Digital Commons Network^™

Conservation And Population Biology: Genetics, Demography And Habitat Requirements Of The Atlantic Coast Beach Mice, Haakon Myklevoll Kalkvik

Electronic Theses and Dissertations

The conservation biology field seeks to preserve biodiversity and the processes shaping that variation. Conservation biology is intimately tied to evolutionary research, in order to identify evolutionary distinct lineages that may be in danger of disappearing. Interestingly, patterns and processes of lineage divergence and persistence change with respect to spatial and temporal scale. I seek to evaluate biodiversity, the factors that have shaped this heterogeneity, and how this variability persists. To accomplish this I used a phylogeographic approach as well as niche and population modeling on the Peromyscus maniculatus species group found widely distributed in North America. My emphasis was …

Manipulation Of Host Signal Transduction Pathways And Cytoskeleton Functions By Invasive Bacterium Listeria Monocytogenes And Chlamydia Trachomatis, Shahanawaz Jiwani

Electronic Theses and Dissertations

Infectious disease remains one of the leading causes of morbidity and mortality worldwide. Many bacteria that cause disease have the capacity to enter into eukaryotic cells such as epithelial cells and tissue macrophages. Gaining access into the intracellular environment is one of the most critical steps in their survival and/or in pathogenesis. The entry mechanisms employed by these organisms vary considerably, but most mechanisms involve sabotaging and manipulating host cell functions. Invasion of epithelial cells involves triggering host signal transduction mechanisms to induce cytoskeleton rearrangement, thereby facilitating bacterial uptake. My work focuses on understanding the molecular mechanisms employed by bacterial …

Beyond Building A Tree: Phylogeny Of Pitvipers And Exploration Of Evolutionary Patterns, Allyson Fenwick

Electronic Theses and Dissertations

As generic and higher-scale evolutionary relationships are increasingly well understood, systematists move research in two directions: 1) understanding specieslevel relationships with dense taxon sampling, and 2) evaluating evolutionary patterns using phylogeny. In this study I address both foci of systematic research using pitvipers, subfamily Crotalinae. For direction one, I evaluate the relationships of 96% of pitvipers by combining independent sets of molecular and phenotypic data. I find the inclusion of species with low numbers of informative characters (i.e. less than 100) negatively impacts resolution of the phylogeny, and the addition of independent datasets has no effect on or a small …

Assessment Of Molecular Interactions Via Magnetic Relaxation: A Quest For Inhibitors Of The Anthrax Toxin, Oscar Santiesteban

Electronic Theses and Dissertations

Anthrax is severe disease caused by the gram-positive Bacillus anthracis that can affect humans with deadly consequences. The disease propagates via the release of bacterial spores that can be naturally found in animals or can be weaponized and intentionally released into the atmosphere in a terrorist attack. Once inhaled, the spores become activated and the anthrax bacterium starts to reproduce and damage healthy macrophages by the release of the anthrax toxin. The anthrax toxin is composed of three virulent factors: (i) anthrax protective antigen (APA), (ii) anthrax lethal factor (ALF), and (iii) anthrax edema factor (AEF) that work in harmony …

Defective Dynamics Of Mitochondria In Amyotrophic Lateral Sclerosis And Huntington's Disease, Wenjun Song

Electronic Theses and Dissertations

Mitochondria play important roles in neuronal function and survival, including ATP production, Ca2+ buffering, and apoptosis. Mitochondrial dysfunction is a common event in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD); however, what causes the mitochondrial dysfunction remains unclear. Mitochondrial fission is mediated by dynamin-related protein 1 (DRP1) and fusion by mitofusin 1/2 (MFN1/2) and optic atrophy 1 (OPA1), which are essential for mitochondrial function. Mutations in the mitochondrial fission and fusion machinery lead to neurodegeneration. Thus, whether defective mitochondrial dynamics participates in ALS and HD requires further investigation. ALS is a fatal …

Novel Immunogens Of Cellular Immunity Revealed Using In Vitro Human Cell-Based Approach, Brian Schanen

Electronic Theses and Dissertations

In the last 150 years, tremendous headway has been made in our understanding of the human immune system. Pioneers in the field such as Paul Ehrlich, Elie Metchnikoff, Louis Pasteur, Robert Koch and Walter Reed carried out seminal studies that established the groundwork for our understanding of humoral and cellular immunity in humans. However, this direct line of evidence into human immunology was diverted in the mid-20th century with the adoption of a model which allowed for investigators to use a reductionist-approach with the promise to resolve immunity at a molecular level. This revolutionary model was the scientific commercialization of …

Somatechnologies Of Body Size Modification: Posthuman Embodiment And Discourses Of Health, Meghan Griffin

