Digital Commons Network^™

Trop-2 Inhibits Prostate Cancer Cell Adhesion To Fibronectin Through The Β1 Integrin-Rack1 Axis., Marco Trerotola, Jing Li, Saverio Alberti, Lucia R. Languino

Department of Cancer Biology Faculty Papers

Trop-2 is a transmembrane glycoprotein upregulated in several human carcinomas, including prostate cancer (PrCa). Trop-2 has been suggested to regulate cell-cell adhesion, given its high homology with the other member of the Trop family, Trop-1/EpCAM, and its ability to bind the tight junction proteins claudin-1 and claudin-7. However, a role for Trop-2 in cell adhesion to the extracellular matrix has never been postulated. Here, we show for the first time that Trop-2 expression in PrCa cells correlates with their aggressiveness. Using either shRNA-mediated silencing of Trop-2 in cells that endogenously express it, or ectopic expression of Trop-2 in cells that …

Forage News [2012-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference
• KFGC Presents Awards
• Alfalfa Intensive Training Seminar
• Kentuckian Featured at National Hay Convention
• AFGC Conference in Covington
• Kentucky's 2012 National Forage Spokesman to speak at Farm Bureau Forage Commodity Conference
• Dr. Peter Ballerstedt to Speak at Forages at KCA During the KCA Convention
• Neutral Detergent Fiber Digestibility (NDFD): A Good Predictor of Forage Quality
• Where Does Nitrogen Fertilizer Come From?
• The Cost of Pasture vs. Hay

Cyberterrorism In The Context Of Contemporary International Law, Yaroslav Shiryaev

San Diego International Law Journal

The present Article addressed the legal issues surrounding cyberterrorism. In the first chapter, the author explains why cyberterrorism should be described as “the use of electronic networks taking the form of a cyber-attack to commit a) a substantive act criminalized by the existing legal instruments prohibiting terrorism, or b) an act of terrorism under international customary law.” Further, with a special emphasis on existing anti-terrorism conventions and customary international law, it was demonstrated which actors are likely to engage in acts of cyberterrorism (non-state actors, corporations and individuals), as well as which targets are protected by law and which aims …

"There's No Place Like Home" Doma Deportation: The Forced Expatriation Of Bi-National Same-Sex Couples From The United States To Canada, Anh "Annie" Nguyen

San Diego International Law Journal

This comment will focus on bi-national same-sex couples who are forced to expatriate from the united states to canada because of DOMA’s detrimental effects on their relationship. more specifically, part I focuses on DOMA’s constitutionality, effects on bi-national same-sex couples, and current legal challenges. Part II provides a historical analysis of the united states’ attitude towards same-sex unions before describing current legislation regarding same-sex couples. Part III describes canada’s recognition of same-sex marriage and support of immigration equality, comparing and contrasting the canadian approach with the united states’ approach. Part IV explains the current legal and financial issues that bi-national …

Factors Associated With Stress Among Adolescents In The City Of Nawabshah, Pakistan, Yasmin Parpio, Salima Farooq, Saleema A. Gulzar, Ambreen Tharani, Tazeen Saeed Ali, Fawad Javed

School of Nursing & Midwifery

Objective: To identify the risk factors of stress among school-going adolescents in rural Nawabshah, Pakistan.
Methods: The cross-sectional study was conducted in 2005, comprising 800 school-going children of 10-16 years of age in Nawabshah, through simple random sampling. Data was collected using a structured questionnaire to assess the potential risk factors of stress. A modified version of Perceived stress scale was utilized to measure stress level. SPSS 12 was used for statistical analysis, while multiple linear regression analysis was run to identify the factors associated with stress in the study population.
Results: Of the total, 529 (66%) children belonged to …

Perception Of African Youth On Personal Computer Utilization: The Case Of Ethiopia And Rwanda, S. Negash

Faculty Articles

The tendency to pursue innovativeness and adopt new technologies has been found more likely with younger individuals and a strong relationship between attitude and personal computer (PC) utilization has been found. However, research in these areas is mainly focused on high-income countries. Do these findings hold for low-income countries? What are the perceptions of African youth on the factors that impact PC use? There is a dearth of micro-level studies that promote understanding about the behavior of individuals in low-income countries. This study looked at demographic data including age, gender, grade level, region, and prior experience among 228 youth from …

Tmc Library Holiday Hours; New Class Offered At The Library: Creating Your Own Ebooks; New Mobile Resources Library Guide, Vol, 10 (11), Texas Medical Center Library

Insider Express (2003-2013)

No abstract provided.

