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2012

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Trajectories Of Depressive Symptoms And Illicit Drug Use: Longitudinal Temporal Associations And Comorbidity In A Community Sample Of Adults, Yulia Khodneva Jan 2012

Trajectories Of Depressive Symptoms And Illicit Drug Use: Longitudinal Temporal Associations And Comorbidity In A Community Sample Of Adults, Yulia Khodneva

All ETDs from UAB

Cross-sectional studies of the community and treatment samples suggest substantial comorbidity between depression and illicit drug use disorders. Controversy exists whether such pattern of comorbidity is seen among drug using behaviors and depressive symptoms that fall short of the DSM-IV criteria for a clinical disorder. This dissertation research applied principles of the life course perspective and trajectory modeling to describe heterogeneity and comorbidity of subthreshold depressive symptoms with opioid, cocaine and amphetamine use in middle age. Secondary analysis of community-dwelling adults from the Coronary Artery Risk Development in Young Adults (CARDIA) study was performed. The CARDIA cohort, N=5115 at inception …

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Histomorphometry And Quantitative Analysis Of Longer-Term Implant Interfaces, Dave Darko Kojic Jan 2012

Histomorphometry And Quantitative Analysis Of Longer-Term Implant Interfaces, Dave Darko Kojic

All ETDs from UAB

Objective: This investigation was to evaluate (>10 year) bone response around custom (HA plasma coated) dental implants and HA particulate. Materials and Methods: Three individual post mortem mandibular COI Implants with surrounding bone were processed at six transverse locations to obtain non-decalcified ground sections (20-80µm)(n=36) and stained initially with methylene blue/basic fuchsin. Slides were evaluated to select (n= 8) slides for regions of interest along the perimeter of the implant, using optical microscopy (Olympus BX51 microscope) with a Retiga EXi color digital camera (Olympus, Center Valley, PA) and Bioquant VR software (R&M Biometrics, Nashville, TN) at an original magnification …

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An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee Jan 2012

An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee

All ETDs from UAB

Pre-diabetes is a major contributor to increased morbidity and mortality in the US. Without proper and timely intervention the majority of individuals with pre-diabetes will develop Type 2 diabetes. African Americans (AA) and people living in the Stroke Belt have increased odds of developing pre-diabetes compared to Whites and people living outside the Stroke Belt. While several covariates have been identified as contributors to the increased odds of pre-diabetes there is little consensus on which covariates may be responsible for the disparities of pre-diabetes. The reasons for disparities in pre-diabetes are complex and require further investigation. This study explored the …

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The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand Jan 2012

The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand

All ETDs from UAB

Environmental ozone exposure remains a major public health concern with over one-third of the United States population experiencing unhealthful levels. Epidemiological studies indicate exposure increases morbidity in those with pre-existing disease such as asthma, though the biological mechanisms underlying this phenomenon remain elusive. CD11c+ cells within the respiratory tract include dendritic cells (DCs), which are the most efficient antigen presenters and play major roles controlling immune responses. In addition, DCs are thought necessary for asthma pathogenesis and exacerbation. Therefore the link between ozone associated asthma morbidity may be DCs. We hypothesize ozone exposure may site specifically alter DC phenotypes, numbers, …

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Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix Jan 2012

Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix

All ETDs from UAB

The facultative pathogen Streptococcus pneumoniae is capable of producing a polysaccharide (PS) capsule that prevents bacterial recognition and clearance by the host immune system. Over 90 antigenically distinct capsule serotypes have been identified. Because anti-capsule antibodies can mediate bacterial clearance, capsule diversity is critical to S. pneumoniae survival. However, the mechanisms of capsule evolution remain unclear. Due to the complex interaction of capsule synthesis (cps) genes, it is commonly thought that pneumococcal serotypes evolve once and that all clinically relevant serotypes are genetically derived from a single founding clone. In this dissertation we demonstrate a novel mechanism of capsule evolution …

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Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa Jan 2012

Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa

All ETDs from UAB

A precise molecular identification of transmitted/founder (T/F) HIV-1 genomes responsible for productive infection in humans can be an enabling strategy for elucidating mechanisms of virus transmission, immunopathogenesis and prevention. Previously, we reported a single genome sequencing approach, which when combined with a mathematical model of early random virus diversification, allowed for an unambiguous identification of T/F HIV-1 subtype B and C envelope (env) genes. Here, we apply this method to the identification and molecular cloning of full-length HIV-1 genomes and env genes of the less well-studied, but nonetheless important, HIV-1 subtypes A and D. Twelve subtype A (n=5), D (n=5) …

