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2012

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Enrollment By Major, Office Of Institutional Research And Effectiveness, Mississippi State University Jan 2012

Enrollment By Major, Office Of Institutional Research And Effectiveness, Mississippi State University

Bulldog Basics

No abstract provided.

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Plasmodium Knowlesi And Wuchereria Bancrofti: Their Vectors And Challenges For The Future, Indra Vythilingam Jan 2012

Plasmodium Knowlesi And Wuchereria Bancrofti: Their Vectors And Challenges For The Future, Indra Vythilingam

Research Publications (2011 to 2015)

Malaria and filariasis still continue to pose public health problems in developing countries of the tropics. Although plans are in progress for the elimination of both these parasitic vector borne diseases, we are now faced with a daunting challenge as we have a fifth species, Plasmodium knowlesi a simian malaria parasite affecting humans. Similarly in peninsular Malaysia, filariasis was mainly due to Brugia malayi. However, we now see cases of Wuchereria bancrofti in immigrant workers coming into the country. In order to successfully eliminate both these diseases we need to know the vectors involved and introduce appropriate control measures to …

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Progress Of Key Strategies In Development Of Electrospun Scaffolds: Bone Tissue, Sumit Pramanik, Belinda Pingguan-Murphy, Noor Azuan Abu Osman Jan 2012

Progress Of Key Strategies In Development Of Electrospun Scaffolds: Bone Tissue, Sumit Pramanik, Belinda Pingguan-Murphy, Noor Azuan Abu Osman

Research Publications (2011 to 2015)

There has been unprecedented development in tissue engineering (TE) over the last few years owing to its potential applications, particularly in bone reconstruction or regeneration. In this article, we illustrate several advantages and disadvantages of different approaches to the design of electrospun TE scaffolds. We also review the major benefits of electrospun fibers for three-dimensional scaffolds in hard connective TE applications and identify the key strategies that can improve the mechanical properties of scaffolds for bone TE applications. A few interesting results of recent investigations have been explained for future trends in TE scaffold research.

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Protective Role Of Phyllanthus Niruri Extract Against Thioacetamide-Induced Liver Cirrhosis In Rat Model, Zahra A. Amin, Mehmet Bilgen, Mohammed A. Alshawsh, Hapipah Mohd Ali, A. Hamid A. Hadi, Mahmood Ameen Abdulla Jan 2012

Protective Role Of Phyllanthus Niruri Extract Against Thioacetamide-Induced Liver Cirrhosis In Rat Model, Zahra A. Amin, Mehmet Bilgen, Mohammed A. Alshawsh, Hapipah Mohd Ali, A. Hamid A. Hadi, Mahmood Ameen Abdulla

Research Publications (2011 to 2015)

A preclinical study was performed to determine if the extract from Phyllanthus niruri (PN) plays a protective role against liver cirrhosis induced by thioacetamide (TAA) in rats. Initially, acute toxicity was tested and the results showed that the extract was benign when applied to healthy rats. Next, the therapeutic effect of the extract was investigated using five groups of rats: control, TAA, silymarin, and PN high dose and low dose groups. Significant differences were observed between the TAA group and the other groups regarding body and liver weights, liver biochemical parameters, total antioxidant capacity, lipid peroxidation, and oxidative stress enzyme …

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Quorum Quenching Bacillus Sonorensis Isolated From Soya Sauce Fermentation Brine., Wai Fong Yin, Hun Jiat Tung, Choon Kook Sam, Chong Lek Koh, Kok Gan Chan Jan 2012

Quorum Quenching Bacillus Sonorensis Isolated From Soya Sauce Fermentation Brine., Wai Fong Yin, Hun Jiat Tung, Choon Kook Sam, Chong Lek Koh, Kok Gan Chan

Research Publications (2011 to 2015)

