Digital Commons Network^™

Processes And Pathways: How Do Mathematics And Science Partnerships Measure And Promote Growth In Teacher Content Knowledge?, Patricia S. Moyer-Packenham, A. Westenskow

Teacher Education and Leadership Faculty Publications

Intense focus on student achievement results in mathematics and science has brought about claims that K-12 teachers should be better prepared to teach basic concepts in these disciplines. The focus on teachers' mathematics and science content knowledge has been met by efforts to increase teacher knowledge through funded national initiatives focusing on mathematics and science. The purpose of the present study was to look across projects in the National Science Foundation's Math and Science Partnership Program to determine how partnerships developed processes for measuring growth in teacher content knowledge. Pre- and post-testing was the most common process for measuring growth …

An Expanded Age Range For Meningococcal Meningitis: Molecular Diagnostic Evidence From Population-Based Surveillance In Asia, Soon Kim, Dong Kim, Bai Dong, Jung Kim, Dang Anh, Paul E. Kilgore

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

To understand epidemiologic patterns of meningococcal disease in Asia, we performed a retrospective molecular analysis of cerebrospinal fluid (CSF) specimens collected in prospective surveillance among children aged < 5 years of age in China, South Korea, and Vietnam.

Methods

A total of 295 isolates and 2,302 CSFs were tested by a meningococcal species- and serogroup-specific polymerase chain reaction (PCR) assay targeting the Neisseria meningitidis (Nm) ctrA gene. Multi-locus sequence typing (MLST) was performed in Nm gene amplification analysis and incidence rates for meningococcal meningitis were estimated.

Results

Among 295 isolates tested, 10 specimens from Vietnam were confirmed as serogroup B and all were Sequence Type (ST) 1576 by MLST. …

Tracking Of In-111-Labeled Human Umbilical Tissue-Derived Cells (Hutc) In A Rat Model Of Cerebral Ischemia Using Spect Imaging, Ali S. Arbab, Christine Thiffault, Bradford Navia, Stephen J. Victor, Klaudyne Hong, Li Zhang, Quan Jiang, Nadimpalli Rs Varma, Asm Iskander, Michael Chopp

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In order to increase understanding of how infused cells work, it becomes important to track their initial movement, localization, and engraftment efficiency following transplantation. However, the available in vivo cell tracking techniques are suboptimal. The study objective was to determine the biodistribution of intravenously administered Indium-111 (In-111) oxine labeled human umbilical tissue-derived cells (hUTC) in a rat model of transient middle cerebral occlusion (tMCAo) using single photon emission computed tomography (SPECT).

Methods

Rats received 3 million In-111 labeled hUTC (i.v.) 48 hrs after tMCAo. Following the administration of either hUTC or equivalent dose of In-111-oxine (18.5 MBq), animals …

Using Learned Under-Sampling Pattern For Increasing Speed Of Cardiac Cine Mri Based On Compressive Sensing Principles, Pooria Zamani, Mohammad Kayvanrad, Hamid Soltanian-Zadeh

Wayne State University Associated BioMed Central Scholarship

Abstract

This article presents a compressive sensing approach for reducing data acquisition time in cardiac cine magnetic resonance imaging (MRI). In cardiac cine MRI, several images are acquired throughout the cardiac cycle, each of which is reconstructed from the raw data acquired in the Fourier transform domain, traditionally called k-space. In the proposed approach, a majority, e.g., 62.5%, of the k-space lines (trajectories) are acquired at the odd time points and a minority, e.g., 37.5%, of the k-space lines are acquired at the even time points of the cardiac cycle. Optimal data acquisition at the even time points is learned …

Fibroblast-Secreted Hepatocyte Growth Factor Mediates Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance In Triple-Negative Breast Cancers Through Paracrine Activation Of Met, Kelly L. Mueller, Julie M. Madden, Gina L. Zoratti, Charlotte Kuperwasser, Karin List, Julie L. Boerner

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer, resistance to EGFR TKIs correlates with amplification of the hepatocyte growth factor (HGF) receptor tyrosine kinase Met. Breast cancers do not respond to EGFR TKIs, even though EGFR is overexpressed. This intrinsic resistance to EGFR TKIs in breast cancer does not correlate with Met amplification. In several tissue monoculture models of human breast cancer, Met, although expressed, is not phosphorylated, suggesting a requirement for a paracrine-produced ligand. In fact, HGF, the ligand for Met, is not …

Hdm2 Antagonist Mi-219 (Spiro-Oxindole), But Not Nutlin-3 (Cis-Imidazoline), Regulates P53 Through Enhanced Hdm2 Autoubiquitination And Degradation In Human Malignant B-Cell Lymphomas, Angela M. Sosin, Angelika M. Burger, Aisha Siddiqi, Judith Abrams, Ramzi M. Mohammad, Ayad M. Al-Katib

