Digital Commons Network^™

Prevalence And Factors Associated With Hepatitis B Immunization And Infection Among Men Who Have Sex With Men In Beijing, China, Chao Wang, You Xin Wang, Xiao Jie Huang, Xia Li, Tong Zhang, Manshu Song, Li Juan Wu, Juan Du, Xiao Qin Lu, Shuang Shao, Fei Fei Zhao, Michele Ball, Hao Wu, Wei Wang

Research outputs 2012

Background: Among the Chinese population of 1.3 billion, there are an estimated 93 million carriers of hepatitis B virus (HBV). Men who have sex with men (MSM) are at increased risk for HBV infection; however, the prevalence of HBV immunization and infection among Chinese MSM remains undetermined. Methods: A cross-sectional survey of 1,114 eligible participants was conducted in Beijing, China. Multiple methods were used to recruit study participants. Demographic information and potential correlated factors were collected by questionnaire. Additionally, blood specimens were collected and tested for sexually transmitted infections and serologic markers of hepatitis B immunization and infection. Results: Laboratory …

Transposon Mutagenesis Identifies Uropathogenic Escherichia Coli Biofilm Factors, Maria Hadjifrangiskou, Alice P. Gu, Jerome S. Pinkner, Maria Kostakioti, Ellisa W. Zhang, Sarah E. Greene, Scott J. Hultgren

Open Access Publications

No abstract provided.

The Structure Of The Papd-Papgii Pilin Complex Reveals An Open And Flexible P5 Pocket, Bradley Ford, Denis Verger, Karen Dodson, Ender Volkan, Maria Kostakioti, Jennifer Elam, Jerome Pinkner, Gabriel Waksman, Scott Hultgren

Open Access Publications

No abstract provided.

Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia Coli Catheter-Associated Urinary Tract Infections In Mice, Pascale S. Guiton, Corinne K. Cusumano, Kimberly A. Kline, Karen W. Dodson, Zhenfu Han, James W. Janetka, Jeffrey P. Henderson, Michael G. Caparon, Scott J. Hultgren

Open Access Publications

No abstract provided.

Interaction Of Card With Rna Polymerase Mediates Mycobacterium Tuberculosis Viability, Rifampin Resistance, And Pathogenesis, Leslie A. Weiss, Phillip G. Harrison, Bryce E. Nickels, Michael S. Glickman, Elizabeth A. Campbell, Seth A. Darst, Christina L. Stallings

Open Access Publications

No abstract provided.

Challenging Presentations Of Cavernous Sinus Thrombophlebitis, Courtney L. Kraus, Susan M. Culican

Open Access Publications

No abstract provided.

Immune Modulation By Group B Streptococcus Influences Host Susceptibility To Urinary Tract Infection By Uropathogenic Escherichia Coli, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Scott J. Hultgren, Amanda L. Lewis

Open Access Publications

No abstract provided.

Faculty Masthead, Mjlst Editorial Board

Minnesota Journal of Law, Science & Technology

No abstract provided.

Research And Development Of A Weighted Most Recent Common Ancester Algorithm For Metagenomic Taxonomic Assignment, Hellen Butungi

All Master’s Theses

The new generation of metagenomics has gained tremendous popularity in recent years. This has been majorly due to rapid advances in DNA sequencing technology, which has produced large amounts of sequence data in relatively shorter times, compared to conventional DNA sequencing methods. There is a need to taxonomically characterise these data by assigning individual sequence reads to their constituent taxa. However, there is lack of up-to-date and customized software tools to accomplish this task, and for taxonomic characterisation, an automated taxonomic classification scheme is necessary. The overall objective of this study was to improve the accuracy of the most recent …

Differential Replication Of Pathogenic And Nonpathogenic Strains Of West Nile Virus Within Astrocytes, Katherine L. Hussmann, Melanie A. Samuel, Kwang S. Kim, Michael S. Diamond, Brenda L. Fredericksen

Open Access Publications

No abstract provided.

Regional Dissemination Of A Trimethoprim-Resistance Gene Cassette Via A Successful Transposable Element, Amy S. Labar '10, Jennifer S. Millman '09, E. Ruebrush, Iruka N. Okeke

Biology Faculty Scholarship

No abstract provided.