An N-acylhomoserine lactone (AHL)-degrading bacterial strain, L62, was isolated from a sample of fermentation brine of Chinese soya sauce by using rich medium agar supplemented with soya sauce (10% v/v). L62, a rod-shaped Gram positive bacterium with amylolytic activity, was phylogentically related to Bacillus sonorensis by 16S ribosomal DNA and rpoB sequence analyses. B. sonorensis L62 efficiently degraded N-3-oxohexanoyl homoserine lactone and N-octanoylhomoserine lactone. However, the aiiA homologue, encoding an autoinducer inactivation enzyme catalyzing the degradation of AHLs, was not detected in L62, suggesting the presence of a different AHL-degrading gene in L62. To the best of our knowledge, this …

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Silencing Quorum Sensing Through Extracts Of Melicope Lunu-Ankenda, L.Y. Tan, W.F. Yin, Kok Gan Chan Jan 2012

Silencing Quorum Sensing Through Extracts Of Melicope Lunu-Ankenda, L.Y. Tan, W.F. Yin, Kok Gan Chan

Research Publications (2011 to 2015)

Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads …

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Somatic Embryogenesis And Plant Regeneration From Bulb, Leaf And Root Explants Of African Blue Lily (Agapanthus Praecox Ssp. Minimus), J.S. Yaacob, A.I.M. Yussof, R.M. Taha, S. Mohajer Jan 2012

Somatic Embryogenesis And Plant Regeneration From Bulb, Leaf And Root Explants Of African Blue Lily (Agapanthus Praecox Ssp. Minimus), J.S. Yaacob, A.I.M. Yussof, R.M. Taha, S. Mohajer

Research Publications (2011 to 2015)

The African blue lily (Agapanthus praecox ssp. minimus) is a valuable plant, reported to contain medicinal compounds such as saponins, sapogenins and phytoecdysteroids, besides gaining popularity as an ornamental and landscape species. This paper reports on high efficiency and rapid in vitro propagation of Agapanthus praecox ssp. minimus via somatic embryogenesis from tissues derived from sterile root, leaf and bulb explants obtained from one-month-old aseptic seedlings of this species. Detailed observations on developmental stages of somatic embryos (from globular to coleoptilar) of this monocotyledonous species were also reported in the present investigation. Friable callus which gave rise to high plant …

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The Antimicrobial Effect Of 0.1 Ppm Ozonated Water On 24-Hour Plaque Microorganisms In Situ, S. Sadatullah, N.H. Mohamed, Fathilah Abdul Razak Jan 2012

The Antimicrobial Effect Of 0.1 Ppm Ozonated Water On 24-Hour Plaque Microorganisms In Situ, S. Sadatullah, N.H. Mohamed, Fathilah Abdul Razak

Research Publications (2011 to 2015)

Ozone is a known oxidant present in the atmosphere and is commercially produced by simple ozonizer machines. It is a powerful antimicrobial agent in its gaseous and aqueous forms. Ozone readily dissolves in water and retains its antimicrobial property even in the dissolved state. In this study, the effect of 0.1 ppm ozonated water was analyzed on 24-hour supragingival plaque (SP) samples in situ. SP wascollected from the two most posterior teeth in the contra-lateral quadrants before and after a 30-second rinse with either distilled water (control group) or 0.1 ppm ozonated water (test group). The plaque was used to …

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The Antimicrobial Efficacy Of Elaeis Guineensis: Characterization, In Vitro And In Vivo Studies, S. Vijayarathna, Z. Zakaria, Y. Chen, L.Y. Latha, J.R. Kanwar, S. Sasidharan Jan 2012

The Antimicrobial Efficacy Of Elaeis Guineensis: Characterization, In Vitro And In Vivo Studies, S. Vijayarathna, Z. Zakaria, Y. Chen, L.Y. Latha, J.R. Kanwar, S. Sasidharan

Research Publications (2011 to 2015)

The urgent need to treat multi-drug resistant pathogenic microorganisms in chronically infected patients has given rise to the development of new antimicrobials from natural resources. We have tested Elaeis guineensis Jacq (Arecaceae) methanol extract against a variety of bacterial, fungal and yeast strains associated with infections. Our studies have demonstrated that E. guineensis exhibits excellent antimicrobial activity in vitro and in vivo against the bacterial and fungal strains tested. A marked inhibitory effect of the E. guineensis extracts was observed against C. albicans whereby E. guineensis extract at 1/2, 1, or 2 times the MIC significantly inhibited C. albicans growth …

