Digital Commons Network^™

Processes And Pathways: How Do Mathematics And Science Partnerships Measure And Promote Growth In Teacher Content Knowledge?, Patricia S. Moyer-Packenham, A. Westenskow

Teacher Education and Leadership Faculty Publications

Intense focus on student achievement results in mathematics and science has brought about claims that K-12 teachers should be better prepared to teach basic concepts in these disciplines. The focus on teachers' mathematics and science content knowledge has been met by efforts to increase teacher knowledge through funded national initiatives focusing on mathematics and science. The purpose of the present study was to look across projects in the National Science Foundation's Math and Science Partnership Program to determine how partnerships developed processes for measuring growth in teacher content knowledge. Pre- and post-testing was the most common process for measuring growth …

International White Collar Crime And The Globalization Of Internal Investigations, Lucian E. Dervan

Law Faculty Scholarship

Much has been written about the methods by which counsel may efficiently, thoroughly, and credibly conduct internal investigations. Given the globalization of such matters, however, this article seeks to focus on the challenges present when conducting an internal investigation of potential international white-collar criminal activity. In Part I, this article will examine the challenges of selecting counsel to perform internal investigations abroad. In particular, consideration will be given to global standards regarding the application of the attorney-client privilege and work product protections. In Part II, this article will discuss the influence of data privacy and protection laws in various countries …

Can We Regulate Our Way To Energy Efficiency? Product Standards As Climate Policy, Noah M. Sachs

Law Faculty Publications

In this Article, I demonstrate that the regulatory strategy for energy efficiency is working. Although information disclosure, financial incentives, and other softer alternatives to regulation play a vital role in reducing energy demand, these should be viewed as complements to efficiency regulation, rather than replacements. The regulatory approach has led to substantial cost and energy savings in the past, it has enjoyed bipartisan political support, and it targets products and behaviors that are difficult to address through other policy tools. Given the politics of climate change in the United States, which make federal carbon taxes or a cap-and-trade system infeasible, …

Outsourcing Childcare, Meredith Johnson Harbach

Law Faculty Publications

Existing discourse on childcare decisions proceeds as if there were one "right" answer to the question of who should care for children. The law has preferences, too. But the reality is that parents, like businesses, make diverse, strategic decisions about when to keep work in-house, and when to collaborate with outside partners. This Article uses the lens of business outsourcing to gain fresh perspective on childcare decisionmaking, and the law's relationship to it. The outsourcing framework provides three key insights. First, it enables us to better understand the diversity of childcare decisions and the reasons underlying them. Second, the outsourcing …

Cirt Newsletter--January 2012, Center For Instruction & Research Technology (Cirt)

CIRT News

This issue contains:

Faculty Spotlight: Using Google Calendar and Blackboard to Facilitate Program Communication

UNF Member Resources for Teaching and Research

Upcoming Events

Digital Thinking: Video Assignments

Update on Online ISQ Pilot

Best Practices Online: Rubrics

Blackboard News

CIRT Teaching Online (TOL) Seminar 2012

CIRT Launches Blog

App Review: Image to Text

News from ITS

New Faces and Places in CIRT

Rtbs: Your Audio Companion, 3am, Cori Schwabe, Casey Mattison, Kathryn Kawa, Allea Grummert, Nick Holle, Gabbi Silke, Derrick Sloan, Brittany Guindon, Amanda Hinrichs

College of Journalism and Mass Communications: Student Advertising Projects

Radio Talking Book Service, a non-profit organization that assists the visually impaired by providing a free radio reading service, came to the University of Nebraska-Lincoln with a challenge: increase brand and service awareness throughout Nebraska.

We began by conducting both secondary and primary research, developing key insights and examining all possible target audiences. We investigated the day-to-day life of the visually impaired, learning that many who have experienced vision loss suffer from decreasing independence and increasing feelings of loneliness. Our primary research revealed that these individuals turn first to eye care professionals, resource organizations for the visually impaired and residential …

Obscuration In Active Galactic Nuclei, Robert Nikutta

Theses and Dissertations--Physics and Astronomy

All classes of Active Galactic Nuclei (AGN) are fundamentally powered by accretion of gas onto a supermassive black hole. The process converts the potential energy of the infalling matter to X-ray and ultraviolet (UV) radiation, releasing up to several 10¹² solar luminosities.

Observations show that the accreting "central engines" in AGN are surrounded by dusty matter. The dust occupies a "torus" around the AGN which is comprised of discrete clumps. If the AGN radiation is propagating through the torus on its way to an observer, it will be heavily re-processed by the dust, i.e. converted from UV to infrared …

Front Matter, North American Bird Bander

North American Bird Bander

No abstract provided.