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by small-molecule inhibitors (SMIs). HDM2 have been developed and are under various stages of preclinical and clinical investigation. Previously, we examined the anti-lymphoma activity of MI-319, the laboratory grade of a new class of HDM2 SMI, the spiro-oxindole, in follicular lymphoma. Since then, MI-219, the clinical grade has become readily available. This study further examines the preclinical effects and mechanisms of MI-219 in a panel of human lymphoma …

Development Of An In-Cell Förster Resonance Energy Transfer Technique To Study Protein Structure Inside Living Cells, Victoria Lynn Murray

Wayne State University Dissertations

The goal of my thesis is to develop an in-cell fluorescence technique that allows for measurement of the distances between fluorescence acceptors and donors within a protein or between two proteins inside the correct intracellular compartment of living cells. The successful achievement of this goal will allow us to obtain high-resolution structural information from a protein, one key step towards high-resolution structural biology of proteins inside the living cell.

To achieve this goal, we will apply the fluorescence resonance energy transfer (FRET) technique to the specifically labeled proteins inside the cells. Our rationale is to specifically label the protein(s) of …

The Proton-Coupled Folate Transporter: Biology And Therapeutic Applications To Cancer, Sita Desmoulin

Wayne State University Dissertations

Folates are essential cofactors of tumor cell proliferation and survival required for nucleotide biosynthesis and amino acid metabolism. In cancer therapy, inhibition of folate-dependent metabolic pathways has been achieved through the use of antifolates. Unfortunately, the efficacy of many clinically approved antifolates is limited by a lack of tumor selectivity. Facilitative transport of folates into mammalian cells is achieved by the reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT). As PCFT is a folate-proton symporter with an acidic pH optimum, PCFT may provide a mechanism for targeting cytotoxic antifolates to tumors, based on their acidic microenvironments. To establish the …

Empathic Dialogue: From Formalism To Value Principles, Mitchell F. Crusto

SMU Law Review

No abstract provided.

Llc, Living-Learning Communities At The University Of North Florida, University Of North Florida

Student Affairs Printed Materials

Brochure: Information regarding the living-learning communities and eligibility guidelines available in campus housing, Housing and Residence Life. Date: 2012

Differential Responses Of Eastern Red-Backed Salamanders (Plethodon Cinereus) To Conspecifics And Centipedes, A. A. Burgett, Geoffrey R. Smith

Faculty Publications

No abstract provided.

Temporal Variation In The Abundance Of Poblana Alchichica In Near-Shore Habitat Of The High Elevation Lake, Lago De Alchichica, Puebla, Mexico, G. A. Woolrich-Pina, Geoffrey R. Smith, J. A. Lemos-Espinal, R. Montoya-Ayala, L. E. Avila-Bocanegra, E. B. Carduno

Faculty Publications

No abstract provided.

Changing Lives In A Semester: A Teaching Approach To Help With Tenure And Promotion While Providing An Experience They'll Never Forget, Roslynn Brain

Environment and Society Faculty Publications

Do all university courses have to be structured in a traditional way? For many, the answer is a resounding, NO! Generally, we assume a course needs to have a midterm, final and at least one major project. Although this may fit well with many standard courses, it can be a wonderful experience to deviate away from the norm and delve into the world of service learning.

Spatial Conversions And Alternative Futures: Sitla / Blm: A Preliminary Analysis, Richard E. Toth

Environment and Society Faculty Publications

No abstract provided.

Targeted Subendothelial Matrix Oxidation By Myeloperoxidase Triggers Myosin Ii-Dependent De-Adhesion And Alters Signaling In Endothelial Cells, M Rees, L Dang, T Thai, D Owen, E Malle, S Thomas

Medical Papers and Journal Articles

During inflammation, myeloperoxidase (MPO) released by circulating leukocytes accumulates within the subendothelial matrix by binding to and transcytosing the endothelium. Oxidative reactions catalyzed by subendothelial-localized MPO are implicated as a key cause of endothelial dysfunction in inflammatory vascular diseases. Whilst the subendothelial matrix is a reactive target for MPO-derived oxidants in disease, the functional implications of oxidative matrix modification for the endothelium are largely unknown. Here we show that hypochlorous acid (HOCl) produced by endothelial-transcytosed MPO oxidizes the subendothelial matrix, involving covalent crosslinking of the adhesive matrix protein fibronectin. Real-time biosensor and live cell imaging studies showed that HOCl-mediated matrix …

Does Prognosis And Socioeconomic Status Impact On Trust In Physicians? Interviews With Patients With Coronary Disease In South Australia, S Meyer, P Ward, M Jiwa

Medical Papers and Journal Articles

Objectives: There is concern across a range of healthcare settings worldwide that trust in physicians is declining. Decreased trust may lead to lesser tolerance of prognosis uncertainty and an increased demand for tests, referrals and second opinions. Literature suggests that there has been a recent cultural shift towards decreased trust in, and increased questioning of, medical advice. We investigated the impact of varying prognosis and socioeconomic status (SES) on trust in physicians, and patient questioning of medical advice.