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Examination Of Urban High School Dropouts With High Self-Efficacy: A Phenomenological Study, Ronald Bayles Jan 2012

Examination Of Urban High School Dropouts With High Self-Efficacy: A Phenomenological Study, Ronald Bayles

All ETDs from UAB

The purpose of this study was to explore the lived experience of urban students in Central Alabama with high self-efficacy who have dropped out of school to pursue a GED. This study: (a) provided a platform that gave voice to students to share their lived experience as they made the decision to drop out of high school, (b) identified the character traits of students with high self-efficacy, and (c) revealed the essence of what motivated students to move to resilience after appearing to give up. A qualitative research design was used. The phenomenological approach provided the opportunity for participants to …

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Sonication Treatment Of Diesel Fuel Laden Sump Water, Roxanne E. Bessette Jan 2012

Sonication Treatment Of Diesel Fuel Laden Sump Water, Roxanne E. Bessette

All ETDs from UAB

Diesel engines are the work horses of industry and transportation. Pervasive diesel fuel use impacts stormwater, by increasing petroleum releases to surface waters. Sump containment of diesel-adulterated stormwater commonly keeps diesel from contacting surface waters. Once contained, the quandary lies in effective stormwater treatment that allows discharges within the local watershed. On-site treatment of diesel sump water ordinarily involves gravity oil-water separation technologies. These technologies' treatment times range from hours to days. Commonly, they cannot meet National Pollution Discharge Elimination System (NPDES) stormwater discharge standards for oil and grease because they best remove `free' oil not commonly occurring emulsions. Oil-water …

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Understanding The Mechanisms Underlying Pgc-1Α-Mediated Regulation Of Interneuron-Specific Genes, Ashruta Patel Jan 2012

Understanding The Mechanisms Underlying Pgc-1Α-Mediated Regulation Of Interneuron-Specific Genes, Ashruta Patel

All ETDs from UAB

The expression of parvalbumin (Pvalb), a calcium buffering protein expressed in subsets of inhibitory neurons throughout the brain, is reduced in numerous psychiatric and neurological disorders, yet little is known about its transcriptional regulation. Previous work from the Cowell Lab has shown that the expression of Pvalb and other interneuron-specific genes in the mouse brain is dependent on the transcriptional coactivator peroxisome proliferator activated receptor coactivator 1α (PGC-1α ) and that overexpression of PGC-1α in neuroblastoma cells is sufficient to robustly induce Pvalb. The Cowell Lab determined that expression of Pvalb requires a region upstream of the human Pvalb transcription …

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A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger Jan 2012

A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger

All ETDs from UAB

Parkinson's Disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. Gene multiplication of alpha-synuclein causes an autosomal dominant inheritance pattern of PD. A mouse model overexpressing alpha-synuclein demonstrates some of the phenotype seen in PD. In a microarray of these mice, a downregulation of angiogenin was observed prior to symptom onset, demonstrating a potential link of angiogenin to pathology in this model. Angiogenin has also been associated with the onset of Amyotrophic Lateral Sclerosis (ALS), and is neuroprotective in models of ALS through activation of the Akt …

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The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein Jan 2012

The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein

All ETDs from UAB

In recent years, hydrogen sulfide (H2S) has been identified as a ubiquitous cell signaling molecule. In addition to its diverse physiological roles, H2S has emerged as a possible drug therapy, with a wide range of applications. Along with cytoprotective effects in pathological states such as ischemia-reperfusion injury, H2S has been shown to decrease aerobic metabolism in a reversible manner. This dissertation is focused on exploring H2S-induced hypometabolism and the implications therein for human health and disease. We have shown that rats exposed to 80 ppm H2S gas in combination with low oxygen (10.5% O2) for 6 hr exhibit decreases in …

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Examination Of Bafilomycin And Atp6v0c As Putative Mediators Of App Clearance In A Pre-Clinical Model Of Alzheimer's Disease, Charles Alan Taylor Jan 2012

Examination Of Bafilomycin And Atp6v0c As Putative Mediators Of App Clearance In A Pre-Clinical Model Of Alzheimer's Disease, Charles Alan Taylor

