Digital Commons Network^™

Cdk Inhibitors (P16/P19/P21) Induce Senescence And Autophagy In Cancer-Associated Fibroblasts, "Fueling" Tumor Growth Via Paracrine Interactions, Without An Increase In Neo-Angiogenesis., Claudia Capparelli, Barbara Chiavarina, Diana Whitaker-Menezes, Timothy G Pestell, Richard Pestell, James Hulit, Sebastiano Andò, Anthony Howell, Ubaldo E. Martinez-Outshoorn, Federica Sotgia, Michael P. Lisanti

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Here, we investigated the compartment-specific role of cell cycle arrest and senescence in breast cancer tumor growth. For this purpose, we generated a number of hTERT-immortalized senescent fibroblast cell lines overexpressing CDK inhibitors, such as p16(INK4A), p19(ARF) or p21(WAF1/CIP1). Interestingly, all these senescent fibroblast cell lines showed evidence of increased susceptibility toward the induction of autophagy (either at baseline or after starvation), as well as significant mitochondrial dysfunction. Most importantly, these senescent fibroblasts also dramatically promoted tumor growth (up to ~2-fold), without any comparable increases in tumor angiogenesis. Conversely, we generated human breast cancer cells (MDA-MB-231 cells) overexpressing CDK inhibitors, …

Forage News [2012-10], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• 13th Kentucky Grazing Conference
• AFGC Returns to Kentucky - Register Soon
• 33rd Kentucky Alfalfa Conference
• Heart of America Grazing Conference
• Hay Testing - A Wise Investment
• UK Beef Cow Forage Supplement Tool - A Web Based APP
• KFGC Field Day
• Kentucky Grazing School
• Bale Weight, Nutrient Removal, and Feed Value of Hay: An On-Farm Perspective
• Beware of Cyanide (Prussic Acid) Poisoning
• Nitrate Rumors can Kill Cattle

Global Kentucky (Fall 2012), University Of Kentucky International Center

Global Kentucky

No abstract provided.

The Puzzling Non-Consequences Of Societal Distrust Of Courts: Explaining The Use Of Russian Courts, Kathryn Hendley

Cornell International Law Journal

Russians' lack of trust in courts as an institution has been repeatedly documented through public opinion polling. Yet the caseload data show a steady increase in the use of courts by both individuals and firms in Russia. But these data cannot explain why Russians choose to use the courts. The Article makes use of two publicly available datasets grounded in representative surveys of Russian citizens and firms to investigate this puzzle. The existing literature assumes that the lack of legitimacy of courts in Russia forestalls use. While confirming the societal disdain for courts, the analysis reveals that this attitude has …

Evaluation Of A Mechanical Ventilator Education Program For Intern Physicians In An Intensive Care Nursery, William Bucher, Brian Glynn

Division of Pulmonary, Allergy, and Critical Care Medicine Posters

Background: Thomas Jefferson University Hospital is a large urban Academic Medical Center with a level III Intensive Care Nursery (ICN). A new group of pediatric interns rotate through the ICN every year and receive limited education on mechanical ventilation. We developed a live, one hour training session performed by a Respiratory Therapist and a Respiratory Challenge Test to be completed by the physicians before and after each session. Clinical training was defined as routine training acquired during daily rotation in the ICN. We hypothesized that classroom and clinical training would be more effective than clinical training alone.

Method: After a …

Nebraska Transcript (University Of Nebraska College Of Law), Volume 45, Number 2, Fall 2012

Nebraska Transcript

Dean’s Message 2

Faculty Updates

Profile: Rob Denicola 4

Potuto Gives Chancellor’s Distinguished Lecture 6

Faculty Notes 8

Berger Receives Tenure 15

Schutz Granted Tenure 21

Shoemaker Joins Faculty 28

Stohs Opens Entrepreneurship Clinic 29

Thimmesch Joins Faculty 30

Feature: Client Counseling Competition Champions 31

Around the College

Bresel Experiences on Capitol Hill 38

Externships 39

Department of Defense Externship 42

Hilgers Joins Career Services 44

Big Ten Law Deans Meet at College 45

Karlan Delivers Lane Lecture 46

Laurin Lectures on Roberts Court 48

Admissions Report 50

Baughman Joins Admissions Office 52

Student Accolades 53

Students Volunteer at Voices …

Experience Of Caregivers With The Survivors Of Hepatitis C, Noureen Shehzad Jiwani, Raisa B. Gul, Rubina Sultan

School of Nursing & Midwifery

Objectives: To assess and describe the experiences of those caring for hepatitis C patients in Karachi, Pakistan.

Methods: Using a qualitative approach, the study adopted a descriptive exploratory design for which 8 caregirers were selected through snowball sampling technique from different parts of Karachi. Data was collected between May and July 2010 through semi-structured interviews from the caregivers. The interviews were recorded on tape and were transcribed verbatim. The data was manually analysed for extracting themes and categories.

