Digital Commons Network^™

Child Fatalities In Tennessee 2010, Tennessee. Department Of Health.

Child Fatalities in Tennessee Report

No abstract provided.

Artemis And Metnase Mediated Processing Of 3΄-Blocked Dna Lesions: Role In Radio/Chemoresistance And Dna Repair, Susovan Mohapatra

Theses and Dissertations

DNA double-strand breaks (DSB) with chemically modified end-termini are the most significant lesions resulting from radio/chemotherapeutic intervention of cancer and non homologous end-joining (NHEJ) factor Artemis nuclease has been implicated in the repair of such breaks. To examine whether the resolution of terminally blocked DNA DSBs is the biologically relevant function of Artemis, Artemis deficient fibroblasts were stably complemented with wild type or an endonuclease deficient D165N mutant Artemis. Physiological levels of wild type (WT) Artemis completely restored DSB repair proficiency and resistance to γ-radiation, bleomycin, and neocarzinostatin. Cells expressing the D165N mutants remained as chemo/radiosensitive and as repair deficient …

Biobehavioral Correlates In Fibromyalgia, Ann Trivigno Mcnallen

Theses and Dissertations

Introduction: Fibromyalgia (FMS) is a chronic pain syndrome characterized by non-restorative sleep, and fatigue. Over 75% of individuals with FMS complain of poor sleep quality and fatigue. These have been ranked by patients with FMS as having great impact on quality of life. A literature review suggested that poor sleep quality may be a predictor of increased stress and FMS symptom onset in those affected. However, no experimental studies have demonstrated a causal relationship between poor sleep and stress in people with FMS. Methods: Using a single stage cross-sectional design, the primary study aim was to compare 25 women with …

The Role Of Fyn And B-Cell Expressed Adam10 In Early B Cell Development, Germinal Center Formation And Terminal B Cell Differentiation, Natalia Chaimowitz

Theses and Dissertations

In these studies we sought to determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In particular, ADAM10 has been identified as a key regulator of lymphocyte development. Here we report that ADAM10 is dispensable for early B cell development within the bone marrow. However, deletion of ADAM10 from all peripheral B cells or in post-switch cells leads to severe …

The Role Of High Affinity Nicotinic Acetylcholine Receptors On Anxiety-Like Behavior: A Study In Female Mice, Jessicka Hall

Theses and Dissertations

Tobacco dependence is high in women who suffer from anxiety disorders yet little is known about the contributions of nicotinic acetylcholine receptors (nAChRs) on anxiety-like behavior. β2*nAChRs (*denotes assembly with other subunits) are the most abundantly expressed nAChRs in the brain yet little is known about the contributions of β2*nAChRs on anxiety-like behavior in female mice. In this study, antagonism and nicotine effects on anxiety-like behavior was investigated across the life span in 6, 12 and 24-month-old drug-naïve knockout (KO), heterozygous (HET) and a gain of function α6L9S mice and wild type (WT). HET mice showed increased sensitivity to di-hydrobeta-erythroidine …

Non-Canonical Roles For Stat1 And Stat2 In Mitochondrial Biogenesis And Fasting Homeostasis., Jennifer Sisler

Theses and Dissertations

The signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. In addition to their nuclear effects, we report that STAT1 and STAT2 inhibit the expression of mitochondrial encoded mRNAs by activating type I interferons (IFNβ) under basal conditions. STAT1-/- livers also exhibit elevated levels of nuclear encoded components of the electron transport chain (ETC). Treatment of wild-type mice with IFNβ inhibits both mitochondrial and …

Transient Camk-Ii Activation Is Necessary For Left-Right Asymmetry In The Zebrafish Embryo, Ludmila Francescatto

Theses and Dissertations

Despite external bilateral symmetry, the internal organs of vertebrates are asymmetrically arranged. The development of Left-Right (LR) asymmetry is dependent on the activity of a ciliated organ known as the Kupffer’s vesicle (KV) or the embryonic node, in zebrafish and mouse, respectively. Cilia beating within the KV are essential to generate a counterclockwise flow of fluid, which leads to left-sided Ca2+ elevation. Ca2+ is a crucial morphogenic second messenger during vertebrate development. Ca2+ elevation activates targets, such as CaMK-II, which is also known as the multifunctional Ca2+/calmodulin-dependent protein kinase. Studies have linked CaMK-II to secretion (mediated through synapsin I) and …

Effects Of Light Limitation On Plant-­Rhizobia And Plant-Mycorrhiza Interactions, Jess A. Millar