All ETDs from UAB

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and the most common form of dementia. Fundamental hallmarks of AD include progressive hippocampal neuron death, neurofibrillary tangles associated with tau deposits, and accumulation of amyloid plaques containing amyloid beta (Aß), a cleavage product derived from amyloid precursor protein (APP). Deficits in the clearance of APP, due to lysosomal dysfunction for instance, result in the accumulation of APP C-terminal fragments (APP-CTFs) and toxic species of Aß (Aß40-42) (1). Defective lysosomal proteolysis represents a mechanism that may contribute to AD pathologies, including protein aggregation and neuronal cell death. Therefore the lysosome represents an …

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The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor Jan 2012

The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor

All ETDs from UAB

THE IMPACT OF COMMUNITY HEALTH CENTERS ON PROSTATE CANCER SCREENING BEHAVIORS OF AFRICAN AMERICAN MALES: A MIXED METHODS STUDY MICHAEL C. TAYLOR UAB SCHOOL OF PUBLIC HEALTH DEPARTMENT OF HEALTH BEHAVIOR ABSTRACT Federally qualified community health centers have a significant impact upon uninsured and low income populations in the United States by providing low cost primary care and preventive services. The purpose of this mixed methods study was to determine the impact of community health centers (CHCs) on African American males' prostate cancer screening behavior in a major Southern city. A sequential explanatory mixed method model was used to assess …

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Surviving Stem: Mentoring, Self-Effiacay And Career Intentions Of Female Graduate Students In Science, Technology, Engineering, And Math, Elizabeth Allyne Yost Jan 2012

Surviving Stem: Mentoring, Self-Effiacay And Career Intentions Of Female Graduate Students In Science, Technology, Engineering, And Math, Elizabeth Allyne Yost

All ETDs from UAB

The state of women in STEM (Science, Technology, Engineering, and Math) is not equitable to that of their male counterparts. While great strides have been taken in the last few years, many areas of STEM are still unable to draw equitable numbers of women into the academy. One way to encourage women to enter in and remain in the academy is through mentoring. Through mentoring, women are able to see that a career path is possible for them and better learn how to navigate the structure of the academy. Mentoring has also been shown to increase self-efficacy, which the Social …

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Serotonin Signaling In Angiogenesis, Ali Zamani Jan 2012

Serotonin Signaling In Angiogenesis, Ali Zamani

All ETDs from UAB

Serotonin (5-hydroxytryptamine, 5-HT) is a well-known "happy" neurotransmitter. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed class of antidepressant medications to raise the serotonin level in the brain. However, the majority of serotonin in the human body is present outside of the brain and stored in platelets in blood circulation. Blood coagulation is a common feature of malignant solid tumors and leads to significant serotonin release from activated platelets into tumor environment. Due to the unique feature of platelet in lacking nucleus, the impact of platelet and serotonin on cancer progression has been overlooked by studies focusing on cancer …

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Possible Effects Of The Presence Of Common Household Chemicals In The Environment: The Growth Of An Aquatic Bacterial Species On High Concentrations Of Caffeine, Adrienne M. Gibson, Roderick M. Morgan, Nick Macdonald, Alexey G. Nikitin Jan 2012

Possible Effects Of The Presence Of Common Household Chemicals In The Environment: The Growth Of An Aquatic Bacterial Species On High Concentrations Of Caffeine, Adrienne M. Gibson, Roderick M. Morgan, Nick Macdonald, Alexey G. Nikitin

Open Access Publishing Support Funded Articles

Caffeine is a prevalent chemical in the environment, often being found in aquatic ecosystems. Past studies have shown that some bacterial species can metabolize caffeine, but little research has been done to study the effect of different caffeine concentrations on the growth of the bacteria. The goal of the current study is to gain a better understanding of how aquatic bacteria, which have been selected for growth on caffeine, utilize caffeine as a source of carbon. To study the effect of caffeine concentrations on bacterial growth, we isolated a bacterium from an aquarium that had been exposed to caffeine. The …

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The Price Of Pleasure: Children Hurt Too, Jeffrey A. Parness, Zachary Townsend Jan 2012

