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Cytotoxic And Antibacterial Activities Of Leaf Extracts Of Astragalus Gombiformis Pomel (Fabaceae) Growing Wild In Tunisia, Hassen Teyeb, Nahla Zanina, Mohamed Neffati, Wahiba Douki, Mohamed Fadhel Najjar

Turkish Journal of Biology

Many species of the genus Astragalus have been long used in folk medicine because of their biological properties. The aim of this study was to investigate the antibacterial and cytotoxic activities of extracts from the leaves of wild Astragalus gombiformis Pomel. Antibacterial activity was assayed against several common human pathogenic bacterial strains using the paper disk-agar diffusion method. Cytotoxicity was measured against human lung carcinoma cells using the colorimetric MTT assay. The strongest cytotoxic activity against the human A549 lung epithelial carcinoma cell line was detected for dichloromethane extracts at IC_{50} = 85 ± 21.7 µg/mL. The best incubation time …

The Growth And Reproduction Of White Bream (Blicca Bjoerkna L. 1758) In An Oligo-Mesotrophic Lake In Northwest Anatolia (Sapanca, Turkey), Hacer Canan Okgerman, Mahmut Elp, Si̇bel Atasağun

Turkish Journal of Biology

Growth parameters and the reproduction period of white bream (Blicca bjoerkna L. 1758) sampled from Sapanca Lake were determined monthly between November 2000 and October 2001. Three hundred and fifty white bream specimens caught ranged in age from 1^+ to 9^+ years, and the majority of the samples consisted of individuals of the 5^+-year-old age group. The von Bertalanffy equation was determined as Lt = 22.169 (1 - exp {-0.215[t + 0.986]}), Ø': 2.02 for males and Lt = 31.917 (1 - exp {-0.122[t + 1.087]}), Ø': 2.10 for females. The length-weight relationship was estimated as W = 0.0046 TL …

Organizational Chart, Academic Affairs, Office Of The Provost

Office of the Provost

No abstract provided.

2012-2013 Boise State University Graduate Catalog, Boise State University Office Of The Registrar

University Catalogs

No abstract provided.

2012-2013 Boise State University Undergraduate Catalog, Boise State University

University Catalogs

No abstract provided.

Annual Report (2012): The Cancer Center Statistical Report, Lehigh Valley Health Network

LVHN Annual & Statistical Reports

No abstract provided.

Annual Report (2012): Inspire Annual Report On Philanthropy, Lehigh Valley Health Network

LVHN Annual & Statistical Reports

No abstract provided.

The Influence Of Strata On The Nutrient Recycling Within A Tropical Certified Organic Coffee Production System, F. Mamani-Pati, D. E. Clay, S. A. Clay, H. Smeltkop, M. A. Callata

Agronomy, Horticulture and Plant Science Faculty Publications

In tropical Bolivia coffee plantations, the plant community can be separated into high (trees), middle (coffee), and low (weed) strata. Understanding the importance of each stratum is critical for improving the sustainability of the system. The objective of this study was to determine the importance of strata on nutrient recycling. Litter falls from the upper and middle strata were collected monthly using cone-shaped traps and divided by species into leaves, branches, flowers, and fruits. Dry biomass additions to the soil from high and middle strata totaled 12,655 kg (ha yr)⁻¹ annually. About 76% of the biomass was provided by …

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation In Adipose Tissue, And Increases Hepatic Steatosis In Leptin-Deficient Mice, Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, Angela L. Slitt

Biomedical and Pharmaceutical Sciences Faculty Publications

The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep^ob/ob-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers of obesity and type 2 diabetes were measured in C57Bl/6J, Keap1-KD, Lep^ob/ob, and Lep^ob/ob-Keap1-KD mice. Lep^ob/ob-Keap1-KD mice exhibited less lipid accumulation, smaller adipocytes, decreased food intake, and reduced lipogenic gene expression. Enhanced Nrf2 activity impaired insulin signaling, prolonged hyperglycemia in response to glucose challenge, and induced insulin resistance in Lep^ob/ob background. Nrf2 augmented …

Division Of Research And Economic Development Annual Report For Fy2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

Annual report for the Division of Research and Economic Development of the University of Rhode Island for the year 2011-2012.

