Digital Commons Network^™

Forty Years Of Increasing Suicide Mortality In Poland: Undercounting Amidst A Hanging Epidemic?, Peter Höfer, Ian R H Rockett, Peeter Värnik, Elmar Etzersdorfer, Nestor D Kapusta

Faculty & Staff Scholarship

No abstract provided.

Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward

Honors Theses

Opportunistic fungal infections have become problematic in recent years. There has been an emergence of new fungal pathogens, development of antifungal resistance, and increasing prevalence. In addition, toxicity, resistance, and lack of efficacy as a single agent limit the effectiveness of current antifungal drugs. Therefore, new drugs targeting new pathways are greatly needed. An analog derived from the marine natural product phloeodictine, analog PHL5-34A, was identified as having strong in vitro antifungal activity. In this study, its mechanism of action (MOA) was investigated in the model yeast, Saccharomyces cerevisiae. This study made use of a collection of 166 yeast mutants …

Working Towards A Solution To The Obesity Epidemic: A Marketer's Perspective, Elizabeth Ann Clippard

Honors Theses

The obesity epidemic is a social issue in that critics are quick to blame business and government for failing the consumers. The truth is that all three parties have failed each other by allowing such a cultural change to occur. The issue is similar to the tobacco public health crisis following the spike in lung cancer in the 1950s and 60s. The tobacco companies were blamed entirely for their unhealthy products and the government still spends millions today regulating their products. In order to improve upon this course of action, I believe that a more cooperative solution exists in order …

Angiotensin Ii As A Potential Regulator Of Inflammatory Cytokines In Inducing Hypertension In Systemic Lupus Erythematosus, Khush Singh Aujla

Honors Theses

The disease Systemic Lupus Erythematosus is a chronic inflammatory, autoimmune disorder that primarily affects women during their reproductive years. Women with SLE are at a greater risk of developing hypertension, which increases their risk of mortality from a cardiac related event. A proposed mechanism for SLE hypertension suggests that inflammation in the kidneys causes renal dysfunction, presumably resulting in less water excretion, increased plasma volume, and thus high blood pressure. This experiment tests the hypothesis that the T-cells from a mouse model of SLE hyper secrete the inflammatory cytokines IL-17, IL-10, and DFN- y, and are more sensitive to the …

An Investigation Of Host Variation In The Host-Parasite Interaction Of Sciurus Carolinensis And Cuterebra Emasculator, Miles Moore Debardeleben

Honors Theses

Within a population, susceptibility to parasitism may vary. Individuals possessing certain intrinsic or extrinsic traits are often more likely to be parasitized than individuals within that population that do not possess those certain traits. As a result, parasites can have profound effects of the population dynamics of theirs hosts. Much research has been done on the host-parasite interaction of the eastern grey squirrel {Sciurus caroUnensis) and the tree squirrel hot fly {Cuterebra emasculator). However, relatively little research has been done on host susceptibility to this parasite. Knowing that bot flies can lower reproductive success, reduce fitness, and cause death of …

Investigation Of Brown Recluse (Loxosceles Reclusa) And Black Widow (Latrodectus Mactans) Spider-Bite Diagnoses By Medical Professionals Across Three Regions Of Mississippi, Hillary Michelle Howell

Honors Theses

During 4 weeks of the spring of 2011 and 5 weeks of the fall of 2011, interviews were conducted with medical professionals practicing in Mississippi regarding the diagnosis of brown recluse {Loxosceles reclusa) and black widow {Latrodectus mactans) spider bites. During the spring, a total of 19 interviews were held with emergency room physicians and dermatologists practicing in urban and rural, non-medically underserved areas of Mississippi. The participants varied in their location of practice across the 3 regions of Mississippi. During the fall, a total of 5 interviews were conducted with nurse practitioners and one pediatrician practicing in rural, medically …

Strict Liability In Negligence, Kenneth S. Abraham

DePaul Law Review

No abstract provided.

Reflections On Tort And The Administrative State, Robert L. Rabin

DePaul Law Review

No abstract provided.

An Alternative Explanation For No-Fault's Demise, Nora Freeman Engstrom

DePaul Law Review

No abstract provided.

