Digital Commons Network^™

Investigations Of Oxidative Stress Effects And Their Mechanisms In Rat Brain After Systemic Administration Of Ceria Engineered Nanomaterials, Sarita S. Hardas

Theses and Dissertations--Chemistry

Advancing applications of engineered nanomaterials (ENM) in various fields create the opportunity for intended (e.g. drug and gene delivery) or unintended (e.g. occupational and environmental) exposure to ENM. However, the knowledge of ENM-toxicity is lagging behind their application development. Understanding the ENM hazard can help us to avoid potential human health problems associated with ENM applications as well as to increase their public acceptance. Ceria (cerium [Ce] oxide) ENM have many current and potential commercial applications. Beyond the traditional use of ceria as an abrasive, the scope of ceria ENM applications now extends into fuel cell manufacturing, diesel fuel additives …

Removal Of Arsenic(Iii) From Water With A New Solid-Supported Thiol, Partha Jana

Theses and Dissertations--Chemistry

Arsenic is a highly toxic, easily transportable and widespread contaminant in groundwater throughout the world. Arsenic causes acute toxicity by disrupting biological functions. In groundwater arsenic concentrations can reach up to a few milligrams per liter. Current regulations on arsenic content in drinking water are becoming more stringent and require the standard to be reduced to a few parts per billion. Arsenic exists as oxyanions in aqueous solution in either trivalent or pentavalent oxidation states depending on the oxidation-reduction potential and pH of the medium. Several treatment methods are available for removing arsenic from water. However, cost, operational complexity of …

Biosensing Systems For The Detection Of Bacterial Quorum Sensing Molecules: A Tool For Investigating Bacteria-Related Disorders And Food Spoilage Prevention, Nilesh G. Raut

Theses and Dissertations--Chemistry

Quorum sensing enables bacteria to communicate with bacteria of the same or different species, and to modulate their behavior in a cell-density dependent manner. Communication occurs by means of small quorum sensing signaling molecules (QSMs) whose concentration is proportional to the population size. When a QSM threshold concentration is reached, certain genes are expressed, thus allowing control of several processes, such as, virulence factor production, antibiotic production, and biofilm formation. Not only many pathogenic bacteria are known to produce QSMs, but also QSMs have been identified in some bacteria-related disorders. Therefore, quantitative detection of QSMs present in clinical samples may …

Region 11 Meld Na Exception Prospective Study, Robert A. Fisher, Douglas M. Heuman, Ann M. Harper, Martha K. Behnke, Alastair D. Smith, Mark W. Russo, Steven Zacks, John W. Mcgillicuddy, James Eason, Michael K. Porayko, Patrick Northup, Michael R. Marvin, Johnathan Hundley, Satheesh Nair

Surgery Faculty Publications

Introduction. Hyponatremia complicates cirrhosis and predicts short term mortality, including adverse outcomes before and after liver transplantation.

Material and methods. From April 1, 2008, through April 2, 2010, all adult candidates for primary liver transplantation with cirrhosis, listed in Region 11 with hyponatremia, were eligible for sodium (Na) exception.

Results. Patients with serum sodium (SNa) less than 130 mg/dL, measured two weeks apart and within 30 days of Model for End Stage Liver Disease (MELD) exception request, were given preapproved Na exception. MELD Na was calculated [MELD + 1.59 (135-SNa/30 days)]. MELD Na was capped at 22, and subject to …

Primary Closure Without Diversion In Management Of Operative Blunt Duodenal Trauma In Children, Katherine Smiley, Tiffany Wright, Sean Skinner, Joseph A. Iocono, John M. Draus

Surgery Faculty Publications

Background. Operative blunt duodenal trauma is rare in pediatric patients. Management is controversial with some recommending pyloric exclusion for complex cases. We hypothesized that primary closure without diversion may be safe even in complex (Grade II-III) injuries. Methods. A retrospective review of the American College of Surgeons' Trauma Center database for the years 2003-2011 was performed to identify operative blunt duodenal trauma at our Level 1 Pediatric Trauma Center. Inclusion criteria included ages < 14 years and duodenal injury requiring operative intervention. Duodenal hematomas not requiring intervention and other small bowel injuries were excluded. Results. A total of 3,283 hospital records were reviewed. Forty patients with operative hollow viscous injuries and seven with operative duodenal injuries were identified. …

