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The Utah Statesman, October 9, 2012, Utah State Univesity

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Current Volume 23 : Issue 8, Nova Southeastern University

Student Newspapers

No abstract provided.

Withanolide Compounds As Inhibitors Of Fibrosis And Identification Of Molecular Targets For Anti-Fibrotic Drug Development, Royce Mohan, Paola Bargagna-Mohan

Ophthalmology and Visual Science Faculty Patents

Provided are methods for screening for drugs effective for treating fibrotic conditions. One screening method comprises exposing a cell to a test compound, monitoring the effect of the test compound on the amount or form of a cell molecule, comparing the amount or form of the cell molecule with the result obtained by treatment of the cell with an anti-fibrotic -effective amount of a withanolide compound, and selecting a drug effective for treating a fibrotic disease based on the ability of the test compound to provide the effect obtained by the withanolide compound on the cell molecule. Also provided is …

Aqueous-Based Initiator Attachment And Atrp Grafting Of Polymer Brushes From Poly(Methyl Methacrylate) Substrates, Sreelatha S. Balamurugan, Balamurugan Subramanian, Jowell G. Bolivar, Robin L. Mccarley

Faculty Publications

Many polymers, such as PMMA, are very susceptible to swelling or dissolution by organic solvents. Growing covalently attached polymer brushes from these surfaces by atom-transfer radical polymerization (ATRP) is challenging because of the typical requirement of organic solvent for initiator immobilization. We report an unprecedented, aqueous-based route to graft poly(N-isopropylacrylamide), PNIPAAm, from poly(methyl methacrylate), PMMA, surfaces by ATRP, wherein the underlying PMMA is unaffected. Successful attachment of the ATRP initiator, N-hydroxysuccinimidyl-2-bromo-2- methylpropionate, on amine-bearing PMMA surfaces was confirmed by XPS. From this surface-immobilized initiator, thermoresponsive PNIPAAm brushes were grown by aqueous ATRP to yield optically transparent PNIPAAm-grafted PMMA surfaces. This …

Thr 163 Phosphorylation Causes Mcl-1 Stabilization When Degradation Is Independent Of The Adjacent Gsk3-Targeted Phosphodegron, Promoting Drug Resistance In Cancer, Shanna K. Nifoussi, Julie A. Vrana, Aaron M. Domina, Alfredo De Biasio, Jingang Gui, Mark A. Gregory, Stephen R. Hann, Ruth W. Craig

Dartmouth Scholarship

The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance of Mcl-1 expression is an important determinant of drug resistance in cancer. Phosphorylation at Thr 163 in the PEST region, stimulated by 12-O-tetradecanoylphorbol acetic acid (TPA)-induced activation of extracellular signal-regulated kinase (ERK), is associated with Mcl-1 stabilization in BL41-3 Burkitt lymphoma cells. This contrasts with the observation that Thr 163 phosphorylation in normal fibroblasts primes glycogen synthase kinase (GSK3)-induced phosphorylation at Ser 159, producing a …

Daily Eastern News: October 09, 2012, Eastern Illinois University

October

No abstract provided.

The Role Of Micrornas In Breast Cancer Migration, Invasion And Metastasis, Joy Tang, Fazlul H. Sarkar, Aamir Ahmad

Honors College Theses

MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been implicated in several human cancers, including breast cancer. miRNAs are known to regulate cell cycle and development, and thus may serve as useful targets for exploration in anticancer therapeutics. The link between altered miRNA signatures and breast cancer development and metastasis can be observed either through the loss of tumor suppressor miRNAs, such …

Fort Hays State University Faculty Senate Minutes, October 9, 2012, Fhsu Faculty Senate

Faculty Senate

No abstract provided.

Bfs News Online, Georgia Southern University

Art: News & Publications (2008-2023)

• Marc Moulton receives Faculty Award for Excellence in Research/Creative Scholarly Activity

The George-Anne, Georgia Southern University

The George-Anne

• Eye Scanners Possible in Lakeside Remodel
• News
• Opinions
• Arts & Entertainment
• Classifieds
• Puzzles/ Comics
• Sports

The New Hampshire, Vol. 102 [103], No. 10 (Oct. 9, 2012), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 102, but it is the 103rd volume in the series. This was corrected in pencil.

