Digital Commons Network^™

Biophysical Characterization Of A Riboflavin-Conjugated Dendrimer Platform For Targeted Drug Delivery, Amanda B. Witte, Christine M. Timmer, Jeremy J. Gam, Seok Ki Choi

University Faculty Publications and Creative Works

The present study describes the biophysical characterization of generation-five poly(amidoamine) (PAMAM) dendrimers conjugated with riboflavin (RF) as a cancer-targeting platform. Two new series of dendrimers were designed, each presenting the riboflavin ligand attached at a different site (isoalloxazine at N-3 and d-ribose at N-10) and at varying ligand valency. Isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) were used to determine the binding activity for riboflavin binding protein (RfBP) in a cell-free solution. The ITC data shows dendrimer conjugates have K D values of ≥465 nM on a riboflavin basis, an affinity ∼93-fold lower than that of free riboflavin. …

Children With Juvenile Arthritis At Increased Risk For Cancer, But Uab Research Casts Doubt On One Suspected Cause, Alicia Rohan

Browse All News

No abstract provided.

Daily Eastern News: January 13, 2012, Eastern Illinois University

January

No abstract provided.

Biophysical Characterization Of A Riboflavin-Conjugated Dendrimer Platform For Targeted Drug Delivery, Amanda B. Witte, Christine M. Timmer, Jeremy J. Gam, Seok Ki Choi

University Faculty Publications and Creative Works

The present study describes the biophysical characterization of generation-five poly(amidoamine) (PAMAM) dendrimers conjugated with riboflavin (RF) as a cancer-targeting platform. Two new series of dendrimers were designed, each presenting the riboflavin ligand attached at a different site (isoalloxazine at N-3 and d-ribose at N-10) and at varying ligand valency. Isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) were used to determine the binding activity for riboflavin binding protein (RfBP) in a cell-free solution. The ITC data shows dendrimer conjugates have K D values of ≥465 nM on a riboflavin basis, an affinity ∼93-fold lower than that of free riboflavin. …

February 13th 2012, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Cost-Effectiveness Of Reclassification Sampling For Prevalence Estimation, Airat Bekmetjev, Dirk Vanbruggen, Brian Mclellan, Benjamin Dewinkle, Eric Lunderberg, Nathan L. Tintle

Faculty Work Comprehensive List

Background: Typically, a two-phase (double) sampling strategy is employed when classifications are subject to error and there is a gold standard (perfect) classifier available. Two-phase sampling involves classifying the entire sample with an imperfect classifier, and a subset of the sample with the gold-standard.

Methodology/Principal Findings: In this paper we consider an alternative strategy termed reclassification sampling, which involves classifying individuals using the imperfect classifier more than one time. Estimates of sensitivity, specificity and prevalence are provided for reclassification sampling, when either one or two binary classifications of each individual using the imperfect classifier are available. Robustness of …

February 13, 2012, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Spartan Daily February 13, 2012, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 138, Issue 8

Medical School Watercooler Newsletter - February 12, 2012, Lindsey Lyle

Watercooler Newsletter

This is the February 12, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Gold Humanism Honor Society Members Participate in 'Focus on Compassion' Week
• USA Physicians Featured at Go Red for Women
• COM Dean to Present Lectures at Medical Scholars Forum
• Forensics Building Under Construction
• Next Week's DSS - Dr. K. John McLaughlin
• USA Physicians Named Best Doctors

Meditation-State Functional Connectivity (Msfc): Strengthening Of The Dorsal Attention Network And Beyond, Brett Froeliger, Eric L. Garland, Rachel V. Kozink, Leslie A. Modlin, Nan-Kuei Chen, F. Joseph Mcclernon, Jeffrey M. Greeson, Paul Sobin

College of Science & Mathematics Departmental Research

Meditation practice alters intrinsic resting-state functional connectivity (rsFC) in the default mode network (DMN). However, little is known regarding the effects of meditation on other resting-state networks. The aim of current study was to investigate the effects of meditation experience and meditation-state functional connectivity (msFC) on multiple resting-state networks (RSNs). Meditation practitioners (MPs) performed two 5-minute scans, one during rest, one while meditating. A meditation naïve control group (CG) underwent one resting-state scan. Exploratory regression analyses of the relations between years of meditation practice and rsFC and msFC were conducted. During resting-state, MP as compared to CG exhibited greater rsFC …

Differences In Immunity Offered By The Influenza Vaccination Among Active Duty Us Air Force Personnel From 2007-2011, Billy D. Pruett

Master of Public Health Program Student Publications

OBJECTIVE: To investigate the potential difference in vaccine effectiveness among Active Duty Air Force (ADAF) personnel vaccinated against influenza from 2007-2011. Particularly, to determine if any difference in the protection offered is based on sex, vaccine type, or both.

