul 2012

Probabilistic Risk Assessment And Decision Support Tools For The Evaluation Of Oil Transport In The Gulf Of Finland, North-Eastern Baltic Sea, Annukka Lehikoinen, Emilia Luoma, Maria Hänninen, Jenni Storgård, Sakari Kuikka

International Congress on Environmental Modelling and Software

The maritime traffic in the Gulf of Finland (GoF), North-eastern BalticSea, is predicted to rapidly grow in the near future, which increases theenvironmental risks through both direct environmental effects and by increasing therisk of severe oil accident. A multidisciplinary group of researchers has developeda prototype of risk assessment and decision support model, applying BayesianNetworks (BNs), for the evaluation of environmental risks arising from the oiltransport. It consists of sub-models on tanker collisions, causation probability(human factor), the resulting leak size, and the efficacy of open sea oil recovery.This meta-model is based on three alternative growth scenarios concerning themaritime traffic of the …

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Estimating Impact Assessment And Adaptation Strategies Under Climate Change Scenarios For Crops At Eu27 Scale, Marcello Donatelli, A. K. Srivastava, G. Duveiller, S. Niemeyer Jul 2012

Estimating Impact Assessment And Adaptation Strategies Under Climate Change Scenarios For Crops At Eu27 Scale, Marcello Donatelli, A. K. Srivastava, G. Duveiller, S. Niemeyer

International Congress on Environmental Modelling and Software

Policy makers at European and national level demand for estimates of potential vulnerability of agricultural production. Estimates are requested specific to province level, and articulated for crops. The base of such estimates is the biophysical representation of crop responses both under conditions of no adaptation, and exploring the level of adaptation which could be acted on autonomously by farmers. However, producing such estimates poses significant challenges due to the usability of climate inputs to simulation models, to reliability and completeness of data, to the level of abstraction to be chosen, and to technological aspects. This study provides an impact assessment …

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Assessment Of Phytoplankton Productivity Using Satellite Data For Peter The Great Gulf, Oksana Zhdanova, Alexander Abakumov Jul 2012

Assessment Of Phytoplankton Productivity Using Satellite Data For Peter The Great Gulf, Oksana Zhdanova, Alexander Abakumov

International Congress on Environmental Modelling and Software

The biological productivity of ecological systems is very important characteristic for study of the natural environment. For aquatic ecosystems the biological productivity can be determined on the base of phytoplankton productivity. The distribution of phytoplankton in a vertical column of water under the influence of sun intensity, temperature and mineral content is simulated. Change in the concentration of mineral substances and phytoplankton is influenced by diffusion. Photosynthetic activity radiation and temperature of water satisfy the climatic conditions typical of Peter the Great Bay. A remote sensing data probing the seas and oceans plays an important role in the study of …

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Drivers Of Change In Southern European Agriculture: Online Participatory Approaches For The Analysis Of Planned And Autonomous Adaptation Strategies, Dragana Bojovic, Laura Bonzanigo, Carlo Giupponi Jul 2012

Drivers Of Change In Southern European Agriculture: Online Participatory Approaches For The Analysis Of Planned And Autonomous Adaptation Strategies, Dragana Bojovic, Laura Bonzanigo, Carlo Giupponi

International Congress on Environmental Modelling and Software

Together with socio-economic and policy changes, climate change deeply affects sustainable patterns of water management. The presented work explores how online participatory tools can be linked to a decision support system (DSS), in order to set up a web based DSS for assessment and evaluation of autonomous and planned water-saving adaptation strategies in irrigated production systems. Innovative online participatory tools are developed and tested. The paper presents online participation (eParticipation) as a means to establish communication with the main “agents” (farmers) of the socio-ecosystem of interest. This is composed of two phases: (i) assessment of farmers’ perceptions of ongoing changes …

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Phosphorus Use And Management Strategies: Exploring Scenarios Of Smallholder’S Soil Fertility, Food Production And Livelihood With A Multi-Agent System Model, Quang Bao Le, Roland W. Scholz, Roman Seidl, Quyet Manh Vu, Tien Minh Tran Jul 2012

Phosphorus Use And Management Strategies: Exploring Scenarios Of Smallholder’S Soil Fertility, Food Production And Livelihood With A Multi-Agent System Model, Quang Bao Le, Roland W. Scholz, Roman Seidl, Quyet Manh Vu, Tien Minh Tran

International Congress on Environmental Modelling and Software

Phosphorus (P) is a key nutrient for food production. However, excess P use, e.g. in form of inorganic fertilizer application, can lead to environmental pollution, biodiversity losses and low profitability. Continuous cultivation with underuse of P fertilizer results in low food productivity and soil degradation due to soil nutrient mining or soil erosion. The concern is most serious for smallholder farmers in developing countries whose food production and livelihood is tied directly to their access to and efficient use of P as key nutrient for plant growth. This paper introduces a multi-agent system modeling framework for assessing long-term impacts of …

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Simulating Shocks With The Hypercycles Model Of Economic Production, Christopher Watts, Claudia R. Binder Jul 2012

Simulating Shocks With The Hypercycles Model Of Economic Production, Christopher Watts, Claudia R. Binder

