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2012

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Development And Content Validity Of The Military Concussion Readiness Inventory For Service Members, Michelle L. Gutierrez Jan 2012

Development And Content Validity Of The Military Concussion Readiness Inventory For Service Members, Michelle L. Gutierrez

All ETDs from UAB

The aim of this study was to develop and establish content validity of a new questionnaire entitled the Military Concussion Readiness Inventory (MCRI). The MCRI was designed to identify functional impairments and predict readiness for return-to-duty in service members (SM) who experienced mild traumatic brain injury (mTBI) due to a blast. The items on the MCRI were linked to the The International Classification of Functioning, Disability and Health (ICF) classifications. Nineteen male SM participated in a nominal group technique process to generate items for the MCRI. The items were classified according to the ICF before sending items to the Delphi …

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Hcn Channels And Regulation Of Neocortical Network Activity, Asher Albertson Jan 2012

Hcn Channels And Regulation Of Neocortical Network Activity, Asher Albertson

All ETDs from UAB

Hyperpolarization activated non-specifc cation (HCN) channels are unique channels that activate following membrane hyperpolarization. Expressed primarily along the apical dendrites of pyramidal neurons, they pass a non-inactivating, inward current (Ih). HCN channel activation at resting membrane potentials profoundly impacts the synaptic and intrinsic properties of pyramidal neurons. Activated channels decrease intrinsic membrane excitability, hyperpolarize the resting membrane potential, and increase excitatory post-synaptic potentials (EPSP) summation. Loss of HCN channels is commonly observed in models of epilepsy. This dissertation tests the hypothesis that the influence of HCN channels on individual neuron excitability translates to an influence on network excitability. Furthermore, we …

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Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint Jan 2012

Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint

All ETDs from UAB

Since the initial report identifying mutations in GFAP as the primary genetic defect in the astrogliopathy Alexander Disease (AxD) much progress has been made in elucidating the molecular details underpinning the pathogenic role of mutant GFAP in astrocytes. In particular, data collected from mouse, fly, and cell culture models of AxD have isolated several prominent cellular changes that are associated with mutant GFAP expression including oxidative stress, proteasome inhibition, reduced expression of the astrocyte glutamate transporter GLT-1, and loss of neurons; these models have also successfully recapitulated the pathological hallmark of AxD--protein aggregates known as Rosenthal fibers (RFs). To date, …

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Modulation Of Wzy-Dependent Capsule Production In Streptococcus Pneumoniae By The Phosphotyrosine-Specific Phosphatase Cpsb, Kimball Aaron Geno Jan 2012

Modulation Of Wzy-Dependent Capsule Production In Streptococcus Pneumoniae By The Phosphotyrosine-Specific Phosphatase Cpsb, Kimball Aaron Geno

All ETDs from UAB

Biosynthesis of capsule polysaccharide in the Gram-positive pathogen Streptococcus pneumoniae is regulated in part through the action of a phosphoregulatory system comprised of the products of the capsule biosynthetic operon genes cpsBCD. CpsC and CpsD together comprise an autophosphorylating tyrosine kinase whose homologs are implicated in chain length regulation in other systems in both Gram-positive and Gram-negative organisms. CpsB is the cognate phosphatase for the system. Unlike Gram-negative organisms, which use a low molecular weight phosphotyrosine phosphatase in phosphoregulation of capsule synthesis, Gram-positive organisms utilize a polymerase and histidinol phosphatase (PHP) superfamily phosphatase. Deletion of cpsB has resulted in conflicting …

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Trajectories Of Depressive Symptoms And Illicit Drug Use: Longitudinal Temporal Associations And Comorbidity In A Community Sample Of Adults, Yulia Khodneva Jan 2012

Trajectories Of Depressive Symptoms And Illicit Drug Use: Longitudinal Temporal Associations And Comorbidity In A Community Sample Of Adults, Yulia Khodneva

All ETDs from UAB

Cross-sectional studies of the community and treatment samples suggest substantial comorbidity between depression and illicit drug use disorders. Controversy exists whether such pattern of comorbidity is seen among drug using behaviors and depressive symptoms that fall short of the DSM-IV criteria for a clinical disorder. This dissertation research applied principles of the life course perspective and trajectory modeling to describe heterogeneity and comorbidity of subthreshold depressive symptoms with opioid, cocaine and amphetamine use in middle age. Secondary analysis of community-dwelling adults from the Coronary Artery Risk Development in Young Adults (CARDIA) study was performed. The CARDIA cohort, N=5115 at inception …

