Digital Commons Network^™

The Evolution Of Host Specificity In The Vertebrate Gut Symbiont Lactobacillus Reuteri, Steven Frese

Department of Food Science and Technology: Dissertations, Theses, and Student Research

The vertebrate gut is home to one of the densest populations of life on Earth. This microbial community has a profound effect on host health, nutrition, development, behavior, and evolution. However, very little is known about how these microbes have evolved with their vertebrate hosts, how and whether they select hosts or how they remain associated with their hosts. Recent work identified Lactobacillus reuteri as an organism that is composed of host-specific sub-populations, each population associated with a different host animal. Representatives from each host-associated population were tested for their ability to colonize gnotobiotic mice, which only rodent strains could …

Stopover Decisions Of Migratory Shorebirds: An Assessment Of Habitat Use, Food Availability, Behavior And Phenology, Ryan Stutzman

School of Natural Resources: Dissertations, Theses, and Student Research

Habitat loss and alteration from land use change, species invasion, and more recently, climate change has reduced biodiversity and ecosystem function worldwide. Habitat decisions have important implications to individual fitness as well as population dynamics and community structure. Resource limitation, predation, competition, and unfavorable abiotic conditions all have the potential to influence survival and future reproductive potential. Understanding how changes to ecosystem structure and function impact species and populations of conservation concern is essential for conservation delivery to be effective. Similar to many migratory species, shorebird populations are declining worldwide and declines may be related to the loss of important …

Trophic Complexity And The Adaptive Value Of Damage-Induced Plant Volatiles., Ian Kaplan

Department of Entomology Faculty Publications

Indirect plant defenses are those facilitating the action of carnivores in ridding plants of their herbivorous consumers, as opposed to directly poisoning or repelling them. Of the numerous and diverse indirect defensive strategies employed by plants, inducible volatile production has garnered the most fascination among plant-insect ecologists. These volatile chemicals are emitted in response to feeding by herbivorous arthropods and serve to guide predators and parasitic wasps to their prey. Implicit in virtually all discussions of plant volatile-carnivore interactions is the premise that plants “call for help” to bodyguards that serve to boost plant fitness by limiting herbivore damage. This, …

Successful Emergent Literacy Head Start Teachers Of Urban African American Boys Living In Poverty, John Michael Holland

Theses and Dissertations

This integrated methods study used a sequential explanatory design to explore the culturally relevant teaching beliefs of successful emergent literacy Head Start teachers of urban African American boys living in poverty. The study utilized emergent literacy gain scores as a measure of success, a survey of culturally relevant teaching beliefs to describe variation in beliefs within the sample, and two rounds of interviews to explore the context of teacher agency with urban African American boys living in poverty. The four teachers interviewed expressed culturally relevant beliefs integral to their teaching practices. These beliefs were conveyed through descriptions of relationships with …

Mapping Marketing Library Services Related Literature In Lis Open Access Journals, Anna Kaushik

Library Philosophy and Practice (e-journal)

Open access initiative explores the new way to access scholarly literature free of cost which published in diverse online journals on different subjects. This study aims to identify growth and publication patterns of marketing library and information services related literature published in LIS open access journals by various bibliographic points of view. The results of the study demonstrated that maximum quantity of articles published in marketing library services, most productive year count as 2002 and huge amount of articles focused on library marketing theme. Results further revealed that wide spectrum of articles published in foreign open access LIS journals by …

Sex Differences And Within-Family Associations In The Broad Autism Phenotype, Jessica Klusek, M Losh, G Martin

Faculty Publications

No abstract provided.

Lack Of P53 Affects The Expression Of Several Brain Mitochondrial Proteins: Insights From Proteomics Into Important Pathways Regulated By P53, Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B. Klein, Daret K. St. Clair, D. Allan Butterfield

Chemistry Faculty Publications

The tumor suppressor protein p53 has been described "as the guardian of the genome" for its crucial role in regulating the transcription of numerous genes responsible for cells cycle arrest, senescence, or apoptosis in response to various stress signals. Although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. There is the link between p53 and oxidative stress, the latter a crucial factor that contributes to neurodegenerative processes like …

