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Differential Activity Of The Kras Oncogene By Method Of Activation: Implications For Signaling And Therapeutic Intervention, Nathan Ihle

Dissertations and Theses (Open Access)

Despite having been identified over thirty years ago and definitively established as having a critical role in driving tumor growth and predicting for resistance to therapy, the KRAS oncogene remains a target in cancer for which there is no effective treatment. KRas is activated b y mutations at a few sites, primarily amino acid substitutions at codon 12 which promote a constitutively active state. I have found that different amino acid substitutions at codon 12 can activate different KRas downstream signaling pathways, determine clonogenic growth potential and determine patient response to molecularly targeted therapies. Computer modeling of the KRas structure …

Regulation Of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae, Yanyu Wang

Dissertations and Theses (Open Access)

Cells govern their activities and modulate their interactions with the environment to achieve homeostasis. The heat shock response (HSR) is one of the most well studied fundamental cellular responses to environmental and physiological challenges, resulting in rapid synthesis of heat shock proteins (HSPs), which serve to protect cellular constituents from the deleterious effects of stress. In addition to its role in cytoprotection, the HSR also influences lifespan and is associated with a variety of human diseases including cancer, aging and neurodegenerative disorders. In most eukaryotes, the HSR is primarily mediated by the highly conserved transcription factor HSF1, which recognizes target …

Cellular Uptake Of Neutrohpil Elastase Links Inflammation To Adaptive Immunity, Elizabeth A. Mittendorf

Dissertations and Theses (Open Access)

Many tumors arise from sites of inflammation providing evidence that innate immunity is a critical component in the development and progression of cancer. Neutrophils are primary mediators of the innate immune response. Upon activation, an important function of neutrophils is release of an assortment of proteins from their granules including the serine protease neutrophil elastase (NE). The effect of NE on cancer has been attributed primarily to its ability to degrade the extracellular matrix thereby promoting invasion and metastasis. Recently, it was shown that NE could be taken up by lung cancer cells leading to degradation of insulin receptor substrate-1 …

Characterization Of Selective Inhibition Of Adenylyl Cyclase Activity By Small Molecule Inhibitor Nky80, Cameron S. Brand

Dissertations and Theses (Open Access)

The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule cyclic AMP (cAMP), are involved in many isoform specific physiological functions. Decreasing AC5 activity has been shown to have potential therapeutic benefit, including reduced stress on the heart, pain relief, and attenuation of morphine dependence and withdrawal behaviors. However, AC structure is well conserved, and there are currently no isoform selective AC inhibitors in clinical use.

P-site inhibitors inhibit AC directly at the catalytic site, but with an uncompetitive or noncompetitive mechanism. Due to this mechanism and nanomolar potency in cell-free systems, attempts at ligand-based drug …

Neural Responses To Food Pictures And Their Association With Dietary Intake, Edward Christenson

Theses and Dissertations

BACKGROUND: Food-related visual cues may affect eating behavior and energy intake. The purpose of this study was to determine the neural response to pictures of food and whether or not the neural responses were associated with energy intake. METHODS: Using a cross-sectional design, 60 adults participated in this study. Each participant reported to the laboratory in a fasted state, were fitted with a 128-electrode electroencephalogram (EEG) net, and were shown pictures grouped into three categories: high-calorie foods, low-calorie foods, and distractor pictures. These pictures were shown in random order. Furthermore, participants were shown these pictures in one passive condition and …

Examination Of The Effectiveness Of Bioretention Cells And Porous Paving Practices In Aiken, Sc, Casey Johnson

All Theses

This work seeks to quantify the impact and effectiveness of green infrastructure practices, specifically bioretention cells and porous asphalts, for the reduction of peak flow and volume of stormwater that discharges into the headwaters of the Sand River watershed in Aiken, SC. Stormwater runoff flows and volumes were monitored in the upper Sand River watershed that includes the urban Aiken area, along with two nested subwatersheds, prior to, during, and after the construction of the bioretention cells and porous asphalt sites. Flow data from these monitoring stations were analyzed and the data suggested that there was no significant reduction in …