Anthós

Plants respond with a sink stimulation of photosynthesis when colonized by bacterial and fungal mutualists, which compensates for costs of carbohydrate allocation to the microbes. Problems may arise when light is limited and plants cannot increase photosynthesis. We hypothesize that under such conditions the costs for maintaining the mutualism outweigh the benefits, which ultimately turns the beneficial microbes into parasites exploiting resources and reducing host fitness. We study these plant-­‐microbe interactions under different light availabilities using lima bean plants, rhizobia (nitrogen-­‐fixing bacteria), and mycorrhizal fungi. In our study, we apply two levels of light (full light and light intensity reduced …

New Records Of Alien Gastropoda In The Hawaiian Islands: 1996–2010, Kenneth Hayes, Norine Yeung, Jaynee Kim, Robert Cowie

Department of Biology Faculty Publications

The alien nonmarine gastropods of the Hawaiian islands were cataloged by Cowie (1997) and were reviewed by Cowie (1998a). Subsequent new records (both for the archipelago and for individual islands) were reported by Cowie (1998b, 1999, 2000), Kraus (2003), and, specifically associated with the horticultural industry between 2004 and 2006, by Hayes et al. (2007), reviewed and analyzed by Cowie et al. (2008). Subsequent surveys, covering 196 sites across the six largest main Hawaiian islands during 2006–2010, have resulted in the additional new records reported here. We surveyed 29 locations on Kaua'i, 48 on O'ahu, 13 on Moloka'i, 50 on …

Surfactant-Sensitized Spectrophotometric Determination Of Hg(Ii) In Water Samples Using 2-(2-Thiazolylazo)- P-Cresol As Ligand And Cetylpyridinium Chloride As Cationic Surfactant, Ramazan Gürkan, Tuğba Çepken, Hali̇l İbrahi̇m Ulusoy

Turkish Journal of Chemistry

A new, reliable, surfactant-sensitized method is described for the spectrophotometric determination of total and dissolved inorganic mercury at trace levels. The method is based on the ternary complex formation of Hg(II) with 2-(2-thiazolylazo)-p-cresol and a cationic surfactant, cetylpyridinium chloride, at pH 9.5. The detection and quantification limits of the method with surfactant were 6 and 19 \mu g L^{-1}, while those of the method without surfactant were 22 and 67 \mu g L^{-1}, respectively. The method obeys Beer's law at up to approximately 10 mg L^{-1} Hg(II) in an aqueous surfactant medium. The relative errors and relative standard deviations of …

Determination Of Cadmium In High Salt Content Matrices By Flow Injection Cold Vapor Atomic Absorption Spectrometry, Orkun Alp, Hakan Demi̇röz, Osman Yavuz Ataman, Nusret Ertaş

Turkish Journal of Chemistry

Flow injection cold vapor atomic absorption spectrometry (FI-CVAAS) was used for determination of cadmium in high salt matrices such as dialysis concentrates and textile leach solutions. The parameters such as acidity, concentration of reducing agent, reaction coil length, and carrier gas flow rate were investigated to obtain the best sensitivity. No significant background signal was observed even at high salt concentrations. Under the optimized conditions the limit of detection value (3s_b m^{-1}, where s_b is the standard deviation of the blank signals and m is the slope of the calibration graph) was found to be 0.05 ng mL^{-1} for an …

Novel Biologically Active Glycosides From The Aerial Parts Of Cephalaria Gazipashensis, Nazli Böke Sarikahya, Süheyla Kirmizigül

Turkish Journal of Chemistry

Two new triterpene glycosides, 3-O-\beta-D-glucopyranosyl- (1\to 4)-\beta-D-xylopyranosyl-(1\to 3)-\alpha-L-rhamnopyranosyl- (1\to 3)-\alpha-L-arabinopyranosyl olean-12-ene 28-O-\beta -D- glucopyranosyl-(1\to 6)-\beta-D-glucopyranosyl ester (gazipashoside A, 1) and 3-O-\beta-D-glucopyranosyl-(1\to 4)-\beta-D-xylopyranosyl- (1\to 3)-\alpha-L-rhamnopyranosyl-(1\to 2)-\alpha-L-arabinopyranosyl hederagenin 28-O-\beta -D-glucopyranosyl-(1\to 6)-\beta-D-glucopyranosyl ester (gazipashoside B, 2), were isolated together with 11 known compounds including 7 triterpene, 1 flavonoid, and 3 iridoidal metabolites from the aerial parts of Cephalaria gazipashensis (Dipsacaceae). The structures of all compounds were elucidated by extensive evaluation of the spectroscopic data (1D- and 2D- NMR, HRESI-MS), as well as chemical examinations. The antimicrobial effects of all pure compounds were tested against gram-positive and gram-negative bacteria. The results indicated that the …