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Histomorphometry And Quantitative Analysis Of Longer-Term Implant Interfaces, Dave Darko Kojic Jan 2012

Histomorphometry And Quantitative Analysis Of Longer-Term Implant Interfaces, Dave Darko Kojic

All ETDs from UAB

Objective: This investigation was to evaluate (>10 year) bone response around custom (HA plasma coated) dental implants and HA particulate. Materials and Methods: Three individual post mortem mandibular COI Implants with surrounding bone were processed at six transverse locations to obtain non-decalcified ground sections (20-80µm)(n=36) and stained initially with methylene blue/basic fuchsin. Slides were evaluated to select (n= 8) slides for regions of interest along the perimeter of the implant, using optical microscopy (Olympus BX51 microscope) with a Retiga EXi color digital camera (Olympus, Center Valley, PA) and Bioquant VR software (R&M Biometrics, Nashville, TN) at an original magnification …

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An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee Jan 2012

An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee

All ETDs from UAB

Pre-diabetes is a major contributor to increased morbidity and mortality in the US. Without proper and timely intervention the majority of individuals with pre-diabetes will develop Type 2 diabetes. African Americans (AA) and people living in the Stroke Belt have increased odds of developing pre-diabetes compared to Whites and people living outside the Stroke Belt. While several covariates have been identified as contributors to the increased odds of pre-diabetes there is little consensus on which covariates may be responsible for the disparities of pre-diabetes. The reasons for disparities in pre-diabetes are complex and require further investigation. This study explored the …

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The Influence Of Microscale Heterogeneity Of The Collagen Network Of Healthy Rabbit Ventricular Subepicardium On Action Potential Propagation And Interstitial Potential Distributions, Claire Elizabeth Bourgeois Jan 2012

The Influence Of Microscale Heterogeneity Of The Collagen Network Of Healthy Rabbit Ventricular Subepicardium On Action Potential Propagation And Interstitial Potential Distributions, Claire Elizabeth Bourgeois

All ETDs from UAB

The goal of the present study was to identify the microstructural variability in myocyte orientation and in the arrangement of the collagen network to explore the interstitial compartment's contribution to discontinuous propagation. Microstructural data was obtained from healthy rabbit ventricular subepicardium through a sequence of image processing steps. Collagen quantity was measured in successive serial sections using established histological techniques. Binary 2D maps of collagen quantity were obtained from each section as a difference of images acquired under (i) brightfield illumination with a rhodamine filter and (ii) polarized illumination. Images were then registered by x-y translation and rotation to align …

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A Phenomenological Study Of Obesity And Its Impact On Functional Status, Life-Space Mobility, And Physical Activity In Southern African American Older Women, Pamela G. Bowen Jan 2012

A Phenomenological Study Of Obesity And Its Impact On Functional Status, Life-Space Mobility, And Physical Activity In Southern African American Older Women, Pamela G. Bowen

All ETDs from UAB

The majority of work on health disparities has focused on public policy and identifying disparate conditions. Obesity is a significant public health problem that has reached epidemic proportions, considered the second leading cause of preventable death, encourages a sedentary lifestyle, and can lead to a higher prevalence of functional impairments. Moreover, obesity increases the risk that persons may develop one or more serious medical conditions, such as cardiovascular disease, hypertension, stroke, Type 2 diabetes, and osteoarthritis, especially among African Americans. In the United States, African American women are more likely to be classified as overweight or obese. In fact, approximately …

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The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand Jan 2012

The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand

All ETDs from UAB

Environmental ozone exposure remains a major public health concern with over one-third of the United States population experiencing unhealthful levels. Epidemiological studies indicate exposure increases morbidity in those with pre-existing disease such as asthma, though the biological mechanisms underlying this phenomenon remain elusive. CD11c+ cells within the respiratory tract include dendritic cells (DCs), which are the most efficient antigen presenters and play major roles controlling immune responses. In addition, DCs are thought necessary for asthma pathogenesis and exacerbation. Therefore the link between ozone associated asthma morbidity may be DCs. We hypothesize ozone exposure may site specifically alter DC phenotypes, numbers, …