Professor Rabin And The Administrative State , Peter H. Schuck

DePaul Law Review

No abstract provided.

Pure Confusion: Should Pure Licensors Share The Products Liability Of Manufacturers And Sellers Of Dangerously Defective Products?, Stephen C. Jarvis

DePaul Law Review

No abstract provided.

The Federal Employers' Liability Act: Sense And Nonsense About Causation, Michael D. Green

DePaul Law Review

No abstract provided.

Against Categorical Preemption: Vaccines And The Compensation Piece Of The Preemption Puzzle, Catherine M. Sharkey

DePaul Law Review

No abstract provided.

Why No Duty?, Stephen D. Sugarman

DePaul Law Review

No abstract provided.

Whom Must The Clergy Protect: The Interests Of At-Risk Children In Conflict With Clergy-Penitent Privilege, Paul Winters

DePaul Law Review

No abstract provided.

Angiotensin Ii: A Potential Link Between Inflammation And Hypertension In Sle, Khush Singh Aujla

Honors Theses

The disease Systemic Lupus Erythematosus is a chronic inflammatory, autoimmune disorder that primarily affects women during their reproductive years. Women with SLE are at a greater risk of developing hypertension, which increases their risk of mortality from a cardiac related event. A proposed mechanism for SLE hypertension suggests that inflammation in the kidneys causes renal dysfunction, presumably resulting in less water excretion, increased plasma volume, and thus high blood pressure. This experiment tests the hypothesis that the T-cells from a mouse model of SLE hyper secrete the inflammatory cytokines IL-17, IL-10, and IFN- y, and are more sensitive to the …

Defects In Acute Rsponses To Tlr4 In Btk-Deficient Mice Result In Impaired Dendritic Cell-Induced Ifn-Γ Production By Natural Killer Cells, Joan Ní Gabhann, Shaun Spence, Claire Wynne, Siobhán Smith, Jennifer C. Byrne, Barbara Coffey, Kevin Stacey, Adrien Kissenpfennig, James A. Johnston, Caroline A. Jefferies

Articles

This study defines a critical role for Btk in regulating TLR4-induced crosstalk between antigen presenting cells (APCs) and natural killer (NK) cells. Reduced levels of IL-12, IL- 18 and IFN-γ were observed in Btk-deficient mice and ex vivo generated macrophages and dendritic cells (DCs) following acute LPS administration, whilst enhanced IL-10 production was observed. In addition, upregulation of activation markers and antigen presentation molecules on APCs was also impaired in the absence of Btk. APCs, by virtue of their ability to produce IL-12 and IL-18, are strong inducers of NK-derived IFN-γ. Co-culture experiments demonstrate that Btk-deficient DCs were unable to …

Bi-Lateral Changes To Hippocampal Cholesterol Levels During Epileptogenesis And In Chronic Epilepsy Following Focal-Onset Status Epilepticus In Mice, Steve Meaney, Maura Heverin, Tobias Engel, Eva Jimenez-Mateosa, Reza Al-Aaudia, David Henshall

Articles

Brain cholesterol homeostasis has been shown to be disrupted in neurodegenerative conditions such as Alzheimer's and Huntington's diseases. Investigations in animal models of seizure-induced brain injury suggest that brain cholesterol levels are altered by prolonged seizures (status epilepticus) and are a feature of the pathophysiology of temporal lobe epilepsy. The present study measured hippocampal sterol levels in a model of unilateral hippocampal injury triggered by focal-onset status epilepticus, and in chronically epileptic mice. Status epilepticus was induced by intra-amygdala microinjection of kainic acid and ipsilateral and contralateral hippocampus analyzed. No significant changes were found for ipsilateral or contralateral hippocampal levels …

Point Of Care Diagnostics: Status And Future, Vladimir Gubala, Leanne Harris, Antonio J. Ricco, Ming X. Tan, David Williams

Articles

The most commonly used test for monitoring heparin therapy is the activated partial thromboplastin time (aPTT). The response of available aPTT reagents to heparin varies significantly. The aim of this study was to highlight the differences between aPTT reagents stored in a dried format to select the most suitable formulations to be used for the development of point-of-care diagnostic devices used for monitoring of unfractionated heparin dose response.