Theoretical Studies Of The Ground And Low-Lying Excited States Of [3,3']Bidiazirinylidene(C2n4), Tetramethyleneethane Diradical, And Arsenic And Selenium Oxides, Rashel Makane Mokambe Sumpter

Theses and Dissertations

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Reforming State Mental Health Parity Law, Stacey A. Tovino

Faculty Articles

This Article is the final installment in a three-part project that presents a comprehensive challenge to lingering legal distinctions between physical and mental illness in the context of health insurance. The first installment in this series narrowly inquired as to whether the postpartum mood disorders should be classified as physical or mental illnesses in a range of health law contexts, including the context of health insurance. The second installment was broader in scope and challenged a number of federal provisions that allow publicly- and privately-funded health care programs and plans to provide mental health insurance benefits that are less comprehensive …

Suicide Gatekeeper Training For Mental Health Professionals And Paraprofessionals As A Community Based Prevention Strategy, Andrew Guilfoyle

ECU Research Week

No abstract provided.

Biological Children Of Foster Carers. Are They Being Heard?, Anna Targowska, Susan Teather

ECU Research Week

No abstract provided.

Foreword: Sea State: An Introduction To Reflections On Fisheries, Oil Spills, And Emerging Issues In Ocean Law And Policy, Susan E. Farady

Roger Williams University Law Review

No abstract provided.

Students’ Attributions Of Instructor Credibility As A Function Of Instructors’ Out-Of-Class Support, Adam C. Jones, Paul Schrodt

Basic Communication Course Annual

This investigation examined the impact that instructor out-of-class support (OCS) and sex differences have on students’ perceptions of instructor credibility. Participants (N = 634) were randomly assigned to one of six experimental conditions manipulating the degree to which an instructor responds with a highly supportive, moderately supportive, or non-supportive message following a hypothetically stressful situation. Multivariate analyses revealed a two-way interaction effect of instructor OCS by student sex on perceptions of instructor credibility. Significant and meaningful main effects for instructor OCS on all three dimensions of credibility (i.e., competence, trustworthiness, and caring) were also obtained, with students attributing more credibility …

I Need Help: Help Seeking Behaviors, Communication Anxiety And Communication Center Usage, C. Leigh Nelson, Toni S. Whitfield, Michelle Moreau

Basic Communication Course Annual

A web-based survey of 357 respondents enrolled in basic communication courses was conducted to examine communication center usage, communication apprehension, and help seeking behaviors. There was no significant difference between students who attended the communication center and those who did not in their communication apprehension and help seeking behaviors. There were significant correlations between help seeking behaviors and communication apprehension. Demographics, communication apprehension, and communication center usage and awareness predicted multiple types of help seeking behaviors.

Index Of Titles And Authors, Volumes 1-23

Basic Communication Course Annual

No abstract provided.

Basic Communication Course Annual Vol. 24

Basic Communication Course Annual

Full issue (298 pages, 12.1 MB)

[Introduction To] Believing And Acting: The Pragmatic Turn In Comparative Religion And Ethics, G. Scott Davis

Bookshelf

How should religion and ethics be studied if we want to understand what people believe and why they act the way they do? In the 1980s and '90s postmodernist worries about led to debates that turned on power, truth, and relativism. Since the turn of the century scholars impressed by 'cognitive science' have introduced concepts drawn from evolutionary biology, neurosciences, and linguistics in the attempt to provide 'naturalist' accounts of religion. Deploying concepts and arguments that have their roots in the pragmatism of C. S. Peirce, Believing and Acting argues that both approaches are misguided and largely unhelpful in answering …

The Parasite That Causes Whirling Disease, Myxobolus Cerebralis, Is Genetically Variable Within And Across Spatial Scales, Nilanjan Lodh, Billie L. Kerans, Lori Stevens

Clinical Lab Sciences Faculty Research and Publications

Understanding the genetic structure of parasite populations on the natural landscape can reveal important aspects of disease ecology and epidemiology and can indicate parasite dispersal across the landscape. Myxobolus cerebralis (Myxozoa: Myxosporea), the causative agent of whirling disease in the definitive host Tubifex tubifex, is native to Eurasia and has spread to more than 25 states in the USA. The small amounts of data available to date suggest that M. cerebralis has little genetic variability. We examined the genetic variability of parasites infecting the definitive host T. tubifex in the Madison River, MT, and also from …

Minimalist Ensemble Algorithms For Genome-Wide Protein Localization Prediction, J.-R. Lin, A. M. Mondal, R. Liu, Jianjun Hu

Faculty Publications

Background

Computational prediction of protein subcellular localization can greatly help to elucidate its functions. Despite the existence of dozens of protein localization prediction algorithms, the prediction accuracy and coverage are still low. Several ensemble algorithms have been proposed to improve the prediction performance, which usually include as many as 10 or more individual localization algorithms. However, their performance is still limited by the running complexity and redundancy among individual prediction algorithms.

