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2012

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Using Monte Carlo Tree Search For Replanning In A Multistage Simultaneous Game, Daniel Beard, Philip Hingston, Martin Masek Jan 2012

Using Monte Carlo Tree Search For Replanning In A Multistage Simultaneous Game, Daniel Beard, Philip Hingston, Martin Masek

Research outputs 2012

In this study, we introduce MC-TSAR, a Monte Carlo Tree Search algorithm for strategy selection in simultaneous multistage games. We evaluate the algorithm using a battle planning scenario in which replanning is possible. We show that the algorithm can be used to select a strategy that approximates a Nash equilibrium strategy, taking into account the possibility of switching strategies part way through the execution of the scenario in the light of new information on the progress of the battle.

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A Multimodal Problem For Competitive Coevolution, Philip Hingston, Tirtha Ranjeet, Chiou Peng Lam, Martin Masek Jan 2012

A Multimodal Problem For Competitive Coevolution, Philip Hingston, Tirtha Ranjeet, Chiou Peng Lam, Martin Masek

Research outputs 2012

Coevolutionary algorithms are a special kind of evolutionary algorithm with advantages in solving certain specific kinds of problems. In particular, competitive coevolutionary algorithms can be used to study problems in which two sides compete against each other and must choose a suitable strategy. Often these problems are multimodal - there is more than one strong strategy for each side. In this paper, we introduce a scalable multimodal test problem for competitive coevolution, and use it to investigate the effectiveness of some common coevolutionary algorithm enhancement techniques.

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In-Ground Optical Fibre Bragg Grating Pressure Switch For Security Applications, Gary Allwood, Graham Wild, Steven Hinckley Jan 2012

In-Ground Optical Fibre Bragg Grating Pressure Switch For Security Applications, Gary Allwood, Graham Wild, Steven Hinckley

Research outputs 2012

In this study, a fibre Bragg grating (FBG) was embedded beneath three common flooring materials acting as a pressure switch for in-ground intrusion detection. This is achieved using an intensiometric detection system, where a laser diode and FBG were optically mismatched so that there was a static dc offset from the transmitted and reflected optical power signals. As pressure was applied, in the form of a footstep, a strain induced wavelength shift occurred that could then be detected by converting the wavelength shift into an intensity change. The change in intensity caused a significant change in the DC offset which …

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Scd1 Plays A Tumor-Suppressive Role In Survival Of Leukemia Stem Cells And The Development Of Chronic Myeloid Leukemia, H Zhang, H Li, N Ho, Dongguang Li, Shaoguang Li Jan 2012

Scd1 Plays A Tumor-Suppressive Role In Survival Of Leukemia Stem Cells And The Development Of Chronic Myeloid Leukemia, H Zhang, H Li, N Ho, Dongguang Li, Shaoguang Li

Research outputs 2012

Chronic myeloid leukemia (CML) is derived from a stem cell, and it is widely accepted that the existence of leukemia stem cells (LSCs) is one of the major reasons for the relapse of CML treated with kinase inhibitors. Key to eradicating LSCs is to identify genes that play a critical role in survival regulation of these stem cells. Using BCR-ABL-induced CML mouse model, here we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated in LSCs and that Scd1 plays a tumor-suppressive role in LSCs with no effect on the function of normal hematopoietic stem cells. Deletion …

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A Technical Guide To Effective And Accessible Web Surveys, Gregory Baatard Jan 2012

A Technical Guide To Effective And Accessible Web Surveys, Gregory Baatard

Research outputs 2012

The Internet is becoming an increasingly prominent medium for the administration of surveys. Although individual findings vary, the majority of the literature agrees that the appropriateness and response rates of web surveys is expected to rise in the future as we enter a generation of "digital natives" and mail-based communication becomes increasingly antiquated. Just about every aspect and tenet of traditional survey methodology has received attention in academic literature, positioning it as one of the most mature data collection techniques and a mainstay in all areas of research. While much of this accumulated knowledge is applicable and relevant to web …

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Comparative Genomics Of Brachyspira Pilosicoli Strains: Genome Rearrangements, Reductions And Correlation Of Genetic Compliment With Phenotypic Diversity, Luke Mappley, Michael Black, Manal Abuoun, Alistair C. Darby, Martin J. Woodward, Julian Parkhill, A. Keith Turner, Matthew I. Bellgard, Tom La, Nyree D. Phillips, Roberto M. La Ragione, David J. Hampson Jan 2012