Electronic Theses and Dissertations

This project focuses on persistent gaps in philosophies of the body: the enduring mindbody divide in accounts of phenomenology, the unfulfilled promises of representing and inhabiting the body in online and virtual spaces, and the difference between health as quantified in medical discourse versus health as lived experience. These tensions are brought to light through the electronic food journal genre where the difficulty in capturing pre-noetic, outsideconsciousness aspects of experience and embodied health are thrown into relief against circulating cultural discourses surrounding health, body size, self-surveillance, and self-care. The electronic food journal genre serves as a space for users to …

Hidden Variable, Heather Harms

Electronic Theses and Dissertations

Hidden Variable is a novel that blends linear storytelling with the novel-in-stories form. It poses questions about the nature of identity as well as the feasibility of personal power, particularly with respect to disorders of the mind. Darla Pierson, the novel’s protagonist, is a woman in crisis. She is steeped in selfloathing brought on by the knowledge that she has, in effect, become her dead father—a genius with an epic libido, habitually using and discarding people. Her father has another habit that Darla doesn’t share: being struck by lightning. After the second strike kills him, Darla makes a conscious attempt …

Medical School Prerequisite Courses Completed At Two-Year Colleges By Medical School Matriculants: An Analysis At The University Of Central Florida, Erin Myszkowski

Electronic Theses and Dissertations

Many medical school admissions personnel and pre-health advisors advise premedical students not to take the medical school prerequisite courses at two-year colleges because they believe the courses are less academically rigorous than the same courses at four-year institutions (Losada, 2009; Marie, 2009; Thurlow, 2008, 2009a, 2009b). According to this belief, premedical students who complete the medical school prerequisite courses at a two-year college could be at a disadvantage in regard to medical school admission compared to those students who complete the medical school prerequisite courses at a four-year institution. In an effort to analyze these perceptions, this study examined factors …

Enriching Students With Developmental Delays In An Early Childhood Classroom Using Ipads With Mathematics Applications, Selma Powell

Electronic Theses and Dissertations

Laws and legislation related to early childhood and special education have shaped the field and impacted the need for early intervention services, but the outcomes of those services both academically and socially at the forefront. Children with developmental delays today are eligible for school services beginning at birth across the country, the new challenging is determining the impact of services on the social and academic outcomes. Many children with developmental delays are served in inclusive early intervention classrooms. A need for developmentally appropriate quality mathematics instruction exists to prepare students to meet the demands of a global economy; students must …

Geographical Assessment Of Microalgae Biofuels Potential Incorporating Resource Availability, Jason C. Quinn, Kimberly Catton, Sara Johnson, Thomas H. Bradley

Mechanical and Aerospace Engineering Faculty Publications

Previous assessments of the economic feasibility and large-scale productivity of microalgae biofuels have not considered the impacts of land and carbon dioxide (CO2) availability on the scalability of microalgae-based biofuels production. To accurately assess the near-term productivity potential of large-scale microalgae biofuel in the US, a geographically realized growth model was used to simulate microalgae lipid yields based on meteorological data. The resulting lipid productivity potential of Nannochloropsis under large-scale cultivation is combined with land and CO2 resource availability illustrating current geographically feasible production sites and corresponding productivity in the US. Baseline results show that CO2 transport constraints will limit …

Integrated Assessment Of Anthropogenic, Climate, And Policy Induced Changes Of Phosphorus Export In The United States Laurentian Great Lakes Watersheds, Meredith Ballard Labeau

Dissertations, Master's Theses and Master's Reports - Open

Anthropogenic activities have increased phosphorus (P) loading in tributaries to the Laurentian Great Lakes resulting in eutrophication in small bays to most notably, Lake Erie. Changes to surface water quality from P loading have resulted in billions of dollars in damage and threaten the health of the world’s largest freshwater resource. To understand the factors affecting P delivery with projected increasing urban lands and biofuels expansion, two spatially explicit models were coupled. The coupled models predict that the majority of the basin will experience a significant increase in urban area P sources while the agriculture intensity and forest sources of …

Biophysics, Environmental Stochasticity, And The Evolution Of Thermal Safety Margins In Intertidal Limpets, W. Wesley Dowd, M. W. Denny

Biology Faculty Works

As the air temperature of the Earth rises, ecological relationships within a community might shift, in part due to differences in the thermal physiology of species. Prediction of these shifts – an urgent task for ecologists – will be complicated if thermal tolerance itself can rapidly evolve. Here, we employ a mechanistic approach to predict the potential for rapid evolution of thermal tolerance in the intertidal limpet Lottia gigantea. Using biophysical principles to predict body temperature as a function of the state of the environment, and an environmental bootstrap procedure to predict how the environment fluctuates through time, we create …