Africa In The Time Of Cholera: A History Of Pandemics From 1817 To The Present [Book Review], Iruka N. Okeke

Biology Faculty Scholarship

No abstract provided.

Cloning Of The Gene, Purification As Recombinant Protein And Functional Characterization Of Leishmania Mexicana Cytochrome B5 Reductase, Ala Azhari

USF Tampa Graduate Theses and Dissertations

Leishmania are protozoan parasites that are transmitted by a sand fly vector. These parasites affect not only humans but also wild animals including domestic dogs and rodents, which form an additional challenge and public health problem to control the disease. Leishmaniasis is an important disease with worldwide distribution, including Saudi Arabia, the Middle East, and other tropical and subtropical areas around the world. Due to the expansion of irrigation and agricultural activities, more exposure to sand fly occurs, which leads to the expansion of leishmaniasis infections as newly emerging disease.

Emerging drug resistance in leishmaniasis is an additional problem, contributed …

Bayesian Inference On Mixed-Effects Models With Skewed Distributions For Hiv Longitudinal Data, Ren Chen

USF Tampa Graduate Theses and Dissertations

Statistical models have greatly improved our understanding of the pathogenesis of HIV-1 infection

and guided for the treatment of AIDS patients and evaluation of antiretroviral (ARV) therapies.

Although various statistical modeling and analysis methods have been applied for estimating the

parameters of HIV dynamics via mixed-effects models, a common assumption of distribution is

normal for random errors and random-effects. This assumption may lack the robustness against

departures from normality so may lead misleading or biased inference. Moreover, some covariates

such as CD4 cell count may be often measured with substantial errors. Bivariate clustered

(correlated) data are also commonly encountered in …

Design Of Novel Inhibitors For Infectious Diseases Using Structure-Based Drug Design: Virtual Screening, Homology Modeling And Molecular Dynamics, Divya Ramamoorthy

USF Tampa Graduate Theses and Dissertations

The main aim of the study in this thesis was to use structure-based protocols to design new drugs for enzymes, DXS and DXR in the non mevalonate pathway. Another aim of this study was to identify the dimer interface in E.coli FabH as an allosteric binding site for designing new class of anti-infective drugs. We have attempted to identify potential inhibitors for DXS by docking the NCI Diversity set compounds, compound libraries available from GSK-MMV and St. Jude's Children's research center. FabH dimer interface has been identified as a potential target using SiteMap, Alanine mutagenesis and docking studies.

The first …

Perceived Barriers For Implementing Primary Sexually Transmitted Infection Prevention, Rachel Monique Stewart-Campbell

USF Tampa Graduate Theses and Dissertations

Adolescents continue to be at increased risk for contracting sexually transmitted infections (STI's). This research study describes the perception of barriers that providers in the Tampa Bay area encounter when implementing primary STI prevention programs for adolescents within the community context. This study used semi structured interviews to explore perceived barriers for implementing primary such programs for adolescents in the Tampa Bay area programs. Participants reported faith based institutions/churches and schools as common sectors for presenting a variety of barriers for implementing their program. Perceptions of barriers were described as, the need to tailor program messages and presentations based on …

Perceived Stress And The Buffering Hypothesis Of Perceived Social Support On Facebook, John G. Lynch

Antioch University Dissertations & Theses

Online social networking sites have experienced a surge in popularity since their inception. Serving as a hub for communities of all ages, Web sites such as MySpace, Friendster and Facebook bridge geographic and time limitations and offer their members the opportunity to connect with anyone on the Internet at any time. The growing accessibility of technology for computer-mediated communication, outside of such Web sites offers similar opportunities. Although critics share concern over potential for the loss of intimacy, the possibility for increased levels of perceived social support through limitless networking options should not be overlooked. When we consider the strong …

The Phenomenology Of Court-Ordered Treatment: From The Perspective Of Methamphetamine Dependent Adults, Justin Steffener

Antioch University Dissertations & Theses

This phenomenological study was designed to explore with a sample of methamphetamine dependent adults their perceptions of the process involved in their experiences of court-ordered treatment. The motivation for this study derives from the researcher's wish to unearth ways to better understand and support the needs of adults suffering from addiction. A significant amount of research has already been conducted in regards to the treatment of methamphetamine addiction from the standpoint of quantitative measurements of treatment outcomes, but limited information is presently available from the perspective of the suffers. The stringent selection of the sample was composed of six individuals …

Antimicrobial Peptides As Therapeutic Agents., Mathew Upton, Paul Cotter, John Tagg

School of Biomedical Sciences

No abstract provided.