Data Acquisition From Cemetery Headstones, Cameron Smith Christiansen

Theses and Dissertations

Data extraction from engraved text is discussed rarely, and nothing in the open literature discusses data extraction from cemetery headstones. Headstone images present unique challenges such as engraved or embossed characters (causing inner-character shadows), low contrast with the background, and significant noise due to inconsistent stone texture and weathering. Current systems for extracting text from outdoor environments (billboards, signs, etc.) make assumptions (i.e. clean and/or consistently-textured background and text) that fail when applied to the domain of engraved text. Additionally, the ability to extract the data found on headstones is of great historical value. This thesis describes a novel and …

Bringing Staff (Faculty) Up To Speed: Cd-Rom Access Via A Wan At The University Of The Witwatersrand, South Africa, Julie Wilcocks

Proceedings of the IATUL Conferences

No abstract provided.

Reconceiving And Repackaging Journal Information For Electronic Delivery, John Tagler

Proceedings of the IATUL Conferences

No abstract provided.

Electronic Library Concept: Putting Plans Into Practice, Shirley Leung

Proceedings of the IATUL Conferences

No abstract provided.

On The World Wide Web: Cost Effective Solutions To Database Searching, Bart Decastro

Proceedings of the IATUL Conferences

In a recent questionnaire survey of Cambridge Scientific subscribers, over 90% expressed preference for the delivery of abstracting/indexing services through the Internet. This fact has been the rationale for Cambridge Scientific's Internet initiative. Thirty-six of Cambridge Scientific's databases, previously available in print and CD-ROM, are now searchable through the World Wide Web. More recently, these databases have been clustered into eight sets, each with a unified index, covering critical areas of research. (1) AIDS and cancer genetics, (2) aquatic sciences and fisheries, (3) biotechnology and bioengineering, (4) biological sciences, (5) environmental sciences and pollution management, (6) materials science and technology, …

The Dost-Esep Libraries: The First Library Network In The Philippines, David T. Lourdes

Proceedings of the IATUL Conferences

No abstract provided.

New Media And New Library Partnerships Downunder, Gulcin Cribb, Janine Schmidt

Proceedings of the IATUL Conferences

No abstract provided.

Libraries - Planning And Management In A Time Of Change 2, Janice Yeadon, Susan Howard

Proceedings of the IATUL Conferences

No abstract provided.

New Types Of Services And Documents In The Internet, And Their Impact On Information Transfer 2, Paul Nieuwenhuysen, Patrick Vanouplines

Proceedings of the IATUL Conferences

No abstract provided.

New Types Of Services And Documents In The Internet, And Their Impact On Information Transfer 1, Paul Nieuwenhuysen, Patrick Vanouplines

Proceedings of the IATUL Conferences

No abstract provided.

Changing Patterns Of Communication And Electronic Publishing, Arthur J. Meadows

Proceedings of the IATUL Conferences

No abstract provided.

Libraries - Planning And Management In A Time Of Change 1, Susan Howard, Janice Yeadon

Proceedings of the IATUL Conferences

No abstract provided.

The Academic Library As An «One Stop Shop» Information Provider For The Small And Medium Sized Enterprises, Kjell Birger Hansen

Proceedings of the IATUL Conferences

No abstract provided.

Scholarly Communication - Historical Development And New Possibilities, Nancy Fjällbrant

Proceedings of the IATUL Conferences

No abstract provided.

Characterization Of The Role Of Mitochondrial Function During Tumor Development And Muscle Wasting, Xiao Wang

Open Access Dissertations

Mitochondria play important roles in multiple cellular processes including energy metabolism, cell death, and aging. Regulated energy production and utilization is critical in maintaining energy homeostasis in normal cells and functional organisms. However, mitochondria go through a series of morphological and functional alterations during carcinogenesis. The metabolic profile in transformed cells is altered to accommodate their fast proliferation, confer resistance to cell death, or facilitate metastasis. On the organism level, mitochondrial function is crucial especially in tissues that require high energy supply, such as brain and skeletal muscle. Mitochondrial dysfunction has been implied in various neurodegenerative disorders and deteriorating chronic …

Gsu View, 2012-11-26, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

Discovery Of Highly Potent And Selective α4β2-Nicotinic Acetylcholine Receptor (Nachr) Partial Agonists Containing An Isoxazolylpyridine Ether Scaffold That Demonstrate Antidepressant-Like Activity. Part Ii, Li Fang Yu, J. Brek Eaton, Allison Fedolak, Han Kun Zhang, Taleen Hanania, Dani Brunner, Ronald J. Lukas, Alan P. Kozikowski