Electrospun Chitosan Nanofibers For Virus Removal, Bingyu Bai

Dissertations, Master's Theses and Master's Reports - Open

Electrospinning uses electrostatic forces to create nanofibers that are far smaller than conventional fiber spinning process. Nanofibers made with chitosan were created and techniques to control fibers diameter and were well developed. However, the adsorption of porcine parvovirus (PPV) was low. PPV is a small, nonenveloped virus that is difficult to remove due to its size, 18-26 nm in diameter, and its chemical stability. To improve virus adsorption, we functionalized the nanofibers with a quaternized amine, forming N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC). This was blended with additives to increase the ability to form HTCC nanofibers. The additives changed the viscosity …

Synthesis Of Pdms-Metal Oxide Hybrid Nanocomposites Using An In Situ Sol-Gel Route, Qiaoyu Lu

Dissertations, Master's Theses and Master's Reports - Open

Organic-inorganic hybrid nanocomposites are widely studied and applied in broad areas because of their ability to combine the flexibility, low density of the organic materials with the hardness, strength, thermal stability, good optical and electronic properties of the inorganic materials. Polydimethylsiloxane (PDMS) due to its excellent elasticity, transparency, and biocompatibility has been extensively employed as the organic host matrix for nanocomposites. For the inorganic component, titanium dioxide and barium titanate are broadly explored as they possess outstanding physical, optical and electronic properties.

In our experiment, PDMS-TiO₂ and PDMS-BaTiO₃ hybrid nanocomposites were fabricated based on in-situ sol-gel technique. By …

Charge And Spin Transport In Nanoscale Junction From First Principles, Subhasish Mandal

Dissertations, Master's Theses and Master's Reports - Open

Recently nanoscale junctions consisting of 0-D nanostructures (single molecule) or 1-D nanostructures (semiconducting nanowire) sandwiched between two metal electrodes are successfully fabricated and characterized. What lacks in the recent developments is the understanding of the mechanism behind the observed phenomena at the level of atoms and electrons. For example, the origin of observed switching effect in a semiconducting nanowire due to the influence of an external gate bias is not yet understood at the electronic structure level. On the same context, different experimental groups have reported different signs in tunneling magneto-resistance for the same organic spin valve structure, which has …

Assessing Success Of Forest Restoration Efforts In Degraded Montane Cloud Forests In Southern Mexico, Rocio Elizabeth Jimenez Vazquez

Dissertations, Master's Theses and Master's Reports - Open

Montane cloud forests are home to great biodiversity. However, non-sustainable anthropogenic activities have led to the loss of forest cover in southern Mexico. Increasing conservation, restoration and sustainable use of forest resources prevents the loss of cloud forests. In this study, success of forest restoration was evaluated in a degraded forest of Highlands Chiapas. The goal of this study was to assess the structure and composition of native tree species. We evaluated vegetation composition at three sites that had undergone enrichment plantings. Floristic composition and structure of the herbaceous, seedling, sapling, and overstory layers were measured. A total of sixty-six …

Restoration Of Forest Wetlands: Case Studies In Michigan And Finland, Laura C. Kangas

Dissertations, Master's Theses and Master's Reports - Open

Forested wetlands throughout the world are valuable habitats; especially in relatively species-poor northern regions, they can be considered biological hotspots. Unfortunately, these areas have been degraded and destroyed. In recent years, however, the biological importance of wetlands has been increasingly recognized, resulting in the desire to restore disturbed habitats or create in place of destroyed ones. Restoration work is taking place across the globe in a diversity of wetland types, and research must be conducted to determine successful techniques. As a result, two studies of the effects of wetland restoration and creation were conducted in forested wetlands in northern Michigan …

Biofilm Responses To Salmon Carcass Analog Addition In Central Idaho Streams, Jonathan D. Ebel

Dissertations, Master's Theses and Master's Reports - Open

Pacific salmon populations have declined due to human activity in the Pacific Northwest, resulting in decreased delivery of marine-derived nutrients to streams. Managers use artificial nutrient additions to increase juvenile salmon growth and survival and assume that added nutrients stimulate biofilm production, which propagates up the food web to juvenile salmon. We assessed biofilm responses (standing crop, nutrient limitation, and metabolism) to experimental additions of salmon carcass analog in tributaries of the Salmon River, Idaho in 2010 and 2011. Biofilm standing crop and nutrient limitation did not respond to analog, but primary productivity and respiration increased in the subset of …

Nitrogen Deposition Effects On Production And Decomposition Of Coarse Woody Debris, Bethany Jeanne Lyons