Design: Semistructured, audio-recorded transcribed interviews were conducted. The interview schedule was developed with reference to the Health Belief Model. Interviews were conducted …

Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2011/12. State Of The Fisheries, W.J Fletcher, K. Santoro

Status Reports of the Fisheries and Aquatic Resources

The Status Reports of the Fisheries and Aquatic Resources of Western Australia provide the public with an annual update on the state of the fish and other aquatic resources of Western Australia managed by the Department. These reports outline the cumulative risk status for each of the ecological resources (assets) within WA’s six Bioregions using an Ecosystem-Based Fisheries Management (EBFM) approach.

Synthesis Of Knowledge On Tremolite In Talc, Chantal Dion, Guy Perrault, Mounia Rhazi

États de la question, rapports d’expertise et revues de littérature

Le talc est largement utilisé dans différents milieux de travail, notamment dans les secteurs de la céramique, des peintures (peinture antirouille), des composés à joint pour gypse, des cosmétiques, du plastique et du caoutchouc. Puisque certains talcs peuvent contenir des amphiboles dont la trémolite, possiblement sous la morphologie asbestiforme (ou fibreuse) et non asbestiforme (fragments de clivage), il est important d'en connaître la provenance et la composition afin de mettre en place des stratégies de surveillance de l'exposition et des moyens de prévention adéquats pour les travailleurs et autres utilisateurs.

Plusieurs définitions et applications du terme amiante sont utilisées pour …

Synthèse Des Connaissances Sur La Trémolite Contenue Dans Le Talc, Chantal Dion, Guy Perrault, Mounia Rhazi

États de la question, rapports d’expertise et revues de littérature

Le talc est largement utilisé dans différents milieux de travail, notamment dans les secteurs de la céramique, des peintures (peinture antirouille), des composés à joint pour gypse, des cosmétiques, du plastique et du caoutchouc. Puisque certains talcs peuvent contenir des amphiboles dont la trémolite, possiblement sous la morphologie asbestiforme (ou fibreuse) et non asbestiforme (fragments de clivage), il est important d'en connaître la provenance et la composition afin de mettre en place des stratégies de surveillance de l'exposition et des moyens de prévention adéquats pour les travailleurs et autres utilisateurs.

Plusieurs définitions et applications du terme amiante sont utilisées pour …

Gera Conference Program [2012], Gera

Georgia Educational Research Association Conference

Conference program for 2012.

The Hospital’S Role Within A Regional Disaster Response: A Comparison Study Of An Urban Hospital Versus A Rural Hospital, Ali Alshehri

Theses

The goal of this research is to evaluate the hospital's role in a regional disaster response. It focuses on identifying the level of the hospital's preparedness and its response to disasters and includes a comparison study between an urban and a rural hospital in New York state. The findings of this work show some differences between the urban and rural hospitals in terms of their capabilities and available resources and the effect of the community infrastructures on their preparedness. Both hospitals have similarities in the way participants view the hospital's role during a regional disaster response. It is noted that …

Hospital As A Critical Infrastructure In The Community Disaster Response System, Yixuan Li

Theses

The Department of Homeland Security lists 19 groups of sectors as Critical Infrastructure Key Resources (CIKR) such as Water, Emergency Services, and Healthcare and Public Health (HPH). Protection of those interdependent sectors is of vital interest for the country in the event of disaster. Hospital infrastructure systems are basic HPH elements of the CIKR. Local hospitals deliver essential routine healthcare services as well as serving as frontline responders during non-routine disaster events. Currently, hospitals generally extend their routine healthcare activities for external community disaster preparedness and response services. This extension takes the form of coordination with other responders within the …

Synthesis Of A Difluorometric Cross-Membrane Molecular Probe For Studying Amphipathic Systems, Danielle Raymond

Theses

A surfactant is an amphiphile which consists of a hydrophobic and hydrophilic end. In nonpolar solvents containing a small amount of water surfactants can form reverse micelles. Extensive research has been done using fluorescent probes to study several properties of these amphiphilic aggregates including mechanism of formation, critical micelle concentration, aggregate number and size, nanopolarity, and viscosity. Dr. Langner's group at RIT proposed the structure of a difluorometric, ratiometric probe that can transverse the membrane of a reverse micelle created in a system of decane/water/AOT/butyl alcohol. This probe has a dansyl and a coumarin portion making it amphiphilic and could …

