Digital Commons Network^™

Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto Nathan, Michael Tonsor, Robert Struble

Faculty Research & Creative Activity

Olfactory dysfunction often precedes other clinical symptoms in chronic neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Estrogen deficiency and apoE genotype are known risk factors in these diseases and these factors also affect olfaction. Therefore we examined the effects of estradiol replacement following ovariectomy on expression of apoE and markers of cell proliferation, neuronal maturation, synaptogenesis and reactive gliosis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Estradiol replacement increased apoE staining in the olfactory nerve and glomerular layers. Estradiol increased astrocyte density and olfactory epithelium (OE) thickness regardless of the genotype. In addition estradiol …

The Sibling Relationship: Friendship Or Rivalry?, Edel Wallace

Dissertations

The aim of this study is to examine the sibling relationship from the perspective of both siblings in order to add to the understanding of potentially one of the most important relationship of an individual’s life. In particular, questions were asked about how the relationship is affected in terms of warmth, conflict and rivalry by a number of variables; gender, level of contact and number of siblings in the family. This study also sought to determine if there is a gender divide in the type of support provided between siblings.

A quantitative, self-completion questionnaire was used in order to conduct …

Nebline, September 2012

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Feature: Extend Your Growing Season with a Cold Frame or Hotbed

Farm Views

Urban Agriculture

Food & Fitness

Home & Family Living

Horticulture

Environmental Focus

4-H & Youth

Community Focus

Extension Calendar

Nutrition Education Program

Family and Community Education (FCE) Clubs

and other extension news and events

Using The Neandertal And Denisova Genetic Data To Understand The Common Mapt 17q21 Inversion In Modern Humans, Núria Setó-Salvia, Federico Sánchez-Quinto, Eudald Carbonell, Carlos Lorenzo, David Comas, Jordi Clarimón

Human Biology Open Access Pre-Prints

The polymorphic inversion on 17q21, that includes the MAPT gene, represents a unique locus in the human genome characterized by a large region with strong linkage disequilibrium. Two distinct haplotypes, H1 and H2, exist in modern humans, and H1 has been unequivocally related to several neurodegenerative disorders. Recent data indicates that recurrent inversions of this genomic region have occurred through primate evolution, with the H2 haplotype being the ancestral state. Neandertals harbored the H1 haplotype, however until now no data was available for the Denisova hominin. Neandertals and Denisovans are sister groups that share a common ancestor with modern humans. …

Vocal Expression Of Emotions In Mammals: Mechanisms Of Production And Evidence, Elodie Briefer

Communication Skills Collection

Emotions play a crucial role in an animal’s life because they facilitate responses to external or internal events of significance for the organism. In social species, one of the main functions of emotional expression is to regulate social interactions. There has recently been a surge of interest in animal emotions in several disciplines, ranging from neuroscience to evolutionary zoology. Because measurements of subjective emotional experiences are not possible in animals, researchers use neurophysiological, behavioural and cognitive indicators. However, good indicators, particularly of positive emotions, are still lacking. Vocalizations are linked to the inner state of the caller. The emotional state …

Safe And Sound

Animal Sheltering 2010-12

The ASV Guidelines In Real Life, Part Six

Gene Transcripts Encoding Hypoxia-Inducible Factor (Hif) Exhibit Tissue- And Muscle Fiber Type-Dependent Responses To Hypoxia And Hypercapnic Hypoxia In The Atlantic Blue Crab, Callinectes Sapidus, Kristin M. Hardy, Chandler R. Follett, Louis E. Burnett, Sean Lema

Biological Sciences

Hypoxia inducible factor (HIF) is a transcription factor that under low environmental oxygen regulates the expression of suites of genes involved in metabolism, angiogenesis, erythropoiesis, immune function, and growth. Here, we isolated and sequenced partial cDNAs encoding hif-α and arnt/hif-β from the Atlantic blue crab, Callinectes sapidus, an estuarine species that frequently encounters concurrent hypoxia (low O₂) and hypercapnia (elevated CO₂). We then examined the effects of acute exposure (1 h) to hypoxia (H) and hypercapnic hypoxia (HH) on relative transcript abundance for hif-α and arnt/hif-β in …

Investigation Of The Importance Of Rock Chemistry For Saxicolous Lichen Communities Of The New Idria Serpentinite Mass, San Benito County, California, Usa, Nishanta Rajakaruna, Kerry Knudsen, Alan M. Fryday, Ryan E. O'Dell, Nathaniel S. Pope, Fred C. Olday, Suzie Woolhouse