Comparative Genomics Of Brachyspira Pilosicoli Strains: Genome Rearrangements, Reductions And Correlation Of Genetic Compliment With Phenotypic Diversity, Luke Mappley, Michael Black, Manal Abuoun, Alistair C. Darby, Martin J. Woodward, Julian Parkhill, A. Keith Turner, Matthew I. Bellgard, Tom La, Nyree D. Phillips, Roberto M. La Ragione, David J. Hampson

Research outputs 2012

Background: The anaerobic spirochaete Brachyspira pilosicoli causes enteric disease in avian, porcine and human hosts, amongst others. To date, the only available genome sequence of B. pilosicoli is that of strain 95/1000, a porcine isolate. In the first intra-species genome comparison within the Brachyspira genus, we report the whole genome sequence of B. pilosicoli B2904, an avian isolate, the incomplete genome sequence of B. pilosicoli WesB, a human isolate, and the comparisons with B. pilosicoli 95/1000. We also draw on incomplete genome sequences from three other Brachyspira species. Finally we report the first application of the high-throughput Biolog phenotype screening …

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Multiple Γ-Secretase Product Peptides Are Coordinately Increased In Concentration In The Cerebrospinal Fluid Of A Subpopulation Of Sporadic Alzheimer's Disease Subjects, Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne Fagan, David Holtzman, Randall Bateman, Hamid Sohrabi, Ralph Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki Jan 2012

Multiple Γ-Secretase Product Peptides Are Coordinately Increased In Concentration In The Cerebrospinal Fluid Of A Subpopulation Of Sporadic Alzheimer's Disease Subjects, Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne Fagan, David Holtzman, Randall Bateman, Hamid Sohrabi, Ralph Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki

Research outputs 2012

Background: Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β peptide (Aβ), while cleavage of APP or Alcα by α- and γ-secretases generates non-aggregatable p3 or p3-Alcα peptides. Aβ and p3-Alcα can be recovered from human cerebrospinal fluid (CSF). We have previously reported alternative processing of APP and Alcα in the CSF of some patients with sporadic mild cognitive impairment (MCI) and AD (SAD). Results: Using the sandwich enzyme-linked immunosorbent assay (ELISA) system that detects total p3-Alcα, we determined levels of …

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Systematic Review Of Predictive Performance Of Injury Severity Scoring Tools, Hideo Tohira, Ian Jacobs, David Mountain, Nicholas Gibson, Allen Yeo Jan 2012

Systematic Review Of Predictive Performance Of Injury Severity Scoring Tools, Hideo Tohira, Ian Jacobs, David Mountain, Nicholas Gibson, Allen Yeo

Research outputs 2012

Many injury severity scoring tools have been developed over the past few decades. These tools include the Injury Severity Score (ISS), New ISS (NISS), Trauma and Injury Severity Score (TRISS) and International Classification of Diseases (ICD)-based Injury Severity Score (ICISS). Although many studies have endeavored to determine the ability of these tools to predict the mortality of injured patients, their results have been inconsistent. We conducted a systematic review to summarize the predictive performances of these tools and explore the heterogeneity among studies. We defined a relevant article as any research article that reported the area under the Receiver Operating …

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Effects Of Lowering Body Temperature Via Hyperhydration, With And Without Glycerol Ingestion And Practical Precooling On Cycling Time Trial Performance In Hot And Humid Conditions, Megan Ross, Nikki Jeacocke, Paul Laursen, David Martin, Christopher Abbiss, Louise Burke Jan 2012

Effects Of Lowering Body Temperature Via Hyperhydration, With And Without Glycerol Ingestion And Practical Precooling On Cycling Time Trial Performance In Hot And Humid Conditions, Megan Ross, Nikki Jeacocke, Paul Laursen, David Martin, Christopher Abbiss, Louise Burke

Research outputs 2012

Background: Hypohydration and hyperthermia are factors that may contribute to fatigue and impairment of endurance performance. The purpose of this study was to investigate the effectiveness of combining glycerol hyperhydration and an established precooling technique on cycling time trial performance in hot environmental conditions.Methods: Twelve well-trained male cyclists performed three 46.4-km laboratory-based cycling trials that included two climbs, under hot and humid environmental conditions (33.3 ± 1.1°C; 50 ± 6% r.h.). Subjects were required to hyperhydrate with 25 g.kg-1 body mass (BM) of a 4°C beverage containing 6% carbohydrate (CON) 2.5 h prior to the time trial. On two occasions, …