International Congress on Environmental Modelling and Software

Padgett’s hypercycles model of economic production (Padgett et al. 2003) is an agent-based simulation that demonstrates the emergence of novel forms of social organisation among limited-intelligence agents. In this paper we argue that it can be extended to explore issues of resilience and the responses to shocks in complex systems of agent-environment interactions. Based on learning by doing, a simple search heuristic enables a population of firms to adapt and find system states containing a collectively self-sustaining subset of firms with production rules and mix of materials in the environment. The self-sustaining systems Padgett finds persist in spite of variability …

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Uncertainty Propagation Between Web Services – A Case Study Using The Ehabitat Wps To Identify Unique Ecosystems, Michael Schulz, Jon Olav Skøien, Lydia Gerharz, Grégoire Dubois, Edzer Pebesma Jul 2012

Uncertainty Propagation Between Web Services – A Case Study Using The Ehabitat Wps To Identify Unique Ecosystems, Michael Schulz, Jon Olav Skøien, Lydia Gerharz, Grégoire Dubois, Edzer Pebesma

International Congress on Environmental Modelling and Software

Protected areas (PAs) are designed to protect ecosystems and their associated species against anthropogenic threats. When assessing the importance of the current network of PAs, and when considering new areas which should be protected, one of the criteria is the uniqueness of the ecosystems found inside the existing or planned PA when compared to other parks. As a helping tool for park managers and potential funders, eHabitat has been designed using the Open Geospatial Consortiums (OGC) Web Processing Service (WPS) interface specification. It allows end-users to compute, using different data and models, the likelihood of finding ecosystems with similar properties, …

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A New Species Of Saphonecrus (Hymenoptera, Cynipoidea) Associated With Plant Galls On Castanopsis (Fagaceae) In China, Zhiwei Liu, Xiao-Hui Yang, Dao-Hong Zhu, Yi-Yuan He Jul 2012

A New Species Of Saphonecrus (Hymenoptera, Cynipoidea) Associated With Plant Galls On Castanopsis (Fagaceae) In China, Zhiwei Liu, Xiao-Hui Yang, Dao-Hong Zhu, Yi-Yuan He

Faculty Research & Creative Activity

A new cynipid species, Saphonecrus hupingshanensis Liu, Yang, et Zhu, sp. nov. (Hymenoptera: Cynipidae: Synergini), is described from China. This is the first species of the inquilinous tribe Synergini ever known to have an association with chinquapins (Fagaceae: Castanopsis). The biology and implication to species diversity of Cynipidae in eastern and southeast Asia are discussed.

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Etiquette In Making The Transition Into Private Practice, David G. Dunning Jul 2012

Etiquette In Making The Transition Into Private Practice, David G. Dunning

Journal Articles: College of Dentistry

In this article, the author offers several tips for students who are making transition into private dental practice. It suggests not disclosing the agreed terms and information related with negotiating practice or dentist or organization. It states that the initial focus should not be concentrated on salary or compensation or practice performance indicators. It mentions that before getting into details of each opportunity, students needs to decide their priorities.

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Eiu Political Science Review -- Fall 2012, Eastern Illinois University Department Of Political Science Jul 2012

Eiu Political Science Review -- Fall 2012, Eastern Illinois University Department Of Political Science

EIU Political Science Review

The EIU Political Science Review is a new online journal created specifically for undergraduate students of political science. The journal consists of a variety of high-quality, peer reviewed undergraduate papers. Nearly any type of political science paper from a EIU political science course (3000-4000) can be submitted to the journal including: position papers, analytical critiques, research papers, book reviews, case briefs, and many more. If you're interested in submitting one of your own pieces of work please read below for more information.

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Germline Transgenesis And Insertional Mutagenesis In Schistosoma Mansoni Mediated By Murine Leukemia Virus, Gabriel Rinaldi, Sabine E. Eckert, Isheng J. Tsai, Suttas Suttiprapa, Kristine J. Kines, Jose F. Tort, Victoria H. Mann, Daniel J. Turner, Matthew Berriman, Paul J. Brindley Jul 2012

Germline Transgenesis And Insertional Mutagenesis In Schistosoma Mansoni Mediated By Murine Leukemia Virus, Gabriel Rinaldi, Sabine E. Eckert, Isheng J. Tsai, Suttas Suttiprapa, Kristine J. Kines, Jose F. Tort, Victoria H. Mann, Daniel J. Turner, Matthew Berriman, Paul J. Brindley

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Functional studies will facilitate characterization of role and essentiality of newly available genome sequences of the human schistosomes, Schistosoma mansoni, S. japonicum and S. haematobium. To develop transgenesis as a functional approach for these pathogens, we previously demonstrated that pseudotyped murine leukemia virus (MLV) can transduce schistosomes leading to chromosomal integration of reporter transgenes and short hairpin RNA cassettes. Here we investigated vertical transmission of transgenes through the developmental cycle of S. mansoni after introducing transgenes into eggs. Although MLV infection of schistosome eggs from mouse livers was efficient in terms of snail infectivity, >10-fold higher transgene copy …

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