METHODS:

Ten reagents were analysed in terms of their performance in liquid and in dried form after storage for 24 h and 14 days. Performance was assessed by measurement of the clotting …

Eae/Ase Recommendations For Image Acquisition And Display Using Three-Dimensional Echocardiography., Roberto M. Lang, Luigi P. Badano, Wendy Tsang, David H. Adams, Eustachio Agricola, Thomas Buck, Francesco F. Faletra, Andreas Franke, Judy Hung, Leopoldo Pérez De Isla, Otto Kamp, Jaroslaw D. Kasprzak, Patrizio Lancellotti, Thomas H. Marwick, Marti L. Mcculloch, Mark J. Monaghan, Petros Nihoyannopoulos, Natesa G. Pandian, Patricia A. Pellikka, Mauro Pepi, David A. Roberson, Stanton K. Shernan, Girish S. Shirali, Lissa Sugeng, Folkert J. Ten Cate, Mani A. Vannan, Jose Luis Zamorano, William A. Zoghbi, American Society Of Echocardiography, European Association Of Echocardiography

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Theism And Psychological Science: A Call For Rapprochement, Michael J. Vogel, Tyler A. Gerdin, Mark R. Mcminn

Faculty Publications - Doctor of Psychology (PsyD) Program

The authors offer two arguments for the inclusion of theism in natural science. First, an argument against excluding theism is offered. Though early roots of science promoted a view that it is a way to accumulate knowledge that is untainted by presuppositions and traditions, postmodern critiques call this into question. Scientists have sometimes rejected religion as a context-dependent, tradition-based way of knowing, yet science itself is also context-dependent and tradition-based. Second, an argument for including theism in psychological is offered. Theistic beliefs are relevant insofar as they are part of human experience for many, they represent a form of human …

Counseling And Psychotherapy Within And Across Faith Traditions (Chapter 17 In The Oxford Handbook Of The Psychology Of Spirituality), Mark R. Mcminn

Faculty Publications - Doctor of Psychology (PsyD) Program

This chapter begins with general considerations for religiously and spiritually oriented psychotherapy, including the importance of seeing religion and spirituality as d.imensions of cultural diversity, considering clients' welfare and autonomy, and maintaining competence. Three types of religious and spiritual intervention approaches are then discussed: assimilative, accommodative, and collaborative. Assimilative approaches introduce spiritual interventions or considerations into a standard psychotherapy approach. Accommodative approaches involve adapting a standard psychotherapy regimen to include religious or spiritual matters. Collaborative approaches entail a mental health professional and religious leader working in tandem for the sake of clients' welfare. Next, specific issues related to counseling within …

Spiritual Well-Being Scale: Mental And Physical Health Relationships (Chapter 48 Of Oxford Textbook Of Spirituality In Healthcare), Raymond F. Paloutzian, Rodger K. Bufford, Ashley J. Wildman

Faculty Publications - Doctor of Psychology (PsyD) Program

The existence of this handbook documents the recent increase in research on and practical attention to the role of spirituality in healthcare. One essential companion to the concept of spirituality is spiritual well-being (SWB).[1] That is, although the degree and type of spirituality per se can no doubt play an important role in how well a person faces the dilemmas related to health issues,[2,3] the degree to which a person perceives or derives a sense of wellbeing from that spirituality may be equally or more important. In this connection, SWB is an outcome indicator, or barometer, of how well a …

Social And Emotional Skills Training With Second Step: A Violence Prevention Curriculum, Pam Dell Fitzgerald, Leihua Van Schoiack Edstrom

Faculty Publications - Doctor of Psychology (PsyD) Program

Second Step: A Violence Prevention Curriculum is a school-based program developed to prevent and reduce aggressive behavior. Three separate age-appropriate curricula are available: preschool/kindergarten level, elementary level, and middle school level. Designed to be teacher-friendly and convenient for classroom use, the curricula aim to prevent and decrease aggression by helping children develop habits of prosocial behavior and thought. Instructional strategies are evidence-based and are built on a broad foundation of research. In addition, these curricula employ strategies that have been found to be effective for prevention of delinquency and substance abuse, and to support children's academic success. Each of the …