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Can Exercise Ameliorate Treatment Toxicity During The Initial Phase Of Testosterone Deprivation In Prostate Cancer Patients? Is This More Effective Than Delayed Rehabilitation?, Robert Newton, Dennis Taaffe, Nigel Spry, Prue Cormie, Suzanne Chambers, Robert Gardiner, David Shum, David Joseph, Daniel Galvao Jan 2012

Can Exercise Ameliorate Treatment Toxicity During The Initial Phase Of Testosterone Deprivation In Prostate Cancer Patients? Is This More Effective Than Delayed Rehabilitation?, Robert Newton, Dennis Taaffe, Nigel Spry, Prue Cormie, Suzanne Chambers, Robert Gardiner, David Shum, David Joseph, Daniel Galvao

Research outputs 2012

Background: There has been substantial increase in use of androgen deprivation therapy as adjuvant management of prostate cancer. However, this leads to a range of musculoskeletal toxicities including reduced bone mass and increased skeletal fractures compounded with rapid metabolic alterations, including increased body fat, reduced lean mass, insulin resistance and negative lipoprotein profile, increased incidence of cardiovascular and metabolic morbidity, greater distress and reduced quality of life. Numerous research studies have demonstrated certain exercise prescriptions to be effective at preventing or even reversing these treatment toxicities. However, all interventions to date have been of rehabilitative intent being implemented after a …

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A Randomised Trial Of Robotic And Open Prostatectomy In Men With Localised Prostate Cancer, Robert Gardiner, J Yaxley, G Coughlin, N Dunglison, S Occhipinti, S Younie, R Carter, S Williams, R J Medcraft, Bennett Nigel, M F Lavin, Suzanne Chambers Jan 2012

A Randomised Trial Of Robotic And Open Prostatectomy In Men With Localised Prostate Cancer, Robert Gardiner, J Yaxley, G Coughlin, N Dunglison, S Occhipinti, S Younie, R Carter, S Williams, R J Medcraft, Bennett Nigel, M F Lavin, Suzanne Chambers

Research outputs 2012

Background: Prostate cancer is the most common male cancer in the Western world however there is ongoing debate about the optimal treatment strategy for localised disease. While surgery remains the most commonly received treatment for localised disease in Australia more recently a robotic approach has emerged as an alternative to open and laparoscopic surgery. However, high level data is not yet available to support this as a superior approach or to guide treatment decision making between the alternatives. This paper presents the design of a randomised trial of Robotic and Open Prostatectomy for men newly diagnosed with localised prostate cancer …

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Multigene Interactions And The Prediction Of Depression In The Wisconsin Longitudinal Study, N S Roetker, J A Yonker, C. Lee, V Chang, J J Basson, C L Roan, T S Hauser, R M Hauser, Craig Atwood Jan 2012

Multigene Interactions And The Prediction Of Depression In The Wisconsin Longitudinal Study, N S Roetker, J A Yonker, C. Lee, V Chang, J J Basson, C L Roan, T S Hauser, R M Hauser, Craig Atwood

Research outputs 2012

Objectives: Single genetic loci offer little predictive power for the identification of depression. This study examined whether an analysis of gene-gene (G x G) interactions of 78 single nucleotide polymorphisms (SNPs) in genes associated with depression and agerelated diseases would identify significant interactions with increased predictive power for depression. Design: A retrospective cohort study. Setting: A survey of participants in the Wisconsin Longitudinal Study. Participants: A total of 4811 persons (2464 women and 2347 men) who provided saliva for genotyping; the group comes from a randomly selected sample of Wisconsin high school graduates from the class of 1957 as well …

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Cca3101/4101 Environmental Humanities: The History Of A Unit Through An Ecopedagogical Lens, John Ryan Jan 2012

Cca3101/4101 Environmental Humanities: The History Of A Unit Through An Ecopedagogical Lens, John Ryan

