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Hepatitis B Virus Genotypes And Subgenotypes In The Eastern Black Sea Region Of Turkey, Nese Kaklikkaya, Metin Sancaktar, Rahmet Guner, Celal K. Buruk, Iftihar Koksal, Ilknur Tosun, Faruk Aydin

Saudi Medical Journal

OBJECTIVE: To determine the hepatitis B virus (HBV) genotypes and subgenotypes in patients with HBV infection in the Eastern Black Sea region of Turkey. METHODS: One hundred and thirty-seven patients9 samples collected over 5 years (January 2005 to January 2010) at Farabi Hospital in Karadeniz Technical University, Trabzon, Turkey were included in the study. All patients were positive for hepatitis B surface antigen (HBsAg) and HBV DNA. The HBV genotypes were determined by the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method using an amplified segment of the pre-S region of HBV. RESULTS: One hundred and twenty-five of …

Detection Of European Strain Of Echinococcus Multilocularis In North America, Emily J. Jenkins, Andrew S. Peregrine, Janet E. Hill, Christopher Somers, Karen Gesy, Brian Barnes, Bruno Gottstein, Lydden Polley

Harold W. Manter Laboratory of Parasitology: Library Materials

To the Editor: In 2009, an alveolar hydatid cyst, the intermediate stage of the cestode Echinococcus multilocularis, was detected in the liver of a dog from Quesnel, British Columbia (BC), Canada, 600 km west of the nearest known record of this parasite in central North America. Alveolar hydatid cysts normally occur in rodent intermediate hosts. However, humans can serve as aberrant intermediate hosts; cysts generally originate in the liver and, in about one third of cases, metastasize throughout the body. Detection of the larval stage of this pathogen in an unusual host in a new geographic region required application …

Spatial Ecology Of Urban Raccoons In Northeastern Ohio: Implications For Oral Rabies Vaccination, Are R. Berentsen, Mike R. Dunbar, Chadd E. Fitzpatrick, W. David Walter

The Prairie Naturalist

In 1977, rabies was detected in a raccoon (Procyon lotor) in West Virginia, and since the mid-1980s raccoon variant rabies has spread throughout the eastern United States and moved west as far as the eastern edge of Cleveland, Ohio. The primary tool to combat this spread is the distribution of oral rabies vaccine (ORV) baits. A thorough knowledge of raccoon space use is critical in determining bait placement, particularly in urban areas. We monitored nine raccoons in urban areas of Cleveland, Ohio, calculated home range sizes, monitored raccoon movement with respect to potential movement barriers, and used resource selection functions …

Nitrocellulose Paper Based Microfluidic Platform Development And Surface Functionalization With Anti-Ige Aptamers, Jennifer Guerin Ward

Master's Theses

The purpose of this thesis project was to demonstrate the ability to utilize the capabilities of aptamers so that they may act as capture reagents for paper microfluidic devices. Several characterization experiments were conducted as a precursor before the final experimentation was performed. Paper characterization, manufacturing protocols for printing and heating, as well as 3D chip fabrication were all performed and analyzed. The results confirmed that the control of fluid through a 3D microfluidic device based in nitrocellulose is possible.

For the biochemistry portion of this thesis report, antibodies and aptamers were chosen to react with IgE, an antibody that …

Trips And Bits: An Essay On Compulsory Licenses, Expropriation, And International Arbitration, Peter B. Rutledge

Scholarly Works

This essay examines the potential for arbitration to resolve disputes between private companies and developing countries over the propriety of compulsory licenses. At bottom, my thesis is that arbitration supplies the medium through which to mediate the tension between the profit-seeking goals of private multinational companies and the development goals of foreign nations, especially in the developing world. The compulsory license debate raises a clash of fundamental interests between the patent holder, the patent holder’s state, and the host state. Arbitration can play an important role in balancing those interests, albeit a highly unusual one. Arbitration provides an essential forum …

The Gender Of Lying: Feminist Perspectives On The Non-Disclosure Of Hiv Status

UBC Law Review

No abstract provided.