Jefferson Alumni Bulletin – Volume 61, Number 1, Winter 2012

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Features:

• The Gift of Time for Patients with Advanced Bile Duct Cancer
• Celiac Disease: Overcoming a Stealth Public Health Menace
• Light Therapy for a Blue Planet and Beyond

Dfvf: Database Of Fungal Virulence Factors, Tao Lu, Bo Yao, Chi Zhang

School of Biological Sciences: Faculty Publications

Fungal pathogens cause various diseases for plant and animal hosts. Despite the extensive impact of fungi on human health and life, the threats posed by emerging fungal pathogens are poorly understood. Specifically, there exist few fungal virulence gene databases, which prevent effective bioinformatics studies on fungal pathogens. Therefore, we constructed a comprehensive online database of known fungal virulence factors, which collected 2058 pathogenic genes produced by 228 fungal strains from 85 genera. This database creates a pivotal platform capable of stimulating and facilitating further bench studies on fungal pathogens.

Novel Design Of Functionalized Carbon Nanotube Electrodes And Membranes For Fuel Cells And Energy Storage, Xin Su

Theses and Dissertations--Chemical and Materials Engineering

A novel electrochemical method to generate nm-scale bubbles at the tips of CNTs can temporarily block the membrane. A 92% blocking efficiency is achieved when the bubbles are stabilized in 30-60 nm diameter „wells‟ at the tips of CNTs. This well is formed by the electrochemical oxidation of the conductive CNTs partially into the polymer matrix of the membrane. Meanwhile, the nanoscale bubbles can be removed with 0.004 atm pressure to recover the transport through the CNT membrane. The CNT membrane with nanoscale bubble valve system was used to demonstrate electrochemical energy storage.

Uniform ultrathin Pt films were electrodeposited onto …

Protein Based Biomimetic Approachs To Surface Hemocompatibility And Biocompatibility Enhancement, Matthew Thomas Dickerson

Theses and Dissertations--Chemical and Materials Engineering

T. pallidum can survive a primary immune response and continue growing in the host for an extended period of time. T. pallidum is thought to bind serum fibronectin (FN) through Tp0483 on the surface to obscure antigens. A Tp0483 fragment (rTp0483) was adsorbed onto functionalized self-assembled monolayers (SAMs) with FN. FN capture by adsorbed rTp0483 depended greatly on surface chemistry with COO- groups being best for FN binding. Hemocompatibility was determined by analysis of plasma protein adsorption, intrinsic pathway activation, and platelet activation. rTp0483+FN bound an equal or lesser amount of fibrinogen (Fg), human serum albumin (HSA), and factor XII …

Effect Of Ionic Surfactants On Electrostatic Charging Of Spray Droplets, Mark T. Warren

Theses and Dissertations--Chemical and Materials Engineering

Dust capture for small coal particles (<2.5µm) can be improved if one takes advantage of electrostatic charges that resides on the surface of coal dust particles and on the surface of water spray droplets used to capture coal dust. Traditional dust capture methods that use water sprays are ineffective in capturing small dust particles since the motion of small dust particles is governed by electrostatic forces. If additives such as ionic surfactants could be added to water that would enhance the surface charge on water spray droplets, dust capture with water sprays could be improved.

The results presented show that n-sodium octyl sulfate causes the greatest charge enhancement versus the longer chained n-sodium dodecyl sulfate and n-sodium octadecyl sulfate. This can be explained by considering the factors that lead to droplet charge enhancement. Those factors are the mass of surfactant ions at the droplet surface, and the diffusion rate of the surfactant ions from the bulk droplet to the surface of the droplet. Sodium octyl sulfate will have a faster diffusion rate to the droplet surface because of its relatively short length, and will also maximize the mass …

Membrane Immobilized Reactive Fe/Pd Nanoparticles: Modeling And Tce Degradation Results, Ruo He

Theses and Dissertations--Chemical and Materials Engineering

Detoxification of chlorinated organic compound is an important and urgent issue in water remediation nowadays. Trichloroethylene (TCE), as a model compound in this study, has been proved to be degraded effectively by bimetallic nanoparticles (NPs) in solution phase. In this study, Fe/Pd bimetallic NPs were synthesized in poly (acrylic acid) (PAA) functionalized polyvinylidene fluoride (PVDF) microfiltration membranes. TCE dechlorination with these bimetallic NPs was conducted under different pH values and different metal loadings to study the role of corrosion on reaction rates.