On The Global Stability Of A Generalized Cholera Epidemiological Model, Yuanji Cheng, Jin Wang, Xiuxiang Yang

Mathematics & Statistics Faculty Publications

In this paper, we conduct a careful global stability analysis for a generalized cholera epidemiological model originally proposed in [J. Wang and S. Liao, A generalized cholera model and epidemic/endemic analysis, J. Biol. Dyn. 6 (2012), pp. 568-589]. Cholera is a water-and food-borne infectious disease whose dynamics are complicated by the multiple interactions between the human host, the pathogen, and the environment. Using the geometric approach, we rigorously prove the endemic global stability for the cholera model in three-dimensional (when the pathogen component is a scalar) and four-dimensional (when the pathogen component is a vector) systems. This work unifies the …

Hospital As A Critical Infrastructure In The Community Disaster Response System, Yixuan Li

Theses

The Department of Homeland Security lists 19 groups of sectors as Critical Infrastructure Key Resources (CIKR) such as Water, Emergency Services, and Healthcare and Public Health (HPH). Protection of those interdependent sectors is of vital interest for the country in the event of disaster. Hospital infrastructure systems are basic HPH elements of the CIKR. Local hospitals deliver essential routine healthcare services as well as serving as frontline responders during non-routine disaster events. Currently, hospitals generally extend their routine healthcare activities for external community disaster preparedness and response services. This extension takes the form of coordination with other responders within the …

Attitudes Toward Complementary And Alternative Medicine In College Students As A Function Of Nationality, Familiarity, And Personality Traits, Joanna Ho

All-Inclusive List of Electronic Theses and Dissertations

Personal and cultural forces leading to health care choices that deviate from conventional medicine have been minimally investigated. Success with treatment of illnesses is reliant on an adequate understanding of factors that influence attitudes and beliefs about medicine. The purpose of this study was to examine the relationship between attitudes toward complementary and alternative medicine (CAM) among college students as a function of American or Asian nationality, Familiarity/Exposure to CAM, and the personality construct of Openness to Experience. A web-based survey instrument was administered to 72 Asian international and 76 American college students at Indiana State University. No significant differences …

^{99m}Tc Labeled Levofloxacin As An Infection Imaging Agent: A Novel Method For Labeling Levofloxacin Using Cysteine\Cdot Hcl As Co-Ligand And In Vivo Study, Syed Ali Raza Naqvi, Malik Muhammad Ishfaq, Zulfiqar Ali Khan, Saeed Ahmad Nagra, Iftikhar Hussain Bukhari, Abdullah Ijaz Hussain, Nasir Mahmood, Sohail Anjum Shahzad, Asma Haque, Tanveer Hussain Bokhari

Turkish Journal of Chemistry

Levofloxacin was labeled with ^{99m}Tc using cysteine\cdot HCl as co-ligand and SnCl_2.2H_2O as reducing agent. The influence of various parameters such as amount of cysteine\cdot HCl, reducing agent, pH value, and reaction time on labeling process was studied. After optimizing the conditions the labeling was performed at pH 5 using 1 mg of levofloxacin, 500 \mu g of cysteine\cdot HCl, 50 \mu g of SnCl_2.2H_2O, and 15 min reaction time. The radiochemical purity was determined with the help of instant thin layer chromatography (ITLC) and reverse phase high performance liquid chromatography (RP-HPLC) which was more than 95% and was stable …

Progressive Supranuclear Palsy, James B. Hoelzle

Psychology Faculty Research and Publications

No abstract provided.

Synthesis Of Linezolid-Like Molecules And Evaluation Of Their Antimicrobial Activities, Serap Başoğlu, Meltem Yolal, Ahmet Demi̇rbaş, Hakan Bektaş, Rza Abbasoğlu, Nesli̇han Demi̇rbaş

Turkish Journal of Chemistry

3-Fluoro-4-(morpholin-4-yl)aniline (2), prepared from 3,4-difluoronitrobenzene, was converted to the corresponding Schiff base (3) by treatment with indol-3-carbaldehyde. The treatment of thiourea 4 and carbothioamide derivatives 9 with ethyl bromoacetate or 4-substituted phenacyl bromides generated the corresponding thiazolidinone (5 and 13) and thiazoline (6 and 12) derivatives, respectively. The acidic or basic treatment of carbothioamide 9 produced 1,3,4-thiadiazole (11) or 1,2,4-triazole (10) compounds, respectively. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, ^1H-NMR, ^{13}C-NMR, and LC-MS) data. The antimicrobial activity study revealed that all compounds showed good antitubercular activities.