The Price Of Pleasure: Children Hurt Too, Jeffrey A. Parness, Zachary Townsend

Faculty Articles, Papers, and Other Scholarship

In her two recent articles on pregnancy support, “Preglimony” in the Stanford Law Review and “The Price of Pleasure” in the Northwestern Law Review, Professor Shari Motro argues that American laws should no longer treat “lovers as strangers.” To minimize “the fundamental gender imbalance,” she urges that the relationship between an unwed heterosexual couple whose sex prompts pregnancy “demands it own legal category.” She calls for a new paradigm that generally holds men financially responsible to women for the burdens of pregnancy, employing both contract and tort principles. Professor Motro invites conversation on her self-described utopian notions. Most curious for …

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Genomic Arrangement Of Regulons In Bacterial Genomes, Yanbin Yin, Han Zhang, Ying Xu Jan 2012

Genomic Arrangement Of Regulons In Bacterial Genomes, Yanbin Yin, Han Zhang, Ying Xu

Faculty Articles, Papers, and Other Scholarship

Regulons, as groups of transcriptionally co-regulated operons, are the basic units of cellular response systems in bacterial cells. While the concept has been long and widely used in bacterial studies since it was first proposed in 1964, very little is known about how its component operons are arranged in a bacterial genome. We present a computational study to elucidate of the organizational principles of regulons in a bacterial genome, based on the experimentally validated regulons of E. coli and B. subtilis. Our results indicate that (1) genomic locations of transcriptional factors (TFs) are under stronger evolutionary constraints than those of …

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Global Representation In Psychiatric Research, Bruce L. Brown, Michael Zhang, Dawson W. Hedges Jan 2012

Global Representation In Psychiatric Research, Bruce L. Brown, Michael Zhang, Dawson W. Hedges

Faculty Publications

To monitor global representation in the psychiatric literature, we compared publication rates in the ten psychiatric journals with the highest impact factors in 1998 and 2008 by world regions. In both 1998 and 2008, North America, Northern Europe, Western Europe and Oceania produced the majority of psychiatric research papers published in these journals, despite representing only a small fraction of the world’s population. This suggests that much of the world’s population continues to be underrepresented in highly influential psychiatric journals.

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Examining A Brief Suicide Screening Tool In Older Adults Engaging In Risky Alcohol Use, Scott R. Braithwaite, Jessica D. Ribeiro, Jon J. Peaff, Thomas E. Joiner Jan 2012

Examining A Brief Suicide Screening Tool In Older Adults Engaging In Risky Alcohol Use, Scott R. Braithwaite, Jessica D. Ribeiro, Jon J. Peaff, Thomas E. Joiner

Faculty Publications

Alcohol misuse increases risk of suicidal behavior in older adults. TheDepressive Symptom Inventory-Suicidality Subscale (DSI-SS; Metalsky & Joiner,1997) and its relation to suicide attempt history was examined to see if it differedfor older adults as a function of their alcohol use. Structural equation modelingwas used in a sample (N= 1,061) of older adult outpatients to examine the scale’smeasurement invariance and population heterogeneity and its relation to suicideattempt history. Analyses supported the equivalence of the DSI-SS in risky andnonrisky drinkers. The DSI-SS significantly predicted past suicide attempts. Find-ings support the viability of the DSI-SS as suicide screening tool for older adults.

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Subliminal Activation Of Social Ties Moderates Cardiovascular Reactivity During Acute Stress, Wendy C. Birmingham, Mckenzie Carlisle, Bert N. Uchino, David M. Sanbonmatsu, Timothy W. Smith, Matthew R. Cribbet, Kathleen C. Light, Allison A. Vaughn Jan 2012

Subliminal Activation Of Social Ties Moderates Cardiovascular Reactivity During Acute Stress, Wendy C. Birmingham, Mckenzie Carlisle, Bert N. Uchino, David M. Sanbonmatsu, Timothy W. Smith, Matthew R. Cribbet, Kathleen C. Light, Allison A. Vaughn

Faculty Publications

Objective—The quality of one’s personal relationships has been reliably linked to important physical health outcomes, perhaps through the mechanism of physiological stress responses. Most studies of this mechanism have focused on whether more conscious interpersonal transactions influence cardiovascular reactivity. However, whether such relationships can be automatically activated in memory to influence physiological processes has not been determined. The primary aims of this study were to examine if subliminal activation of relationships could influence healthrelevant physiological processes, and to examine this question in the context of a more general relationship model that incorporates both positive and negative dimensions. Method—We randomly assigned …