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The Design And Simulation Of A Planar Microarray Dot Electrode For A Dielectrophoretic Lab-On-Chip Device, Bashar Yafouz, Nahrizul Adib Kadri, Fatimah Ibrahim Jan 2012

The Design And Simulation Of A Planar Microarray Dot Electrode For A Dielectrophoretic Lab-On-Chip Device, Bashar Yafouz, Nahrizul Adib Kadri, Fatimah Ibrahim

Research Publications (2011 to 2015)

Dielectrophoresis (DEP) has been proven as a method of manipulating and analyzing the electrophysiological properties of bioparticles by applying non-uniform electric fields generated through special electrodes. Various electrode geometries have been developed to address different applications. Electric field simulation over electrodes is essential in order to optimize the generated DEP force for cell manipulation. This paper describes the study of electric field distribution over planar multiple microarray dot electrodes using numerical modeling of Comsol Multiphysics 4.2a®. Electric field evaluation for different dot sizes has been demonstrated by applying a range of frequencies to the designed electrodes. Results show that the …

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Cytoprotective Effect Of Benzyl N'-(5-Chloro-Indol-3-Ylmethylidene)- Hydrazinecarbodithioate Against Ethanol-Induced Gastric Mucosal Injury In Rats, H. Hashim, Hapipah Mohd Ali, H. Khaledi, M. Ameen, F.F. Mughrabi Jan 2012

Cytoprotective Effect Of Benzyl N'-(5-Chloro-Indol-3-Ylmethylidene)- Hydrazinecarbodithioate Against Ethanol-Induced Gastric Mucosal Injury In Rats, H. Hashim, Hapipah Mohd Ali, H. Khaledi, M. Ameen, F.F. Mughrabi

Research Publications (2011 to 2015)

Indolic compounds have attracted a lot of attention due to their interesting biological properties. The present study was performed to evaluate the subacute toxicity and anti-ulcer activity of BClHC against ethanol-induced gastric ulcers. Experimental animal groups were orally pre-treated with different doses of BClHC (50, 100, 200 and 400 mg/kg) in 10% Tween 20 solution (vehicle). Blank and ulcer control groups were pre-treated with vehicle. The positive group was orally pretreated with 20 mg/kg omeprazole. After one hour, all groups received absolute ethanol (5 mL/kg) to generate gastric mucosal injury except the blank control group which was administered the vehicle …

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Cu(Ii) Removal Onto Fungal Derived Biosorbents: Biosorption Performance And The Half Saturation Constant Concentration Approach, C.C. Tay, H.H. Liew, S.K. Yong, S. Surif, G. Redzwan, S. Abdul-Talib Jan 2012

Cu(Ii) Removal Onto Fungal Derived Biosorbents: Biosorption Performance And The Half Saturation Constant Concentration Approach, C.C. Tay, H.H. Liew, S.K. Yong, S. Surif, G. Redzwan, S. Abdul-Talib

Research Publications (2011 to 2015)

This study investigates the removing of Cu(II) using Pleurotus ostreatus fungal and Pleurotus ostreatus spent mushroom compost. In these batch biosorption experiments, the half saturation constant of biosorption was determined through Langmuir Linearization 1 plot of biosorbent concentration. This new approach was employed to minimize the use of biosorbent and to obtain results in shorter time. The half saturation constant of Cu(II) biosorption was 0.36 g for fungal Pleurotus ostreatus and 0.7 g for Pleurotus ostreatus spent mushroom substrate. There were three optimum operational parameters undertaken, which were the initial pH of 6, contact time of 10 minutes and 50 …