Instruction Matters: Purdue Academic Course Transformation Impact Annual Report -- November 2012, Donalee Attardo, John Campbell, Tomalee Doan, Mike Eddy, Chantal Levesque-Bristol, Gabriela Weaver, Cliff Weill

IMPACT Reports

Provides overview and breadth of the IMPACT classroom; Covers use of technology for pedagogical improvements, collaborative classrooms, and program assessment dimensions. Discusses challenges and next steps of program

An Evaluation Of The Challenges Of Forensic Investigation And Unsolved Murders In Nigeria, Ngboawaji Daniel Nte

African Journal of Criminology and Justice Studies

The work attempts to evaluate the challenges facing forensic investigation capacity of the police and other internal security agencies in Nigeria in the face of high prevalence of unsolved murders in Nigeria in the past three decades. In carrying out this research both primary and secondary data were employed to add to the scientific fervour of the work. Consequently, the work discovered that poor/lack of forensic skills and equipment negatively impacts on the forensic investigation capacity of the police and other security agents. These impediments tend to further complicate the mystery of unsolved murders in a nation where even high …

Montana Kaimin, November 1, 2012, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The Natural History Of The Ants Of Michigan's E.S. George Reserve: A 26 Year Study, Mary Talbot

Faculty Scholarship

The results of a 26-summer study of the ants on an 1146 acre (464 ha) natural history preserve in southeastern Michigan are presented. Habitat distribution and nest construction for each of the 87 species are recorded. The sites of collections of each species on the Reserve are shown on maps. In addition, records of colony populations, brood development and nuptial flights of many of the species are presented.

Educational Policies Committee Agenda, November 1, 2012, Utah State University

Educational Policies Committee

• Subcommittee Reports
• Curriculum Subcommittee
• Course Approvals
• Academic Standards Subcommittee
• General Education Subcommittee

Daily Eastern News: November 01, 2012, Eastern Illinois University

November

No abstract provided.

Full Issue, Indiana Audubon Quarterly

Indiana Audubon Quarterly

No abstract provided.

Orca Is Regulated By Ubiquitin-Mediated Degradation To Control Orc2 Function, Amy E. Ikui

Publications and Research

No abstract provided.

Storage Stability Of Biofuel, M. Varman, Haji Hassan Masjuki, M.Y. Cheah, Y.H. Cheng, M.A. Kalam, A.M. Liaquat, M. Shahabuddin, M. Mofijur

Research Publications (2011 to 2015)

Biofuel is one of the prime candidates to take over the role played by fossil fuel as the main source of energy in the future. Numerous studies have been done on the potential of biofuel to produce similar power output generated by the current petrol and diesel which are depleting without any drawbacks. The objective of this particular study is to investigate 4 of the more established vegetable oil in the energy industry namely jatropha, palm, coconut and canola oil in terms of storage stability of biofuel at room temperature and 80ºC. The biofuels were tested in terms of density, …

Hydration Status Of Lifesaving Athletes During International Competition, Wade Sinclair, Nick J. Marshall

International Journal of Aquatic Research and Education

This study investigated the hydration status of lifesaving athletes in situ during an International competition. Participants were 10 lifesaving athletes (6 male and 4 female) competing in pool- and ocean-based competition across three consecutive days. Assessment included upon-waking urine samples and body mass across 7 days including travel, training and competition days. Urine specific gravity was significantly lower while traveling compared to predeparture (p < 0.05). There were no gender differences for sweat rates, body mass changes, fluids consumed or percentage dehydration during the training sessions (p > 0.05). Sweat rates were higher than previously reported and there were no significant differences identified for daily body mass changes (p > 0.05). The results of the current study found that lifesaving athletes were capable of maintaining …