Front Matter, North American Bird Bander

North American Bird Bander

No abstract provided.

Front Matter, North American Bird Bander

North American Bird Bander

No abstract provided.

An Expanded Age Range For Meningococcal Meningitis: Molecular Diagnostic Evidence From Population-Based Surveillance In Asia, Soon Kim, Dong Kim, Bai Dong, Jung Kim, Dang Anh, Paul E. Kilgore

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

To understand epidemiologic patterns of meningococcal disease in Asia, we performed a retrospective molecular analysis of cerebrospinal fluid (CSF) specimens collected in prospective surveillance among children aged < 5 years of age in China, South Korea, and Vietnam.

Methods

A total of 295 isolates and 2,302 CSFs were tested by a meningococcal species- and serogroup-specific polymerase chain reaction (PCR) assay targeting the Neisseria meningitidis (Nm) ctrA gene. Multi-locus sequence typing (MLST) was performed in Nm gene amplification analysis and incidence rates for meningococcal meningitis were estimated.

Results

Among 295 isolates tested, 10 specimens from Vietnam were confirmed as serogroup B and all were Sequence Type (ST) 1576 by MLST. …

Tracking Of In-111-Labeled Human Umbilical Tissue-Derived Cells (Hutc) In A Rat Model Of Cerebral Ischemia Using Spect Imaging, Ali S. Arbab, Christine Thiffault, Bradford Navia, Stephen J. Victor, Klaudyne Hong, Li Zhang, Quan Jiang, Nadimpalli Rs Varma, Asm Iskander, Michael Chopp

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In order to increase understanding of how infused cells work, it becomes important to track their initial movement, localization, and engraftment efficiency following transplantation. However, the available in vivo cell tracking techniques are suboptimal. The study objective was to determine the biodistribution of intravenously administered Indium-111 (In-111) oxine labeled human umbilical tissue-derived cells (hUTC) in a rat model of transient middle cerebral occlusion (tMCAo) using single photon emission computed tomography (SPECT).

Methods

Rats received 3 million In-111 labeled hUTC (i.v.) 48 hrs after tMCAo. Following the administration of either hUTC or equivalent dose of In-111-oxine (18.5 MBq), animals …

Fibroblast-Secreted Hepatocyte Growth Factor Mediates Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance In Triple-Negative Breast Cancers Through Paracrine Activation Of Met, Kelly L. Mueller, Julie M. Madden, Gina L. Zoratti, Charlotte Kuperwasser, Karin List, Julie L. Boerner

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer, resistance to EGFR TKIs correlates with amplification of the hepatocyte growth factor (HGF) receptor tyrosine kinase Met. Breast cancers do not respond to EGFR TKIs, even though EGFR is overexpressed. This intrinsic resistance to EGFR TKIs in breast cancer does not correlate with Met amplification. In several tissue monoculture models of human breast cancer, Met, although expressed, is not phosphorylated, suggesting a requirement for a paracrine-produced ligand. In fact, HGF, the ligand for Met, is not …

Signaling In Colon Cancer Stem Cells, Sanchita Roy, Adhip Pn Majumdar

Wayne State University Associated BioMed Central Scholarship

Abstract

Hdm2 Antagonist Mi-219 (Spiro-Oxindole), But Not Nutlin-3 (Cis-Imidazoline), Regulates P53 Through Enhanced Hdm2 Autoubiquitination And Degradation In Human Malignant B-Cell Lymphomas, Angela M. Sosin, Angelika M. Burger, Aisha Siddiqi, Judith Abrams, Ramzi M. Mohammad, Ayad M. Al-Katib

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by small-molecule inhibitors (SMIs). HDM2 have been developed and are under various stages of preclinical and clinical investigation. Previously, we examined the anti-lymphoma activity of MI-319, the laboratory grade of a new class of HDM2 SMI, the spiro-oxindole, in follicular lymphoma. Since then, MI-219, the clinical grade has become readily available. This study further examines the preclinical effects and mechanisms of MI-219 in a panel of human lymphoma …

The Proton-Coupled Folate Transporter: Biology And Therapeutic Applications To Cancer, Sita Desmoulin

Wayne State University Dissertations

Folates are essential cofactors of tumor cell proliferation and survival required for nucleotide biosynthesis and amino acid metabolism. In cancer therapy, inhibition of folate-dependent metabolic pathways has been achieved through the use of antifolates. Unfortunately, the efficacy of many clinically approved antifolates is limited by a lack of tumor selectivity. Facilitative transport of folates into mammalian cells is achieved by the reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT). As PCFT is a folate-proton symporter with an acidic pH optimum, PCFT may provide a mechanism for targeting cytotoxic antifolates to tumors, based on their acidic microenvironments. To establish the …

Docu-Commencement, Brian Wallace, Kay Healy, James Johnson, Jennifer Levonian, Gilbert Plantinga

Books, pamphlets, catalogues, and scrapbooks

New print, photographic, sculptural, video, and installation works based on intensive artist residencies held during Bryn Mawr College’s 2012 Commencement weekend.