Synthesis Of Some New Urea And Thiourea Derivatives And Evaluation Of Their Antimicrobial Activities, Yildiz Gülkok, Tuba Bi̇çer, Fatma Kaynak Onurdağ, Selda Özgen, Mustafa Fethi̇ Şahi̇n, Deni̇z Songül Doğruer

Turkish Journal of Chemistry

In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/chloro-3-methyl-2(3H)- benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by ^1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a …

Synthesis And Antioxidant And Antimicrobial Evaluation Of Novel 4-Substituted-1h-1,2,4-Triazole Derivatives, Sultan Baytaş, Evi̇n Kapçak, Tülay Çoban, Hati̇ce Özbi̇lge

Turkish Journal of Chemistry

A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H- 1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5- (substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole derivatives (5a-p) were synthesized and evaluated for their in vitro scavenging of DPPH and superoxide radical, and lipid peroxidation inhibition effects as well as their antimicrobial properties. DPPH radical scavenging capacity was found to be equipotent with BHT and found in compounds containing 1,2,4-triazole-5(4H)-thione moiety (4a,b). With regard to antimicrobial properties, compound 5k showed slight antimicrobial activity against all the test microorganisms.

Crisis Response Information Networks, Shan L. Pan, Gary Pan, Dorothy Leidner

Research Collection School Of Accountancy

In the past two decades, organizational scholars have focused significant attention on how organizations manage crises. While most of these studies concentrate on crisis prevention, there is a growing emphasis on crisis response. Because information that is critical to crisis response may become outdated as crisis conditions change, crisis response research recognizes that the management of information flows and networks is critical to crisis response. Yet despite its importance, little is known about the various types of crisis information networks and the role of IT in enabling these information networks. Employing concepts from information flow and social network theories, this …

Formative Research On Hpv Vaccine Acceptability With Latina Farmworkers, John S. Luque, Heide Castañeda, Dinorah Martinez Tyson, Natalia Vargas, Meade

Community Health: Faculty Publications

The purpose of this study was to identify the barriers and benefits to human papillomavirus (HPV) vaccination in a low-income, Latina farmworker population in central Florida. This study reports on formative qualitative research conducted on perceptions of benefits, barriers, costs, place, and promotion related to the HPV vaccine from surveys and interviews with a sample of 46 low-income, Latina farm workers and 19 health care workers serving this population. It was found that Latina farmworkers hold many misperceptions about the HPV vaccine and the potential links between HPV infection and cervical cancer. In addition, it was observed that HPV vaccination …

Simultaneous Detection Of Six Diarrhea-Causing Bacterial Pathogens With An In-House Pcr-Luminex Assay, Jie Liu, Jean Gratz, Athanasia Maro, Happy Kumburu, Gibson Kibiki, Mami Taniuchi, Arif Mahmud Howlader, Shihab U. Sobuz, Rashidul Haque, Kaisar A. Talukder, Shahida Qureshi, Anita K. M. Zaidi, Doris M. Haverstick, Eric R. Houpta

Department of Paediatrics and Child Health

Diarrhea can be caused by a range of pathogens, including several bacteria. Conventional diagnostic methods, such as culture, biochemical tests, and enzyme-linked immunosorbent assay (ELISA), are laborious. We developed a 7-plex PCR-Luminex assay to simultaneously screen for several of the major diarrhea-causing bacteria directly in fecal specimens, including pathogenic Aeromonas, Campylobacter jejuni, Campylobacter coli, Salmonella, Shigella, enteroinvasive Escherichia coli (EIEC), Vibrio, and Yersinia. We included an extrinsic control to verify extraction and amplification. The assay was first validated with reference strains or isolates and exhibited a limit of detection of 10(3) to 10(5) CFU/g of stool for each pathogen as …