Exploring Resilience: Strengths Of Trafficking Survivors In Cambodia, Glori G. Gray, Lilia E. U. Luna, Winston Seegobin

Faculty Publications - Doctor of Psychology (PsyD) Program

Western literature provides an array of information regarding resilience within at-risk youth. Resilience research within non-Western contexts, and more specifically with exploited youth, is more limited. Despite exploitation, some youth develop a hardy ability to overcome adversity, allowing them more mastery over their environments and even increased psychological steadfastness. This project involved exploring the protective factors of resilience and psychological functioning in Cambodian youth, specifically a group of 24 survivors of sexual trafficking and another group of 24 rural youth without reported exploitation. The ages of participants ranged from J 3 to 22 years, with the average age being 15.62 …

Representing Parents With Severe Mental Illness In Child Welfare Cases, Joshua B. Kay

Articles

Parents with severe mental illness are at greater risk than others of becoming involved in the child protection system, and their cases are more likely than others to result in termination of parental rights. Among women with severe mental illness, 26-75% lose custody to one or more of their children, rates far higher than for women without mental illness. Lawyers who represent mentally ill parents in child protection matters face a number of challenges, including maintaining a productive attorney-client relationship, advocating for appropriate services and reasonable accommodations for their clients’ disabilities, and refuting assumptions about their clients’ parenting abilities that …

Qualitative Inquiry Into Church-Based Assets For Hiv/Aids Prevention And Control: A Forum Focus Group Discussion Approach, Godwin N. Aja, Naomi N. Modeste, Susanne B. Montgomery

The Qualitative Report

Assets church members believed they needed to engage in effective HIV/AIDS prevention and control activities. We used the three-step forum focus group discussion (FFGD) methodology to elicit responses from 32 church leaders and lay members, representing five denominations in Aba, Nigeria. Concrete resources, health expertise, finances, institutional support, capacity building, and spiritual support connected to the collective interest of members were indicated as useful for church members to engage in HIV/AIDS prevention and control activities. Adequate planning and delivery of cost-effective, appropriate and sustainable health promotion programs require an understanding of perceived church-based assets.

Conversing Life: An Autoethnographic Construction, Christopher N. Hoelson, Rod Burton

The Qualitative Report

This autoethnography is a constructed account of a co-exploration into the nature and effects of a longitudinal dyadic conversation process from a relational constructionist perspective. The conversations, between me as participant autoethnographer and a co-participant, aimed at maximising personal learning for both. Through co-created contexts of mutual engagement and respectful presence, we were able to focus our learning on the spontaneous process and content of the conversations. The qualitative data were sampled purposively from diary entries summarizing the conversations which spanned a period of five years. The data were analysed into themes and together, with selected illustrative examples of significant …

Using Realist Synthesis To Develop An Evidence Base From An Identified Data Set On Enablers And Barriers For Alcohol And Drug Program Implementation, Barbara Hunter, Lynda Berends, Sarah Maclean

The Qualitative Report

The purpose of this paper is to show how “realist synthesis” methodology (Pawson, 2002) was adapted to review a large sample of community based projects addressing alcohol and drug use problems. Our study drew on a highly varied sample of 127 projects receiving funding from a national non-government organisation in Australia between 2002 and 2008. Open and pattern coding led to the identification of 10 barrier and nine enabler mechanisms influencing project implementation across the sample. Eight case studies (four demonstrating successful implementation; four demonstrating less than successful implementation) were used for depth exploration of these mechanisms. High level theories …

Grandparental Death: Through The Lens Of An Asian Child, Wing-Fu Lai

The Qualitative Report

Bereavement has been extensively studied over the years, yet scholarly work depicting, with the first-person perspective, the experience of childhood bereavement is severely lacking. The research question I set out to answer here is: What is it like as an Asian child to experience bereavement following grandparental death? As such, self-introspection was exercised, and this, together with the diaries and free writings generated at the time of my grandma’s death, was used as the basis for autoethnographic reflections. It is hoped that my story presented here can offer a psychological portrayal of an Asian child enduring grandparental death, and illuminate …