Digital Commons Network^™

Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth By Targeting Vegfr- 2 Regulated Akt/Mtor/P70s6k Signaling Pathways, Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, Xianglin Shi

Toxicology and Cancer Biology Faculty Publications

Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the growing tumor to receive oxygen and nutrients. Cancer prevention using natural products has become an integral part of cancer control. We studied the antiangiogenic activity of quercetin using ex vivo, in vivo and in vitro models. Rat aortic ring assay showed that quercetin at non-toxic concentrations significantly inhibited microvessel sprouting and exhibited a significant inhibition in the proliferation, migration, invasion and tube formation of endothelial cells, which are key events in the process of angiogenesis. Most importantly, quercetin treatment inhibited ex vivo angiogenesis …

The Us Challenge To Stay The Worlds Technical Leader In Innovation, Robert J. Twiggs

Robert "Bob" Twiggs STEM Education Collection

A PowerPoint presentation created by Professor Bob Twiggs titled "The US Challenge to Stay the Worlds Technical Leader in Innovation" from October 18, 2012.

Charger Times Vol. 1, No. 7, 2012-10-18, University Of Alabama In Huntsville

Charger Times (2012-2014)

No abstract provided.

Functional Classification Of Skeletal Muscle Networks. Ii. Applications To Pathophysiology, Yu Wang, Jack Winters, Shankar Subramaniam

Biomedical Engineering Faculty Research and Publications

In our preceding companion paper (Wang Y, Winters J, Subramaniam S. J Appl Physiol. doi: 10.1152/japplphysiol.01514.2011), we used extensive expression profile data on normal human subjects, in combination with legacy knowledge to classify skeletal muscle function into four models, namely excitation-activation, mechanical, metabolic, and signaling-production model families. In this paper, we demonstrate how this classification can be applied to study two well-characterized myopathies: amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD). Using skeletal muscle profile data from ALS and DMD patients compared with that from normal subjects, normal young in the case of DMD, we delineate molecular mechanisms …

The Cowl - V.77 - N.6 - Oct 18, 2012

The Cowl

The Cowl - student newspaper of Providence College. Vol 77 - No. 6 - October 18, 2012. 28 pages.

The Alestle - Vol. 65 No. 10 - 10/18/2012, Southern Illinois University Edwardsville

The Alestle

Vol. 65 No. 10

Cultural Historian From Emory University To Discuss Legacies Of Racism In Deep South, College Of Liberal Arts

University of Mississippi News

Lecture will examine the links between mental illness, racism and anti-Semitism.

The George-Anne, Georgia Southern University

The George-Anne

• Dining Plans Revamped in 2013
• News
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• Arts & Entertainment
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Changes In Eeg During Ultralong Running, M. Doppelmayr, P. Sauseng, H. Doppelmayr, I. Mausz

Journal of Human Performance in Extreme Environments

There are only a few studies using human electroencephalograms (EEGs) to investigate bioelectrical changes in the brain during exercise (running or cycling). These studies report an increase in EEG alpha amplitude during and immediately after exercise. However, only exercises within a relatively short time interval of approximately 1 hour have been investigated. Thus, we focussed on long-lasting exercise and report three single case studies, performed on the same participant, during extended exercise and under different thermal conditions. EEG was recorded during a 12-, 24-, and 56-hour ultramarathon. The 56-hour race was performed under extreme thermal stress in Death Valley, CA, …

Cyanolyase: A Database Of Phycobilin Lyase Sequences, Motifs And Functions, Wendy M. Schluchter, Anthony Bretaudeau, Francois Coste, Florian Humily, Laurence Garczarek, Gildas Le Corguille, Christophe Six, Morgane Ratin, Olivier Collin, Frederic Partensky

Biological Sciences Faculty Publications

CyanoLyase (http://cyanolyase.genouest.org/) is a manually curated sequence and motif database of phycobilin lyases and related proteins. These enzymes catalyze the covalent ligation of chromophores (phycobilins) to specific binding sites of phycobiliproteins (PBPs). The latter constitute the building bricks of phycobilisomes, the major light-harvesting systems of cyanobacteria and red algae. Phycobilin lyases sequences are poorly annotated in public databases. Sequences included in CyanoLyase were retrieved from all available genomes of these organisms and a few others by similarity searches using biochemically characterized enzyme sequences and then classified into 3 clans and 32 families. Amino acid motifs were computed for each family …