METHODS: The proposed study incorporated a cross-sectional design using the Department of Defense’s (DoD) comprehensive databases. Laboratory-confirmed influenza and other Influenza-Like Illness (ILI) cases were identified for each of the four influenza seasons of interest, vaccination status and history was then verified, and 2x2 tables were constructed in order to calculate odds ratios.

RESULTS: No consistent difference in vaccine effectiveness in …

We Are...Marshall, February 8, 2012, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar

Michigan Tech Publications, Part 1

This paper describes the functionalization of magnetoelastic (ME) materials with Parylene-C coating to improve the surface reactivity to cellular response. Previous study has demonstrated that vibrating ME materials were capable of modulating cellular adhesion when activated by an externally applied AC magnetic field. However, since ME materials are not inherently biocompatible, surface modifications are needed for their implementation in biological settings. Here, the long-term stability of the ME material in an aqueous and biological environment is achieved by chemical-vapor deposition of a conformal Parylene-C layer, and further functionalized by methods of oxygen plasma etching and protein adsorption. In vitro cytotoxicity …

A Lesson Plan For Communicating The Sustainability Of An Enterprise, Clare L. Comm, Dennis F. X. Mathaisel

Atlantic Marketing Journal

Sustainability is the ability to endure. For any organization or any enterprise, sustainability is the ability to remain productive long term while minimizing waste and creating value. An organization can achieve sustainability if it aligns itself with the product and service needs of its customers and wants and interests of its multiple stakeholders. The enterprise, whether it is an ecological, environmental, human, or service enterprise, must possess five “abilities” to be sustainable: availability; dependability; capability; affordability; and marketability. This paper presents a lesson plan or strategy for how an enterprise should communicate/promote sustainability to its stakeholders based on these five …

February 11, 2012 (Pages 755-922), Pennsylvania Legislative Reference Bureau

Volume 42 (2012)

No abstract provided.

A Parametric Investigation Of Pattern Separation Processes In The Medial Temporal Lobe, Sarah E. Motley

Theses and Dissertations

The hippocampus is thought to be involved in memory formation and consolidation, with computational models proposing the process of pattern separation as a means for encoding overlapping memories. Previous research has used semantically related targets and lures to investigate hippocampal responses to mnemonic interference. Here, we attempted to define the response function of the hippocampus and its inputs during pattern separation by parametrically varying target-lure similarity in a continuous recognition task. We also investigated the effect of task demands (intentional versus incidental encoding) on pattern separation processes. We collected functional magnetic resonance imaging (fMRI) data while participants were shown a …

Senior Recital: Nathan Riehl, Tenor, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

Analysis Of Saint John's Maple Syrup Records: 1942-2009, Stephen G. Saupe

Headwaters

No abstract provided.

"Clover, Bee, And Reverie": College Of Saint Benedict Convocation Address, August 26, 2009, Cynthia N. Malone

Headwaters

No abstract provided.

A Moral Paradox Of Martial Training, Charles W. Wright

Headwaters

No abstract provided.

Curation-Friendly Tools For The Scientific Researcher, Brian Westra

Online Northwest

In this session we’ll look at two examples of tools that research faculty can use to manage data during the research process; define criteria for evaluating capacity for data curation support; and examine what it takes to do pilot cases between the library and research faculty. Finally, we’ll discuss other software and services that you or your research faculty are using to manage research data early in the data lifecycle.

