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A Novel Allosteric Inhibitor Of Macrophage Migration Inhibitory Factor (Mif), Fengwei Bai, Oluwatoyin A. Asojo, Pier Cirillo, Mihai Ciustea, Michel Ledzidet, Paul A. Aristoff, Lin Leng, Raymond A. Koski, Thomas J. Powell, Richard Bucala, Karen G. Anthony

Faculty Publications

Macrophage migration inhibitory factor (MIF) is a catalytic cytokine and an upstream mediator of the inflammatory pathway. MIF has broad regulatory properties, dysregulation of which has been implicated in the pathology of multiple immunological diseases. Inhibition of MIF activity with small molecules has proven beneficial in a number of disease models. Known small molecule MIF inhibitors typically bind in the tautomerase site of the MIF trimer, often covalently modifying the catalytic proline. Allosteric MIF inhibitors, particularly those that associate with the protein by noncovalent interactions, could reveal novel ways to block MIF activity for therapeutic benefit and serve as chemical …

Montana Kaimin, August 31, 2012, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The Role Of Meis1 In Hematopoietic Development, Mi Cai

All Theses and Dissertations (ETDs)

Previous work has identified Mesp1 as an important regulator of the epithelial–mesenchymal transition: EMT) and of cardiovascular cell fate in differentiating embryonic stem cells: ESCs). To understand the molecular mechanisms underlying the actions of Mesp1, we sought to identify transcription targets of Mesp1. Mesp1 rapidly induced expression of PDGFRα in differentiating ESCs and directly bound to evolutionary conserved E-boxes within the PDGFRα promoter. This result suggested that PDGFRα could be a direct target of Mesp1. However, we found that PDGFRα was not sufficient for the induction of EMT in ESCs or the induction of Flk1+ mesoderm, but that it may …

Challenges Of Permitting Ballast Water Discharges From Commercial Vessels In U.S. Waters, Paul Rodriguez

Theses

On February 5, 2009, the US Environmental Protection Agency (US EPA) issued the Vessel General Permit (VGP), under the Clean Water Act (CWA), for discharges incidental to the normal operation of vessels, including ballast water discharges. This set forth permit requirements for most commercial vessel discharges within 3 nautical miles of U.S. shore. Since it will expire in December 2013, the US EPA recently issued a draft 2013 VGP. One of the significant changes is the proposal of numerical ballast water discharge standards requiring most commercial vessels to install ballast water treatment systems onboard.

The objective of this thesis is …

Design Of Bioluminescent Protein-Nanoparticle Complexes For Targeted Imaging, Ashley N. Melchior

Open Access Theses

Early detection of diseased cells can greatly alter the course of a disease process and create a better outcome for the patient. Lymphangioleiomyomatosis (LAM) is a disease characterized by gradual destruction of lung tissue caused by infiltration and proliferation of smooth muscle-like cells. Currently little can be done to treat the disease other than to ease symptoms. Early LAM diagnosis can greatly impact the course of the disease and the patient’s quality of life. In this work a sensitive imaging platform composed of a ligand targeted poly(amido)amine (PAMAM) nanocarrier complexed with Renilla luciferase (RLuc) is developed to target the lung …

Gsu View, 2012-08-30, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

Comparative Transcriptome Analysis Of Two Olive Cultivars In Response To Nacl-Stress, Christos Bazakos, Maria E. Manioudaki, Ioannis Therios, Demetrios Voyiatzis, Dimitris Kafetzopoulos, Tala Awada, Panagiotis Kalaitzis

School of Natural Resources: Faculty Publications

Background: Olive (Olea europaea L.) cultivation is rapidly expanding and low quality saline water is often used for irrigation. The molecular basis of salt tolerance in olive, though, has not yet been investigated at a system level. In this study a comparative transcriptomics approach was used as a tool to unravel gene regulatory networks underlying salinity response in olive trees by simulating as much as possible olive growing conditions in the field. Specifically, we investigated the genotype-dependent differences in the transcriptome response of two olive cultivars, a salt-tolerant and a salt-sensitive one.

Methodology/Principal Findings: A 135-day long …

Chanticleer | Vol 61, Issue 1, Jacksonville State University

Chanticleer

No abstract provided.