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Dentatin Induces Apoptosis In Prostate Cancer Cells Via Bcl-2, Bcl-Xl, Survivin Downregulation, Caspase-9, -3/7 Activation, And Nf-Κb Inhibition, I.A. Arbab, Chung Yeng Looi, A.B. Abdul, F.K. Cheah, Won Fen Wong, M.A. Sukari, R. Abdullah, S. Mohan, S. Syam, Aditya Arya, Mohd Rais Mustafa Jan 2012

Dentatin Induces Apoptosis In Prostate Cancer Cells Via Bcl-2, Bcl-Xl, Survivin Downregulation, Caspase-9, -3/7 Activation, And Nf-Κb Inhibition, I.A. Arbab, Chung Yeng Looi, A.B. Abdul, F.K. Cheah, Won Fen Wong, M.A. Sukari, R. Abdullah, S. Mohan, S. Syam, Aditya Arya, Mohd Rais Mustafa

Research Publications (2011 to 2015)

This study was set to investigate antiproliferative potential of dentatin (a natural coumarin isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the underlying mechanism of action. Treatment with dentatin dose-dependently inhibited cell growth of PC-3 and LNCaP prostate cancer cell lines, whereas it showed less cytotoxic effects on normal prostate epithelial cell line (RWPE-1). The inhibitory effect of dentatin on prostate cancer cell growth was due to induction of apoptosis as evidenced by Annexin V staining and cell shrinkage. We found that dentatin-mediated accumulation of reactive oxygen species (ROS) and downregulated expression levels of antiapoptotic molecules …

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Dimensional Profile Of Oral Mucosa Around Combined Tooth-Implant-Supported Bridgework In Macaque Mandible, C.H. Siar, C.G. Toh, T.B.T. Ali, D. Seiz, S.T. Ong Jan 2012

Dimensional Profile Of Oral Mucosa Around Combined Tooth-Implant-Supported Bridgework In Macaque Mandible, C.H. Siar, C.G. Toh, T.B.T. Ali, D. Seiz, S.T. Ong

Research Publications (2011 to 2015)

Purpose: A stable oral mucosa is crucial for long-term survival and biofunctionality of implants. Most of this evidence is derived from clinical and animal studies based solely on implant-supported prosthesis. Much less is known about the dimensions and relationships of this soft tissue complex investing tooth-implant-supported bridgework (TISB). The aim here was to obtain experimental evidence on the dimensional characteristics of oral mucosa around TISB with two different abutment designs. Methods: Sixteen 3-unit TISB were constructed bilaterally in the mandible of eight adult Macaca fascicularis. An implant system with a standard progressive thread design was the bone-anchoring implant in the …

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Distinct Genetic Lineages Of Bactrocera Caudata (Insecta: Tephritidae) Revealed By Coi And 16s Dna Sequences, Phaik Eem Lim, Ji Tan, I. Wayan Suana, Praphathip Eamsobhana, Hoi Sen Yong Jan 2012

Distinct Genetic Lineages Of Bactrocera Caudata (Insecta: Tephritidae) Revealed By Coi And 16s Dna Sequences, Phaik Eem Lim, Ji Tan, I. Wayan Suana, Praphathip Eamsobhana, Hoi Sen Yong

Research Publications (2011 to 2015)

The fruit fly Bactrocera caudata is a pest species of economic importance in Asia. Its larvae feed on the flowers of Cucurbitaceae such as Cucurbita moschata. To-date it is distinguished from related species based on morphological characters. Specimens of B. caudata from Peninsular Malaysia and Indonesia (Bali and Lombok) were analysed using the partial DNA sequences of cytochrome c oxidase subunit I (COI) and 16S rRNA genes. Both gene sequences revealed that B. caudata from Peninsular Malaysia was distinctly different from B. caudata of Bali and Lombok, without common haplotype between them. Phylogenetic analysis revealed two distinct clades, indicating distinct …