The Long-Term Impact Of War On Health And Wellbeing In Northern Vietnam: Some Glimpses From A Recent Survey, Bussarawan Teerawichitchainan, Kim Korinek

Research Collection School of Social Sciences

War is considered one of the most intransigent obstacles to development; yet, the long-run effects of war on individual health have rarely been examined in the context of developing countries. Based on unique data recently collected as a pilot follow-up to the Vietnam Longitudinal Survey, this study examines health status of northern Vietnamese war cohorts (those who entered adulthood during the Vietnam War and now represent Vietnam’s older-adult population). To ascertain whether and how war impacts old-age physical and mental health, we compare multi-dimensional measures of health among war survivors, including civilians, combatants, noncombatants, and nonveterans involved in militia activities. …

Rickettsia Felis In Ctenocephalides Felis From Guatemala And Costa Rica, Adriana Troyo, Danilo Alvarez, Lizeth Taylor, Gabriela Abdalla, Olger Calderon-Arguedas, Maria L. Zambrano, Gregory A. Dasch, Kim A. Lindblade, Laya Hun, Marina Eremeeva, Alejandra Estevez

Environmental Health Sciences: Faculty Publications

Rickettsia felis is an emerging human pathogen associated primarily with the cat flea Ctenocephalides felis. In this study, we investigated the presence of Rickettsia felis in C. felis from Guatemala and Costa Rica. Ctenocephalides felis were collected directly from dogs and cats, and analyzed by polymerase chain reaction for Rickettsia-specific fragments of 17-kDa protein, OmpA, and citrate synthase genes. Rickettsia DNA was detected in 64% (55 of 86) and 58% (47 of 81) of flea pools in Guatemala and Costa Rica, respectively. Sequencing of gltA fragments identified R. felis genotype URRWXCal2 in samples from both countries, and genotype Rf2125 in …

Modeling Diffusion In Social Networks Using Network Properties, Duc Minh Luu, Ee Peng Lim, Tuan Anh Hoang, Chong Tat Freddy Chua

Research Collection School Of Computing and Information Systems

"Diffusion of items occurs in social networks due to spreading of items through word of mouth and exogenous factors. These items may be news, products, videos, advertisements or contagious viruses. When a user purchases or consumes one of such items, we say that she adopts the item and she becomes an item adopter. Previous research has studied diffusion process at both the macro and micro levels. The former models the number of item adopters in the diffusion process while the latter determines which individuals adopt item. Both macro and micro level models have their merits and limitations. In this paper, …

Virality And Susceptibility In Information Diffusions, Tuan-Anh Hoang, Ee Peng Lim

Research Collection School Of Computing and Information Systems

Viral diffusion allows a piece of information to widely and quickly spread within the network of users through word-ofmouth. In this paper, we study the problem of modeling both item and user factors that contribute to viral diffusion in Twitter network. We identify three behaviorial factors, namely user virality, user susceptibility and item virality, that contribute to viral diffusion. Instead of modeling these factors independently as done in previous research, we propose a model that measures all the factors simultaneously considering their mutual dependencies. The model has been evaluated on both synthetic and real datasets. The experiments show that our …

High Acceptability For Cell Phone Text Messages To Improve Communication Of Laboratory Results With Hiv-Infected Patients In Rural Uganda: A Cross-Sectional Survey Study, Mark J. Siedner, Jessica E. Haberer, Mwebesa B. Bwana, Norma C. Ware, David Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Patient-provider communication is a major challenge in resource-limited settings with large catchment areas. Though mobile phone usership increased 20-fold in Africa over the past decade, little is known about acceptability of, perceptions about disclosure and confidentiality, and preferences for cell phone communication of health information in the region.

Methods: We performed structured interviews of fifty patients at the Immune Suppression Syndrome clinic in Mbarara, Uganda to assess four domains of health-related communication: a) cell phone use practices and literacy, b) preferences for laboratory results communication, c) privacy and confidentiality, and d) acceptability of and preferences for text messaging to …

Mean Cd4 Cell Count Changes In Patients Failing A First-Line Antiretroviral Therapy In Resource-Limited Settings, Alexandra Calmy, Eric Balestre, Fabrice Bonnet, Andrew Boulle, Eduardo Sprinz, Robin Wood, Eric Delaporte, Eugène Messou, James Mcintyre, Kamal Marhoum El Filali, Mauro Schechter, N. Kumarasamy, David Bangsberg, Patrick Mcphail, Stefaan Van Der Borght, Carlos Zala, Matthias Egger, Rodolphe Thiébaut, François Dabis, Art-Linc Of Iedea Collaboration (Asia, South America, East, Southern And West Africa)

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Changes in CD4 cell counts are poorly documented in individuals with low or moderate-level viremia while on antiretroviral treatment (ART) in resource-limited settings. We assessed the impact of on-going HIV-RNA replication on CD4 cell count slopes in patients treated with a first-line combination ART.