The Pacifican August 30, 2012, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Charger Times Vol. 1, No. 11, 2012-08-30, University Of Alabama In Huntsville

Charger Times (2012-2014)

No abstract provided.

Exosome-Mediated Shuttling Of Microrna-29 Regulates Hiv Tat And Morphine-Mediated Neuronal Dysfunction., Guoku Hu, H Yao, A D. Chaudhuri, Sowmya V. Yelamanchili, H Wen, P D. Cheney, Howard S. Fox, Shilpa J. Buch

Journal Articles: Pharmacology & Experimental Neuroscience

Neuronal damage is a hallmark feature of HIV-associated neurological disorders (HANDs). Opiate drug abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Opiates such as morphine have been shown to enhance HIV transactivation protein Tat-mediated toxicity in both human neurons and neuroblastoma cells. In the present study, we demonstrate reduced expression of the tropic factor platelet-derived growth factor (PDGF)-B with a concomitant increase in miR-29b in the basal ganglia region of the brains of morphine-dependent simian immunodeficiency virus (SIV)-infected macaques compared with the SIV-infected controls. In vitro relevance …

Genetic Modulation Of Lipid Profiles Following Lifestyle Modification Or Metformin Treatment: The Diabetes Prevention Program, Toni I. Pollin, Tamara Isakova, Kathleen A. Jablonski, Paul I.W. De Bakker, Andrew Taylor, Jarred B. Mcateer, Qing Pan, Edward Horton, Linda M. Delahanty, David Altshuler, Alan R. Shuldiner, Ronald Goldberg, Jose C. Florez, George A. Bray

Epidemiology Faculty Publications

Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polymorphisms modifies the effects of lifestyle and/or metformin interventions on lipid levels and nuclear magnetic resonance (NMR) lipoprotein subfraction size and number. Twenty-three loci previously associated with fasting LDL-C, HDL-C, or triglycerides replicated (P = 0.04–1×10−17). Except for total HDL particles (r = −0.03, …

Spartan Daily August 30, 2012, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 139, Issue 3

Polar Scientist, Author Mcclintock To Sign New Book Sept. 26, Jim Bakken

Browse All News

No abstract provided.

The Missouri Miner, August 30, 2012

The Missouri Miner Newspaper

No abstract provided.

The Impact Of Northern Sea Route On China’S Shipping Industry, Minyu Tang

World Maritime University Dissertations

No abstract provided.

Dry Bulk Carrier Demolition Market Forecast And Analysis, Chao Wang

World Maritime University Dissertations

No abstract provided.

Freight Forecasting Of Dry Bulk Market Based On The Bp Neural Network, Qianran Huang

World Maritime University Dissertations

No abstract provided.

Extendsim-Based Research On Transport Process Optimization Of Emergency Cold-Chain Logistics, Ran Zhang

World Maritime University Dissertations

No abstract provided.

Analysis Of Die5 And Lia5 Reveals The Importance Of Dna Repair In Programmed Dna Rearrangement Of Tetrahymena Thermophila, Wan-Yi: Annie) Shieh

All Theses and Dissertations (ETDs)

During its somatic nuclear differentiation, the single cell eukaryote Tetrahymena thermophila undergoes genome-wide programmed DNA rearrangement to eliminate transposon-like elements from its future soma. This process involves small RNA-directed heterochromatin formation followed by extensive nuclear reorganization to form subnuclear domains. While more has been known about small RNAs and heterochromatin, the mechanisms and players involved in the process of nuclear reorganization and the subsequent removal of transposon-like elements from the somatic genome are just starting to unravel. My thesis work centers on the study of two novel nuclear proteins Die5p: Chapter 2) and Lia5p: Chapter 3) and their roles in …

Workshop On Research And Resource Commons In Scientific Research: Final Report, Michael W. Carroll

Joint PIJIP/TLS Research Paper Series

In November of 2011, the Washington College of Law at American University convened and hosted a two-day workshop in collaboration with the Creative Commons to develop a strategy for promoting a commons or scientific research and related resources. The workshop brought together interested stakeholders from across the scientific research enterprise: scientists, administrators, librarians, publishers, societies, technologists, lawyers, policy makers, students, funders, and Open Science advocates, including both U.S. and international representatives. This diverse group discussed the current state of policy and technology as it relates to a scientific research commons, and identified key opportunities and challenges, as well as next …

The George-Anne, Georgia Southern University

The George-Anne

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Sowfia Project - Work Package 3 Interim Report, D Magagna, D Greaves, D Conley, E Aires, Leitao J Chambel, M Witt, C Embling, Bj Godley, J-B Saulnier, H Mouslim, T Simas, Am O’Hagan, J O’Callaghan, B Holmes, J Sundberg, Y Torre-Enciso

School of Engineering, Computing and Mathematics

No abstract provided.