Exhibition held at Bryn Mawr College Class of 1912 Rare Book Room, Canaday Library, from October 25 to December 14, 2012.

Bridging The Great Divide--A Response To Linda Greenhouse And Reva B. Siegel's Before (And After) Roe V. Wade: New Questions About Backlash, Lolita Buckner Inniss

Publications

This essay discusses the history of Roe v. Wade as recently addressed by Linda Greenhouse and Reva B. Siegel. Going beyond their assertions, I suggest that an additional, more encompassing inquiry focuses on what factors are implicated in the politics of abortion and how these factors relate to larger social, political, and cultural conflicts both before and after Roe. By naming party politics and the Catholic Church, Greenhouse and Siegel posit two crucial elements that shaped the abortion debate. I assert, however, that what is not discussed in their Article is the way numerous other factors have figured into …

Pushing The Learning Curve Of Public Relations In Asia, Jurrien Gregor Halff

Research Collection Lee Kong Chian School Of Business

No abstract provided.

Targeted Subendothelial Matrix Oxidation By Myeloperoxidase Triggers Myosin Ii-Dependent De-Adhesion And Alters Signaling In Endothelial Cells, M Rees, L Dang, T Thai, D Owen, E Malle, S Thomas

Medical Papers and Journal Articles

During inflammation, myeloperoxidase (MPO) released by circulating leukocytes accumulates within the subendothelial matrix by binding to and transcytosing the endothelium. Oxidative reactions catalyzed by subendothelial-localized MPO are implicated as a key cause of endothelial dysfunction in inflammatory vascular diseases. Whilst the subendothelial matrix is a reactive target for MPO-derived oxidants in disease, the functional implications of oxidative matrix modification for the endothelium are largely unknown. Here we show that hypochlorous acid (HOCl) produced by endothelial-transcytosed MPO oxidizes the subendothelial matrix, involving covalent crosslinking of the adhesive matrix protein fibronectin. Real-time biosensor and live cell imaging studies showed that HOCl-mediated matrix …

The Competitive Dynamics Of New Dvd Releases, Anirban Mukherjee, Vrinda Kadiyali

Research Collection Lee Kong Chian School Of Business

In the U.S. motion picture industry, DVDs are increasingly a major source of revenue for moviestudios. Two important strategic decisions for DVDs are the release date and price. Industry evidencesuggests studios consider various release options as evidenced by their pre-release announcements. Whendeciding DVD release dates and prices, studios must consider the following. First, weeks of high demandpotential, increase sales. Second, intense competition in weeks of peak demand might reduce marketshare, lower margins and lead to higher costs of release. Third, deferring a DVD release (e.g. to a nonpeakdemand week) after the movie’s theatrical run reduces the potential sales of the …

Use And Abuse Of Scientific Knowledge: The Portrayal In The Media, Huma Baqai

Business Review

The utility of science and media to the human race is not a point of debate. The new paradigm is the interplay between science and media. Both are cost and time intensive endeavors, having a huge impact on public life and conduct. The use and benefits of sciences are innumerable and stand uncontested. The abuse of science comes from three sources. And this abuse happens because science sells. The three sources of abuse are: Politics·Media·Advertising These three sources are intrinsically linked. Our focus will be "media".

Survival Of Microencapsulated Probiotic Lactobacillus Paracasei Lbc-1e During Manufacture Of Mozzarellacheese And Simulated Gastric Digestion, Megan Jane Ostler, Jeff Broadbent, W. R. Mcmanus, D. J. Mcmahon

Nutrition, Dietetics, and Food Sciences Faculty Publications

An erythromycin-resistant strain of probiotic Lactobacillus paracasei ssp. paracasei LBC-1 (LBC-1e) was added to part-skim Mozzarella cheese in alginate-microencapsulated or free form at a level of 108 and 107 cfu/g, respectively. Survival of LBC-1e and total lactic acid bacteria (LAB) was investigated through the pasta filata process of cheese making (in which the cheese curd was heated to 55°C and stretched in 70°C-hot brine), followed by storage at 4°C for 6 wk and simulated gastric and intestinal digestion. This included incubation in 0.1 M and 0.01 M HCl, 0.9 M H3PO4, and a simulated intestinal juice consisting of pancreatin and …