Results: The analyses of data led to one theme - \'deadly, dangerous, and devastating. Two associated categories could also be noted: \'perceptions …

Genealib Archive 2012-10, Genealib

GENEALIB Archive

No abstract provided.

Spark: Fall, 2012, Calvin Alumni Association

Spark

Commencement honors more than 900 grads

DeVos Communication Center and Prince Conference Center turn ten

Bykers share Spoelhof award

Campus museum to display mineral magnificence

Calvin launches public health major

Calvin honors outstanding senior athletes

Appreciation and Anticipation: Michael and Andrea Le Roy sense affirmation in the call to Calvin by Michael Van Denend

Beyond the Dream: Honduras native Ana Barahona follows her role-model teachers to Calvin by Lynn Bolt Rosendale

..for such a time as this: An interview with Anne Zaki by Myrna DeVries Anderson

Distinguished Alumni Awards

Is civil discourse possible in today's politics?

Econ alums connect and …

Speechlessness And Trauma: Why The International Criminal Court Needs A Public Interviewing Guide, Philip A. Sandick

Northwestern Journal of Human Rights

No abstract provided.

Pro Bono Newsletter, University Of Michigan Law School

Newsletters

Fall 2012 issue of the University of Michigan Law School Pro Bono Program's newsletter.

A World Of Difference, Katie Vloet

Law Quadrangle (formerly Law Quad Notes)

People who pursue environmental law as a career have their reasons, many of which we will highlight in the alumni profiles that follow. No matter the reasons, this is an exciting-some would say unsettled-time in the field of environmental law.

Faculty News, University Of Michigan Law School

Law Quadrangle (formerly Law Quad Notes)

Gordon hired as first director of Zell Entrepreneurship and Law program; Primus joins lead authors in contributing to Modern Criminal Procedure; Scarnecchia: teaching at Law School is a "privilege"; Katz study impacts ruling in voting rights case; legal historian Brand joins faculty; criminal law, legal philosophy prof. Mendlow joins faculty; affordable care act opinion cites Caminker paper; Bagenstos testifies before Senate Committee in support of ENDA; finances of low-income Americans reveal where system falls short, Barr writes in new book; Radin's book tackles boilerplate; Logue argues some regulation could be outsourced to insurance companies; Hakimi argues for new legal …

The Dog Days In American Public Schools: Observations And Suggestions Regarding The Laws, Challenges And Amazing Benefits Of Allowing Service Animals To Accompany Children With Special Needs To School, Joshua T. Walthall

Campbell Law Review

No abstract provided.

Assessing The Impact Of The Ultimate Penal Sanction On Homicide Survivors: A Two State Comparison, Marilyn Peterson Armour, Mark S. Umbreit

Marquette Law Review

Numerous studies have examined the psychological sequelae that result from the murder of a loved one. Except for the death penalty, however, sparse attention has been paid to the impact of the murderer’s sentence on homicide survivors’ well-being. Given the steadfastness of the public’s opinion that the death penalty brings satisfaction and closure to survivors, it is surprising that there has been no systematic inquiry directly with survivors about whether obtaining the ultimate punishment affects their healing. This Study used in-person interviews with a randomly selected sample of survivors from four time periods to examine the totality of the ultimate …

Fitting An Old Tiger With New Teeth: Protecting Public Employee Funds Investing In Complex Financial Instruments, Richard E. Mendales

Marquette Law Review

State employee benefit funds invested heavily in complex financial instruments before the crash of 2008. These investments were tempting to the funds because the instruments carried higher yields than those offered by traditional securities in the low interest climate created largely by Federal Reserve policies after the turn of the century. The risks of the unconventional securities were concealed by investment-grade ratings issued by credit rating agencies and by deceptive marketing practices. With the crash, funds incurred major losses, which, unlike losses by private funds, are not insured by the federal Pension Benefit Guaranty Corporation.

This Article deals both with …

How Will Houston Deal With A Pandemic? New Class: Tracking Your Publications, Vol. 10 (10), Texas Medical Center Library

Insider Express (2003-2013)

No abstract provided.

Montanan, Fall 2012, University Of Montana--Missoula

Montanan Magazine, 1969-2024

This is the magazine of the University of Montana with news about the University for UM alumni as well as current faculty, students, staff, and administrators. This is volume 29, number 3.

New Deal Leftists, Henry Wallace And "Gideon's Army," And The Progressive Party In Montana, 1937-1952, Hugh T. Lovin

Great Plains Quarterly (through 2013)

Many forces occupied America's sociopolitical terrain to the left of New Dealers who dominated U.S. President Franklin Roosevelt's administration of the 1930s. Some fastened themselves temporarily to the New Dealers' coattails. Ideologically motivated, others touted their special panaceas for ending the Great Depression that had begun in 1929, and certain of the mainstream Democratic Party's expatriates added to this cacophony by pursuing their own agendas. Comprised principally of the Democratic Party's out-of-power people, another group wanted to restore Roosevelt's reforming to its 1933-34 height, change the federal government's thrust to the leftward in. certain particulars, and impose New Deal-style reform …