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Early Neutralizing Igg Response To Chikungunya Virus In Infected Patients Targets A Dominant Linear Epitope On The E2 Glycoprotein, Y.W. Kam, F.M. Lum, T.H. Teo, W.W.L. Lee, D. Simarmata, S. Harjanto, C.L. Chua, Y.F. Chan, J.K. Wee, A. Chow, R.T.P. Lin, Y.S. Leo, R. Le Grand, I.C. Sam, J.C. Tong, P. Roques, K.H. Wiesmuller, L. Renia, O. Rotzschke, L.F.P. Ng Jan 2012

Early Neutralizing Igg Response To Chikungunya Virus In Infected Patients Targets A Dominant Linear Epitope On The E2 Glycoprotein, Y.W. Kam, F.M. Lum, T.H. Teo, W.W.L. Lee, D. Simarmata, S. Harjanto, C.L. Chua, Y.F. Chan, J.K. Wee, A. Chow, R.T.P. Lin, Y.S. Leo, R. Le Grand, I.C. Sam, J.C. Tong, P. Roques, K.H. Wiesmuller, L. Renia, O. Rotzschke, L.F.P. Ng

Research Publications (2011 to 2015)

Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune mechanisms, which control viral multiplication and dissemination, are not yet known. Here, we studied the antibody response against the CHIKV surface antigens in infected patients. With plasma samples obtained during the early convalescent phase, we showed that the naturally-acquired IgG response is dominated by IgG3 antibodies specific mostly for a single linear epitope E2EP3. E2EP3 is located at the N-terminus of the E2 glycoprotein and prominently exposed on the viral envelope. E2EP3-specific antibodies are neutralizing and their removal from …

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Efficacy Of Boesenbergia Rotunda Treatment Against Thioacetamide-Induced Liver Cirrhosis In A Rat Model, Mahmood Ameen Abdulla, S.M. Salama, M. Bilgen, A.S. Al Rashdi Jan 2012

Efficacy Of Boesenbergia Rotunda Treatment Against Thioacetamide-Induced Liver Cirrhosis In A Rat Model, Mahmood Ameen Abdulla, S.M. Salama, M. Bilgen, A.S. Al Rashdi

Research Publications (2011 to 2015)

Background. Experimental research in hepatology has focused on developing traditional medicines into potential pharmacological solutions aimed at protecting liver from cirrhosis. Along the same line, this study investigated the effects of ethanol-based extract from a traditional medicine plant Boesenbergia rotunda (BR) on liver cirrhosis. Methodology/Results. The BR extract was tested for toxicity on 3 groups of rats subjected to vehicle (10% Tween 20, 5mL/kg) and 2g/kg and 5g/kg doses of the extract, respectively. Next, experiments were conducted on a rat model of cirrhosis induced by thioacetamide injection. The rats were divided into five groups and, respectively, administered orally with 10% …

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Electrical Characterization Of Gold-Dna-Gold Structures In Presence Of An External Magnetic Field By Means Of I-V Curve Analysis, N.M. Khatir, S.M. Banihashemian, V. Periasamy, R. Ritikos, Wan Haliza Abd Majid, S.A. Rahman Jan 2012

Electrical Characterization Of Gold-Dna-Gold Structures In Presence Of An External Magnetic Field By Means Of I-V Curve Analysis, N.M. Khatir, S.M. Banihashemian, V. Periasamy, R. Ritikos, Wan Haliza Abd Majid, S.A. Rahman

Research Publications (2011 to 2015)

This work presents an experimental study of gold-DNA-gold structures in the presence and absence of external magnetic fields with strengths less than 1,200.00 mT. The DNA strands, extracted by standard method were used to fabricate a Metal-DNA-Metal (MDM) structure. Its electric behavior when subjected to a magnetic field was studied through its current-voltage (I-V) curve. Acquisition of the I-V curve demonstrated that DNA as a semiconductor exhibits diode behavior in the MDM structure. The current versus magnetic field strength followed a decreasing trend because of a diminished mobility in the presence of a low magnetic field. This made clear that …

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Growth Inhibition Of Human Gynecologic And Colon Cancer Cells By Phyllanthus Watsonii Through Apoptosis Induction, S. Ramasamy, N. Abdul Wahab, N. Zainal Abidin, S. Manickam, Z. Zakaria Jan 2012