Role Of Extracytoplasmic Function Sigma Factors In Porphyromonas Gingivalis, Suhasini Yanamandra Sai

Theses and Dissertations

Porphyromonas gingivalis is a major etiological agent that is responsible for the cause and progression of periodontal diseases. The bacterium is exposed to various environmental conditions and oxidative stress conditions while it is in the oral cavity. So, P. gingivalis should have an efficient regulatory system in order to adjust and survive in the oral cavity. But little is known about the regulatory mechanisms that help the bacteria to survive in the oral cavity. So, it is essential to understand and characterize these regulatory mechanisms. The response and adaptation of P. gingivalis to environmental stress conditions occur at the level …

Identifying Sortase A Variants With Higher Catalytic Effeciency, Muna Suliman

Theses and Dissertations

In the past two decades, the field of protein engineering has evolved rapidly to include new genetic and chemical techniques to alter protein function. Protein engineering seeks to improve enzyme properties through powerful methods that specifically incorporate novel or improved function in proteins. One such method is protein ligation, which is used to selectively link synthetic and recombinant polypeptides. Due to the limitations of current protein labeling techniques, simple site-specific modification methods remain in high demand. Use of enzyme-based labeling has been the focus of various studies because of its substrate specificity. Sortase-mediated transpeptidation is one approach that has been …

Health Cover(Age)Ing, Rebecca L. Rausch

Nebraska Law Review

Though uneven costs based on an arbitrarily selected physical feature might seem discriminatory, health insurance fat taxes are perfectly legal under federal law. The Americans with Disabilities Act of 1990 (ADA) and Title VII of the Civil Rights Act of 1964 (Title VII) generally do not protect people because of their fatness. The recently enacted Patient Protection and Affordable Care Act of 2010 (ACA) also allows, and encourages, this new regime to continue, under the guise of wellness programs. Ironically, despite the name, these programs do not necessarily measure wellness, nor are they required to do so. The legality of …

Civilians On The Battlefield: By Using U.S. Civilians In The War On Terror, Is The Pot Calling The Kettle Black?, Joshua P. Nauman

Nebraska Law Review

Since 9/11, America has been engaged in the so-called War on Terror. While some in academia debate whether the conflict against al- Qaeda and associated groups is in fact a “war,” the fact remains that the United States has been and continues to be actively involved in combat or combat-like activities around the world aimed at stopping or minimizing the ability of terrorists to attack the United States or its allies. In many, if not most, instances of the United States’ application of combat power, civilians are present and actively involved in the process. At the same time, the United …

Helping Government Agencies Become More Effective And Efficient: Discovering ‘Catalytic Combinations’ In Public Child Welfare Reform, Dara Menashi, Christopher Behan, Kathleen Noonan

The Foundation Review

· This article describes work of the Annie E. Casey Foundation’s Casey Strategic Consulting Group (CSCG), a 10-year, multistate initiative that embeds outside experts – both public-system and traditional management consulting – in child and family services systems to improve system performance and outcomes.

· The article describes five types of levers that were influenced in different combinations to promote change in different state systems. We call these “catalytic combinations.”

· In numerous states, including Maine, Louisiana, Virginia, and Indiana, the CSCG initiative produced measurable improvements in key performance areas, including shortening stays in foster care, improving rates of permanent …

Defining, Building, And Measuring Capacity: Findings From An Advocacy Evaluation, Debra A. Strong, Jung Y. Kim

The Foundation Review

· Funders often focus their grants to build capacity, recognizing the important roles that leadership, skills, and infrastructure have on an organization’s effectiveness in carrying out its mission.

· This article reports on results from Mathematica Policy Research’s evaluation of Consumer Voices for Coverage, a program funded by the Robert Wood Johnson Foundation to support the role of consumer health advocacy coalitions in 12 states.

· The foundation based the program on a study that identified six core advocacy capacities, and designed it to strengthen these capacities.

· The evaluation found that the level of funding, substantial and targeted technical …

Changemaking: Building Strategic Competence, Prudence Brown

The Foundation Review

· Foundations have begun to recognize that how they go about their work is as important as what they support. To be better armed to address the urgent challenges facing Detroit’s children, the Skillman Foundation has adopted a changemaking role that draws upon and leverages its knowledge, networks, and civic reputation to supplement its grantmaking investments.

· Effective changemaking depends on the accrual of trust and respect that is built over time in relationships with community residents and stakeholders, public and private partners, and others with influence and resources.

· Changemaking required the foundation to build new strategic competencies such …