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Knowing Your Partner Is Not Enough: Spousal Importance Moderates The Link Between Attitude Familiarity And Ambulatory Blood Pressure, Wendy C. Birmingham, Bert N. Uchino, David M. Sanbonmatsu Jan 2012

Knowing Your Partner Is Not Enough: Spousal Importance Moderates The Link Between Attitude Familiarity And Ambulatory Blood Pressure, Wendy C. Birmingham, Bert N. Uchino, David M. Sanbonmatsu

Faculty Publications

Close relationships have been linked to cardiovascular morbidity and mortality. More research is needed, however, on the social and biological processes responsible for such links. In this study, we examined the role of relationship-based attitudinal processes (i.e., attitude familiarity and partner importance) on ambulatory blood pressure during daily life. Forty-seven married couples completed a questionnaire regarding their own attitudes, perceptions of their partner’s attitudes, and perceptions of partner importance. They also underwent a 1-day ambulatory assessments of daily spousal interactions and blood pressure. Partner importance was related to better interpersonal functioning (e.g., partner responsiveness) and lower ambulatory systolic blood pressure. …

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Performance Monitoring Following Conflict: Internal Adjustments In Cognitive Control?, Scott A. Baldwin, Michael J. Larson, Peter E. Clayson Jan 2012

Performance Monitoring Following Conflict: Internal Adjustments In Cognitive Control?, Scott A. Baldwin, Michael J. Larson, Peter E. Clayson

Faculty Publications

The purpose of this study was to investigate the effects of strategic conflict-related adjustments in cognitive control processes on indices of performance monitoring. Previous research has examined the ability of parametric task-related manipulations to bias attention to errors; however, the present study sought to elucidate the effects of internal adjustments in control mediated by the anterior cingulate cortex on error-related conflict processing. High-density event-related potentials (ERPs) were obtained from 124 healthy individuals (68 female, 66 male) during a modified Eriksen flanker task. Behavioral measures (i.e., error rates, response times [RTs]) and N2 amplitudes showed significant conflict adaptation (i.e., previous-trial congruencies …

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Procreative Sex And Same Sex Parents, Jeffrey A. Parness, Zachary Townsend Jan 2012

Procreative Sex And Same Sex Parents, Jeffrey A. Parness, Zachary Townsend

Faculty Articles, Papers, and Other Scholarship

New state-sanctioned family units headed by couples in committed relationships are on the rise. They include marriages encompassing same sex couples, civil unions, and domestic partnerships. These new family units can originate in state statutes or in judicial decisions. The pace of change is so fast that new units occasionally replace units only recently recognized, as when same sex marriages replace civil unions or domestic partnerships. U.S. Supreme Court precedents permit broad governmental discretion in sanctioning new families and in recognizing parentage therein. Yet such discretion is limited by constitutionally-recognized parental rights and interests when children are born of sex. …

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Influences On Active Family Leisure And A Healthy Lifestyle Among Adolescents, Shallie M. Taylor, Peter Ward, Ramon Zabriskie, Brian Hill, Carl Hanson Jan 2012

Influences On Active Family Leisure And A Healthy Lifestyle Among Adolescents, Shallie M. Taylor, Peter Ward, Ramon Zabriskie, Brian Hill, Carl Hanson

Faculty Publications

The purpose of this study was to examine how attitude, subjective norm, and perceived behavioral control influence adolescents’ intent to participate in active family leisure within the theory of plan behavior framework. Adolescents (N = 472) completed an online questionnaire about their perceptions and actual participation in active family leisure. Structural equation modeling was used to analyze the data. A post-hoc analysis also considered individual leisure and its role on active family leisure. Attitude, subjective norm, and perceived behavioral control were significant predictors of intent to participate in active family leisure.