Research outputs 2012

In 2011 the author taught, for the first time, the well-established unit CCA3101/4101 Environmental Humanities in the School of Communications and Arts at ECU (Edith Cowan University) in Western Australia. The unit has a 20-year history through associate professor Rod Giblett and parallels the development of the environmental humanities as a field in Australia, advanced since the 1990s by environmental scholars Deborah Bird Rose, Val Plumwood, Libby Robin, and Rod Giblett. The interdisciplinary field represents growing scholarly interest in the ecological aspects of humanities disciplinesincluding literature, visual arts, theology, philosophy, and cultural studies—and the development of humanities-based approaches for addressing …

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Assessing Sprint Paddle Ability In Competitive Surfers, Joseph Coyne, Jeremy Sheppard Jan 2012

Assessing Sprint Paddle Ability In Competitive Surfers, Joseph Coyne, Jeremy Sheppard

Research outputs 2012

No abstract provided.

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A Brief Examination Of Strength And Paddle-Conditioning Considerations For Competitive Surfers, Jeremy Sheppard, Phil Walshe, Joseph Coyne Jan 2012

A Brief Examination Of Strength And Paddle-Conditioning Considerations For Competitive Surfers, Jeremy Sheppard, Phil Walshe, Joseph Coyne

Research outputs 2012

No abstract provided.

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Reliability And Validity Of Unilateral And Bilateral Isometric Strength Measures Using A Customised, Portable Apparatus, Nicolas Hart, Sophia Nimphius, Jodie Wilkie, Robert Newton Jan 2012

Reliability And Validity Of Unilateral And Bilateral Isometric Strength Measures Using A Customised, Portable Apparatus, Nicolas Hart, Sophia Nimphius, Jodie Wilkie, Robert Newton

Research outputs 2012

No abstract provided.

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The Genetic Associations And Epistatic Effects Of The Ccr5 Promoter And Ccr2-V64i Polymorphisms On Susceptibility To Hiv-1 Infection In A Northern Han Chinese Population, Jiapeng Lu, Aijuan Sheng, Youxin Wang, Ling Zhang, Jingjing Wu, Manchu Song, Yan He, Xinwei Yu, Feifei Zhao, Yezhou Liu, Shuang Shao, Jie Lan, Hao Wu, Wei Wang Jan 2012

The Genetic Associations And Epistatic Effects Of The Ccr5 Promoter And Ccr2-V64i Polymorphisms On Susceptibility To Hiv-1 Infection In A Northern Han Chinese Population, Jiapeng Lu, Aijuan Sheng, Youxin Wang, Ling Zhang, Jingjing Wu, Manchu Song, Yan He, Xinwei Yu, Feifei Zhao, Yezhou Liu, Shuang Shao, Jie Lan, Hao Wu, Wei Wang

Research outputs 2012

The outcome of human immunodeficiency virus (HIV)-1 infection and course to AIDS are variable among individuals. Both chemokine receptor 5 (CCR5) and CCR2 gene polymorphisms play essential roles in the susceptibility of HIV-1 infection. To investigate the main and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on HIV-1 infection in the Northern Han Chinese, subjects of 91 HIV-1-infected patients and 91 health controls were recruited. Single-nucleotide polymorphisms (SNPs) in the CCR5 promoter region and CCR2-V64I variants were genotyped. In the single-locus analysis, CCR5 58755-G and CCR5 59653-T alleles were significantly associated with HIV-1 infection (odds ratio [OR]=0.529, 95% …

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Humanity's Bioregional Places: Linking Space, Aesthetics, And The Ethics Of Reinhabitation, John Ryan Jan 2012

Humanity's Bioregional Places: Linking Space, Aesthetics, And The Ethics Of Reinhabitation, John Ryan

Research outputs 2012

Originally theorized as a radical environmental movement, bioregionalism connects humanity to the specificities of a place. To establish greater cohesion between environments and cultures, bioregionalism endeavors to integrate societal activities and the nuances of natural spaces known as bioregions. The criticism of bioregionalism, however, pertains to the shortcomings of circumscribing culture within ecological boundaries. In light of its criticism, bioregionalism can strengthen its theoretical basis and its potential for cultural change by engaging critically with space, aesthetics, and ethics. This engagement first involves the recognition of bioregionalism as an ethical possibility based on the fundamental spatial unit of the watershed. …

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Changes In Dairy Food And Nutrient Intakes In Australian Adolescents, Carole Parker, Wendy Vivian, Wendy H. Oddy, Lawrie J Beilin, Trevor A. Mori, Therese O'Sullivan Jan 2012