Growth Inhibition Of Human Gynecologic And Colon Cancer Cells By Phyllanthus Watsonii Through Apoptosis Induction, S. Ramasamy, N. Abdul Wahab, N. Zainal Abidin, S. Manickam, Z. Zakaria

Research Publications (2011 to 2015)

Phyllanthus watsonii Airy Shaw is an endemic plant found in Peninsular Malaysia. Although there are numerous reports on the anti cancer properties of other Phyllanthus species, published information on the cytotoxicity of P. watsonii are very limited. The present study was carried out with bioassay-guided fractionation approach to evaluate the cytotoxicity and apoptosis induction capability of the P. watsonii extracts and fractions on human gynecologic (SKOV-3 and Ca Ski) and colon (HT-29) cancer cells. P. watsonii extracts exhibited strong cytotoxicity on all the cancer cells studied with IC(50) values of ≤ 20.0 µg/mL. Hexane extract of P. watsonii was further …

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Identification And Characterisation Of The Early Differentiating Cells In Neural Differentiation Of Human Embryonic Stem Cells, P. Noisa, T.S. Ramasamy, F.R. Lamont, J.S.L. Yu, M.J. Sheldon, A. Russell, X. Jin, W. Cui Jan 2012

Identification And Characterisation Of The Early Differentiating Cells In Neural Differentiation Of Human Embryonic Stem Cells, P. Noisa, T.S. Ramasamy, F.R. Lamont, J.S.L. Yu, M.J. Sheldon, A. Russell, X. Jin, W. Cui

Research Publications (2011 to 2015)

One of the challenges in studying early differentiation of human embryonic stem cells (hESCs) is being able to discriminate the initial differentiated cells from the original pluripotent stem cells and their committed progenies. It remains unclear how a pluripotent stem cell becomes a lineage-specific cell type during early development, and how, or if, pluripotent genes, such as Oct4 and Sox2, play a role in this transition. Here, by studying the dynamic changes in the expression of embryonic surface antigens, we identified the sequential loss of Tra-1-81 and SSEA4 during hESC neural differentiation and isolated a transient Tra-1-81(-)/SSEA4(+) (TR-/S4+) cell population …

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Irradiation Effect On In Vitro Organogenesis, Callus Growth And Plantlet Development Of Gerbera Jamesonii, N.A. Hasbullah, R.M. Taha, A. Saleh, N. Mahmad Jan 2012

Irradiation Effect On In Vitro Organogenesis, Callus Growth And Plantlet Development Of Gerbera Jamesonii, N.A. Hasbullah, R.M. Taha, A. Saleh, N. Mahmad

Research Publications (2011 to 2015)

The present work was carried out to study the effects of gamma irradiation on in vitro growth of explants, callus and the formation of shoots and plantlets. Irradiation is known to exhibit or inhibit the differentiation of cells and growth of plants in vitro, which helps in producing new plant varieties. Gamma irradiation is one of the physical mutagens that are widely used for mutation breeding. A gradual decline was observed in the number of shoots regenerated from irradiated petiole explants compared to control. Numbers of shoots regenerated from irradiated petiole explant cultured on Murashige & Skoog medium supplemented with …

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Novel Antiviral Activity Of Baicalein Against Dengue Virus, Keivan Zandi, Boon Teong Teoh, Sing Sin Sam, Pooi Fong Wong, Mohd Rais Mustafa, Sazaly Abubakar Jan 2012

Novel Antiviral Activity Of Baicalein Against Dengue Virus, Keivan Zandi, Boon Teong Teoh, Sing Sin Sam, Pooi Fong Wong, Mohd Rais Mustafa, Sazaly Abubakar

Research Publications (2011 to 2015)

Background: Dengue is a serious arboviral disease currently with no effective antiviral therapy or approved vaccine available. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the natural compounds, bioflavonoids derived mainly from plants are of interest because of their biological and medicinal benefits. Methods: In the present study, antiviral activity of a bioflavonoid, baicalein, was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cells using focus forming unit reduction assay and quantitative RT-PCR. Results: Baicalein inhibited DENV-2 replication in Vero cells with IC50= 6.46 μg/mL and SI= 17.8 when …