To Kill A Vampire?: Through The Hearth, Charlsie Lamos

All Theses

Long before Dracula was terrorizing English families, Emily Brontë's Heathcliff captivated Victorian audiences. Critics such as James Twitchell propose that Emily Brontë carefully creates the possibility of Heathcliff as a metaphorical vampire, using his unknown parentage and his physical descriptions throughout the novel as evidence for this claim. Indeed, my thesis examines how Heathcliff exhibits characteristics of the vampire in his decimation of the English families in the novel by consuming the Earnshaw's and Linton's properties, monies, and women. In Brontë's and Bram Stoker's novels, the vampires prey upon humanity, consuming property, lives, and bloodlines. However, although vampires are often …

Community By [Design] By Community: Product & Process, Aaron Bowman

All Theses

In his seminal work De Architectura (The Ten Books on Architecture), the Roman architect Vitruvius proposed a definition that became a lasting benchmark for the elements of [DESIGN] -Firmness, Commodity, and Delight. While this three-part definition provided a common lens through which to view [DESIGN], it also created a divide between the trained 'specialists' who create [DESIGN] and the Community who experience and interact with it. For Vitruvius, [DESIGN] provided a physical demarcation of place and created a shared association that was collectively understood as a Community. As the idea of Community has become increasingly dissociated with place in the …

Preliminary Investigation Into The Design Of Thermally Responsive Forster Resonance Energy Transfer Colloids, Monte Bedford

All Theses

While nuclear imaging techniques (Magnetic Resonance Imaging, Computed Tomography, and Positron Emission Tomography) have proven effective for diagnosis and treatment of disease in the human body, fluorescence-enhanced optical imaging offers additional benefits. Fluorescent imaging provides high resolution with real-time response, persistent lifetime (hours to days), cell targeting, and transdermal penetration with minimal physical encumbrance. Malignant cells can be targeted by absorbance of exogenous fluorescent nanoprobe contrast agents. Imaging is improved by fluorescent enhancement, especially by energy transfer between attached dyes. Also for use against cancer are heat-active treatments, such as hyperthermal, photothermal, and chemothermal therapies. Helpful to these treatments is …

Can The Application Of A Landscape Designed Learning Environment Enhance Education?, Virginia Bailey

All Theses

There is a need for a restructuring the way that a child's learning environment is designed. Currently, the mainstream educational design process ignores the notion that children have different ways of learning. Furthermore, when there are so many distractions, how we successfully reach a child's mind has become a challenge. The current school system is structured in a manner that does not address the presence of these distractions, often causing overstimulation and inattentiveness. Designing for children should be approached in a way that all senses are engaged. Having opportunities for hands-on learning inside and outside of the classroom is important …

Measuring Learning Through Cross Sectional Testing, Steve Lovett, Jennie Johnson

Management Faculty Publications

The measurement of student learning is becoming increasingly important in U.S. higher education. One way to measure learning is through longitudinal testing, but this becomes especially difficult when applied to cumulative learning within programs in situations of low persistence. In particular, many Hispanic Serving Institutions (HSIs) find themselves in such situations. Cross sectional testing is a pragmatic alternative, so long as maturity and selection effects can be estimated. The purpose of this paper is to demonstrate the utility and mechanics of measuring learning through cross sectional testing.