Changes In Dairy Food And Nutrient Intakes In Australian Adolescents, Carole Parker, Wendy Vivian, Wendy H. Oddy, Lawrie J Beilin, Trevor A. Mori, Therese O'Sullivan

Research outputs 2012

Dairy nutrients, such as calcium, are particularly important in adolescence, a critical time for growth and development. There are limited Australian data following individuals through adolescence, evaluating changes in dairy nutrient and dairy product consumption. We used a validated food frequency questionnaire to investigate consumption in adolescents participating in both the 14 and 17 year follow-ups of the Western Australian Pregnancy Cohort (Raine) Study. Most adolescents did not reach age and gender specific recommended daily intakes for calcium or magnesium at 14 years, and this decreased as they aged to 17 years (from 33.0% to 29.2% meeting for calcium, P < 0.05, and from 33.6% to 20.5% meeting for magnesium, P < 0.01). Mean intakes of calcium, potassium, riboflavin and vitamin A also decreased with age (P < 0.01). Mean dairy intake decreased from 536 ± 343 g/day to 464 ± 339 g/day (P < 0.01), due mostly to a decrease in regular milk, although flavoured milk consumption increased in boys. Cheese and butter were the only products to show a significantly increased consumption over the period. Girls decreased from 2.2 to 1.9 serves/day of dairy, while boys remained relatively steady at 2.9 to 2.8 serves/day. Our findings suggest that dairy product consumption decreases over adolescence. This may have implications for bone mass, development and later health.

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Measurement And Simulation Of Dissolved Oxygen In Zayandehrood River, Ahmad Reza Rahsepar, Mehdi Khiadani, Mohammad Mehdi Amin Jan 2012

Measurement And Simulation Of Dissolved Oxygen In Zayandehrood River, Ahmad Reza Rahsepar, Mehdi Khiadani, Mohammad Mehdi Amin

Research outputs 2012

Aims: This study aims to simulate dissolved oxygen of Zayandehrood river from regulating dam to Polle-Kalleh bridge using MIKE11 software that is a hydrodynamics and water quality model. Materials and Methods: During 5 months the samples were taken from four hydrometric stations and water quality parameters such as dissolved oxygen, pH, BOD (1 day, 3 days, 5 days, and 7 days), NH 4 , NO 3 - phosphate (PO4 3- ), and temperature were measured. Morphological and hydrological data were provided and introduced into the model. The model was calibrated and its accuracy was investigated. Results: The results indicated that …

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Olfactory Discrimination Predicts Cognitive Decline Among Community-Dwelling Older Adults, Hamid Sohrabi, Kristyn Bates, Mg Weinborn, A N Johnston, A Bahramian, Kevin Taddei, Simon Laws, Mark Rodrigues, Michael Morici, Matthew Howard, Georgia Martins, A Mackay-Sim, Se Gandy, Ralph Martins Jan 2012

Olfactory Discrimination Predicts Cognitive Decline Among Community-Dwelling Older Adults, Hamid Sohrabi, Kristyn Bates, Mg Weinborn, A N Johnston, A Bahramian, Kevin Taddei, Simon Laws, Mark Rodrigues, Michael Morici, Matthew Howard, Georgia Martins, A Mackay-Sim, Se Gandy, Ralph Martins

Research outputs 2012

The presence of olfactory dysfunction in individuals at higher risk of Alzheimer's disease has significant diagnostic and screening implications for preventive and ameliorative drug trials. Olfactory threshold, discrimination and identification can be reliably recorded in the early stages of neurodegenerative diseases. The current study has examined the ability of various olfactory functions in predicting cognitive decline in a community-dwelling sample. A group of 308 participants, aged 46-86 years old, were recruited for this study. After 3 years of follow-up, participants were divided into cognitively declined and non-declined groups based on their performance on a neuropsychological battery. Assessment of olfactory functions …

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Theory, Figures Of Merit, And Design Recipe Of The Plasmonic Structure Composed Of A Nano-Slit Aperture Surrounded By Surface Corrugations, Guangyuan Li, Feng Xiao, Kun Li, Kamal Alameh, Anshi Xu Jan 2012

Theory, Figures Of Merit, And Design Recipe Of The Plasmonic Structure Composed Of A Nano-Slit Aperture Surrounded By Surface Corrugations, Guangyuan Li, Feng Xiao, Kun Li, Kamal Alameh, Anshi Xu