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The Relationship Between Hospitalists And Primary Care Physicians, James Robert Burkhart Jan 2012

The Relationship Between Hospitalists And Primary Care Physicians, James Robert Burkhart

All ETDs from UAB

THE RELATIONSHIP BETWEEN HOSPITALISTS AND PRIMARY CARE PHYSICIANS JAMES R. BURKHART EXECUTIVE DOCTOR OF SCIENCE IN ADMINISTRATION-HEALTH SERVICES ABSTRACT A study of the relationship between primary care physicians (PCPs) and hospitalists was conducted by surveying the Florida Academy of Family Physicians (FAFP) membership to determine whether they had an established relationship with a hospitalist or hospitalist group. The survey responses were then matched with Blue Cross and Blue Shield of Florida (BCBSF) administrative claims data to provide two groupings of study respondents with data regarding patients' average length-of-stay, average 30 day readmission rate, and average hospital claims payment. The survey …

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Effects Of Mobile Internet Use On College Student Pedestrian Injury Risk, Katherine Walker Byington Jan 2012

Effects Of Mobile Internet Use On College Student Pedestrian Injury Risk, Katherine Walker Byington

All ETDs from UAB

Unintentional pedestrian injury is a leading cause of death in the United States. Given the complexity of accurately judging the safety of a street crossing, the task likely becomes even more challenging when pedestrians become distracted by attempting to multitask. Newly introduced cell phone functionalities such as mobile internet may introduce distraction that goes beyond the basic cognitive demand of a phone conversation or even text messaging, both of which distract pedestrians and increase unsafe behavior. The present study examined participants' pedestrian behavior while distracted by mobile internet applications. In addition, we aimed to explore college students' perceptions of the …

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Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix Jan 2012

Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix

All ETDs from UAB

The facultative pathogen Streptococcus pneumoniae is capable of producing a polysaccharide (PS) capsule that prevents bacterial recognition and clearance by the host immune system. Over 90 antigenically distinct capsule serotypes have been identified. Because anti-capsule antibodies can mediate bacterial clearance, capsule diversity is critical to S. pneumoniae survival. However, the mechanisms of capsule evolution remain unclear. Due to the complex interaction of capsule synthesis (cps) genes, it is commonly thought that pneumococcal serotypes evolve once and that all clinically relevant serotypes are genetically derived from a single founding clone. In this dissertation we demonstrate a novel mechanism of capsule evolution …

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Cytokine Signaling In A Mouse Model Of Parkinson's Disease, Shuwen Cao Jan 2012

Cytokine Signaling In A Mouse Model Of Parkinson's Disease, Shuwen Cao

All ETDs from UAB

The protein alpha-synuclein (α-SYN), which is found in the Lewy bodies of dopaminergic (DA) neurons in the substantia nigra (SN), has an important role in the pathogenesis of Parkinson's disease (PD). Fcγ receptors (FcγR) are proteins present on the surface of microglia, which bind immunoglobulin G (IgG) and other ligands. Our studies in an AAV-synuclein mouse model of PD showed that over-abundance of α-SYN triggered the expression of NF-κB p65, and led to microglial activation and DA neurodegeneration; however, in mice deficient of gamma chain subunit of the Fc receptors (FcγR-/- mice), α-SYN-induced NF-κB signaling was blocked, while microglial activation …

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Identifying The Common Characteristics Of Comprehensive School Physical Activity Programs In Louisiana, Kyrie’ A. Deslatte Jan 2012

Identifying The Common Characteristics Of Comprehensive School Physical Activity Programs In Louisiana, Kyrie’ A. Deslatte

Honors Capstones

No abstract provided.

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Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa Jan 2012

Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa

All ETDs from UAB

A precise molecular identification of transmitted/founder (T/F) HIV-1 genomes responsible for productive infection in humans can be an enabling strategy for elucidating mechanisms of virus transmission, immunopathogenesis and prevention. Previously, we reported a single genome sequencing approach, which when combined with a mathematical model of early random virus diversification, allowed for an unambiguous identification of T/F HIV-1 subtype B and C envelope (env) genes. Here, we apply this method to the identification and molecular cloning of full-length HIV-1 genomes and env genes of the less well-studied, but nonetheless important, HIV-1 subtypes A and D. Twelve subtype A (n=5), D (n=5) …