From Mothers' Pensions To Aid To Dependent Children In The Great Plains: The Course From Charity To Entitlement, R. Alton Lee

Great Plains Quarterly (through 2013)

The most important third-party movement in American history emerged out of the social and economic chaos brewing in the Great Plains in the last two decades of the nineteenth century. The maelstrom, labeled Populism, contained a powerful, indeed a truly revolutionary message-that man was his brother's keeper. This concept proved to have consistent influence in America, dating from the Populists, through the Progressives and the New Deal depression era, to the Great Society of the 1960s. Henry Loucks of South Dakota, one-time president of the National Farmers' Alliance and Industrial Union and chairman of the Populist convention in Omaha in …

Journal Of The National Collegiate Honors Council, Volume 13, Number 2, Fall/Winter 2012 (Complete Isue)

Journal of the National Collegiate Honors Council Online Archive

Honors Around the Globe: Countries and Contributors

Australia—Deirdre Barron and Margaret Zeegers

Brazil—Eunice M. L. Soriano de Alencar, Aderson Luiz Costa Jr., and Denise de Souza Fleith

Chile—Frederick J. Conway, Carlos Alberto Cioce Sampaio, and Juan Carlos Skewes

China—Ikuo Kitagaki and Donglin Li

Mexico—Mohammad Ayub Khan and Ruben Morales-Menendez

Netherlands—Vladimir Bartelds, Johannes Boonstra, Trijntje van Dijk, Lyndsay Drayer, Pierre Van Eijl, Stan van Ginkel, Bouke van Gorp, Nelleke de Jong, G. Johan Offringa, Anton Peeters, Albert Pilot, Karin Scager, Ron Weerheijm, Jeske Weerheijm, Fred Wiegant, Marca V. C. Wolfensberger, and John Zubizarreta

Qatar—Byrad …

Cu2o And Au/Cu2o Particles: Surface Properties And Applications In Glucose Sensing, Yu-Ho Won, Lia A. Stanciu

Birck and NCN Publications

In this work we investigated the surface and facet-dependent catalytic properties of metal oxide particles as well as noble metal/metal oxide heterogeneous structures, with cuprous oxide (Cu2O) and Au/Cu2O being selected as model systems. As an example of application, we explored the potential of these materials in developing electrocatalytic devices. Cu2O particles were synthesized in various shapes, then used for testing their morphology-dependent electrochemical properties applied to the detection of glucose. While we did not attempt to obtain the best detection limit reported to date, the octahedral and hexapod Cu2O particles showed reasonable detection limits of 0.51 and 0.60 mM, …

Tinkering Around The Edges: The Supreme Court's Death Penalty Jurisprudence, John Bessler

All Faculty Scholarship

This Essay examines America's death penalty forty years after Furman and provides a critique of the Supreme Court's existing Eighth Amendment case law. Part I briefly summarizes how the Court, to date, has approached death sentences, while Part II highlights the incongruous manner in which the Cruel and Unusual Punishments Clause has been read. For instance, Justice Antonin Scalia-one of the Court's most vocal proponents of "originalism" conceded that corporal punishments such as handbranding and public flogging are no longer constitutionally permissible; yet, he (and the Court itself) continues to allow death sentences to be imposed. The American Bar Association …

Mcnair Scholars Smartnews, October 2012, Mcnair Scholars Program

EMU McNair Challenger

No abstract provided.

Nanoscience & Microsystems 2012 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Nanoscience & Microsystems APR self-study and review team report for Fall 2012, fulfilling requirements of the Higher Learning Commission.

Temple Bar Business Survey, 2012, Kevin Griffin, Jane Fitzgerald, Sheila Flanagan

Reports / Surveys

No abstract provided.

Genetic Relatedness Of The Novel Human Group C Betacoronavirus To Tylonycteris Bat Coronavirus Hku4 And Pipistrellus Bat Coronavirus Hku5, Patrick Cy Woo, Susanna Kp Lau, Kenneth Sm Li, Alan Kl Tsang, Kwok-Yung Yuen

KIP Articles

No abstract provided.

Police Use Of Force: A Review Of The Literature, Portland State University. Criminology And Criminal Justice Senior Capstone

Criminology and Criminal Justice Senior Capstone Project

Our research led to 22 articles with information relevant to the subject of police use of force. The studies explored a variety of topics, ranging from media coverage of force to characteristics of deadly force encounters and many issues in between. The information presented below is a summary of the most significant and useful data gathered from these studies. The material has been divided into five categories: Definitions and Prevalence, Suspects (those who experience force), Officers (those who use force), Patterns of the practice, and Implications, which include best practices or prevention over abuse. The “Definitions and Prevalence” section provides …

Cows, Congress, And Climate Change: Authority And Responsibility For Federal Agencies To End Grazing On Public Lands, Marya Torrez

Celebrating WCL Student Authors

No abstract provided.

Cutr Connections [October 2012], Cutr

CUTR Newsletters

No abstract provided.