School Food Environment The Frontline For Childhood Obesity Prevention: A Mixed-Method Study Of Nutritional Competencies And Skills Of School Nutrition Professionals In Nebraska, Zainab Rida

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The purpose of this statewide study was to address the nutrition knowledge, attitudes, and perceptions of school foodservice personnel in Nebraska regarding offering/serving healthy school meals. Moreover, this study identified some potential barriers and avenues of action for offering/serving healthy school meals. Data obtained from this study indicates that there is a strong correlation (r= .103, p r .237, p< .01) between the foodservice staff’s self-efficacy and their practices of offering/serving healthy school meals. Fortunately, the relationship between foodservice staff practices of offering/serving healthy school meals and their self-efficacy was positive and significantly predicted practices scores, β =.237, P< 0.01. The finding of the present study also identifies many barriers including lack of time and support that face the foodservice personnel in offering/serving healthy school meals. The findings suggested that there is an urgent need of a full school approach to promote and encourage healthy eating habits among students. Future research is needed to evaluate school wellness policies regarding healthy eating practices in schools. Moreover, establish partnerships with communities and universities for intervention that target students and their parents.

Advisor: Wanda Koszewski

Activation Of Amp-Activated Protein Kinase By 3,39-Diindolylmethane (Dim) Is Associated With Human Prostate Cancer Cell Death In Vitro And In Vivo, Di Chen, Sanjeev Banerjee, Qiuzhi C. Cui, Dejuan Kong, Fazlul H. Sarkar, Q. Ping Dou

Oncology Faculty Publications

There is a large body of scientific evidence suggesting that 3,39-Diindolylmethane (DIM), a compound derived from the digestion of indole-3-carbinol, which is abundant in cruciferous vegetables, harbors anti-tumor activity in vitro and in vivo. Accumulating evidence suggests that AMP-activated protein kinase (AMPK) plays an essential role in cellular energy homeostasis and tumor development and that targeting AMPK may be a promising therapeutic option for cancer treatment in the clinic. We previously reported that a formulated DIM (BR-DIM; hereafter referred as B-DIM) with higher bioavailability was able to induce apoptosis and inhibit cell growth, angiogenesis, and invasion of prostate cancer cells. …

Neutralizing Antibodies And Pathogenesis Of Hepatitis C Virus Infection, Samira Fafi-Kremer, Catherine Fauvelle, Daniel J. Felmlee, Mirjam B. Zeisel, Quentin Lepiller, Isabel Fofana, Laura Heydmann, Françoise Stoll-Keller, Thomas F. Baumert

Peninsula Medical School

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the …

A Literature Review: How Language Parameter Deficits Impact Social Interaction In Children With Autism Spectrum Disorders During Middle Childhood, And Intervention Strategies, Carmen Nicole Grange

McNair Scholars Research Journal

Human growth is dependent upon social interactions, notably essential during the middle childhood years (ages 5-10). Although some children develop differently than others, all experience the same types of mental processes through which, due to a variety of factors, they may become typically achieving, or stunted in their development. Language is a key component of being human. Communication occurs through verbal and nonverbal behavior. People are able to understand what others are trying to encode through multiple processes of interpretation. Humans learn to use language through interaction with others, but are born with the ability to acquire language. Children with …

Developing A Vision Of Pre-College Engineering Education, Jill A. Marshall, Leema K. Berland

Journal of Pre-College Engineering Education Research (J-PEER)

We report the results of a study focused on identifying and articulating an ‘‘epistemic foundation’’ underlying a pre-collegiate focus on engineering. We do so in the context of UTeachEngineering (UTE), a program supported in part by funding by the National Science Foundation and designed to develop a model approach to address the systematic challenges facing this work—from identifying learning goals, to certifying pre- and in-service teachers for engineering courses to developing a research-based high school engineering course. Given the systemic nature of the UTE approach, this model is positioned to serve as a starting point to further the conversation around …

Impact Of Ret Teacher-Developed Curriculum Units On Classroom Experiences For Teachers And Students, Stacy S. Klein-Gardner, Megan E. Johnston, Lisa Benson

Journal of Pre-College Engineering Education Research (J-PEER)

This phenomenological study examined the impact of Research Experiences for Teachers (RET) teacher-developed curriculum on teaching styles and strategies at two RET sites with common Legacy Cycle training. The study was conducted to assess and document program-specific and National Science Foundation (NSF) goals related to classroom practices and outcomes. We set out to define how the RET program influenced teachers’ teaching style and strategies and how teachers’ new curriculum from the RET program affected students. Twenty-seven science and math teachers participated in interviews at the end of their summer research experience, and twenty of these teachers participated in interviews after …

A Model For Professional Development To Promote Engineering Design As An Integrative Pedagogy Within Stem Education, Joel D. Donna

Journal of Pre-College Engineering Education Research (J-PEER)

Engineering design activities can help educators to apply concepts and processes from within and across STEM domains. To facilitate these connections, there is a need for sustained, job-embedded, and collegial professional development that brings together teachers from across STEM domains to engage in design-based activities. These activities can help teachers better understand engineering design processes and can foster collaborations. This can lead to a culture shift within the school by which integration of STEM concepts and process becomes more seamless for both educators and their students. This paper describes a research-based model for professional development to promote engineering pedagogy to …