Research outputs 2012

We theoretically investigate a widely-used plasmonic structure composed of a nano-slit aperture surrounded by surface corrugations. A systematical semi-analytical theory in form of two nested coupled-mode models is developed to provide intuitive physical pictures. Based on the theory, figures of merit (FoMs) of the structures designed for normal and for oblique incidence/beaming are defined for the first time to incorporate the interlinks among key structural parameters, making global optimization simple and efficient. Both the theory and the FoMs are quantitatively validated with exhaustive calculations and shown to be highly accurate on performance prediction and structural optimization. With the theory and …

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Unidirectionally Optical Coupling From Free Space Into Silicon Waveguide With Wide Flat-Top Angular Efficiency, K Li, G Li, Feng Xiao, Fan Lu, Zhonghua Wang, A Xu Jan 2012

Unidirectionally Optical Coupling From Free Space Into Silicon Waveguide With Wide Flat-Top Angular Efficiency, K Li, G Li, Feng Xiao, Fan Lu, Zhonghua Wang, A Xu

Research outputs 2012

A grating coupling scheme from free-space light into silicon waveguide with a remarkable property of wide flat-top angular efficiency is proposed and theoretically investigated. The coupling structure is composed of two cascaded gratings with a proper distance between their peak angular efficiencies. A quantitative semi-analytical theory based on coupled-mode models is developed for performance prediction and validated with the fully vectorial aperiodic Fourier modal method (a-FMM). With the theory, wide flat-top angular response is achieved and the conditions are pointed out. Proof-of-principle demonstrations show that the -1 dB angular widtha figure of merit to evaluate the flat-top performanceis broadened to …

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Gaas Based Long-Wavelength Microring Resonator Optical Switches Utilising Bias Assisted Carrier-Injection Induced Refractive Index Change, S Ravindran, A Datta, Kamal Alameh, Yong Tak Lee Jan 2012

Gaas Based Long-Wavelength Microring Resonator Optical Switches Utilising Bias Assisted Carrier-Injection Induced Refractive Index Change, S Ravindran, A Datta, Kamal Alameh, Yong Tak Lee

Research outputs 2012

We propose and analyse a GaAs-based optical switch having a ring resonator configuration which can switch optical telecommunication signals over the 1300 nm and 1500 nm bands, using bias assisted carrier injection as the switching mechanism. The switching is achieved through variation in the refractive index of the ring resonator produced by changing the injected carrier density through the application of bias voltage. Detail analysis of the switching characteristics reveals that the amount of switching depends on the refractive index change, which indeed is a strong function of injected carrier density and applied bias voltage. An isolation of 25 dB …

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The Trajectories And Correlation Between Physical Limitation And Depression In Elderly Residents Of Beijing, 1992-2009, Xia Li, Wei Wang, Qi Gao, Lijuan Wu, Yanxia Luo, Zhe Tang, Xiuhua Guo Jan 2012

The Trajectories And Correlation Between Physical Limitation And Depression In Elderly Residents Of Beijing, 1992-2009, Xia Li, Wei Wang, Qi Gao, Lijuan Wu, Yanxia Luo, Zhe Tang, Xiuhua Guo

Research outputs 2012

Background Physical limitation and psychological distress have been reported to be related, but studies describing the change of instrumental activities of daily living (IADLs) and depression syndrome over time or exploring the link pattern for their development are limited. The study was to assess distinctive patterns for the development of physical limitation and depression and to explore their correlation to form a proper prevention strategy. Methods Dual trajectory analysis was conducted using data from the Beijing Longitudinal Study of Aging (BLSA) 1992–2009 hosted by Xuanwu hospital for subjects with full information on depression and physical limitation for all available visits. …

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Recreational Use Of Acidic Pit Lakes—Human Health Considerations For Post Closure Planning, Andrea Hinwood, Jane Heyworth, Helen Tanner, C. D. Mccullough Jan 2012

Recreational Use Of Acidic Pit Lakes—Human Health Considerations For Post Closure Planning, Andrea Hinwood, Jane Heyworth, Helen Tanner, C. D. Mccullough