Biological Sciences

Although several lichen inventories exist for European ultramafic sites, only four surveys of serpentine lichens for North America have been published to date. Of those, only one has been conducted in California. We conducted a survey of saxicolous lichens from ultramafic rocks (including nephrite, partially serpentinized peridotite, and serpentinite) and non-ultramafic rocks (including silica-carbonate, shale, and sandstone) at the New Idria serpentinite mass, San Benito County, California. X-ray Fluorescence Analysis of the rocks from which the lichens were collected revealed significant elemental differences between the ultramafic and non-ultramafic rocks for 26 of the 32 major and trace elements analyzed. We …

A Tale Of Two Haplotypes: The Eda2r/Ar Intergenic Region Is The Most Divergent Genomic Segment Between Africans And East Asians In The Human Genome, Amanda M. Casto, Brenna M. Henn, Jeffery M. Kidd, Carlos D. Bustamante, Marcus W. Feldman

Human Biology Open Access Pre-Prints

Single nucleotide polymorphisms (SNPs) with large allele frequency differences between human populations are relatively rare. The longest run of SNPs with an allele frequency difference of one between the Yoruba of Nigeria and the Han Chinese is found on the long arm of the X chromosome in the intergenic region separating the EDA2R and AR genes. It has been proposed that the unusual allele frequency distributions of these SNPs are the result of a selective sweep affecting African populations that occurred after the Out-of-Africa migration. To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure …

An Examination Of Exposure To Traumatic Events And Symptoms And Strengths For Children Served In A Behavioral Health System Of Care, Melissa L. Whitson, Christian M. Connell, Stanley N. Bernard, Joy S. Kaufman

Psychology Faculty Publications

The present study examined how exposure to traumatic events impacts children with severe emotional disturbance who are being served in a school-based system of care. Multilevel growth curve models were used to examine the relationships between a child’s history of traumatic events (physical abuse, sexual abuse, or domestic violence) and behavioral and emotional strengths, internalizing problem behaviors, or externalizing problem behaviors over 18 months. Results indicate that children receiving services (N = 134) exhibited increased emotional and behavioral strengths and decreased internalizing and externalizing problem behaviors from enrollment to 18 months follow-up. Children with a history of traumatic events improved …

Reinterpreting Bateman Gradients: Multiple Mating And Selection In Both Sexes Of A Songbird Species, N.M. Gerlach, J.W Mcglothlin, P.G Parker, E.D Ketterson

Biology Department Faculty Works

Bateman’s principle, which states that male reproductive success should increase with multiple mating, whereas female reproductive success should not, has long been used to explain sex differences in behavior. The statistical relationship between mating success and reproductive success, or Bateman gradient, has been proposed as a way to quantify sex differences in sexual selection. We used a long-term data set on the distribution of paternity in the socially monogamous dark-eyed junco to examine the effect of multiple mating on lifetime reproductive success and to determine the relative contributions of within-pair and extra-pair mating. Both sexes exhibited a strong positive Bateman …

Mapping Shallow Water Habitats Of The Wallabi Group, Houtman Abrolhos Islands, Using Remote Sensing Techniques, Scott N. Evans, Lynda M. Bellchambers, K Murray

Fisheries Research Reports

The use of mapping techniques to identify and quantify habitats is becoming an increasingly important tool for the effective management of marine resources. With a multitude of techniques such as remote sensing, acoustic surveys and towed video all commonly used, the decision on the methodology to use depends on the resolution of output data required to answer the objectives of the survey, the spatial extent and location of survey site as well as the associated costs of surveying

Linfield University Catalog, 2012-2013, Linfield Archives

Student Course Catalogs

No abstract provided.

Graduate Faculty Committee, Wku Graduate Council

Graduate School

Membership of Graduate Committee.

Nest Predation Risk And Growth Strategies Of Passerine Species: Grow Fast Or Develop Traits To Escape Risk?, Yi-Ru Cheng, Thomas E. Martin

Wildlife Biology Faculty Publications

Different body components are thought to trade off in their growth and development rates, but the causes for relative prioritization of any trait remains a critical question. Offspring of species at higher risk of predation might prioritize development of locomotor traits that facilitate escaping risky environments over growth of mass. We tested this possibility in 12 altricial passerine species that differed in their risk of nest predation. We found that rates of growth and development of mass, wings, and endothermy increased with nest predation risk across species. In particular, species with higher nest predation risk exhibited relatively faster growth of …

Poliovirus Infection Transiently Increases Copii Vesicle Budding, Meg Trahey, Hyung Suk Oh, Craig E. Cameron, Jesse C. Hay