One-dimensional mathematical model with pseudo first-order reaction kinetic was introduced to discuss the TCE dechlorination profile in membrane …

Study Of Characterization Of Submicron Coal Particles Dispersed In Air And Capture Of Coal Particles By Water Drops In A Scrubbing Column, Utshab Chakravorty

Theses and Dissertations--Chemical and Materials Engineering

Present day water spray based dust removal technologies do not effectively remove respirable submicron coal and silica dust particles in the underground coal mines causing Coal worker’s pneumoconiosis (CWP). The objective of this research was to study the electrostatic charges present in the airborne coal dust in order to develop efficient water spraying based dust removal technology where water drops charged using ionic compounds and surfactants would be used to capture the oppositely charged coal particles. In an experimental scrubbing column, coal particles dispersed in an air stream by a Fluidized Bed Aerosol Generator were captured by water drops sprayed …

Leptin Promotes Glioblastoma , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn

Journal Articles

The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models …

Course Schedule Spring 2012, William & Mary Law School

Course Information

No abstract provided.

Comparison Of Physical Fitness Levels Among Girls In Child Welfare And School Children Aged 7-9 Years, Wanwisa Sudsatiantanon, Suthep Srimuengkaew, Tatcha Paktapa, Kedsara Rakpongsiri

Asian Medical Journal and Alternative Medicine

Children with a good physical fi tness affect to their ability to perform physical activities and well-being of children in the future. Previous studies found that environmental and lifestyle patterns have different effects on physical fi tness.This study to compare physical fitness among girls in child welfare and school children aged 7-9 years. Participants were 47 females of child welfare and 42 females of school children. Participants in this study receive a questionnaire, body mass index measurement and physical fi tness test. It found that sit & reach and standing broad jump test in school children were lower than child …

Treatment Of Trigeminal Neuralgia With Microvascular Decompression, Pree Nimmannitya

Asian Medical Journal and Alternative Medicine

Trigeminal neuralgia has been discovered for a very long time. In the past, medical technology and medical knowledge could not explain pathophysiology of these symptoms. The treatment has been the trials and errors for a long time until carbamazepine was discovered, which is nowaday still the first line drug for treatment and also the therapeutic diagnosis for trigeminal neuralgia. However carbamazepine's tolerance and side effect are still major problems. Patient diagnosed with trigeminal neuralgia has to suffer with their facial pain and their daily life, because the patient’s activity, such as talking, chewing, can cause a severe pain. This literature …

Present Knowledge In Nutrition For The Elderly, Nusiri Lerdvuthisopon

Asian Medical Journal and Alternative Medicine

Good nutrition determines the quality of life throughout life span. Adequate and balance energy and nutrients intake is the principle of good nutrition in the age. The aim of the review is also to verify and update the knowledge of nutrition in elderly in order to give the essential message that appropriate for the real practice in geriatrics. It pins point on how nutrition can prevent non-communicable chronic diseases, help to sustain biochemical homeostasis, ameliorate the chronic low-grade infl ammation, improve immunity and support the sex hormones imbalance during senescence.

Common Causes In Acute Scrotal Pain, Pat Saksirisampant, Patranuch Noppakulsatit

Asian Medical Journal and Alternative Medicine

Patients with acute scrotal pain can be categorized into 2 major groups, pain-predominant and swelling-predominant group.The pain-predominant group is a very crucial one, which is needed to be diagnosed and treated as quickly as possible. Delayed management may cause loss of testis. The most common conditions are testicular torsion, torsion of the testicular appendage and acute epididymitis. Managements are different in each disease. Testicular torsion is a true emergency condition requiring immediate operation otherwise the patient will lose his testis due to prolonged testicular ischemia. Torsion of the testicular appendage may be conservatively treated with medication, with operation or in …