Self-Enhancement Processing In The Default Network: A Single-Pulse Tms Study, Bruce Luber, Hans C. Lou, Julian Keenan, Sarah H. Lisanby

Department of Biology Faculty Scholarship and Creative Works

Abstract Much research has been done on positive self-evaluation and its relationship to mental health. However, little is known about its neural underpinnings. Imaging studies have suggested that the brain's default network is involved with self-related processing and that one portion of the default network, medial prefrontal cortex (MPFC), is particularly involved with self-evaluation. Here, we used transcranial magnetic stimulation (TMS) to causally demonstrate that this network, and particularly MPFC, is involved with self-evaluative processing. In a first experiment, 27 healthy volunteers judged whether adjectives, evenly divided between desirable and undesirable traits, described themselves or their best friends, and a …

The Diamond, November 1, 2012, Dordt College

Dordt Diamond

• Front Page: Pop Culture Conference Starts NOW!; The Search for the New Provost is Now Underway
• News: Inauguration of President Erik Hoekstra: The Beginning of an "Educational Opus"; Smart Phones: Convenient Distractions?; Fall Festival at Dordt; Zombie vs. Humans: The Plague Strikes Again... and This Time, Even Bigger!; New Defender Sports Logo Met with Both Praise and Hesitation
• Features: The Faces Behind the Dordt College Signet; International Introduction: Niger, West Africa
• Opinion: Trump Stunt; Exclusive: Christian Education; Kids Say the Darndest Things!; You Don't Have to be Afraid of Zombies
• Sports: Despite Losses, Defender Football Has Seen Improvement; Cross Country: …

State Dept. Of Health And Welfare V. Slane Respondent's Brief Dckt. 39766-2012

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Editor’S Notes, John C. Kendall

Indiana Audubon Quarterly

No abstract provided.

Journal Of Cave And Karst Studies, Volume 74, No. 3, December 2012, Table Of Contents, National Speleological Society

KIP Articles

No abstract provided.

Neuronal Synaptobrevin Promotes Longevity In Drosophila Photoreceptors, Mejia Jonathan, Adam Haberman

Biology: Faculty Scholarship

Neurons have unique challenges relative to other cell types. Unlike most other cells, neurons must remain healthy and functional throughout the lifespan of an animal. Premature neuronal loss underlies many age-related neurodegenerative diseases, including Alzheimer and Parkinson Diseases. Despite previous research aimed at understanding the mechanisms of age-related neurodegenerative diseases, little is known about the mechanisms that allow neurons to remain functional for the lifetime of a healthy animal. Understanding these cellular and biochemical processes is essential to promote healthful aging and reduce the severity of neurodegenerative disease. Here we discuss our recent identification of neuron-specific proteins that regulate endosome …

Editorial: Race-Class-Gender Articulation And Crime In The Us, Biko Agozino

African Journal of Criminology and Justice Studies

No abstract provided.

Inactivation Of Bacterial Opportunistic Skin Pathogens By Nonthermal Dc-Operated Afterglow Atmospheric Plasma, L. C. Heller, C. M. Edelblute, A. M. Mattson, X. Hao, J. F. Kolb

Bioelectrics Publications

AIMS: Multidrug-resistant opportunistic pathogens are clinically significant and require the development of new antimicrobial methods. In this study, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus cells were exposed to atmospheric plasma on agar plates and in vitro on porcine skin for the purpose of testing bacterial inactivation.

METHODS AND RESULTS: Microbial inactivation at varying exposure durations was tested using a nonthermal plasma jet generated with a DC voltage from ambient air. The observed reduction in colony forming units was quantified as log₁₀ reductions.

CONCLUSIONS: Direct plasma exposure significantly inactivated seeded bacterial cells by approx. 6 log_{10 …}

The Era Of Boundlessness At St. Mary’S Of The Barrens, 1818-1843: A Brief Historical Analysis, Richard J. Janet Ph.D.