Biological Sciences Faculty Publications

Poliovirus (PV) requires membranes of the host cell's secretory pathway to generate replication complexes (RCs) for viral RNA synthesis. Recent work identified the intermediate compartment and the Golgi apparatus as the precursors of the replication "organelles" of PV (N. Y. Hsu et al., Cell 141:799-811, 2010). In this study, we examined the effect of PV on COPII vesicles, the secretory cargo carriers that bud from the endoplasmic reticulum and homotypically fuse to form the intermediate compartment that matures into the Golgi apparatus. We found that infection by PV results in a biphasic change in functional COPII vesicle biogenesis in cells, …

Fall 2012, Center For Research & Grants

Research Matters (Archival - No longer actively being published)

No abstract provided.

Inflammation, Organomegaly, And Muscle Wasting Despite Hyperphagia In A Mouse Model Of Burn Cachexia., Felipe E Pedroso, Paul B Spalding, Michael C Cheung, Relin Yang, Juan C Gutierrez, Andrea Bonetto, Rui Zhan, Ho Lam Chan, Nicholas Namias, Leonidas G Koniaris, Teresa A Zimmers

Department of Cancer Biology Faculty Papers

BACKGROUND: Burn injury results in a chronic inflammatory, hypermetabolic, and hypercatabolic state persisting long after initial injury and wound healing. Burn survivors experience a profound and prolonged loss of lean body mass, fat mass, and bone mineral density, associated with significant morbidity and reduced quality of life. Understanding the mechanisms responsible is essential for developing therapies. A complete characterization of the pathophysiology of burn cachexia in a reproducible mouse model was lacking.

METHODS: Young adult (12-16 weeks of age) male C57BL/6J mice were given full thickness burns using heated brass plates or sham injury. Food and water intake, organ and …

The Genus Plectrocnemia Stephens In China (Trichoptera, Polycentropodidae), Hua Zhong, Lian-Fang Yang, John C. Morse

Publications

Currently, 21 species of the genus Plectrocnemia are known from China. Examination of material collected from 13 provinces of China from 1990–2005 has revealed 9 new species and 3 new records of this genus, bringing the number of Chinese Plectrocnemia species to 33. Newly described species include: P. monacanthus sp. nov., P. huangi sp. nov., P. maoerensis sp. nov., P. pectinata sp. nov., P. fanjingensis sp. nov., P. platilobus sp. nov., P. paragryphalis sp. nov., P. bifoliolata sp. nov., and P. wuyiensis sp. nov. Two species, Plectrocnemia sinualis Wang & Yang and P. uncata Wang & Yang are synonymized with …

Peyer's Patch M Cells Derived From Lgr5+ Stem Cells Require Spib And Are Induced By Rankl In Cultured Miniguts, Wim De Lau, Pekka Kujala, Kerstin Schneeberger, Sabine Middendorp, Vivian S.W. Li, Nick Barker, Anton Martens, Frans Hofhuis, Rodney P. Dekoter, Peter J. Peters, Edward Nieuwenhuis, Hans Clevers

Paediatrics Publications

Peyer's patches consist of domains of specialized intestinal epithelium overlying gut-associated lymphoid tissue (GALT). Luminal antigens reach the GALT by translocation through epithelial gatekeeper cells, the so-calledMcells. We recently demonstrated that all epithelial cells required for the digestive functions of the intestine are generated from Lgr5-expressing stem cells. Here, we show thatMcells also derive from these crypt-based Lgr5 stem cells. The Ets family transcription factor SpiB, known to control effector functions of bone marrow-derived immune cells, is specifically expressed inMcells. In SpiB-/-mice, Mcells are entirely absent, which occurs in a cell-autonomous fashion. It has been shown that Tnfsf11 (RankL) can …

Mechanisms In Decorin Regulation Of Vascular Endothelial Growth Factor-Induced Human Trophoblast Migration And Acquisition Of Endothelial Phenotype, Neena Lala, Gannareddy V. Girish, Alia Cloutier-Bosworth, Peeyush K. Lala

Paediatrics Publications

Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-placental arteries to establish an efficient exchange of key molecules between maternal and fetal blood. Trophoblast invasion is stringently regulated in situ both positively and negatively by a variety of factors at the fetal-maternal interface to maintain a healthy utero-placental homeostasis. One such factor, decorin, a transforming growth factor (TGF)-beta binding, leucine-rich proteoglycan produced by the decidua, negatively regulates EVT proliferation, migration, and invasiveness independent of TGFbeta.We reported that these decorin actions were mediated by its binding to multiple tyrosine kinase receptors, including vascular endothelial growth factor …

Adobe Medicus 2012 5 September-October, Health Sciences Library And Informatics Center

adobe medicus

No abstract provided.