Positive Emotion And Impulsivity In Individuals With Bipolar I Disorder, Jennifer Y. Nam

Open Access Dissertations

Impulsivity as a symptom during mania is well documented, but less is known about the driving factors behind these impulsive acts. Perhaps this is because impulsivity is a term that encompasses multiple facets. There is evidence for a type of impulsivity in which extreme sensitivity to positive affective states can influence cognitive processes, such as error detection and identification of threatening cues. This can ultimately lead to engagement in impulsive actions during elevated mood states. Among people who are vulnerable to mania, positive moods have larger or more pervasive effects than they have on other people. While there is more …

Examining The Impact Of Pau Jacaré (Piptadenia Gonoacantha) Growth On Soil Fertility In The Brazilian Atlantic Rainforest, Aleksandra Ponomareva

Environmental Analysis Program Mellon Student Summer Research Reports

The Atlantic Rainforest of Brazil is an area of astounding diversity in both flora and fauna, taking its place among the top five “biodiversity hotspots” in the world. However, in the past 40 or 50 years the area has been increasingly threatened by the presence of humans – approximately 93% of the Rainforest has disappeared as a result of exploitation (Turner 2004). Unsustainable farming practices, as well as logging, cattle ranching and mining activities have caused soil infertility, water depletion, erosion and destruction of ecosystems. This project examines the effects of the Pau Jacaré, Piptadenia gonoacantha, tree on soil health …

Assessing The Causal Effect Of Policies: An Approach Based On Stochastic Interventions, Iván Díaz, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Stochastic interventions are a powerful tool to define parameters that measure the causal effect of a realistic intervention that intends to alter the population distribution of an exposure. In this paper we follow the approach described in D\'iaz and van der Laan (2011) to define and estimate the effect of an intervention that is expected to cause a truncation in the population distribution of the exposure. The observed data parameter that identifies the causal parameter of interest is established, as well as its efficient influence function under the non parametric model. Inverse probability of treatment weighted (IPTW), augmented IPTW and …

October 8, 2012, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Statesman, V. 56, I. 06, Stony Brook University

Stony Brook Statesman-Sucolian

v. 56, i. 06

President's Weekly Perspective, 10/8/2012, Robert G. Frank

President Frank's Administration

No abstract provided.

Jiang And Etikala Named Mr. And Ms. Uab 2012, Shannon Thomason

Browse All News

No abstract provided.

The Collegian (2012-10-08), Joe Molina

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 65, No. 7

Current, October 08, 2012, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Unh Professor Pens Book On History Of Fishing The Atlantic, Lori Wright

Media Relations

No abstract provided.

Fus-Nls/Transportin 1 Complex Structure Provides Insights Into The Nuclear Targeting Mechanism Of Fus And The Implications In Als, Chunyan Niu, Jiayu Zhang, Feng Gao, Liuqing Yang, Minze Jia, Haining Zhu, Weimin Gong

Molecular and Cellular Biochemistry Faculty Publications

The C-terminal nuclear localization sequence of FUsed in Sarcoma (FUS-NLS) is critical for its nuclear import mediated by transportin (Trn1). Familial amyotrophic lateral sclerosis (ALS) related mutations are clustered in FUS-NLS. We report here the structural, biochemical and cell biological characterization of the FUS-NLS and its clinical implications. The crystal structure of the FUS-NLS/Trn1 complex shows extensive contacts between the two proteins and a unique α-helical structure in the FUS-NLS. The binding affinity between Trn1 and FUS-NLS (wide-type and 12 ALS-associated mutants) was determined. As compared to the wide-type FUS-NLS (K(D) = 1.7 nM), each ALS-associated mutation caused a decreased …

Influenza-Infected Neutrophils Within The Infected Lungs Act As Antigen Presenting Cells For Anti-Viral Cd8+ T Cells, Matthew M. Hufford, Graham Richardson, Haixia Zhou, Balaji Manicassamy, Adolfo Garcia-Sastre, Richard I. Enelow, Thomas J. Braciale

Dartmouth Scholarship

Influenza A virus (IAV) is a leading cause of respiratory tract disease worldwide. Anti-viral CD8⁺ T lymphocytes responding to IAV infection are believed to eliminate virally infected cells by direct cytolysis but may also contribute to pulmonary inflammation and tissue damage via the release of pro-inflammatory mediators following recognition of viral antigen displaying cells. We have previously demonstrated that IAV antigen expressing inflammatory cells of hematopoietic origin within the infected lung interstitium serve as antigen presenting cells (APC) for infiltrating effector CD8⁺ T lymphocytes; however, the spectrum of inflammatory cell types capable of serving as APC was not …