A Preliminary Study On The Potential Of Manuka Honey And Platelet-Rich Plasma In Wound Healing, Scott A. Sell, Patricia S. Wolfe, Andrew J. Spence, Isaac A. Rodriguez, Jennifer M. Mccoll, Rebecca L. Petrella, Koyal Garg, Jeffery J. Ericksen, Gary L. Bowlin

Ellmer School of Nursing Faculty Publications

Aim. The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey. Materials and Methods. This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product. The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, …

A Chemical Proteomic Probe For Detecting Dehydrogenases: Catechol Rhodanine, Xia Ge, Daniel S. Sem

Chemistry Faculty Research and Publications

The inherent complexity of the proteome often demands that it be studied as manageable subsets, termed subproteomes. A subproteome can be defined in a number of ways, although a pragmatic approach is to define it based on common features in an active site that lead to binding of a common small molecule ligand (ex. a cofactor or a cross-reactive drug lead). The subproteome, so defined, can be purified using that common ligand tethered to a resin, with affinity chromatography. Affinity purification of a subproteome is described in the next chapter. That subproteome can then be analyzed using a common ligand …

How Selective Is Social Learning In Dolphins?, Stan A. Kuczaj Ii, Deirdre Yeater, Lauren Highfill

Psychology Faculty Publications

Social learning is an important aspect of dolphin social life and dolphin behavioral development. In addition to vocal social learning, dolphins discover behaviors for foraging, play, and social interactions by observing other members of their social group. But dolphins neither indiscriminately observe nor mindlessly mimic other dolphins. To the contrary, dolphin calves are quite selective in their choices of who to observe and/or imitate. Calves are most likely to learn foraging behaviors from their mothers, but they are more likely to watch and reproduce the play behaviors of other calves than the play behaviors of adult dolphins (including their mothers). …

Strategies Of Cooperation And Punishment Among Students And Clerical Workers, Maria Bigoni, Gabriele Camera, Marco Casari

ESI Working Papers

We study the individual behavior of students and workers in an experiment where they repeatedly face the same cooperative task. The data show that clerical workers differ from college students in overall cooperation rates, strategy adoption and use of punishment opportunities. Students cooperate more than workers. Cooperation increases in both subject pools when a personal punishment option is available. Students are less likely than workers to adopt strategies of unconditional defection, and more likely to select strategies of conditional cooperation. Finally, students are more likely than workers to sanction uncooperative behavior by adopting decentralized punishment, and also personal punishment when …

Building And Rebuilding Trust With Promises And Apologies, Eric Schniter, Roman M. Sheremeta, Daniel Sznycer

ESI Working Papers

Using trust games, we study how promises and messages are used to build new trust where it did not previously exist and to rebuild damaged trust. In these games, trustees made non-binding promises of investment-contingent returns, then investors decided whether to invest, and finally trustees decided how much to return. After an unexpected second game was announced, but before it commenced, trustees could send a one-way message. This design allowed us to observe the endogenous emergence and natural distribution of trust-relevant behaviors and focus on naturally occurring remedial strategies used by promise-breakers and distrusted trustees, their effects on investors, and …

Why Can’T We Be Friends? Entitlements, Bargaining, And Conflict, Erik O. Kimbrough, Roman M. Sheremeta

ESI Working Papers

We design an experiment to explore the impact of earned entitlements on the frequency and intensity of conflicts in a two-stage conflict game with side-payments. In this game, residents (Proposers) make side-payment offers and contestants (Responders) decide whether to accept the offers and whether to engage in a conflict. When subjects earn their roles, conflicts are 44% more likely to be avoided than when roles are assigned randomly. Earned rights impact behavior in three important ways: (1) residents who have earned their position persistently offer larger side-payments; (2) larger offers lead to a lower probability of conflict, but (3) residents …

Side-Payments And The Costs Of Conflict, Erik O. Kimbrough, Roman M. Sheremeta

ESI Working Papers

Conflict and competition often impose costs on both winners and losers, and conflicting parties may prefer to resolve the dispute before it occurs. The equilibrium of a conflict game with side-payments predicts that with binding offers, proposers make and responders accept side-payments, generating settlements that strongly favor proposers. When side-payments are non-binding, proposers offer nothing and conflicts always arise. Laboratory experiments confirm that binding side-payments reduce conflicts. However, 30% of responders reject binding offers, and offers are more egalitarian than predicted. Surprisingly, non-binding side-payments also improve efficiency, although less than binding. With binding side-payments, 87% of efficiency gains come from …