Method: Naïve patients on a first-line ART regimen with at least two measures of HIV-RNA available after ART initiation were included in the study. The relationships between mean CD4 cell count change and HIV-RNA at 6 and 12 months after ART initiation (M6 and M12) were assessed by linear mixed models adjusted for gender, age, …

Assessment Of Bio-Security Risks Associated With 4-H Animal Science Exhibition Practices In California, Martin H. Smith, Cheryl L. Meehan

Journal of Extension

Bio-security related to animal agriculture is a high priority issue, and recent incidents demonstrate the potential for disease transmission and proliferation involving animals exhibited at public venues. Data collected at the California State Fair and eight county fairs in the north central region of California were used to assess existing bio-security risks associated with 4-H project animals. Outcomes revealed disease transmission risks associated with exhibition practices including housing and visitor contact and highlight the need to develop and provide relevant education resources to 4-H youth, volunteers, and staff.

Education Elementary And Secondary Education: Amend Part 3 Of Article 16 Of Chapter 2 Of Title 20 Of The Official Code Of Georgia Annotated, Relating To Student Health In Elementary And Secondary Education, So As To Require Immunization Against The Human Papillomavirus For Female Students Entering The Sith Grade; Provide For A Beginning Date For Certain Requirements; Provide For A Sunset For Certain Requirements; Provide For Related Matters; Repeal Conflicting Law; And For Other Purposes, Georgia State University Law Review

Georgia State University Law Review

The bill would require all female students entering sixth grade to be vaccinated against the human papillomavirus. Exceptions were provided for children whose parents objected on religious grounds. The bill would have also suspended the vaccination requirement in cases of insufficient supplies of the human papillomavirus vaccine. The bill would have left unchanges requirements that schools keep records of the immunizations and report to the Department of Human Resources annually.

A Case Study Of A Multidisciplinary Service-Learning Project In An Appalachian Regional College Campus On A Health-Related Community Awareness Campaign, Alice L. Crume, Lisa A. Beltz, Dean A. Porr

PRISM: A Journal of Regional Engagement

Abstract

In this case study, faculty from Communication Studies, Biological Sciences, and Management & Information Systems combined resources of six courses and approximately 135 students in a health-related service-learning project during Fall 2010. The project focused on Cystic Fibrosis (CF) concluding with a public event that attracted audience members from two Appalachian Ohio counties. The project’s goal was to disseminate CF-related information to the surrounding communities in order to improve the lives of CF patients and/or their caregivers. This article describes the connection between the students’ lives and the information.

Communication Studies and Biology students were given lectures on CF …

Risky Business: Prior Experience And Substance Users' Perception Of Risk, Sema Taheri

Theses (6 month embargo)

Individuals incarcerated for both drug-defined crimes and non-drug defined crimes are often substance users. In fact, the percent of arrestees in the United States that test positive for any drug at intake range from a low of 52% in Washington, D.C., to a high of 83% in Chicago, IL (ONDCP, 2011). Prior research has noted the negative relationship between risk perception and actual behavior. My study examined the influence of prior experiences and social environment on substance users' perceived risk of substance use. The sample consisted of adults indicating use of any illicit substance in the past year (N=9,277) in …

Coherent Pattern Prediction In Swarms Of Delay-Coupled Agents, Luis Mier-Y-Teran-Romero, Eric Forgoston, Ira B. Schwartz

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

We consider a general swarm model of self-propelling agents interacting through a pairwise potential in the presence of noise and communication time delay. Previous work has shown that a communication time delay in the swarm induces a pattern bifurcation that depends on the size of the coupling amplitude. We extend these results by completely unfolding the bifurcation structure of the mean field approximation. Our analysis reveals a direct correspondence between the different dynamical behaviors found in different regions of the coupling-time delay plane with the different classes of simulated coherent swarm patterns. We derive the spatiotemporal scales of the swarm …