Two-Photon Time-Lapse Microscopy Of Bodipy-Cholesterol Reveals Anomalous Sterol Diffusion In Chinese Hamster Ovary Cells, Frederik W. Lund, Michael A. Lomholt, Lukasz M. Solanko, Robert Bittman, Daniel Wüstner

Publications and Research

Background Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast, have established that vesicular and non-vesicular transport modes contribute to sterol trafficking from the plasma membrane. Significant photobleaching, however, limits the possibilities for in-depth analysis of sterol dynamics using DHE. Co-trafficking studies with DHE and the recently introduced fluorescent cholesterol analog BODIPY-cholesterol (BChol) suggested that the latter probe has utility for prolonged live-cell imaging of sterol transport. Results We found that BChol is very photostable under two-photon (2P)-excitation allowing the acquisition …

Mcdaniel Slough Wetland Restoration Staff Recommendation, Coastal Conservancy

Project Documents

The McDaniel Slough Wetland Restoration Project restored tidal flow and fish passage to 280 acres of former salt marsh wetlands and enhanced associated wildlife habitat. The project removed barriers to anadromous fish, restored tidal influence, deepened historic slough channels, partially removed failing or obsolete levees, and constructed levees to protect adjacent property.. This project improved connectivity by connecting more than 1,300 acres of local, state and federally protected lands along Humboldt Bay. This document summarizes the Coastal Conservancy's Staff Recommendation and authorization to provide funding for the implementation of the project.

Possible Steps Of Complete Disassembly Of Post-Termination Complex By Yeast Eef3 Deduced From Inhibition By Translocation Inhibitors., Shinya Kurata, Ben Shen, Jun O Liu, Nono Takeuchi, Akira Kaji, Hideko Kaji

Department of Biochemistry and Molecular Biology Faculty Papers

Ribosomes, after one round of translation, must be recycled so that the next round of translation can occur. Complete disassembly of post-termination ribosomal complex (PoTC) in yeast for the recycling consists of three reactions: release of tRNA, release of mRNA and splitting of ribosomes, catalyzed by eukaryotic elongation factor 3 (eEF3) and ATP. Here, we show that translocation inhibitors cycloheximide and lactimidomycin inhibited all three reactions. Cycloheximide is a non-competitive inhibitor of both eEF3 and ATP. The inhibition was observed regardless of the way PoTC was prepared with either release factors or puromycin. Paromomycin not only inhibited all three reactions …

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

Kenyon Collegian - October 18, 2012

The Kenyon Collegian

No abstract provided.

2012-10-18 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate Meeting Minutes for October 18, 2012.

Montana Kaimin, October 18, 2012, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

October 18, 2012, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Effects Of Owl Decoys And Non-Threatening Objects On Bird Feeding Behavior, Leah J. Rensel, Jannell D. Wilder

Quercus: Linfield Journal of Undergraduate Research

As traditional agricultural practices change, the scarecrow has also been renovated and modernized to include mock natural predators, such as owls, hawks, and falcons instead of comical human representations. These facsimiles represent an excellent opportunity to examine anti-predatory tactics and vigilance behavior in birds as a response to perceived threats. In this study, we tested songbird reaction to an owl decoy that mimicked the presence of a predator and to a non-threatening object placed in an oak woodland within Oregon’s Willamette Valley. Frequency of bird visitations to bird feeders when either a plastic owl or a cardboard box of similar …

Human Performance On Hard Non-Euclidean Graph Problems: Vertex Cover, Sarah Carruthers, Michael E. J. Masson, Ulrike Stege

The Journal of Problem Solving

Recent studies on a computationally hard visual optimization problem, the Traveling Salesperson Problem (TSP), indicate that humans are capable of finding close to optimal solutions in near-linear time. The current study is a preliminary step in investigating human performance on another hard problem, the Minimum Vertex Cover Problem, in which solvers attempt to find a smallest set of vertices that ensures that every edge in an undirected graph is incident with at least one of the selected vertices. We identify appropriate measures of performance, examine features of problem instances that impact performance, and describe strategies typically employed by participants to …

The Open Road And The Traffic Stop: Narratives And Counter-Narratives Of The American Dream, Nancy Leong