Results

This paper proposed a novel method for rational design of minimalist ensemble algorithms for practical genome-wide protein subcellular localization prediction. The algorithm is based on combining a feature …

Biometric Alternatives To Captcha: Exploring Accessible Interface Options, Anita Foley

Dissertations

In the computing domain the relationship between accessibility and security is a complex and evolving one; accessibility attempts to ensure that as wide a range of individuals as possible are granted access to systems, whereas security attempts to restrict access only to individuals who are entitled to access those systems. A key security concern is to determine whether or not the system is being accessed by a software agent or a real human being, and a number of approaches have been developed to determine the answer to this question. This issue has been discussed throughout the history of computer science …

Investigation And Analysis Of Open Government Data In Ireland, And The Creation Of A Set Of Quality Guidelines To Aid Its Utility Within Mobile Application Development, Peadar Fitzpatrick

Dissertations

Governments are the custodians of vast amount of data. While some of this data may be sensitive in nature, in that it contains personal or confidential information, much of it is in the public interest. Recent years has seen the emergence of Open Government Data (OGD) where governments are now actively making their data available in open and electronically accessible formats. The motivation for the production of such data includes a desire to increase transparency but also a desire to realise the economic potential associated with re-use of this data. A key usage area for this data to date has …

Towards Universally Designed Assistive Technology E-Learning, Karl O'Keeffe

Dissertations

The aim of this dissertation is to provide Assistive Technology (AT) professionals involved in the area of education and training with a set of reusable technological tools and techniques that will enable them to increase the reach, efficiency, effectiveness and accessibility of their training through online delivery. There are a number of broadly accepted reasons why an organisation in any field might choose to make training available online or partially online (blended) rather than relying on traditional face to face methods. Of the four considered here and mentioned above, accessibility is the biggest concern in the context of AT. It …

Productivity Of Field Pea (Pisumsativum L.) And Spring Oat (Avena Sativa L.) Grown As Sole And Intercrops Under Different Nitrogen Levels, Chengchou Han, Christopher Borman, Dori Osantowski, Jeremy Wagnitz, Katja Koehler-Cole, Kevin Korus, Evan Sonderegger, Rodrigo Werle, Tara Wood, John L. Lindquist

Department of Agronomy and Horticulture: Faculty Publications

Intercropping cereal grains and legumes has potential as an alternative cool-season forage crop in low-input farming systems. The objectives of this study were to quantify the effects of density, species proportion, and nitrogen (N) supply on the biomass accumulation of field pea and spring oat grown as sole or intercrops. Greenhouse experiments were conducted using an additive series experimental design. Treatments included three fertilizer N rates and 20 density/proportion combinations in a randomized complete block with four replications. Sole plant densities included 2, 3, 4, 5 plants of each species pot-1 (16 cm in diameter, 16 cm in height). The …

Beef Heifer Development And Profitability, Matthew C. Stockton, Roger K. Wilson, Richard N. Funston Funston

Nebraska Beef Cattle Reports

The determination of the ideal breeding size of beef replacement females is traditionally centered on maximizing pregnancy rate. Relevant physical and economic relationships were combined into a bioeconomic systems model that identified key profit factors. This system-wide approach encapsulated the physical relationships with relevant costs and revenues, including annual and seasonal variations and measures relative to profitability through the application of an incomplete or modified profit function. Optimaloutcomes were relative to heifer size and management regime.

Statistics Used In The Nebraska Beef Report And Their Purpose

Nebraska Beef Cattle Reports

The purpose of beef cattle and beef product research at UNL is to provide reference information that represents the various populations (cows, calves, heifers, feeders, carcasses, retail products, etc.) of beef production. Obviously, researchers cannot apply treatments to every member of a population; therefore, they must sample the population. The use of statistics allows researchers and readers of the Nebraska Beef Report the opportunity to evaluate separation of random (chance) occurrences and real biological effects of a treatment. Following is a brief description of the major statistics used in the beef report. For a more detailed description of the expectations …