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Neural Network Diagnostic System For Dengue Patients Risk Classification, T. Faisal, M.N. Taib, Fatimah Ibrahim Jan 2012

Neural Network Diagnostic System For Dengue Patients Risk Classification, T. Faisal, M.N. Taib, Fatimah Ibrahim

Research Publications (2011 to 2015)

With the dramatic increase of the worldwide threat of dengue disease, it has been very crucial to correctly diagnose the dengue patients in order to decrease the disease severity. However, it has been a great challenge for the physicians to identify the level of risk in dengue patients due to overlapping of the medical classification criteria. Therefore, this study aims to construct a noninvasive diagnostic system to assist the physicians for classifying the risk in dengue patients. Systematic producers have been followed to develop the system. Firstly, the assessment of the significant predictors associated with the level of risk in …

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Optimization Of Culture Condition For Callus Induction From Shoot Buds For Establishment Of Rapid Growing Cell Suspension Cultures Of Mango Ginger ('Curcuma Mangga'), T.C.M. Sundram, M.S.M. Annuar, N. Khalid Jan 2012

Optimization Of Culture Condition For Callus Induction From Shoot Buds For Establishment Of Rapid Growing Cell Suspension Cultures Of Mango Ginger ('Curcuma Mangga'), T.C.M. Sundram, M.S.M. Annuar, N. Khalid

Research Publications (2011 to 2015)

A systematic approach was taken to establish a rapidly growing suspension culture of Curcuma mangga (C. mangga). Various responses were obtained from shoot bud explants cultured on MS basal medium supplemented with different concentrations of 2,4-D, NAA and IAA either alone or in combinations. Different levels of sucrose were also tested. Rapid growing friable callus obtained from shoot explants cultured on MS basal medium supplemented with 1 mg l-1 2,4-D, 30 g l-1 sucrose and 2 g l-1 gelrite were selected for the initiation of suspension cultures based on histological morphology. From various media screened, rapid growing suspension cultures were …

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Expression Of Trpv1 Channels After Nerve Injury Provides An Essential Delivery Tool For Neuropathic Pain Attenuation., H.M. Zakir, R.M. Mostafeezur, A. Suzuki, S. Hitomi, I. Suzuki, T. Maeda, K. Seo, Y. Yamada, K. Yamamura, S. Lev, A.M. Binshtok, K. Iwata, J. Kitagawa Jan 2012

Expression Of Trpv1 Channels After Nerve Injury Provides An Essential Delivery Tool For Neuropathic Pain Attenuation., H.M. Zakir, R.M. Mostafeezur, A. Suzuki, S. Hitomi, I. Suzuki, T. Maeda, K. Seo, Y. Yamada, K. Yamamura, S. Lev, A.M. Binshtok, K. Iwata, J. Kitagawa

Research Publications (2011 to 2015)

Increased expression of the transient receptor potential vanilloid 1 (TRPV1) channels, following nerve injury, may facilitate the entry of QX-314 into nociceptive neurons in order to achieve effective and selective pain relief. In this study we hypothesized that the level of QX-314/capsaicin (QX-CAP)--induced blockade of nocifensive behavior could be used as an indirect in-vivo measurement of functional expression of TRPV1 channels. We used the QX-CAP combination to monitor the functional expression of TRPV1 in regenerated neurons after inferior alveolar nerve (IAN) transection in rats. We evaluated the effect of this combination on pain threshold at different time points after IAN …

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Flavone Enhances Dengue Virus Type-2 (Ngc Strain) Infectivity And Replication In Vero Cells, K. Zandi, R. Lani, P. F. Wong, B. -T. Teoh, S. -S. Sam, J. Johari, Mohd Rais Mustafa, Sazaly Abubakar Jan 2012