Vincentian Studies

Richard Janet analyzes the early history of Saint Mary’s of the Barrens according to the historian Philip Gleason’s view of the development of American Catholicism. Gleason sees the arc of American Catholicism as moving from a period of “boundlessness,” in which institutions engaged in all types of works, to the mid-nineteenth-century period of “consolidation,” in which leaders tried to manage growth in a way that would stabilize those institutions. Gleason’s thesis is discussed in detail. The work of Felix De Andreis, Joseph Rosati, and John Timon is examined. They faced many problems inherent in maintaining a Vincentian community while ministering …

Silencing Of Host Genes Directed By Virus-Derived Short Interfering Rnas In Caenorhabditis Elegans, Xunyang Guo, Wan Xiang Li, Rui Lu

Faculty Publications

Small interfering RNAs (siRNAs) processed from viral replication intermediates by RNase III-like enzyme Dicer guidesequence-specific antiviral silencing in fungi, plants, and invertebrates. In plants, virus-derived siRNAs (viRNAs) can target and silence cellular transcripts and, in some cases, are responsible for the induction of plant diseases. Currently it remains unclear whether viRNAs are also capable of modulating the expression of cellular genes in the animal kingdom, although animal virus-encoded microRNAs (miRNAs) are known to guide efficient silencing of host genes, thereby facilitating virus replication. In this report, we showed that viRNAs derived from a modified nodavirus triggered potent silencing of homologous …

The Fat Controller: Adipocyte Development, Jacqueline M. Stephens

Faculty Publications

Obesity is a condition characterized by excess adipose tissue that results from positive energy balance and is the most common metabolic disorder in the industrialized world. The obesity epidemic shows no sign of slowing, and it is increasingly a global problem. Serious clinical problems associated with obesity include an increased risk for type 2 diabetes, atherosclerosis, and cancer. Hence, understanding the origin and development of adipocytes and adipose tissue will be critical to the analysis and treatment of metabolic diseases. Historically, albeit incorrectly, adipocytes were thought to be inert cells whose singular function was lipid storage. It is now known …

An Alu-Based Phylogeny Of Gibbons (Hylobatidae), Thomas J. Meyer, Adam T. Mclain, J. Michael Oldenburg, Christopher Faulk, Matthew G. Bourgeois, Erin M. Conlin, Alan R. Mootnick, Pieter J. De Jong, Christian Roos, Lucia Carbone, Mark A. Batzer

Faculty Publications

Gibbons (Hylobatidae) are small, arboreal apes indigenous to Southeast Asia that diverged from other apes ∼15-18 Ma. Extant lineages radiated rapidly 6-10 Ma and are organized into four genera (Hylobates, Hoolock, Symphalangus, and Nomascus) consisting of 12-19 species. The use of short interspersed elements (SINEs) as phylogenetic markers has seen recent popularity due to several desirable characteristics: the ancestral state of a locus is known to be the absence of an element, rare potentially homoplasious events are relatively easy to resolve, and samples can be quickly and inexpensively genotyped. During radiation of primates, one particular family of SINEs, the Alu …

An Integrated Map Of Genetic Variation From 1,092 Human Genomes, David M. Altshuler, Richard M. Durbin, Gonçalo R. Abecasis, David R. Bentley, Aravinda Chakravarti, Andrew G. Clark, Peter Donnelly, Evan E. Eichler, Paul Flicek, Stacey B. Gabriel, Richard A. Gibbs, Eric D. Green, Matthew E. Hurles, Bartha M. Knoppers, Jan O. Korbel, Eric S. Lander, Charles Lee, Hans Lehrach, Elaine R. Mardis, Gabor T. Marth, Gil A. Mcvean, Deborah A. Nickerson, Jeanette P. Schmidt, Stephen T. Sherry, Jun Wang, Richard K. Wilson, Huyen Dinh, Christie Kovar, Sandra Lee, Lora Lewis, Donna Muzny, Jeff Reid, Min Wang, Xiaodong Fang

Faculty Publications

By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and …