Multichannel Diffuse Optical Raman Tomography For Bone Characterization In Vivo: A Phantom Study, Jennifer-Lynn H. Demers, Scott C. Davis, Brian W. Pogue, Michael D. Morris

Dartmouth Scholarship

Raman spectroscopy is used to gather information on the mineral and organic components of bone tissue to analyze their composition. By measuring the Raman signal of bone through spatially offset Raman spectroscopy the health of the bone can be determined. We’ve customized a system with 8 collection channels that consist of individual fibers, which are coupled to separate spectrometers and cooled CCDs. This parallel detection system was used to scan gelatin phantoms with Teflon inclusions of two sizes. Raman signals were decoupled from the autofluorescence background using channel specific polynomial fitting. Images with high contrast to background ratios of Raman …

Calibration Of The National Ecological Observatory Network’S Airborne Observation Platform, Nathan Leisso

The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)

The National Ecological Observatory Network (NEON) is a continental-scale ecological observation facility currently under construction by the National Science Foundation (NSF). NEON’s mission is to enable understanding and forecasting of the impacts of land-use change and invasive species by providing the infrastructure and consistent methodologies in these areas. The Airborne Observation Platform (AOP) will play a unique role in scaling individual in-situ measurements to those collected by satellite-based remote sensing. The current payload consists of the NEON Imaging Spectrometer Design Verification Unit (NISDVU), a waveform LIDAR, and a high-resolution camera integrated into a platform integration mount (PIM). Three payloads on …

Seasonality & The Local Food System: The Role Of Seasons In Local Food Education In New York City, Sarah Benoit

Urban Studies Masters Theses

Much of the current research on global and local food insecurity – particularly among poor urban populations – strongly suggests that the impacts of industrial agriculture and the American fast food culture has been detrimental to both urban and rural populations, and to small farmers. Food insecurity and unequal access to healthy and affordable food are critical issues in the metropolis. In response to these concerns, there has been a great deal of mobilization around the concept of local and regional food systems. Food systems analysis examines the viability, equitability, and sustainability of the life cycle of the local food …

Book Reviews, Criticism Editors

Criticism

Evolution in the Arts and Other Theories of Culture History (Thomas Munro) (Reviewed by Herbert M. Schueller, Wayne State University)

The Ethos of the Song of Roland (George Fenwick Jones) (Reviewed by William S. Woods, Newcomb College, Tulane University)

Dryden and the Conservative Myth: A Reading of Absalom and Achitophel (Bernard N. Schilling) (Reviewed by Curt A. Zimansky, University of Iowa)

The Idea of Coleridge's Criticism (Richard Harter Fogle) (Reviewed by Robert F. Gleckner, University of California, Riverside)

The Poetic Voices of Coleridge (Max F. Schulz) (Reviewed by Robert F. Gleckner, University of California, Riverside)

The Structure of Byron's Major …

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

The Daily Gamecock, Wednesday, August 29, 2012, University Of South Carolina, Office Of Student Media

August

No abstract provided.

Sarcopenia, Obesity, And Natural Killer Cell Immune Senescence In Aging: Altered Cytokine Levels As A Common Mechanism, Charles T. Lutz, Lebris S. Quinn

Pathology and Laboratory Medicine Faculty Publications

Human aging is characterized by both physical and physiological frailty. A key feature of frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and endurance that characterize even the healthy elderly. Increases in adiposity, particularly in visceral adipose tissue, are almost universal in aging individuals and can contribute to sarcopenia and insulin resistance by increasing levels of inflammatory cytokines known collectively as adipokines. Aging also is associated with declines in adaptive and innate immunity, known as immune senescence, which are risk factors for cancer and all-cause mortality. The cytokine interleukin-15 (IL-15) is highly expressed in skeletal muscle tissue …