Includes statistics of project proposals, expenditures, URI Foundation Awards, previous annual report summaries and awards received by individual academic and administrative departments.

Division Of Research And Economic Development Monthly Report For January 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For September 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For February-March 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For May-June 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For April 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For November 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For July - October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Effect Of Hla Dr Epitope De-Immunization Of Factor Viii In Vitro And In Vivo, Leonard Moise, Chang Song, William D. Martin, Ryan Tassone, Anne S. De Groot, David W. Scott

Institute for Immunology and Informatics Faculty Publications

T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity. Epitope peptides corresponding to original and modified sequences were validated in HLA binding assays and in immunizations of hemophilic E16 mice, DR3 and DR4 mice and DR3 × E16 mice. Consistent with immunoinformatic predictions, original epitopes …

Teaching Tolerance, Leslie P. Cousens, Federico Mingozzi, Sander Van Der Marel, Yan Su, Richard Garman, Valerie Ferreira, William Martin, David W. Scott, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human lysosomal acid α glucosidase (GAA, rhGAA), ERT unfortunately leads to the development of high titers of anti-rhGAA antibody, decreased effectiveness of ERT, and a fatal outcome for a significant number of children who have Pompe disease. The severity of disease, anti-drug antibody (ADA) development, and the consequences thereof are directly related to the degree of the enzyme deficiency. Babies born with a complete deficiency GAA are said to have cross-reactive immunologic material (CRIM)–negative Pompe disease and are highly likely …

Randomized Comparison Of Two Internet-Supported Natural Family Planning Methods (Preliminary Findings), Richard J. Fehring, Mary Schneider

Randomized Comparison of Two Internet-Supported Methods of Natural Family Planning

The aims of this study were to determine and compare efficacy, satisfaction, ease of use, and motivation in using an internet-based method of Natural Family Planning (NFP) that utilizes either electronic hormonal fertility monitoring (EHFM) or cervical-mucus monitoring (CMM). Four hundred fifty women (mean age 30.1) and their male partners (mean age 31.9) who sought to avoid pregnancy were randomized into either an EHFM (N=228) or CMM NFP group (N=222). Both groups utilized a Web site that provided NFP instructions, an electronic charting system, and support from professional nurses. Participants were assessed for satisfaction, ease of use, and motivation in …

Development Of An Integrated Economic And Ecological Framework For Ecosystem-Based Fisheries Management In New England, D. Jin, P. Hoagland, Tracey Dalton, E. M. Thunberg

Marine Affairs Faculty Publications

We present an integrated economic-ecological framework designed to help assess the implementation of ecosystem-based fisheries management (EBFM) in New England. We develop the framework by linking a computable general equilibrium (CGE) model of a coastal economy to an end-to-end (E2E) model of a marine food web for Georges Bank. We focus on the New England region using coastal county economic data for a restricted set of industry sectors and marine ecological data for three top level trophic feeding guilds: planktivores, benthivores, and piscivores. We undertake numerical simulations to model the welfare effects of changes in alternative combinations of yields from …

Uri Diversity Awards Banquet Program

Programs and Events (Misc)

Program for the awards banquet in which the URI LBTQ Womens’ Group received their nomination award

Research & Innovation For 2011-2012, University Of Rhode Island

Publications (Research and Economic Development)

The 2011-2012 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.

Comparison Of Biomarkers In Blood And Saliva In Healthy Adults, Sarah Williamson, Cindy Munro, Rita Pickler, Mary Jo Grap, R. K. Elswick Jr.