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Monitoring Arm Use In Daily Life Via Rfid Tracking Of Household Objects, Joydip Barman Jan 2012

Monitoring Arm Use In Daily Life Via Rfid Tracking Of Household Objects, Joydip Barman

All ETDs from UAB

After stroke, capacity to complete tasks in the treatment setting with the moreaffected arm is an unreliable index of actual use of that extremity in daily life. Available objective methods for monitoring real-world arm use rely on placing movement sensors on patients. These methods provide information on amount but not type of arm activity, e.g., functional vs. nonfunctional movement. This paper presents an approach that places sensors on patients and household objects, overcoming this limitation. An accelerometer and the transmitter component of a radio-frequency proximity sensor are attached to objects; the receiver component is attached to the arm of interest. …

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A Pilot Study To Determine The Effectiveness Of Bioelectrical Impedance Analysis As A Clinical Assessment Tool Of Nutrition Status In Glioblastoma Multiforme Patients (The Beam Study [Bia Effectiveness As Assessment Tool For Gbm Patients]), Rebecca V. Barnhill Jan 2012

A Pilot Study To Determine The Effectiveness Of Bioelectrical Impedance Analysis As A Clinical Assessment Tool Of Nutrition Status In Glioblastoma Multiforme Patients (The Beam Study [Bia Effectiveness As Assessment Tool For Gbm Patients]), Rebecca V. Barnhill

All ETDs from UAB

Glioblastoma multiforme (GBM) is a rare brain tumor, yet accounts for 80% of malignant brain tumors and has a five-year survival rate of < 5%. Few studies have evaluated nutrition recommendations and outcomes of this disease, including caloric needs. The purpose of this study was to find the best predictive equation for resting energy expenditure (REE) for GBM patients and evaluate bioelectrical impedance analysis (BIA) as a clinical tool for estimating REE and fat free mass (FFM) of GBM patients. REE was measured with indirect calorimetry. FFM was measured with DXA and estimated with BIA. Published predictive equations for REE were calculated to compare to measured REE. Six equations used variables easily attained in a clinical setting and three used FFM. Correlation analysis was used to evaluate the strength of the relationships between measured and predicted REE. Agreement between methods on the group level was assessed by comparing the group means of measured and predicted REE with paired t-tests. The Bland-Altman approach was used to find agreement between the methods on the individual level. Analysis included fifteen newly diagnosed GBM patients (7 male and 8 female; mean age 57.1±11.6 years) to evaluate equations using clinical variables and a subsample of eight to evaluate predictive equations using FFM. All the predictive equations overestimated measured REE. The Mifflin-St Jeor was the only equation using clinical variables which was not significantly different from measured REE (p=0.054) and had the lowest bias (73 kcal/day) and narrowest limits of agreement. Likewise, Cunningham and Wang equations using FFM from DXA were not significantly different from measured (p=0.261 and p=0.072, respectively). BIA overestimated FFM compared to DXA, 54.1 kg and 49.2 kg, respectively (p<0.001). More visits with both DXA and BIA measurements available are needed before predictive equations with clinical variables and predictive equations with FFM can be compared. Due to the ease of obtaining clinical variables and the low bias and narrow limits of agreement found for the Mifflin equation, at this time it appears to be the best predictive equation for individuals with GBM.

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Examination Of Urban High School Dropouts With High Self-Efficacy: A Phenomenological Study, Ronald Bayles Jan 2012

Examination Of Urban High School Dropouts With High Self-Efficacy: A Phenomenological Study, Ronald Bayles

All ETDs from UAB

The purpose of this study was to explore the lived experience of urban students in Central Alabama with high self-efficacy who have dropped out of school to pursue a GED. This study: (a) provided a platform that gave voice to students to share their lived experience as they made the decision to drop out of high school, (b) identified the character traits of students with high self-efficacy, and (c) revealed the essence of what motivated students to move to resilience after appearing to give up. A qualitative research design was used. The phenomenological approach provided the opportunity for participants to …

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A Histologic And Radiologic Analysis Of Bone Formation Under The Elevated Maxillary Sinus Using Venous Coagulum As The Sole Filling Material, Kathleen Ann Beaudry Jan 2012

A Histologic And Radiologic Analysis Of Bone Formation Under The Elevated Maxillary Sinus Using Venous Coagulum As The Sole Filling Material, Kathleen Ann Beaudry