Research outputs 2012

Pit lakes may form in mining voids that extend below groundwater level after mining ceases and many have been found to have elevated metals concentrations and low pH through acidic and metalliferous drainage (AMD). Pit lakes are often used for recreational activities including swimming, fishing and boating and poor water quality may present health risks to recreational users. Pit lakes also provide the opportunity for additional water resource uses. The Collie Coal Basin in south-western Australia currently has a number of pit lakes with moderate AMD effects which are also used for recreational pursuits. Twelve hundred questionnaires were mailed to …

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Fussy Feeders: Phyllosoma Larvae Of The Western Rocklobster (Panulirus Cygnus) Demonstrate Prey Preference, M I Saunders, P A Thompson, A G Jeffs, Christin Sawstrom, N Sachlikidis, L E Beckley, A M Waite Jan 2012

Fussy Feeders: Phyllosoma Larvae Of The Western Rocklobster (Panulirus Cygnus) Demonstrate Prey Preference, M I Saunders, P A Thompson, A G Jeffs, Christin Sawstrom, N Sachlikidis, L E Beckley, A M Waite

Research outputs 2012

The Western Rocklobster (Panulirus cygnus) is the most valuable single species fishery in Australia and the largest single country spiny lobster fishery in the world. In recent years a well-known relationship between oceanographic conditions and lobster recruitment has become uncoupled, with significantly lower recruitment than expected, generating interest in the factors influencing survival and development of the planktonic larval stages. The nutritional requirements and wild prey of the planktotrophic larval stage (phyllosoma) of P. cygnus were previously unknown, hampering both management and aquaculture efforts for this species. Ship-board feeding trials of wild-caught mid-late stage P. cygnus phyllosoma in the eastern …

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Suboptimal Health: A New Health Dimension For Translational Medicine, Wei Wang, Yuxian Yan Jan 2012

Suboptimal Health: A New Health Dimension For Translational Medicine, Wei Wang, Yuxian Yan

Research outputs 2012

Background One critical premise of disease-related biomarkers is the definition of the counterpart normality. Contrary to pre-clinical models that can be carefully tailored according to scientific need, heterogeneity and uncontrollability is the essence of humans in health studies. Fully characterization of consistent parameters that define the normal population is the basis to individual differences normalization irrelevant to a given disease process. Self claimed normal status may not represent health because asymptomatic subjects may carry chronic diseases or diseases at their early stage such as cancer, diabetes and hypertension. Methods This paper exemplifies the characterization of the suboptimal health status (SHS) …

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Sirtuin-1 Mediates The Obesity Induced Risk Of Common Degenerative Diseases: Alzheimer's Disease, Coronary Artery Disease And Type 2 Diabetes, Ian Martins, Andrea Wilson, Wei Ling Lim, Simon Laws, Stephanie Fuller, Ralph Martins Jan 2012

Sirtuin-1 Mediates The Obesity Induced Risk Of Common Degenerative Diseases: Alzheimer's Disease, Coronary Artery Disease And Type 2 Diabetes, Ian Martins, Andrea Wilson, Wei Ling Lim, Simon Laws, Stephanie Fuller, Ralph Martins

Research outputs 2012

Obesity, especially at mid-life, is a major risk factor for atherosclerosis, insulin resistance and the metabolic syndrome, which in turn contrib- ute to coronary artery disease (CAD), Type 2 diabetes and Alzheimer’s disease (AD). The rise in overweight and obesity in all societies is prompting intense research into the causes and effects of the condition. Obesity disrupts many body systems including glucose and lipid me- tabolism, circadian rhythms and liver function. It also causes or increases inflammation and oxi- dative stress. Within cells, the endoplasmic re- ticulum (ER) appears to be particularly suscep- tible to such metabolic disruption. Sirtuin 1 …

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Modular Dynamic Rbf Neural Network For Face Recognition, Sue Inn Ch'ng, Kah Phooi Seng, Li-Minn Ang Jan 2012

Modular Dynamic Rbf Neural Network For Face Recognition, Sue Inn Ch'ng, Kah Phooi Seng, Li-Minn Ang

Research outputs 2012

Over the years, we have seen an increase in the use of RBF neural networks for the task of face recognition. However, the use of second order algorithms as the learning algorithm for all the adjustable parameters in such networks are rare due to the high computational complexity of the calculation of the Jacobian and Hessian matrix. Hence, in this paper, we propose a modular structural training architecture to adapt the Levenberg-Marquardt based RBF neural network for the application of face recognition. In addition to the proposal of the modular structural training architecture, we have also investigated the use of …

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