Host Pathogen Interactions: Is Arabidopsis Thaliana Remembered By Its Nemesis Pseudomonas Syringae?, Daniel Z. Kreiser

Lawrence University Honors Projects

Plants contain innate immune systems that deter pathogen infection. Pattern recognition receptors bind microbe-associated molecular patterns (MAMPs), triggering immunity. MAMPs are proteins exclusive to pathogens that are typically indispensable for their survival. For this reason, MAMPs cannot be mutated or removed without causing pathogen death. However, this does not necessitate constitutive expression of MAMPs. In this study, the MAMP response of Arabidopsis thaliana was utilized to determine differential detection of MAMPs expressed by Pseudomonas syringe pv. tomato DC3000 when pretreated with A. thaliana. Results demonstrated that more MAMPs are detected when P. syringae had previously encountered A. thaliana, …

Simplified Models Of Vector Control Impact Upon Malaria Transmission By Zoophagic Mosquitoes, Samson S. Kiware, Nakul Chitnis, Sarah J. Moore, Gregor J. Devine, Silas Majambere, Stephen Merrill, Gerry F. Killeen

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background

High coverage of personal protection measures that kill mosquitoes dramatically reduce malaria transmission where vector populations depend upon human blood. However, most primary malaria vectors outside of sub-Saharan Africa can be classified as “very zoophagic,” meaning they feed occasionally (

Methods and Findings

We extended a published malaria transmission model to examine the relationship between transmission, control, and the baseline proportion of bloodmeals obtained from humans (human blood index). The lower limit of the human blood index enables derivation of simplified models for zoophagic vectors that (1) Rely on only three field-measurable parameters. (2) Predict immediate and delayed (with …

Co-Infected Diseases And State Health Policy: Botswana And South Africa's Response To Hiv And Tuberculosis, Margaret H. Schmidt

Lawrence University Honors Projects

The emergence of human immunodeficiency virus (HIV) has led to the growth of co-infection with other illnesses including tuberculosis. Many states are now attempting to address the problems presented with co-infected patients from a variety pathogens. In particular sub-Saharan Africa has suffered exponentially more from HIV and TB co-infection than other parts of the world. Thus, why have Botswana and South Africa not created national health policies to treat these diseases together? The following describes the process of how World Health Organization recommendations are translated into state policy. In turn, while donorship and international policy alterations create strong punctuations, the …

Discovery Of A Novel Antibiotic From A Bacillus Bacterium Cultivated From Its Natural Environment, Patrick J. Mcmonagle

Lawrence University Honors Projects

The current primary method of treating bacterial infections is using antibiotics. However, this continued treatment of these illnesses caused by pathogenic bacteria is causing the rate of evolution of these disease-inducing organisms to increase. Antibiotic resistance is forcing scientists to search for new forms of antibiotics to compete with these new ‘super bugs.’ I pursued the search for novel antibiotics through their natural source – antibiotic-producing microorganisms. As microbes have a direct advantage when producing antibiotics, it is my thought that they will be the best resource to discovering new and effective antibiotics. I conducted an exploratory search for antibiotic-producing …

Instructions For Authors

Journal of Health Disparities Research and Practice

The Journal of Health Disparities Research and Practice publishes research to guide the development of evidence-based solutions, policy and programs in an effort to reduce and ultimately eliminate health disparities. Published three times per year (Spring, Summer, Fall), the journal is an on-line publication that explores the problems and challenges of health disparities among the diverse populations of the United States.