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Noninvasive Transcranial Focal Stimulation Via Tripolar Concentric Ring Electrodes Lessens Behavioral Seizure Activity Of Recurrent Pentylenetetrazole Administrations In Rats, Oleksandr Makeyev, Hiram Luna-Munguía, Gabriela Rogel-Salazar, Xiang Liu, Walter G. Besio Jan 2012

Noninvasive Transcranial Focal Stimulation Via Tripolar Concentric Ring Electrodes Lessens Behavioral Seizure Activity Of Recurrent Pentylenetetrazole Administrations In Rats, Oleksandr Makeyev, Hiram Luna-Munguía, Gabriela Rogel-Salazar, Xiang Liu, Walter G. Besio

Electrical, Computer, and Biomedical Engineering Faculty Publications

Epilepsy affects approximately 1% of the world population. Antiepileptic drugs are ineffective in approximately 30% of patients and have side effects. We have been developing a noninvasive transcranial focal electrical stimulation with our novel tripolar concentric ring electrodes as an alternative/complementary therapy for seizure control. In this study we demonstrate the effect of focal stimulation on behavioral seizure activity induced by two successive pentylenetetrazole administrations in rats. Seizure onset latency, time of the first behavioral change, duration of seizure, and maximal seizure severity score were studied and compared for focal stimulation treated (n = 9) and control groups (n = …

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A Folded Neural Network Autoencoder For Dimensionality Reduction, Jing Wang, Haibo He, Danil V. Prokhorov Jan 2012

A Folded Neural Network Autoencoder For Dimensionality Reduction, Jing Wang, Haibo He, Danil V. Prokhorov

Electrical, Computer, and Biomedical Engineering Faculty Publications

Dimensionality reduction has been a long-standing research topic in academia and industry for two major reasons. First, in almost every domain, ranging from biology, social science, economics, to military data processing applications, the increasingly large volume of data is challenging the existing computing capability and raising the computing cost. Second, the notion of "intrinsic structure" allows us to remove some redundant dimensions from high-dimensional observations and reduce it into low-dimensional features without significant information loss. Autoencoder, as a powerful tool for dimensionality reduction has been intensively applied in image reconstruction, missing data recovery and classification. In this paper, we propose …

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Ambient Habitat Noise And Vibration At The Georgia Aquarium, P. M. Scheifele, M. T. Johnson, L. Kretschmer, J. G. Clark, D. Kemper, Gopu R. Potty Jan 2012

Ambient Habitat Noise And Vibration At The Georgia Aquarium, P. M. Scheifele, M. T. Johnson, L. Kretschmer, J. G. Clark, D. Kemper, Gopu R. Potty

Ocean Engineering Faculty Publications

Underwater and in-air noise evaluations were completed in performance pool systems at Georgia Aquarium under normal operating conditions and with performance sound tracks playing. Ambient sound pressure levels at in-pool locations, with corresponding vibration measures from life support system (LSS) pumps, were measured in operating configurations, from shut down to full operation. Results indicate noise levels in the low frequency ranges below 100 Hz were the highest produced by the LSS relative to species hearing thresholds. The LSS had an acoustic impact of about 10 dB at frequencies up to 700 Hz, with a 20 dB re 1 μPa impact …

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Comparison Of Neurobehavioral Effects Of Methylmercury Exposure In Older And Younger Adult Zebrafish (Danio Rerio), Xiaojuan Xu, Daniel Weber, Michael J. Carvan Iii, Ryan Coppens, Crystal Lamb, Stefan Goetz, Lillian A. Schaefer Jan 2012

Comparison Of Neurobehavioral Effects Of Methylmercury Exposure In Older And Younger Adult Zebrafish (Danio Rerio), Xiaojuan Xu, Daniel Weber, Michael J. Carvan Iii, Ryan Coppens, Crystal Lamb, Stefan Goetz, Lillian A. Schaefer

Open Access Publishing Support Funded Articles

It is widely recognized that the nature and severity of responses to toxic exposure are age-dependent. Using active avoidance conditioning as the behavioral paradigm, the present study examined the effect of short-term methylmercury (MeHg) exposure on two adult age classes, 1- and 2-year-olds to coincide with zebrafish in relatively peak vs. declining health conditions. In Experiment 1, 2-year-old zebrafish were randomly divided into groups and were exposed to no MeHg, 0.15% ethanol (EtOH), 0.01, 0.03, 0.1, or 0.3 mM of MeHg (in 0.15% ethanol) for 2 weeks. The groups were then trained and tested for avoidance responses. The results showed …

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Sample Preparation For Service At The National Biomedical Epr Center, Brian Bennett Jan 2012

Sample Preparation For Service At The National Biomedical Epr Center, Brian Bennett

Physics Faculty Research and Publications

No abstract provided.

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