Florida Law Review

American culture is steeped in the mythology of the open road. In our collective imagination, the road represents freedom, escape, friendship, romance, and above all, the possibility for a better life. But our shared dream of the open road comes to a halt in the mundane reality of the traffic stop—a judicially authorized policing procedure in which an officer may pull over a vehicle if she has cause to believe the driver has committed even the most minor traffic violation. I examine the cultural texts—books, movies, songs—celebrating the open road and juxtapose them against those documenting the traffic stop. The …

Critical Habitat And The Challenge Of Regulating Small Harms, Dave Owen

Florida Law Review

This Article investigates how the U.S. Fish and Wildlife Service, the National Marine Fisheries Service, and the courts are implementing the Endangered Species Act’s prohibition on “adverse modification” of “critical habitat.” That prohibition appears to be one of environmental law’s most ambitious mandates, but its actual meaning and effect are contested. Using a database of over 4,000 “biological opinions,” interviews with agency staff, and a review of judicial decisions considering the adverse modification prohibition, this Article assesses the extent to which the Fish and Wildlife Service, the National Marine Fisheries Service, and the courts are relying on the adverse modification …

Planetarian Identity Formation And The Relocalization Of Environmental Law, Sarah Krakoff

Florida Law Review

Local food, local work, local energy production-all are hallmarks of a resurgence of localism throughout contemporary environmental thought and action. The renaissance of localism might be seen as a retreat from the world’s global environmental problems. This Article maintains, however, that some forms of localism are actually expressions, appropriate ones, of a planetary environmental consciousness. This Article’s centerpiece is an in-depth evaluation of local climate action initiatives, including interviews with participants, as well as other data and observations about their ethics, attitudes, behaviors, and motivations. The values and identities being forged in these initiatives form the basis for timely conceptions …

Introduction: Climate Change At Epa, Lisa Heinzerling

Florida Law Review

With the demise of climate legislation in Congress, and the Supreme Court’s rejection of climate-related lawsuits brought under federal common law, rapt attention has turned to the Environmental Protection Agency’s (EPA) efforts to bring greenhouse gases into the regulatory fold. Certainly, as the works in this special issue of the Florida Law Review demonstrate, EPA is not the only important player in the climate arena; indeed, as I will reluctantly suggest, the Agency’s efforts here appear to be waning rather than waxing. Even so, before turning to other aspects of the problem of climate change, discussed in other works in …

Unique Small Rna Signatures Uncovered In The Tammar Wallaby Genome, James Lindsay, Dawn M. Carone, Judy Brown, Laura Hall, Sohaib Qureshi, Sarah E. Mitchell, Nicholas Jannetty, Andrew Pask, Michael O’Neill, Rachel O’Neill

Open Access Author Fund Awardees' Articles

Background

Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. The tammar wallaby, a marsupial mammal, is a powerful comparative model for studying the evolution of regulatory networks. As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short …

Undergraduate Curriculum And Academic Policy Committee Minutes, October 17, 2012

Undergraduate Curriculum and Academic Policy Committee Minutes

Minutes from the Wright State University Faculty Senate Undergraduate Curriculum and Academic Policy Committee meeting held on October 17, 2012.

Nor'easter News Volume 6 Issue 3, Nor'easter News Staff

Nor'easter News

The fifty-sixth issue of the University of New England's student-run newspaper, Nor'easter News.

"The Crescent" Student Newspaper, October 17, 2012, George Fox University Archives

"The Crescent" Student Newspaper

Student newspaper of George Fox University.

The Anchor, Volume 126.06: October 17, 2012, Hope College

The Anchor: 2012

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Glibenclamide Induces Collagen Iv Catabolism In High Glucose-Stimulated Mesangial Cells, Liping Zhu, Pedro Cortes, Clare Hassett, David W. Taube, Jerry Yee

Nephrology Articles

We have shown the full prevention of mesangial expansion in insulin-deficient diabetic rats by treatment with clinically-relevant dosages of glibenclamide (Glib). Studies in mesangial cells (MCs) also demonstrated reduction in the high glucose (HG)-induced accumulation of collagens, proposing that this was due to increased catabolism. In the present study, we investigated the signaling pathways that may be implicated in Glib action. Rat primary MCs were exposed to HG for 8 weeks with or without Glib in therapeutic (0.01 μM) or supratherapeutic (1.0 μM) concentrations. We found that HG increased collagen IV protein accumulation and PAI-1 mRNA and protein expression, in …