Surveillance Of Infectious Diseases Among American Indians And Alaska Natives, Jeanne Bertolli, Amy Roussel, Jennie Harris, Dan Lentine, Julia Gable, Ron Fichtner, Joann Kauffman, Michael Landen, Ralph T. Bryan

Journal of Health Disparities Research and Practice

We assessed participation in public health surveillance networks among Indian Health Service, tribal, and urban (I/T/U) Indian health facilities for a group of infectious diseases, and barriers to participation. We conducted surveys of I/T/U facilities and key informant interviews with representatives of tribal, urban, and national American Indian/Alaska Native (AI/AN) agencies. For the surveys, frequencies and percentages of responses in each response category were calculated. Qualitative methods were used to analyze interview content. The proportion of facilities participating in case reporting is suboptimal across facility types and diseases. Even when reporting is occurring, there is little feedback to tribal agencies. …

Physicians’ Experiences And Opinions Regarding Strategies To Improve Care For Minority Patients, Jared W. Klein, Lindsay O. Schubiner, Margaret Gadon, Matthew K. Wynia

Journal of Health Disparities Research and Practice

Objective: To assess the views and experiences of a select group of physicians interested in minority health issues regarding promising strategies to improve minority care. Methods: Physicians were asked to respond to a 17-item survey assessing the level of agreement, frequency of implementation of and interest in learning more about 7 promising strategies for alleviating disparities. Results: Most physicians (75-95%) agreed that the 7 proposed strategies could be useful to improve the quality of care provided to minority patients, but only 40-66% of physicians had implemented the strategies sometimes or often in their practices. Between 22 and …

An Agent Based Model Of Tumor Growth And Response To Radiotherapy, Nicole O'Neil

Theses and Dissertations

An agent based model was developed to examine the growth of a tumor in a healthy cell population. Response to radiation and impact of mutation and bystander effects were studied. In the growth model, the cancer cells proliferated outward becoming invasive. The mass of cancer cells developed a necrotic core. Various treatment protocols of radiation were compared. Timing of treatments was critical to the success of therapy. The event of mutation was rare. When mutation occurred, either unsuccessful treatment or re-growth could result. Multiple rounds of radiation potentially led to increased mutation. Low levels of the bystander effect had little …

Molecular Epidemiology Of Hiv-Associated Tuberculosis In Dar Es Salaam, Tanzania: Strain Predominance, Clustering, And Polyclonal Disease, Lisa V. Adams, Barry N. Kreiswirth, Robert D. Arbeit, Hanna Soini, Lillian Mtei, Mecky Matee, Muhammad Bakari, Timothy Lahey, Wendy Wieland-Alter

Dartmouth Scholarship

Molecular typing of Mycobacterium tuberculosis can be used to elucidate the epidemiology of tuberculosis, including the rates of clustering, the frequency of polyclonal disease, and the distribution of genotypic families. We performed IS6110 typing and spoligotyping on M. tuberculosis strains isolated from HIV-infected subjects at baseline or during follow-up in the DarDar Trial in Tanzania and on selected community isolates. Clustering occurred in 203 (74%) of 275 subjects: 124 (80%) of 155 HIV-infected subjects with baseline isolates, 56 (69%) of 81 HIV-infected subjects with endpoint isolates, and 23 (59%) of 39 community controls. Overall, 113 (41%) subjects had an …

Portable Microfluidic Chip For Detection Of Escherichia Coli In Produce And Blood, Umut A. Gurkan

Faculty Scholarship

Pathogenic agents can lead to severe clinical outcomes such as food poisoning, infection of open wounds, particularly in burn injuries and sepsis. Rapid detection of these pathogens can monitor these infections in a timely manner improving clinical outcomes. Conventional bacterial detection methods, such as agar plate culture or polymerase chain reaction, are time-consuming and dependent on complex and expensive instruments, which are not suitable for point-of-care (POC) settings. Therefore, there is an unmet need to develop a simple, rapid method for detection of pathogens such as Escherichia coli. Here, we present an immunobased microchip technology that can rapidly detect and …

Biologist Receives Nih Grant To Fight Malaria, Sarah Gardner, Dave Albee

Press Releases

The award is funded through the NIH’s National Institutes of Allergies and Infectious Diseases. Portland State University, Dominican University of California, Geneva Foundation, Walter Reed Army Institute of Research, Drexel University, and Portland VA Research Foundation are all awardees. The lead investigator is Dr. Jane Kelly, a research professor in the Department of Chemistry at Portland State University.

Purification Of Cell-Based Influenza H5n1 Viruses By Liquid Chromatography Technologies, Alan Yung-Chih Hu

Vaccine Technology IV

No abstract provided.

Bacterium-Like Particles As Delivery Vehicles For Multimeric Antigens, Kees Leenhouts

Vaccine Technology IV

No abstract provided.