Ammonia Measurements And Emissions From A California Dairy Using Point And Remote Sensors, Kori D. Moore, E. Young, C. Gurell, Michael D. Wojcik, Randy S. Martin, G. E. Bingham, R. L. Pfeiffer, J. H. Prueger, J. L. Hatfield

Civil and Environmental Engineering Faculty Publications

Ammonia (NH3) is an important trace gas species in the atmosphere that can have negative impacts on human, animal, and ecosystem health. Agriculture has been identified as the largest source of NH3, specifically livestock operations. NH3 emissions from a commercial dairy in California were investigated during June 2008. Cattle were held in open-lot pens, except for young calves in hutches with shelters. Solid manure was stored in the open-lot pens. Liquid manure from feed lanes was passed through a solids settling basin and stored in a holding pond. Passive sensors and open-path Fourier transform infrared spectrometers (OP-FTIR) were deployed around …

Principals' Experiences Regarding Culturally Responsive Leadership Preparation And Practices That Promote Academic Achievement Of African American Students, Monica Brown

All Dissertations

Culturally responsive education improves the educational success of ethnically diverse students (Gay, 2002). The research presented states the case of the need of culturally responsive leadership preparation programs that influence the practice of culturally responsive principals. Emerging evidence has found that preparation programs impact the efficacy of future school leaders (Darling-Hammond, LaPointe, Meyerson, Orr, & Cohen, 2007; Jackson & Kelly, 2002). A large body of literature points to persistent achievement gaps for children of color and especially for African American males and demands that school leadership preparation attend to issues of cultural competence (Dantley, 2005; Evans, 2007; Lopez, Magdeleno, & …

The Contribution Of Poly(Adp-Ribose)Polymerase-1 Activity In The Nucleotide Excision Repair Pathway, Brenee S. King

Biomedical Sciences ETDs

Exposure to ultraviolet radiation (UVR) promotes the formation of UVR-induced, DNA helix distorting photolesions such as (6-4) pyrimidine-pyrimidone photoproducts (6-4 PPs) and cyclobutane pyrimidine dimers (CPDs). Effective repair of such lesions by the nucleotide excision repair (NER) pathway is required to prevent DNA mutations and chromosome aberrations. Poly(ADP-ribose)polymerase-1 (PARP-1) is a zinc-finger protein with well documented involvement in base excision repair (BER). PARP-1 is activated in response to DNA damage and catalyzes the formation of poly(ADP-ribose) subunits (PAR) that assist in the assembly of DNA repair complexes at sites of damage. In this dissertation, I present evidence for PARP-1 contributions …

Hell On The Range: A Story Of Honor, Conscience, And The American West, Daniel J. Herman, Taunalyn F. Rutherford

BYU Studies

In the introduction to Hell on the Range, Daniel Justin Herman informs readers that his account of Arizona's Rim Country War of the 1880s is more than revisionist critique; it is self-critique. Herman, an associate professor of history at Central Washington University, is an Arizonan who, like many growing up in the western United States, was "raised on its romance," and in his youth he viewed "Arizonans--especially cowboys--[as] made of sterner, stronger stuff than people who grew up elsewhere" (xxii). His view of Mormons and Mormonism--an important undercurrent animating much of this book--was informed by his experiences as a non-Mormon …

Avian Diversity And Habitat Use On Wetland Reserve Program Lands In The Lower Missouri River Valley, Eric C. Hopps

The Prairie Naturalist

A primary objective of the Wetland Reserve Program (WRP) is to provide habitat for migratory birds throughout all seasons of the year. Comprehensive avian assessments are lacking and limit our ability to evaluate the benefits of the WRP to continental bird populations. I investigated avian species occurrence on WRP lands within the Lower Missouri River Valley (LMRV), Nebraska, USA, from March 2010 to February 2011. Ten WRP habitat types are described based on plant community assemblages and observed hydrological regimes. Estimates of avian species richness were greatest in lowland forest (n = 115), lowland woodland (n = 83) and upland …

Trailing Clouds Of Zombies, Eric D'Evegnee

BYU Studies

This personal essay draws parallels between zombie apocalypse movies and parenting. The author's deliberate decision to have a large family reminds him of George Romero's Night of the Living Dead, in which the terror comes from the characters' deliberate decisions about how to survive the sheer number of pervasive and persistent undead. His children are equally "pervasive and persistent, and they outnumber me significantly." But he finds a "zombie epiphany" in realizing that his panic over the challenges of raising children is calmed by the joy of special moments in which his children teach him to see beauty and joy.