School of Nursing Publications

Researchers measure biomarkers as a reflection of patient health status or intervention outcomes. While blood is generally regarded as the best body fluid for evaluation of systemic processes, substitution of saliva samples for blood would be less invasive and more convenient. The concentration of specific biomarkers may differ between blood and saliva. The objective of this study was to compare multiple biomarkers (27 cytokines) in plasma samples, passive drool saliva samples, and filter paper saliva samples in 50 healthy adults. Demographic data and three samples were obtained from each subject: saliva collected on filter paper over 1 minute, saliva collected …

Toothbrush Contamination: A Review Of The Literature, Michelle R. Frazelle, Cindy L. Munro

School of Nursing Publications

Toothbrushes are commonly used in hospital settings and may harbor potentially harmful microorganisms. A peer-reviewed literature review was conducted to evaluate the cumulative state of knowledge related to toothbrush contamination and its possible role in disease transmission. A systematic review was conducted on adult human subjects through three distinct searches. The review resulted in seven experimental and three descriptive studies which identified multiple concepts related to toothbrush contamination to include contamination, methods for decontamination, storage, design, and environmental factors. The selected studies found that toothbrushes of healthy and oral diseased adults become contaminated with pathogenic bacteria from the dental plaque, …

A Program For Sustained Improvement In Preventing Ventilator Associated Pneumonia In An Intensive Care Setting, Raquel A. Caserta, Alexandre R. Marra, Marcelino S. Durão, Cláudia Vallone Silva, Oscar Fernando Pavao Dos Santos, Henrique Sutton De Sousa Neves, Michael B. Edmond, Karina Tavares Timenetsky

Internal Medicine Publications

Background Ventilator-associated pneumonia (VAP) is a common infection in the intensive care unit (ICU) and associated with a high mortality.

Methods A quasi-experimental study was conducted in a medical-surgical ICU. Multiple interventions to optimize VAP prevention were performed from October 2008 to December 2010. All of these processes, including the Institute for Healthcare Improvement’s (IHI) ventilator bundle plus oral decontamination with chlorhexidine and continuous aspiration of subglottic secretions (CASS), were adopted for patients undergoing mechanical ventilation.

Results We evaluated a total of 21,984 patient-days, and a total of 6,052 ventilator-days (ventilator utilization rate of 0.27). We found VAP rates of …

Blockade Of Electron Transport At The Onset Of Reperfusion Decreases Cardiac Injury In Aged Hearts By Protecting The Inner Mitochondrial Membrane, Qun Chen, Thomas Ross, Ying Hu, Edward J. Lesnefsky

Internal Medicine Publications

Myocardial injury is increased in the aged heart following ischemia-reperfusion (ISC-REP) compared to adult hearts. Intervention at REP with ischemic postconditioning decreases injury in the adult heart by attenuating mitochondrial driven cell injury. Unfortunately, postconditioning is ineffective in aged hearts. Blockade of electron transport at the onset of REP with the reversible inhibitor amobarbital (AMO) decreases injury in adult hearts. We tested if AMO treatment at REP protects the aged heart via preservation of mitochondrial integrity. Buffer-perfused elderly Fischer 344 24 mo. rat hearts underwent 25 min global ISC and 30 min REP. AMO (2.5 mM) or vehicle was given …

Interactions Between Bile Acids And Nuclear Receptors And Their Effects On Lipid Metabolism And Liver Diseases, David Q.-H. Wang, Brent A. Neuschwander-Tetri, Piero Portincasa, William M. Pandak

Internal Medicine Publications

In this special issue of Journal of Lipids, we acknowledge the contributions by several experts offering timely perspectives on the complex interactions between bile acids and nuclear receptors (NRs) on lipid metabolism and liver diseases at different levels and contexts in the body.

NRs are found within the interior of cells and are defined as ligand-activated transcriptional regulators of several key aspects of body physiology and pathophysiology. NRs regulate gene transcription through interaction with cellular coactivators and corepressors. In the liver, NRs play a key role in a large variety of metabolic processes such as cholesterol, bile acid, fatty acid, …