Arabidopsis Scaffold Protein Rack1a Modulates Rare Sugar D-Allose Regulated Gibberellin Signaling, Hemayet Ullah

Department of Biology Faculty Publications

As energy sources and structural components, sugars are the central regulators of plant growth and development. In addition to the abundant natural sugars in plants, more than 50 different kinds of rare sugars exist in nature, several of which show distinct roles in plant growth and development. Recently, one of the rare sugars, D-allose, an epimer of D-glucose at C3, is found to suppress plant hormone gibberellin (GA) signaling in rice. Scaffold protein RACK1A in the model plant Arabidopsis is implicated in the GA pathway as rack1a knockout mutants show insensitivity to GA in GA-induced seed germination. Using genetic knockout …

Longitudinal Associations Between Executive Control And Developing Mathematical Competence In Preschool Boys And Girls, Caron A. C. Clark, Tiffany Sheffield, Sandra A. Wiebe, Kimberly A. Espy

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Executive control (EC) is related to mathematics performance in middle childhood. However, little is known regarding how EC and informal numeracy differentially support mathematics skill acquisition in preschoolers. A sample of preschoolers (115 girls, 113 boys), stratified by social risk, completed an EC task battery at 3 years, informal numeracy assessments at 3.75 and 4.5 years, and a broad mathematics assessment during kindergarten. Strong associations were observed between latent EC at age 3 and mathematics achievement in kindergarten, which remained robust after accounting for earlier informal numeracy, socioeconomic status, language and processing speed. Relations between EC and mathematics achievement were …

Virtue Ethics, Care Ethics, And "The Good Life Of Teaching", Marissa Silverman

John J. Cali School of Music Scholarship and Creative Works

In "The Good Life of Teaching: An Ethics of Professional Practice," Chris Higgins (2011) reminds people that "self-interest and altruism, personal freedom and social roles, and practical wisdom and personhood" have been ancient philosophical topics that remain vitally important in the practice of contemporary teaching and learning. One of the most fundamental questions Higgins raises is this: "How do we reconcile self-regard and concern for others?" Higgins echoes John Dewey's concern for "balancing the distinctive capacity of an individual with his social service." In other words, and educationally speaking: What does it mean to live "the good life" as an …

A Ten-Year Experience Of A Pharmacist Consulting Team For Statewide Bioterrorism And Emergency Preparedness, Brett Feret, P. Bratberg

Pharmacy Practice and Clinical Research Faculty Publications

No abstract provided.

Bias In A Just World? Sexual Prejudice, Gender Self-Esteem, And Intimate Partner Violence, Crystal D. Mahoy

All-Inclusive List of Electronic Theses and Dissertations

Each year, approximately 835,000 men and 1.3 million women are victims of intimate partner violence (IPV; American Bar Association, n.d). Although the prevalence of same-sex intimate partner violence (IPV) is approximately the same as IPV in heterosexual couples (Alexander, 2002), fewer studies have examined perceptions of IPV in same-sex couples or of IPV perpetrated against heterosexual men compared to heterosexual women. In the current study, Just World Theory (Lerner & Miller, 1978) is used as a framework for understanding factors associated with perceptions of heterosexual and same-sex IPV, including sexual prejudice and gender self-esteem. Perceptions of IPV were examined in …

Five Year Issue-Based Review, September 2012: A Comprehensive Study Of The Southeast District Of University Of Nebraska–Lincoln Extension, Amy L. Virgl

Southeast Research and Extension Center: Reports and Administration

Vision: The Southeast Extension District is a premier provider of research-based information, delivering education ‘… Any time, Any place, Any path, Any pace…’ to multigenerational clientele. An organization with professionals embedded in Nebraska communities that serve to engage the citizenry with their land-grant institution and help them solve complex problems around the important priorities of Food, Fuel, Water, Landscapes, and People.

Our vision requires innovation and attaining excellence in every area and at every level of the organization— personnel recruitment and development, curriculum development, program partnerships, external funding, student recruitment, teaching strategies and delivery systems. Extension professionals are highly regarded …

Temporal Changes In Fish Assemblages Following Hydrological Disturbance, Matthew Dunn, Michael Delong

Student Research and Creative Projects 2012-2013

No abstract provided.

Galactosemia: Analzing A Familial Mutation, Sarah Mueller, Amy Runck

Student Research and Creative Projects 2012-2013

No abstract provided.