All ETDs from UAB

Insufficient bone height is a common obstacle to placing dental implants in the posterior maxilla. Sinus lift procedures using various grafting materials have been shown to be a highly predictable way to increase bone height in the posterior maxilla (Jensen 1998). Given the wide range of materials that have proven successful in augmenting the sinus, the argument could be made that the presence of graft is not critical. Instead, the creation and maintenance of space, provided by two implants, along with the osteoinductive properties of the membrane, the periosteum, and growth factors provided by a blood clot are the only …

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Internet Use, Social Integration, And Psychological Well-Being In Older Adults, Ronald William Berkowsky Jan 2012

Internet Use, Social Integration, And Psychological Well-Being In Older Adults, Ronald William Berkowsky

All ETDs from UAB

Previous studies examining the relationship between information and communication technologies (ICTs) and mental health provide conflicting evidence regarding the possible benefits and detriments of ICT use on mental well-being. While ICTs may enhance social cohesion and motivate individuals to engage in new communication methods to strengthen social bonds and develop new social relationships, ICTs may also motivate individuals to retreat from the real world into a virtual one, thus severing established social ties. These positive and negative changes in social integration can have significant effects on mental health, as research has shown that social relationships and social engagement can drastically …

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Full Scale Calcium Bromide Injection With Subsequent Mercury Oxidation And Removal Within Wet Flue Gas Desulphurization System: Experience At A 700 Mw Coal-Fired Power Facility, Mark Simpson Berry Jan 2012

Full Scale Calcium Bromide Injection With Subsequent Mercury Oxidation And Removal Within Wet Flue Gas Desulphurization System: Experience At A 700 Mw Coal-Fired Power Facility, Mark Simpson Berry

All ETDs from UAB

The Environmental Protection Agency promulgated the Mercury and Air Toxics Standards rule, which requires that existing power plants reduce mercury emissions to meet an emission rate of 1.2 lb/TBtu on a 30-day rolling average and that new plants meet a 0.0002 lb/GWHr emission rate. This translates to mercury removals greater than 90% for existing units and greater than 99% for new units. Current state-of-the-art technology for the control of mercury emissions uses activated carbon injected upstream of a fabric filter, a costly proposition. For example, a fabric filter, if not already available, would require a $200M capital investment for a …

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Sonication Treatment Of Diesel Fuel Laden Sump Water, Roxanne E. Bessette Jan 2012

Sonication Treatment Of Diesel Fuel Laden Sump Water, Roxanne E. Bessette

All ETDs from UAB

Diesel engines are the work horses of industry and transportation. Pervasive diesel fuel use impacts stormwater, by increasing petroleum releases to surface waters. Sump containment of diesel-adulterated stormwater commonly keeps diesel from contacting surface waters. Once contained, the quandary lies in effective stormwater treatment that allows discharges within the local watershed. On-site treatment of diesel sump water ordinarily involves gravity oil-water separation technologies. These technologies' treatment times range from hours to days. Commonly, they cannot meet National Pollution Discharge Elimination System (NPDES) stormwater discharge standards for oil and grease because they best remove `free' oil not commonly occurring emulsions. Oil-water …

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Inclusion Of Tennis In Elementary And Middle School Physical Education Class Curricula, Antonia Wallis Nugent Jan 2012

Inclusion Of Tennis In Elementary And Middle School Physical Education Class Curricula, Antonia Wallis Nugent

All ETDs from UAB

Introduction: Childhood obesity and physical inactivity are two major health issues in the United States linked to several life threatening diseases. Because of a general lack of physical activity (PA) stemming from a sedentary lifestyle at an early age, it is critical that we provide children with a solid foundation of PA to carry into adulthood. Undoubtedly, school is the best place for instruction. Tennis is a unique sport that can be utilized to increase wellbeing in youth as it offers an abundance of health benefits as well as mental and social benefits. Research regarding tennis integration into physical education …

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Memory Profiles In Amnestic Mild Cognitive Impairment And Their Associations With Other Cognitive Domains And Functional Abilities, Timothy J. O'Brien Jan 2012

Memory Profiles In Amnestic Mild Cognitive Impairment And Their Associations With Other Cognitive Domains And Functional Abilities, Timothy J. O'Brien