6 Students, 6 Ipads, 60 Photographs: A Qualitative Study Of Undergraduate Information Practices In The Mobile Landscape, Anne-Marie Deitering, Margaret Mellinger

Online Northwest

We know students use mobile technologies. We expect they will want to use them more. The mobile landscape is changing fast. But what does this actually mean? How does having constant access affect the ways students use information? This is one of the questions librarians at Oregon State University are examining. In the summer of 2011, 2 OSU librarians recruited 6 undergraduate students engaged in research on many levels: in the library, in the lab and in the field. Each student was given an iPad tablet computer at the start of the 2011-2012 school year. In this exploratory study, we …

Old Habits Are Hard To Break: Lessons Learned From A Qualitative Research Study, Stefanie Buck, Anne-Marie Deitering, Hannah Gascho Rempel

Online Northwest

Librarians listened and observed as undergraduate students tackled a typical research-based assignment using broad-based discovery tools, including Google Scholar, Web of Science and Summon. We will discuss what we learned about the research processes our users have developed, how they fit unfamiliar tools into those processes, how they carry early experiences from high school and public libraries into their college searching, and the implications for effectively introducing new tools into our users' research processes.

Volume 47 - Issue 17 - Friday, February 10, 2012, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

Managing Livestock Using Animal Behavior: Mixed Species Stocking And Flerds, D. M. Anderson, Ed L. Frederickson, R. E. Estell

Agriculture Faculty and Staff Scholarship

Mixed-species stocking can foster sound landscape management while offering economic and ecological advantages compared with mono-species stocking. Producers contemplating a mixed-species enterprise should reflect on several considerations before implementing this animal management strategy. Factors applicable to a particular producer's landscape must be considered together with goals and economic constraints before implementing mixed-species stocking. A major consideration when using mixed-species stocking is how to deal with predation losses, especially among small ruminants. An approach being adopted in some commercial operations capitalizes on using innate animal behaviors to form cohesive groups of two or more livestock species that consistently remain together under …

Ua12/2/1 College Heights Herald, Vol. 88, No. 6, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Koch, Cameron. Senator Mitch McConnell Honors Eric Yates
• Hayden, Natalie. WKU Giving Students More Time to Pay Bills
• Blanford, Sidney. Postcrossing Allows for Inexpensive World Exploration
• Koch, Cameron. Damaged Rock House to Be Demolished
• Andrews, Mary. P is for Poet – Clint Waters
• Williams, Joanna. When Talking About Race, Ignorance Isn’t Bliss
• Vogt, Darren. Editorial Cartoon re: Panda Express
• Salman, Adam. Better Communication Needed During Downing University Center Renovations
• Harrison, Taylor. Four Student Government Association Members Attend Rally for Higher Education
• Swanson, Kayla. WKU Volunteer Organizations to Unite for …

Space And The Geographical Imagination On The Dublin Docklands’, Moira Sweeney

Conference Papers

In my practice–based doctoral study Dublin Dockers, Visualising a Changing Community, I am foregrounding the application of ethnographic documentary methods and investigation in examining the world of a docker and stevedore community on Dublin's docks. Through excavating and recuperating narratives which are absent from mainstream media hegemony, the study is unraveling the transformations experienced by a stevedoring constituency as a consequence of globalisation, urban regeneration and the current recession. This paper engages with arguments for the revitalisation of our imaginations on space in the context of an audio visual and textual study of the urban and maritime Dublin dockland space.

Reporter - February 10th 2012, Rit Reporter Staff

University Publications

No abstract provided.

Agronomy & Horticulture Newsletter, February 10, 2012, Kathy Schindler

Department of Agronomy and Horticulture: Monthly Newsletters

Mark the Date!........1

Everyone is invited to the Dessert Potluck........1

Last Call to Vote for your Favorite Picture........1

IANR ALL HANDS session is Today........1

Prepping for Outlook 365 Email Migration........2

New Employee Arrives in Nebraska........2

Plant Breeding and Genetics Seminar Set........3

Thanks to all whohelped with Green Expo........3

Cook-off Winner Announced........3

Short Course Set June 26–28........4

Interviews Set for Soils Position........4

Information For and About Graduate Students........4

Funds Available for Seed-Science Projects........4

Heuermann Lecture features Roberto Lenton........4

Ucc Minutes Feb 10, 2012, Undergraduate Curriculum Council

Undergraduate Currirculum Committee Minutes

No abstract provided.