Flavone Enhances Dengue Virus Type-2 (Ngc Strain) Infectivity And Replication In Vero Cells, K. Zandi, R. Lani, P. F. Wong, B. -T. Teoh, S. -S. Sam, J. Johari, Mohd Rais Mustafa, Sazaly Abubakar

Research Publications (2011 to 2015)

This study investigates the effects of 2-phenyl-1-benzopyran-4-one (flavone) on DENV-2 infectivity in Vero cells. Virus adsorption and attachment and intracellular virus replication were investigated using a foci forming unit assay (FFUA) and quantitative RT-PCR, respectively. Addition of flavone (100 μg/mL) significantly increased the number of DENV-2 foci by 35.66 ± 1.52 and 49.66 ± 2.51 when added during and after virus adsorption to the Vero cells, respectively. The average foci size after 4 days of infection increased by 33 ± 2.11 and 89 ± 2.13. The DENV-2 specific RNA copy number in the flavone-treated infected cells increased by 6.41- and …

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Genetic Risk Factors Of Systemic Lupus Erythematosus In The Malaysian Population: A Minireview, C. Hwa Chia, P. Maude Elvira, K.H. Chua Jan 2012

Genetic Risk Factors Of Systemic Lupus Erythematosus In The Malaysian Population: A Minireview, C. Hwa Chia, P. Maude Elvira, K.H. Chua

Research Publications (2011 to 2015)

SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians. Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population …

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Genome Sequence And Comparative Pathogenomics Analysis Of A Salmonella Enterica Serovar Typhi Strain Associated With A Typhoid Carrier In Malaysia, Kien Pong Yap, Han Ming Gan, Cindy Shuan Ju Teh, Ramani Baddam, Lay Ching Chai, Narender Kumar, Suma Avasthi Tiruvayipati, Niyaz Ahmed, Kwai Lin Thong Jan 2012

Genome Sequence And Comparative Pathogenomics Analysis Of A Salmonella Enterica Serovar Typhi Strain Associated With A Typhoid Carrier In Malaysia, Kien Pong Yap, Han Ming Gan, Cindy Shuan Ju Teh, Ramani Baddam, Lay Ching Chai, Narender Kumar, Suma Avasthi Tiruvayipati, Niyaz Ahmed, Kwai Lin Thong

Research Publications (2011 to 2015)

Salmonella enterica serovar Typhi is a human pathogen that causes typhoid fever predominantly in developing countries. In this article, we describe the whole genome sequence of the S. Typhi strain CR0044 isolated from a typhoid fever carrier in Kelantan, Malaysia. These data will further enhance the understanding of its host persistence and adaptive mechanism.

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Co-Inheritance Of Variants/Mutations In Malaysian Patients With Crohn S Disease, K.H. Chua, C.C. Ng, I. Hilmi, K.L. Goh Jan 2012

Co-Inheritance Of Variants/Mutations In Malaysian Patients With Crohn S Disease, K.H. Chua, C.C. Ng, I. Hilmi, K.L. Goh

Research Publications (2011 to 2015)

Crohnâ��s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohnâ��s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohnâ��s disease development. Based on the sequencing results, a homozygous 5ê��-UTR-59 G to A variant in exon 1 (SNP6) was observed in a patient who carried SNP5, while a heterozygous SNP6 variant was detected in the other patient who carried SNP5. No other associated mutations or polymorphisms were detected in the two patients who …

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Impacts Of An Invasive Snail (Tarebia Granifera) On Nutrient Cycling In Tropical Streams: The Role Of Riparian Deforestation In Trinidad, West Indies, J. M. Moslemi, S. B. Snider, Keeley Macneill, J. F. Gilliam, A. S. Flecker Jan 2012

Impacts Of An Invasive Snail (Tarebia Granifera) On Nutrient Cycling In Tropical Streams: The Role Of Riparian Deforestation In Trinidad, West Indies, J. M. Moslemi, S. B. Snider, Keeley Macneill, J. F. Gilliam, A. S. Flecker

School of Natural Resources: Faculty Publications

No abstract provided.

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