Translational Neuroscience

In our continued efforts to develop α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists as novel antidepressants having a unique mechanism of action, structure-activity relationship (SAR) exploration of certain isoxazolylpyridine ethers is presented. In particular, modifications to both the azetidine ring present in the starting structure 4 and its metabolically liable hydroxyl side chain substituent have been explored to improve compound druggability. The pharmacological characterization of all new compounds has been carried out using [ 3 H]epibatidine binding studies together with functional assays based on 86 Rb + ion flux measurements. We found that the deletion of the metabolically liable hydroxyl group …

Structure-Activity Studies Of 7-Heteroaryl-3-Azabicyclo[3.3.1]Non-6-Enes: A Novel Class Of Highly Potent Nicotinic Receptor Ligands, Scott R. Breining, Matt Melvin, Balwinder S. Bhatti, Gary D. Byrd, Melanie N. Kiser, Christopher D. Hepler, Dawn N. Hooker, Jenny Zhang, Leslie A. Reynolds, Lisa R. Benson, Nikolai B. Fedorov, Serguei S. Sidach, J. Pike Mitchener, Linda M. Lucero, Ronald J. Lukas, Paul Whiteaker, Daniel Yohannes

Translational Neuroscience

The potential for nicotinic ligands with affinity for the α4β2 or α7 subtypes to treat such diverse diseases as nicotine addiction, neuropathic pain, and neurodegenerative and cognitive disorders has been exhibited clinically for several compounds while preclinical activity in relevant in vivo models has been demonstrated for many more. For several therapeutic programs, we sought nicotinic ligands with various combinations of affinity and function across both subtypes, with an emphasis on dual α4β2-α7 ligands, to explore the possibility of synergistic effects. We report here the structure-activity relationships (SAR) for a novel series of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes and characterize many of the analogues …

Sustainable China: Lawrence University Interdisciplinary Initiative Awarded $400,000 Grant, Lawrence University

Press Releases

Few places on the planet offer the complexity of environmental and economic governance as does China. Competing and overlapping bureaucracies with environmental officials at the prefecture, county and township levels often answering to local officials rather than superiors in the central environmental bureaucracy, create opposing perspectives on the balance between economic development and environmental sustainability.

A $400,000 grant from the New York City-based Henry Luce Foundation will support Lawrence University’s long-standing commitment to engaging students with East Asia through the college’s distinctively integrated, multi-disciplinary initiative “Sustainable China: Integrating Culture, Conservation and Commerce.”

The four-year implementation grant builds on two previous …

Treatment Selections Using Risk-Benefit Profiles Based On Data From Comparative Randomized Clinical Trials With Multiple Endpoints, Brian Claggett, Lu Tian, Davide Castagno, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.

The Chanticleer, 2012-11-26, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

The Statesman, V. 56, I. 13, Stony Brook University

Stony Brook Statesman-Sucolian

v. 56, i. 13

Late Embryogenesis Abundant Proteins Protect Human Hepatoma Cells During Acute Desiccation, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Mehmet Toner, Steven C. Hand

Faculty Research & Creative Activity

Expression of late embryogenesis abundant (LEA) proteins is highly correlated with desiccation tolerance in anhydrobiotic animals, selected land plants, and bacteria. Genes encoding two LEA proteins, one localized to the cytoplasm/nucleus (AfrLEA2) and one targeted to mitochondria (AfrLEA3m), were stably transfected into human HepG2 cells. A trehalose transporterwas used for intracellular loading of this disaccharide. Cellswere rapidly and uniformly desiccated to low water content (<0.12 g H2O/g dry weight) with a recently developed spin-drying technique. Immediately on rehydration, control cells without LEA proteins or trehalose exhibited 0% membrane integrity, comparedwith 98% in cells loaded with trehalose and expressing AfrLEA2 or AfrLEA3m; surprisingly, AfrLEA3m without trehalose conferred 94% protection. Cell proliferation across 7 d showed an 18-fold increase for cells dried with AfrLEA3m and trehalose, compared with 27-fold for nondried controls. LEA proteins dramatically enhance desiccation tolerance in mammalian cells and offer the opportunity for engineering biostability in the dried state.