All ETDs from UAB

Mild Cognitive Impairment (MCI) is thought to represent the preclinical stage of Alzheimer's disease. Current criteria for amnestic-MCI do not specify the nature of memory impairments, which could be in learning or retrieval of information in verbal or visual domains. While 1.5 standard deviations (SD) below normative samples has been accepted to define cognitive impairment, this standard may be relatively stringent, or may lack specificity to identify mild functional impairment. Baseline data for 71 individuals with consensus-diagnosed MCI enrolled in the Measuring Independent Living in the Elderly Study (MILES) was utilized to investigate patterns of verbal and visual learning and …

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Do I Belong? Factors Contributing To The Development Of Social Belonging Of Children Who Are Homeless In Southeastern United States Shelters: A Multi-Case Study, Corilyn Mae Ott Jan 2012

Do I Belong? Factors Contributing To The Development Of Social Belonging Of Children Who Are Homeless In Southeastern United States Shelters: A Multi-Case Study, Corilyn Mae Ott

All ETDs from UAB

This qualitative multiple case study explored the factors that contribute to the development of social belonging in the classroom for children who are homeless age's five to seven. Previous empirical research has shown the importance of children who are homeless developing belonging in the classroom and other research has shown the negative effects when belonging does not develop. However, little research has focused on what contributes or impedes children's ability to develop belonging in the classroom while they are homeless. My study filled a gap in the literature by identifying these contributing factors. This study was conducted in two family …

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Cardiovascular Disease Knowledge And Risk Perception Among Women With Recent Preeclampsia: Interventional Education In Disease Management And Prevention, Patsy M. Spratling Jan 2012

Cardiovascular Disease Knowledge And Risk Perception Among Women With Recent Preeclampsia: Interventional Education In Disease Management And Prevention, Patsy M. Spratling

All ETDs from UAB

There is a growing body of evidence linking preeclampsia to future development of cardiovascular disease (CVD). Although CVD is well-known as the leading cause of death in women, a lack of evidence exists demonstrating that women with preeclampsia are routinely informed of their risks for future CVD. The specific aims of this study were to: (1) examine the levels of CVD knowledge and perception of CVD risk pre-CVD education; (2) explore relationships among age, race, parity, marital status, previous preeclampsia, income, education, CVD knowledge, and perception of CVD risk; and (3) examine the effect of a postpartum CVD educational intervention …

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A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger Jan 2012

A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger

All ETDs from UAB

Parkinson's Disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. Gene multiplication of alpha-synuclein causes an autosomal dominant inheritance pattern of PD. A mouse model overexpressing alpha-synuclein demonstrates some of the phenotype seen in PD. In a microarray of these mice, a downregulation of angiogenin was observed prior to symptom onset, demonstrating a potential link of angiogenin to pathology in this model. Angiogenin has also been associated with the onset of Amyotrophic Lateral Sclerosis (ALS), and is neuroprotective in models of ALS through activation of the Akt …

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The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein Jan 2012

The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein

All ETDs from UAB

In recent years, hydrogen sulfide (H2S) has been identified as a ubiquitous cell signaling molecule. In addition to its diverse physiological roles, H2S has emerged as a possible drug therapy, with a wide range of applications. Along with cytoprotective effects in pathological states such as ischemia-reperfusion injury, H2S has been shown to decrease aerobic metabolism in a reversible manner. This dissertation is focused on exploring H2S-induced hypometabolism and the implications therein for human health and disease. We have shown that rats exposed to 80 ppm H2S gas in combination with low oxygen (10.5% O2) for 6 hr exhibit decreases in …

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The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor Jan 2012

The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor

All ETDs from UAB

THE IMPACT OF COMMUNITY HEALTH CENTERS ON PROSTATE CANCER SCREENING BEHAVIORS OF AFRICAN AMERICAN MALES: A MIXED METHODS STUDY MICHAEL C. TAYLOR UAB SCHOOL OF PUBLIC HEALTH DEPARTMENT OF HEALTH BEHAVIOR ABSTRACT Federally qualified community health centers have a significant impact upon uninsured and low income populations in the United States by providing low cost primary care and preventive services. The purpose of this mixed methods study was to determine the impact of community health centers (CHCs) on African American males' prostate cancer screening behavior in a major Southern city. A sequential explanatory mixed method model was used to assess …

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