The Rules Of Facebook Friendship: A Two-Stage Examination Of Interaction Rules In Close, Casual, And Acquaintance Friendships, Erin M. Bryant, Jennifer Marmo

Human Communication and Theatre Faculty Research

The present study examined friendship rules on the online social networking site Facebook. Study 1 used focus group data to inductively create a list of 36 Facebook friendship rules. Study 2 utilized survey data to examine college students’ endorsement of the various rules in close, casual, and acquaintance friendships. Results indicated five categories of Facebook friendship rules, which included rules regarding communication channels, deception and control, relational maintenance, negative consequences for the self, and negative consequences for a friend. Additionally, close friends, casual friends, and acquaintances significantly differed in their endorsement of four of the five rules categories. Results suggested …

Competition Law In Macedonia In 2011-2012: New Perspectives And New Challenges, Adnan Jashari, Nora Ziba Memeti

Yearbook of Antitrust and Regulatory Studies

No abstract provided.

Web-Based Interactive Video Vignettes Create A Personalized Active Learning Classroom For Introducing Big Ideas In Introductory Biology, Leslie Kate Wright, Dina L. Newman, Jean A. Cardinale, Robert Teese

Articles

The typical “flipped classroom” delivers lecture material in video format to students outside of class in order to make space for active learning in class. But why give students passive material at all? We are developing a set of high-quality online educational materials that promote active, hands-on science learning to aid in teaching of core concepts for introductory biology at the college level. Interactive video vignettes (IVVs) incorporate evidence based teaching strategies to address known areas of confusion for entering students. Each IVV includes a live action scenario with undergraduates investigating a biological problem with a realistic experiment that users …

Training Tomorrow’S Lawyers: What Empirical Research Can Tell Us About The Effect Of Law School Pedagogy On Law Student Learning Styles, Eric A. Degroff

Southern Illinois University Law Journal

Generations X and Y, which together account for the vast majority of today’s law school classes, are quite unlike previous generations in their approach to learning.  Legal scholars have begun to note the disparity between the learning styles and thought processes of today’s students and many of their professors, and some have suggested that a more experiential pedagogy might enhance the learning process for many of today’s students.  Unfortunately, the academy has little empirical data to evaluate what kind of difference a more experiential approach would make. The research described in this article was designed to help bridge that gap …

December 2012 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.

Volatile Memory Message Carving: A "Per Process Basis" Approach, Aisha Ibrahim Ali-Gombe

LSU New Orleans Theses and Dissertations

The pace at which data and information transfer and storage has shifted from PCs to mobile devices is of great concern to the digital forensics community. Android is fast becoming the operating system of choice for these hand-held devices, hence the need to develop better forensic techniques for data recovery cannot be over-emphasized. This thesis analyzes the volatile memory for Motorola Android devices with a shift from traditional physical memory extraction to carving residues of data on a “per process basis”. Each Android application runs in a separate process within its own Dalvik Virtual Machine (JVM) instance, thus, the proposed …

Going Natural African American Women And Their Hair, Brittney Dennis

HIM 1990-2015

The study seeks to gain a better understanding of the term "going natural" in regards to women with natural African American hair. The study also seeks to understand natural hair and reclaiming a positive perspective of acceptance and natural appearance. The study will give light to what it is to have natural hair in present day and calls upon the experience of the Black woman on her journey with her hair and her past.