The Granite, 2012, University Of New Hampshire

The Granite – Yearbook

The yearbook of the New Hampshire College of Agriculture and the Mechanic Arts, 1909-1922, the University of New Hampshire, 1923-

Does Memory Predict Decline In Activities Of Daily Living In Older Adults With Alzheimer's Disease?, Sarah West, Robert Mccue, Charles Golden

Archives of Assessment Psychology

As the prevalence of Alzheimer's disease (AD) increases, neuropsychologists will need to make accurate recommendations regarding cognitive and functional decline in these individuals. Since memory impairment is the hallmark of AD, this study examined whether auditory and visual memory could significantly predict deficits in self-care activities. Participants were older adults diagnosed with AD, who received a neuropsychological battery assessing their functional decline and memory. Of auditory memory measures, immediate auditory memory was significantly correlated with declines financial and medication management; none of the auditory memory measures were significantly correlated with declines in driving, dressing, grooming, or feeding abilities. Of the …

The Use Of The Alaskan Native Claims Settlement Act To Justify Disparate Treatment Of Alaska's Tribes, Natalie Landreth, Erin Dougherty

American Indian Law Review

No abstract provided.

Kiss The Ring, But Never Touch The Crown: How U.S. Policy Denies Indian Women Bodily Autonomy And The Save Native Women Act's Attempt To Reverse That Policy, Hossein Dabiri

American Indian Law Review

No abstract provided.

Tribal Membership And Indian Nationhood, Matthew L.M. Fletcher

American Indian Law Review

No abstract provided.

Regaining Control Over The Children: Reversing The Legacy Of Assimilative Policies In Education, Child Welfare, And Juvenile Justice That Targeted Native American Youth, Ryan Seelau

American Indian Law Review

No abstract provided.

Sword Or Submission? American Indian Natural Resource Claims Settlement Legislation, Benjamin A. Kahn

American Indian Law Review

No abstract provided.

Native American Graves Protection And Repatriation Act: Requiring Federal Recognition Digs Its Own Grave, Laura Ruth Talbert

American Indian Law Review

No abstract provided.

The Ball Is In Congress's Court: Contract Support Costs Following Ramah, James J. Linhardt

American Indian Law Review

No abstract provided.

Winner, Best Appellate Brief In The 2012 Native American Law Student Association Moot Court Competition, Jocelyn Jenks, Jacquelyn Amour Jampolsky

American Indian Law Review

No abstract provided.

Nothing As Practical As A Good Theory? The Theoretical Basis Of Hiv Prevention Interventions For Young People In Sub-Saharan Africa: A Systematic Review, Kristien Michielsen, Matthew Chersich, Marleen Temmerman, Tessa Dooms, Ronan Van Rossem

Obstetrics and Gynaecology, East Africa

This paper assesses the extent to which HIV prevention interventions for young people in sub-Saharan Africa are grounded in theory and if theory-based interventions are more effective. Three databases were searched for evaluation studies of HIV prevention interventions for youth. Additional articles were identified on websites of international organisations and through searching references. 34 interventions were included; 25 mentioned the use of theory. Social Cognitive Theory was most prominent (n = 13), followed by Health Belief Model (n = 7), and Theory of Reasoned Action/Planned Behaviour (n = 6). These cognitive behavioural theories assume that cognitions drive sexual behaviour. Reporting …

Sexual Coercion Among In-School Adolescents In Rwanda: Prevalence And Correlates Of Victimization And Normative Acceptance, Els Van Decraen, Kristien Michielsen, Sarah Herbots, Ronan Van Rossem, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Adolescents are particularly vulnerable to sexual coercion, as victim as well as perpetrator. This paper aims to adapt sexual and reproductive health interventions to the reality of young people’s sexuality and relationships. This study assesses the prevalence of forced sex, characteristics of victims and norms regarding sexual coercion among Rwandan adolescents. A survey was completed by 285 senior secondary school students and four focus groups were conducted. Of sexually active respondents, 15.5% (95% CI = [15.1 – 15.9]) reported forced sexual intercourse. Sexual victimization was associated with being female and having (had) a concurrent sexual relationship. Acceptance of sexual coercion …