Dissertations, Master's Theses and Master's Reports - Open

Atmospheric nitrogen deposition has the potential to impact forest productivity, microbial associations, nutrient cycling, decomposition and stand dynamics. However, among the least studied aspects of these processes are the production and decomposition of dead woody biomass, or coarse woody debris (CWD). Coarse woody debris is made up of dead woody material on the ground called down dead wood (DDW) and dead standing trees which are often referred to as snags. Observed reductions in decomposition of CWD have been linked to substrate quality and microbial communities. If the decomposition effect is ubiquitous among litter types, CWD density, C:N, and biomass are …

Automatic Food Intake Assessment Using Camera Phones, Fanyu Kong

Dissertations, Master's Theses and Master's Reports - Open

Obesity is becoming an epidemic phenomenon in most developed countries. The fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended. It is essential to monitor everyday food intake for obesity prevention and management. Existing dietary assessment methods usually require manually recording and recall of food types and portions. Accuracy of the results largely relies on many uncertain factors such as user's memory, food knowledge, and portion estimations. As a result, the accuracy is often compromised. Accurate and convenient dietary assessment methods are still blank and needed in both population and research societies.

In …

Investigation Of The Effect Of Using Data Collection Technology On Students' Attitudes To Science Instruction , R. Douglas Damery

Dissertations, Master's Theses and Master's Reports - Open

The purpose of this project was to investigate the effect of using of data collection technology on student attitudes towards science instruction. The study was conducted over the course of two years at Madison High School in Adrian, Michigan, primarily in college preparatory physics classes, but also in one college preparatory chemistry class and one environmental science class. A preliminary study was conducted at a Lenawee County Intermediate Schools student summer environmental science day camp. The data collection technology used was a combination of Texas Instruments TI-84 Silver Plus graphing calculators and Vernier LabPro data collection sleds with various probeware …

Stability Of Diphenylalanine Pepide [I.E. Peptide] Nanotube Studied By Molecular Dynamics Simulation, Haiqing Zhao

Dissertations, Master's Theses and Master's Reports - Open

No abstract provided.

Poplar Gene Expression Data Analysis Pipelines, Xiang Li

Dissertations, Master's Theses and Master's Reports - Open

Analyzing large-scale gene expression data is a labor-intensive and time-consuming process. To make data analysis easier, we developed a set of pipelines for rapid processing and analysis poplar gene expression data for knowledge discovery. Of all pipelines developed, differentially expressed genes (DEGs) pipeline is the one designed to identify biologically important genes that are differentially expressed in one of multiple time points for conditions. Pathway analysis pipeline was designed to identify the differentially expression metabolic pathways. Protein domain enrichment pipeline can identify the enriched protein domains present in the DEGs. Finally, Gene Ontology (GO) enrichment analysis pipeline was developed to …

Anthroposophy In Fascist Italy, Peter Staudenmaier

History Faculty Research and Publications

No abstract provided.

Determining Efficacy Of Breast Cancer Therapy By Pet Imaging Of Her2 Mrna, Bishnuhari Paudyal, Kaijun Zhang, Changpo Chen, Neil Mehta, Eric Wickstrom, Brian Gray, Jeffrey Mattis, Koon Pak, Mathew L Thakur

Department of Radiology Faculty Papers

No abstract provided.

Optical Imaging For Determination Of Apoptosis Medicated Therapeutic Efficacy, Kaijun Zhang, Bishnuhari Paudyal, Neil Mehta, Brian Gray, Koon Y. Pak, Eric Wickstrom, Mathew L Thakur

Department of Radiology Faculty Papers

No abstract provided.

Rituximab Therapy In Pulmonary Alveolar Proteinosis Improves Alveolar Macrophage Lipid Homeostasis., Anagha Malur, Mani Kavuru, Irene Marshall, Barbara P Barna, Isham Huizar, Reema Karnekar, Mary Jane Thomassen

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

RATIONALE: Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) and the PPARγ-regulated ATP binding cassette (ABC) lipid transporter, ABCG1. An open label proof of concept Phase II clinical trial was conducted in PAP patients using rituximab, a chimeric murine-human monoclonal antibody directed against B lymphocyte specific antigen CD20. Rituximab treatment decreased anti-GM-CSF antibody levels in bronchoalveolar lavage (BAL) fluid, and 7/9 patients …

2011-2012 Georgia Southern University Women's Basketball Media Guide, Georgia Southern University

Women's Basketball Records

• 2011-12 Georgia Southern Women's Basketball Media Guide

Graduate Catalog, Georgia Southern University

Graduate Catalogs

No abstract provided.