Journal Of Sociology & Social Welfare Vol. 39, No. 4 (December 2012)

The Journal of Sociology & Social Welfare

TABLE OF CONTENTS

• DATING VIOLENCE POLICY: MAKING THE GRADE - Richard Hoefer, Beverly Black, and Mashooq Salehin
• EXPLICATING THE SOCIAL MECHANISMS LINKING ALCOHOL USE BEHAVIORS AND ECOLOGY TO CHILD MALTREATMENT - Bridget Freisthler and Megan R. Holmes PRIVATE PENSION PROTECTIONS SINCE ERISA: THE EXPANDED ROLE OF THE INDIVIDUAL - Karen A. Zurlo
• RECONCILIATION IN A COMMUNITY-BASED RESTORATIVE JUSTICE INTERVENTION - David K. Androff
• "WHERE ARE MY RIGHTS?" COMPROMISED CITIZENSHIP IN MIXED-STATUS MARRIAGE: A RESEARCH NOTE - April M. Schueths
• FEAR VS. FACTS: EXAMINING THE ECONOMIC IMPACT OF UNDOCUMENTED IMMIGRANTS IN THE U.S. - David Becerra, David K. Androff, Cecilia Ayón, …

Reconciliation In A Community-Based Restorative Justice Intervention, David K. Androff

The Journal of Sociology & Social Welfare

Truth and Reconciliation Commissions (TRCs) are among the primary means for promoting reconciliation in communities recovering from violent conflict. However, there is a lack of consensus about what reconciliation means or how it is best achieved. In a qualitative study of the first TRC in the U.S., this research interviewed victims of racial violence who participated in the Greensboro Truth and Reconciliation Commission (GTRC), a community-based restorative justice intervention. Findings reveal that participants conceptualized reconciliation as a multileveled process, that different concepts of reconciliation influenced assessments of the success and limitations of the GTRC, and indicate how community-based restorative interventions …

Fear Vs. Facts: Examining The Economic Impact Of Undocumented Immigrants In The U.S., David Becerra, David K. Androff, Cecilia Ayón, Jason T. Castillo

The Journal of Sociology & Social Welfare

Undocumented immigration has become a contentious issue in the U.S. over the past decade. Opponents of undocumented immigration have argued that undocumented immigrants are a social and financial burden to the U.S. which has led to the passage of drastic and costly policies. This paper examined existing state and national data and found that undocumented immigrants do contribute to the economies of federal, state, and local governments through taxes and can stimulate job growth, but the cost of providing law enforcement, health care, and education impacts federal, state, and local governments differently. At the federal level, undocumented immigrants tend to …

Perceived Neighborhood Safety And Psychological Distress: Exploring Protective Factors, Jaime Booth, Stephanie L. Ayers, Flavio F. Marsiglia

The Journal of Sociology & Social Welfare

While a growing body of literature has established a relationship between "disordered" neighborhoods and psychological distress, less is known about the specific mechanisms at work. Using data collected in the 2008 Arizona Health Survey (N = 4,196), hierarchal linear regression was conducted to assess both the independent effect of perception of neighborhood safety on psychological distress, as well as the mediating effects of powerlessness, social isolation and mistrust. The findings suggest that the more safe individuals feel in their neighborhood, the less psychological distress they experience (b = 1.07, SE = .17, p < .001). This relationship appears to be partially mediated by feelings of powerlessness, social isolation and mistrust, indicating potential risk and protective factors.

"Where Are My Rights?" Compromised Citizenship In Mixed-Status Marriage A Research Note, April M. Schueths

The Journal of Sociology & Social Welfare

Immigration policy has shifted its focus from family reunification to strict enforcement of "illegal" immigration. It has become much more difficult for U.S. citizens to adjust their non-citizen spouses' legal status, especially spouses who are undocumented. This paper examines the vulnerabilities of female U.S. citizens married or partnered with undocumented Mexican men. Findings challenge the simplistic notion that marriage with a U.S. citizen creates automatic legalization for undocumented individuals and highlights the creation of a second class citizenry for native-born partners. This study argues that punitive immigration law and policies have profound negative implications for the lives of U.S. citizens.

The Hellenistic Ideal Of The Good Or Virtuous Life., Bernadette Monaco

Undergraduate Honors Theses

This paper explores the Hellenistic Ideal of the good or virtous life by looking at historical backround, the philosophical writings of Plato and Aristotle, and the literary works of Euripides.